Q97X26 - SULSO - GREMLIN Contacts

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Q97X26 - Transposase ISC1190

UniProt:	Q97X26	Sequences: MEAPVAGIDVSKDKLIVYFQGKLYEFTNDRQGFEEIRKILPSGCKVGIESTGVYHVNLAKYLNNEYDVRIINPFILKKFKGFRGKKSDKNDAKKLAEIVVSMGSGFVTSDARELTSQWDFVIRSIARVKNRLRRDLVLLGYRDSLSKKNLEEVLRGGGDSVVLSEVRFLLEELERLEGRKREIEKELEDFVPKDSLIFTIPGIGKTLGCIILARVGDVRRFSDKKRFVAYCGLDPVVESSGKSVVSRGISKRGDAVLRRAFYLAALTAIKVNLIIKRFYEEHKGRLRGKKLIVACARKLAVITWAVLYYNKPFDASE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	317 (308)
Sequences:	4472 (3400)
Seq/√Len:	193.8

SULSO - Q97X26 Q97Y59 Q97WC0 Q97VS0 Q97WZ5 Q97ZN4 Q97X07 Q97XK2 Q97UF7 Q97X12 Q97X29 Q97UQ6 Q97YE1 Q97XM7 Q97UU8 Q97VB2 Q97Y06 Q97Z62 Q97XR9 Q97WY7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
47_G	99_V	4.485	1.00
125_I	177_E	3.147	1.00
18_Y	92_A	2.913	1.00
196_L	312_P	2.829	1.00
164_S	186_E	2.822	1.00
282_H	285_R	2.710	1.00
227_F	300_A	2.668	1.00
168_F	179_R	2.457	1.00
76_L	95_L	2.386	1.00
124_S	127_R	2.368	1.00
215_V	227_F	2.337	1.00
171_E	179_R	2.249	1.00
47_G	95_L	2.198	1.00
118_W	122_I	2.184	1.00
231_C	257_L	2.182	1.00
46_V	66_Y	2.152	1.00
211_I	303_T	2.142	1.00
199_T	312_P	2.139	1.00
8_I	36_I	2.106	1.00
222_S	226_R	2.079	1.00
249_I	293_V	2.053	1.00
276_K	280_E	2.040	1.00
87_S	237_V	2.030	1.00
297_R	301_V	2.027	1.00
125_I	180_K	1.979	1.00
203_I	208_G	1.944	1.00
223_D	226_R	1.938	1.00
196_L	306_V	1.926	1.00
14_K	25_E	1.920	1.00
124_S	131_R	1.914	1.00
175_R	179_R	1.893	1.00
118_W	184_E	1.854	1.00
287_R	290_K	1.851	1.00
119_D	259_R	1.832	1.00
239_S	244_V	1.814	1.00
221_F	230_Y	1.806	1.00
126_A	130_N	1.803	1.00
132_L	173_L	1.800	1.00
6_A	19_F	1.799	1.00
200_I	303_T	1.772	1.00
116_S	214_R	1.760	1.00
233_L	296_A	1.735	1.00
186_E	189_D	1.692	1.00
124_S	172_E	1.682	1.00
121_V	180_K	1.678	1.00
45_K	69_R	1.678	1.00
8_I	15_L	1.676	1.00
172_E	175_R	1.668	1.00
197_I	303_T	1.667	1.00
306_V	312_P	1.651	1.00
231_C	300_A	1.647	1.00
286_L	290_K	1.633	1.00
146_S	149_N	1.622	1.00
172_E	179_R	1.620	1.00
210_I	260_A	1.616	1.00
125_I	173_L	1.609	1.00
48_I	68_V	1.609	1.00
154_L	158_G	1.595	1.00
281_E	285_R	1.576	1.00
196_L	199_T	1.562	1.00
143_D	153_V	1.544	1.00
207_L	260_A	1.529	1.00
305_A	309_Y	1.527	1.00
97_E	101_S	1.514	1.00
184_E	187_L	1.511	1.00
61_Y	64_N	1.509	1.00
11_S	16_I	1.508	1.00
275_I	302_I	1.492	1.00
147_K	151_E	1.473	1.00
122_I	125_I	1.456	1.00
122_I	180_K	1.456	1.00
263_L	266_L	1.452	1.00
279_Y	295_C	1.450	1.00
17_V	36_I	1.442	1.00
275_I	295_C	1.431	1.00
8_I	58_L	1.430	1.00
200_I	306_V	1.423	1.00
150_L	153_V	1.413	1.00
18_Y	93_K	1.401	1.00
16_I	25_E	1.395	1.00
280_E	284_G	1.388	1.00
154_L	157_G	1.387	1.00
269_I	279_Y	1.385	1.00
191_V	198_F	1.383	1.00
181_R	184_E	1.373	1.00
198_F	205_K	1.369	1.00
171_E	175_R	1.365	1.00
132_L	166_V	1.363	1.00
259_R	263_L	1.360	1.00
85_K	237_V	1.358	1.00
29_D	32_G	1.351	1.00
24_Y	39_I	1.351	1.00
118_W	206_T	1.343	1.00
13_D	242_K	1.298	1.00
273_L	277_R	1.297	1.00
265_A	296_A	1.279	1.00
278_F	298_K	1.275	1.00
48_I	59_A	1.263	1.00
173_L	177_E	1.261	1.00
265_A	299_L	1.261	1.00
171_E	178_G	1.252	1.00
40_L	46_V	1.252	1.00
304_W	308_Y	1.251	1.00
146_S	150_L	1.249	1.00
149_N	152_E	1.232	1.00
197_I	208_G	1.230	1.00
119_D	256_V	1.223	1.00
168_F	182_E	1.219	1.00
262_Y	296_A	1.218	1.00
189_D	193_K	1.214	1.00
146_S	157_G	1.211	1.00
214_R	254_D	1.209	1.00
228_V	297_R	1.209	1.00
149_N	153_V	1.202	1.00
203_I	207_L	1.201	1.00
283_K	288_G	1.190	1.00
155_R	158_G	1.188	1.00
123_R	127_R	1.184	1.00
265_A	295_C	1.183	1.00
228_V	234_D	1.181	1.00
120_F	131_R	1.178	1.00
47_G	71_I	1.175	1.00
279_Y	291_L	1.173	1.00
207_L	264_A	1.170	1.00
8_I	17_V	1.169	1.00
125_I	129_K	1.168	1.00
146_S	156_G	1.167	1.00
170_L	174_E	1.166	1.00
102_M	106_F	1.159	1.00
264_A	299_L	1.155	1.00
156_G	159_D	1.153	1.00
184_E	188_E	1.153	1.00
127_R	130_N	1.147	1.00
179_R	182_E	1.143	1.00
146_S	151_E	1.142	1.00
7_G	96_A	1.142	1.00
155_R	159_D	1.141	1.00
11_S	14_K	1.137	1.00
27_T	32_G	1.135	1.00
153_V	158_G	1.130	1.00
124_S	128_V	1.130	1.00
143_D	146_S	1.126	1.00
278_F	282_H	1.118	1.00
146_S	159_D	1.116	1.00
45_K	67_D	1.107	1.00
150_L	157_G	1.106	1.00
74_F	78_K	1.092	1.00
305_A	308_Y	1.090	1.00
16_I	23_L	1.085	1.00
6_A	46_V	1.084	1.00
200_I	299_L	1.083	1.00
262_Y	293_V	1.080	1.00
115_T	256_V	1.080	1.00
203_I	303_T	1.080	1.00
306_V	311_K	1.078	1.00
37_R	61_Y	1.076	1.00
282_H	291_L	1.073	1.00
151_E	158_G	1.070	1.00
128_V	131_R	1.065	1.00
6_A	40_L	1.062	1.00
153_V	156_G	1.056	1.00
148_K	151_E	1.048	1.00
118_W	180_K	1.048	1.00
151_E	159_D	1.046	1.00
152_E	156_G	1.046	1.00
117_Q	121_V	1.044	1.00
302_I	306_V	1.040	1.00
151_E	154_L	1.036	1.00
249_I	258_R	1.029	1.00
145_L	148_K	1.021	1.00
6_A	17_V	1.018	1.00
278_F	295_C	1.014	1.00
145_L	149_N	1.012	1.00
71_I	76_L	1.009	1.00
33_F	61_Y	1.002	1.00
278_F	294_A	1.002	1.00
114_L	183_I	1.000	1.00
33_F	57_N	1.000	1.00
197_I	307_L	0.993	1.00
146_S	153_V	0.992	1.00
151_E	155_R	0.992	1.00
12_K	137_V	0.991	1.00
148_K	152_E	0.986	0.99
55_H	70_I	0.984	0.99
23_L	93_K	0.980	0.99
32_G	35_E	0.977	0.99
218_V	307_L	0.976	0.99
177_E	181_R	0.976	0.99
46_V	62_L	0.974	0.99
93_K	97_E	0.972	0.99
188_E	205_K	0.969	0.99
128_V	132_L	0.968	0.99
175_R	178_G	0.966	0.99
153_V	157_G	0.966	0.99
86_K	91_D	0.965	0.99
17_V	39_I	0.958	0.99
262_Y	266_L	0.958	0.99
146_S	158_G	0.952	0.99
283_K	291_L	0.951	0.99
5_V	100_V	0.948	0.99
10_V	15_L	0.945	0.99
215_V	218_V	0.941	0.99
145_L	153_V	0.932	0.99
265_A	292_I	0.930	0.99
251_K	258_R	0.929	0.99
160_S	186_E	0.926	0.99
266_L	269_I	0.924	0.99
275_I	299_L	0.917	0.99
59_A	68_V	0.909	0.99
50_S	73_P	0.908	0.99
5_V	99_V	0.905	0.99
203_I	299_L	0.897	0.99
38_K	41_P	0.895	0.99
115_T	187_L	0.895	0.99
143_D	158_G	0.893	0.99
112_R	214_R	0.893	0.99
26_F	39_I	0.886	0.99
282_H	286_L	0.885	0.99
115_T	209_C	0.878	0.99
59_A	70_I	0.865	0.99
149_N	154_L	0.864	0.99
26_F	32_G	0.853	0.98
143_D	149_N	0.853	0.98
51_T	54_Y	0.846	0.98
261_F	300_A	0.845	0.98
36_I	40_L	0.842	0.98
147_K	154_L	0.833	0.98
282_H	287_R	0.826	0.98
95_L	98_I	0.821	0.98
168_F	186_E	0.820	0.98
122_I	126_A	0.820	0.98
144_S	156_G	0.817	0.98
289_K	292_I	0.816	0.98
262_Y	289_K	0.811	0.98
103_G	106_F	0.808	0.98
186_E	190_F	0.808	0.98
194_D	212_L	0.807	0.98
84_G	229_A	0.802	0.98
278_F	281_E	0.801	0.98
240_S	244_V	0.796	0.98
266_L	289_K	0.794	0.98
17_V	26_F	0.794	0.98
145_L	152_E	0.785	0.97
31_Q	35_E	0.784	0.97
150_L	158_G	0.783	0.97
223_D	304_W	0.782	0.97
178_G	182_E	0.781	0.97
163_L	167_R	0.774	0.97
281_E	284_G	0.774	0.97
15_L	28_N	0.774	0.97
129_K	173_L	0.772	0.97
144_S	149_N	0.772	0.97
165_E	168_F	0.769	0.97
147_K	150_L	0.768	0.97
230_Y	254_D	0.768	0.97
37_R	64_N	0.768	0.97
146_S	155_R	0.764	0.97
6_A	44_C	0.756	0.97
40_L	62_L	0.756	0.97
69_R	99_V	0.754	0.97
144_S	155_R	0.752	0.97
119_D	123_R	0.752	0.97
196_L	310_N	0.751	0.97
144_S	154_L	0.749	0.97
115_T	210_I	0.742	0.96
143_D	155_R	0.742	0.96
277_R	281_E	0.740	0.96
273_L	276_K	0.740	0.96
154_L	159_D	0.738	0.96
150_L	156_G	0.733	0.96
84_G	252_R	0.733	0.96
10_V	48_I	0.731	0.96
148_K	155_R	0.731	0.96
177_E	180_K	0.730	0.96
32_G	36_I	0.728	0.96
117_Q	168_F	0.726	0.96
269_I	283_K	0.722	0.96
128_V	173_L	0.719	0.96
293_V	296_A	0.717	0.96
102_M	105_G	0.716	0.96
50_S	70_I	0.715	0.96
122_I	184_E	0.715	0.96
16_I	89_K	0.714	0.96
11_S	15_L	0.714	0.96
263_L	289_K	0.714	0.96
143_D	150_L	0.710	0.95
146_S	154_L	0.709	0.95
7_G	92_A	0.707	0.95
226_R	229_A	0.706	0.95
176_L	179_R	0.704	0.95
169_L	172_E	0.702	0.95
266_L	296_A	0.697	0.95
145_L	150_L	0.695	0.95
271_V	276_K	0.694	0.95
143_D	159_D	0.693	0.95
149_N	158_G	0.693	0.95
168_F	172_E	0.692	0.95
274_I	313_F	0.691	0.95
73_P	214_R	0.691	0.95
43_G	67_D	0.690	0.95
79_F	98_I	0.687	0.94
236_V	250_S	0.686	0.94
58_L	62_L	0.684	0.94
144_S	148_K	0.684	0.94
145_L	155_R	0.683	0.94
234_D	250_S	0.682	0.94
149_N	157_G	0.682	0.94
164_S	175_R	0.680	0.94
128_V	176_L	0.678	0.94
121_V	183_I	0.677	0.94
237_V	244_V	0.676	0.94
303_T	306_V	0.676	0.94
15_L	26_F	0.674	0.94
214_R	256_V	0.674	0.94
128_V	169_L	0.673	0.94
191_V	209_C	0.670	0.94
30_R	34_E	0.670	0.94
287_R	291_L	0.666	0.94
150_L	159_D	0.664	0.93
145_L	158_G	0.663	0.93
290_K	294_A	0.663	0.93
164_S	167_R	0.662	0.93
117_Q	165_E	0.662	0.93
253_G	258_R	0.661	0.93
188_E	192_P	0.661	0.93
203_I	211_I	0.661	0.93
144_S	159_D	0.660	0.93
74_F	252_R	0.658	0.93
164_S	168_F	0.656	0.93
131_R	169_L	0.655	0.93
41_P	64_N	0.655	0.93
72_N	75_I	0.654	0.93
120_F	124_S	0.652	0.93
18_Y	96_A	0.649	0.93
32_G	39_I	0.649	0.93
145_L	156_G	0.648	0.93
234_D	251_K	0.646	0.92
239_S	245_V	0.646	0.92
153_V	159_D	0.646	0.92
266_L	292_I	0.646	0.92
45_K	99_V	0.645	0.92
71_I	98_I	0.644	0.92
145_L	154_L	0.641	0.92
88_D	240_S	0.641	0.92
162_V	165_E	0.641	0.92
7_G	62_L	0.641	0.92
143_D	147_K	0.638	0.92
161_V	164_S	0.637	0.92
211_I	257_L	0.635	0.92
200_I	203_I	0.634	0.92
11_S	241_G	0.634	0.92
198_F	208_G	0.633	0.92
151_E	156_G	0.632	0.92
174_E	178_G	0.632	0.92
268_A	275_I	0.631	0.92
146_S	152_E	0.631	0.92
117_Q	183_I	0.631	0.92
150_L	154_L	0.630	0.92
234_D	237_V	0.625	0.91
115_T	213_A	0.622	0.91
85_K	90_N	0.621	0.91
31_Q	39_I	0.620	0.91
182_E	186_E	0.620	0.91
43_G	66_Y	0.619	0.91
301_V	304_W	0.618	0.91
176_L	180_K	0.618	0.91
130_N	134_R	0.618	0.91
121_V	176_L	0.617	0.91
249_I	253_G	0.612	0.90
249_I	294_A	0.610	0.90
37_R	41_P	0.605	0.90
263_L	267_T	0.603	0.90
116_S	256_V	0.603	0.90
128_V	172_E	0.601	0.90
269_I	295_C	0.600	0.89
224_K	304_W	0.600	0.89
34_E	38_K	0.599	0.89
147_K	153_V	0.598	0.89
261_F	296_A	0.595	0.89
144_S	158_G	0.592	0.89
111_A	187_L	0.590	0.89
187_L	191_V	0.590	0.89
114_L	186_E	0.590	0.89
77_K	82_F	0.589	0.89
116_S	254_D	0.589	0.89
260_A	264_A	0.589	0.89
147_K	159_D	0.588	0.89
269_I	292_I	0.588	0.89
234_D	258_R	0.588	0.89
145_L	151_E	0.586	0.88
184_E	206_T	0.585	0.88
217_D	220_R	0.583	0.88
53_V	137_V	0.583	0.88
161_V	186_E	0.581	0.88
277_R	280_E	0.580	0.88
131_R	134_R	0.577	0.88
106_F	109_S	0.576	0.88
33_F	39_I	0.575	0.87
119_D	210_I	0.575	0.87
282_H	294_A	0.575	0.87
113_E	135_D	0.574	0.87
233_L	297_R	0.573	0.87
15_L	58_L	0.572	0.87
185_K	189_D	0.571	0.87
41_P	66_Y	0.570	0.87
37_R	66_Y	0.569	0.87
120_F	165_E	0.567	0.87
236_V	247_R	0.567	0.87
18_Y	23_L	0.565	0.87
6_A	62_L	0.565	0.87
210_I	214_R	0.565	0.87
228_V	301_V	0.564	0.86
48_I	70_I	0.563	0.86
120_F	127_R	0.560	0.86
143_D	156_G	0.559	0.86
33_F	58_L	0.559	0.86
149_N	156_G	0.559	0.86
266_L	270_K	0.553	0.85
90_N	94_K	0.552	0.85
152_E	157_G	0.550	0.85
76_L	94_K	0.550	0.85
261_F	303_T	0.549	0.85
143_D	152_E	0.548	0.85
97_E	100_V	0.547	0.85
178_G	181_R	0.546	0.85
125_I	176_L	0.546	0.85
225_K	297_R	0.545	0.85
147_K	157_G	0.544	0.84
76_L	98_I	0.541	0.84
272_N	313_F	0.539	0.84
298_K	301_V	0.538	0.84
308_Y	311_K	0.534	0.83
117_Q	120_F	0.534	0.83
259_R	262_Y	0.532	0.83
279_Y	283_K	0.532	0.83
48_I	55_H	0.531	0.83
172_E	176_L	0.529	0.83
126_A	129_K	0.529	0.83
38_K	64_N	0.528	0.83
147_K	158_G	0.527	0.83
268_A	272_N	0.524	0.82
268_A	299_L	0.524	0.82
62_L	299_L	0.523	0.82
264_A	268_A	0.523	0.82
218_V	304_W	0.523	0.82
10_V	54_Y	0.522	0.82
111_A	190_F	0.519	0.82
275_I	301_V	0.516	0.81
216_G	220_R	0.516	0.81
248_G	290_K	0.515	0.81
143_D	154_L	0.513	0.81
210_I	256_V	0.513	0.81
143_D	157_G	0.510	0.80
87_S	239_S	0.510	0.80
289_K	293_V	0.509	0.80
167_R	171_E	0.507	0.80
191_V	194_D	0.506	0.80
224_K	301_V	0.504	0.80
132_L	170_L	0.503	0.80
149_N	159_D	0.501	0.79
110_D	160_S	0.500	0.79
147_K	155_R	0.500	0.79

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1hjrA	2	0.3312	93.8	0.93	Contact Map
4ep4A	2	0.3407	90	0.937	Contact Map
1nu0A	1	0.3123	85.2	0.942	Contact Map
2a1jB	2	0.2429	82.9	0.943	Contact Map
3fhfA	1	0.612	80.8	0.945	Contact Map
3psiA	1	0.8297	78.8	0.946	Contact Map
2a1jA	1	0.1861	78.2	0.946	Contact Map
1z00A	1	0.2587	76.3	0.947	Contact Map
1ornA	1	0.6151	75.7	0.947	Contact Map
1kftA	1	0.1703	73.2	0.948	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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