GREMLIN Database
Q97X26 - Transposase ISC1190
UniProt: Q97X26 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 317 (308)
Sequences: 4472 (3400)
Seq/√Len: 193.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_G99_V4.4851.00
125_I177_E3.1471.00
18_Y92_A2.9131.00
196_L312_P2.8291.00
164_S186_E2.8221.00
282_H285_R2.7101.00
227_F300_A2.6681.00
168_F179_R2.4571.00
76_L95_L2.3861.00
124_S127_R2.3681.00
215_V227_F2.3371.00
171_E179_R2.2491.00
47_G95_L2.1981.00
118_W122_I2.1841.00
231_C257_L2.1821.00
46_V66_Y2.1521.00
211_I303_T2.1421.00
199_T312_P2.1391.00
8_I36_I2.1061.00
222_S226_R2.0791.00
249_I293_V2.0531.00
276_K280_E2.0401.00
87_S237_V2.0301.00
297_R301_V2.0271.00
125_I180_K1.9791.00
203_I208_G1.9441.00
223_D226_R1.9381.00
196_L306_V1.9261.00
14_K25_E1.9201.00
124_S131_R1.9141.00
175_R179_R1.8931.00
118_W184_E1.8541.00
287_R290_K1.8511.00
119_D259_R1.8321.00
239_S244_V1.8141.00
221_F230_Y1.8061.00
126_A130_N1.8031.00
132_L173_L1.8001.00
6_A19_F1.7991.00
200_I303_T1.7721.00
116_S214_R1.7601.00
233_L296_A1.7351.00
186_E189_D1.6921.00
124_S172_E1.6821.00
121_V180_K1.6781.00
45_K69_R1.6781.00
8_I15_L1.6761.00
172_E175_R1.6681.00
197_I303_T1.6671.00
306_V312_P1.6511.00
231_C300_A1.6471.00
286_L290_K1.6331.00
146_S149_N1.6221.00
172_E179_R1.6201.00
210_I260_A1.6161.00
125_I173_L1.6091.00
48_I68_V1.6091.00
154_L158_G1.5951.00
281_E285_R1.5761.00
196_L199_T1.5621.00
143_D153_V1.5441.00
207_L260_A1.5291.00
305_A309_Y1.5271.00
97_E101_S1.5141.00
184_E187_L1.5111.00
61_Y64_N1.5091.00
11_S16_I1.5081.00
275_I302_I1.4921.00
147_K151_E1.4731.00
122_I125_I1.4561.00
122_I180_K1.4561.00
263_L266_L1.4521.00
279_Y295_C1.4501.00
17_V36_I1.4421.00
275_I295_C1.4311.00
8_I58_L1.4301.00
200_I306_V1.4231.00
150_L153_V1.4131.00
18_Y93_K1.4011.00
16_I25_E1.3951.00
280_E284_G1.3881.00
154_L157_G1.3871.00
269_I279_Y1.3851.00
191_V198_F1.3831.00
181_R184_E1.3731.00
198_F205_K1.3691.00
171_E175_R1.3651.00
132_L166_V1.3631.00
259_R263_L1.3601.00
85_K237_V1.3581.00
29_D32_G1.3511.00
24_Y39_I1.3511.00
118_W206_T1.3431.00
13_D242_K1.2981.00
273_L277_R1.2971.00
265_A296_A1.2791.00
278_F298_K1.2751.00
48_I59_A1.2631.00
173_L177_E1.2611.00
265_A299_L1.2611.00
171_E178_G1.2521.00
40_L46_V1.2521.00
304_W308_Y1.2511.00
146_S150_L1.2491.00
149_N152_E1.2321.00
197_I208_G1.2301.00
119_D256_V1.2231.00
168_F182_E1.2191.00
262_Y296_A1.2181.00
189_D193_K1.2141.00
146_S157_G1.2111.00
214_R254_D1.2091.00
228_V297_R1.2091.00
149_N153_V1.2021.00
203_I207_L1.2011.00
283_K288_G1.1901.00
155_R158_G1.1881.00
123_R127_R1.1841.00
265_A295_C1.1831.00
228_V234_D1.1811.00
120_F131_R1.1781.00
47_G71_I1.1751.00
279_Y291_L1.1731.00
207_L264_A1.1701.00
8_I17_V1.1691.00
125_I129_K1.1681.00
146_S156_G1.1671.00
170_L174_E1.1661.00
102_M106_F1.1591.00
264_A299_L1.1551.00
156_G159_D1.1531.00
184_E188_E1.1531.00
127_R130_N1.1471.00
179_R182_E1.1431.00
146_S151_E1.1421.00
7_G96_A1.1421.00
155_R159_D1.1411.00
11_S14_K1.1371.00
27_T32_G1.1351.00
153_V158_G1.1301.00
124_S128_V1.1301.00
143_D146_S1.1261.00
278_F282_H1.1181.00
146_S159_D1.1161.00
45_K67_D1.1071.00
150_L157_G1.1061.00
74_F78_K1.0921.00
305_A308_Y1.0901.00
16_I23_L1.0851.00
6_A46_V1.0841.00
200_I299_L1.0831.00
262_Y293_V1.0801.00
115_T256_V1.0801.00
203_I303_T1.0801.00
306_V311_K1.0781.00
37_R61_Y1.0761.00
282_H291_L1.0731.00
151_E158_G1.0701.00
128_V131_R1.0651.00
6_A40_L1.0621.00
153_V156_G1.0561.00
148_K151_E1.0481.00
118_W180_K1.0481.00
151_E159_D1.0461.00
152_E156_G1.0461.00
117_Q121_V1.0441.00
302_I306_V1.0401.00
151_E154_L1.0361.00
249_I258_R1.0291.00
145_L148_K1.0211.00
6_A17_V1.0181.00
278_F295_C1.0141.00
145_L149_N1.0121.00
71_I76_L1.0091.00
33_F61_Y1.0021.00
278_F294_A1.0021.00
114_L183_I1.0001.00
33_F57_N1.0001.00
197_I307_L0.9931.00
146_S153_V0.9921.00
151_E155_R0.9921.00
12_K137_V0.9911.00
148_K152_E0.9860.99
55_H70_I0.9840.99
23_L93_K0.9800.99
32_G35_E0.9770.99
218_V307_L0.9760.99
177_E181_R0.9760.99
46_V62_L0.9740.99
93_K97_E0.9720.99
188_E205_K0.9690.99
128_V132_L0.9680.99
175_R178_G0.9660.99
153_V157_G0.9660.99
86_K91_D0.9650.99
17_V39_I0.9580.99
262_Y266_L0.9580.99
146_S158_G0.9520.99
283_K291_L0.9510.99
5_V100_V0.9480.99
10_V15_L0.9450.99
215_V218_V0.9410.99
145_L153_V0.9320.99
265_A292_I0.9300.99
251_K258_R0.9290.99
160_S186_E0.9260.99
266_L269_I0.9240.99
275_I299_L0.9170.99
59_A68_V0.9090.99
50_S73_P0.9080.99
5_V99_V0.9050.99
203_I299_L0.8970.99
38_K41_P0.8950.99
115_T187_L0.8950.99
143_D158_G0.8930.99
112_R214_R0.8930.99
26_F39_I0.8860.99
282_H286_L0.8850.99
115_T209_C0.8780.99
59_A70_I0.8650.99
149_N154_L0.8640.99
26_F32_G0.8530.98
143_D149_N0.8530.98
51_T54_Y0.8460.98
261_F300_A0.8450.98
36_I40_L0.8420.98
147_K154_L0.8330.98
282_H287_R0.8260.98
95_L98_I0.8210.98
168_F186_E0.8200.98
122_I126_A0.8200.98
144_S156_G0.8170.98
289_K292_I0.8160.98
262_Y289_K0.8110.98
103_G106_F0.8080.98
186_E190_F0.8080.98
194_D212_L0.8070.98
84_G229_A0.8020.98
278_F281_E0.8010.98
240_S244_V0.7960.98
266_L289_K0.7940.98
17_V26_F0.7940.98
145_L152_E0.7850.97
31_Q35_E0.7840.97
150_L158_G0.7830.97
223_D304_W0.7820.97
178_G182_E0.7810.97
163_L167_R0.7740.97
281_E284_G0.7740.97
15_L28_N0.7740.97
129_K173_L0.7720.97
144_S149_N0.7720.97
165_E168_F0.7690.97
147_K150_L0.7680.97
230_Y254_D0.7680.97
37_R64_N0.7680.97
146_S155_R0.7640.97
6_A44_C0.7560.97
40_L62_L0.7560.97
69_R99_V0.7540.97
144_S155_R0.7520.97
119_D123_R0.7520.97
196_L310_N0.7510.97
144_S154_L0.7490.97
115_T210_I0.7420.96
143_D155_R0.7420.96
277_R281_E0.7400.96
273_L276_K0.7400.96
154_L159_D0.7380.96
150_L156_G0.7330.96
84_G252_R0.7330.96
10_V48_I0.7310.96
148_K155_R0.7310.96
177_E180_K0.7300.96
32_G36_I0.7280.96
117_Q168_F0.7260.96
269_I283_K0.7220.96
128_V173_L0.7190.96
293_V296_A0.7170.96
102_M105_G0.7160.96
50_S70_I0.7150.96
122_I184_E0.7150.96
16_I89_K0.7140.96
11_S15_L0.7140.96
263_L289_K0.7140.96
143_D150_L0.7100.95
146_S154_L0.7090.95
7_G92_A0.7070.95
226_R229_A0.7060.95
176_L179_R0.7040.95
169_L172_E0.7020.95
266_L296_A0.6970.95
145_L150_L0.6950.95
271_V276_K0.6940.95
143_D159_D0.6930.95
149_N158_G0.6930.95
168_F172_E0.6920.95
274_I313_F0.6910.95
73_P214_R0.6910.95
43_G67_D0.6900.95
79_F98_I0.6870.94
236_V250_S0.6860.94
58_L62_L0.6840.94
144_S148_K0.6840.94
145_L155_R0.6830.94
234_D250_S0.6820.94
149_N157_G0.6820.94
164_S175_R0.6800.94
128_V176_L0.6780.94
121_V183_I0.6770.94
237_V244_V0.6760.94
303_T306_V0.6760.94
15_L26_F0.6740.94
214_R256_V0.6740.94
128_V169_L0.6730.94
191_V209_C0.6700.94
30_R34_E0.6700.94
287_R291_L0.6660.94
150_L159_D0.6640.93
145_L158_G0.6630.93
290_K294_A0.6630.93
164_S167_R0.6620.93
117_Q165_E0.6620.93
253_G258_R0.6610.93
188_E192_P0.6610.93
203_I211_I0.6610.93
144_S159_D0.6600.93
74_F252_R0.6580.93
164_S168_F0.6560.93
131_R169_L0.6550.93
41_P64_N0.6550.93
72_N75_I0.6540.93
120_F124_S0.6520.93
18_Y96_A0.6490.93
32_G39_I0.6490.93
145_L156_G0.6480.93
234_D251_K0.6460.92
239_S245_V0.6460.92
153_V159_D0.6460.92
266_L292_I0.6460.92
45_K99_V0.6450.92
71_I98_I0.6440.92
145_L154_L0.6410.92
88_D240_S0.6410.92
162_V165_E0.6410.92
7_G62_L0.6410.92
143_D147_K0.6380.92
161_V164_S0.6370.92
211_I257_L0.6350.92
200_I203_I0.6340.92
11_S241_G0.6340.92
198_F208_G0.6330.92
151_E156_G0.6320.92
174_E178_G0.6320.92
268_A275_I0.6310.92
146_S152_E0.6310.92
117_Q183_I0.6310.92
150_L154_L0.6300.92
234_D237_V0.6250.91
115_T213_A0.6220.91
85_K90_N0.6210.91
31_Q39_I0.6200.91
182_E186_E0.6200.91
43_G66_Y0.6190.91
301_V304_W0.6180.91
176_L180_K0.6180.91
130_N134_R0.6180.91
121_V176_L0.6170.91
249_I253_G0.6120.90
249_I294_A0.6100.90
37_R41_P0.6050.90
263_L267_T0.6030.90
116_S256_V0.6030.90
128_V172_E0.6010.90
269_I295_C0.6000.89
224_K304_W0.6000.89
34_E38_K0.5990.89
147_K153_V0.5980.89
261_F296_A0.5950.89
144_S158_G0.5920.89
111_A187_L0.5900.89
187_L191_V0.5900.89
114_L186_E0.5900.89
77_K82_F0.5890.89
116_S254_D0.5890.89
260_A264_A0.5890.89
147_K159_D0.5880.89
269_I292_I0.5880.89
234_D258_R0.5880.89
145_L151_E0.5860.88
184_E206_T0.5850.88
217_D220_R0.5830.88
53_V137_V0.5830.88
161_V186_E0.5810.88
277_R280_E0.5800.88
131_R134_R0.5770.88
106_F109_S0.5760.88
33_F39_I0.5750.87
119_D210_I0.5750.87
282_H294_A0.5750.87
113_E135_D0.5740.87
233_L297_R0.5730.87
15_L58_L0.5720.87
185_K189_D0.5710.87
41_P66_Y0.5700.87
37_R66_Y0.5690.87
120_F165_E0.5670.87
236_V247_R0.5670.87
18_Y23_L0.5650.87
6_A62_L0.5650.87
210_I214_R0.5650.87
228_V301_V0.5640.86
48_I70_I0.5630.86
120_F127_R0.5600.86
143_D156_G0.5590.86
33_F58_L0.5590.86
149_N156_G0.5590.86
266_L270_K0.5530.85
90_N94_K0.5520.85
152_E157_G0.5500.85
76_L94_K0.5500.85
261_F303_T0.5490.85
143_D152_E0.5480.85
97_E100_V0.5470.85
178_G181_R0.5460.85
125_I176_L0.5460.85
225_K297_R0.5450.85
147_K157_G0.5440.84
76_L98_I0.5410.84
272_N313_F0.5390.84
298_K301_V0.5380.84
308_Y311_K0.5340.83
117_Q120_F0.5340.83
259_R262_Y0.5320.83
279_Y283_K0.5320.83
48_I55_H0.5310.83
172_E176_L0.5290.83
126_A129_K0.5290.83
38_K64_N0.5280.83
147_K158_G0.5270.83
268_A272_N0.5240.82
268_A299_L0.5240.82
62_L299_L0.5230.82
264_A268_A0.5230.82
218_V304_W0.5230.82
10_V54_Y0.5220.82
111_A190_F0.5190.82
275_I301_V0.5160.81
216_G220_R0.5160.81
248_G290_K0.5150.81
143_D154_L0.5130.81
210_I256_V0.5130.81
143_D157_G0.5100.80
87_S239_S0.5100.80
289_K293_V0.5090.80
167_R171_E0.5070.80
191_V194_D0.5060.80
224_K301_V0.5040.80
132_L170_L0.5030.80
149_N159_D0.5010.79
110_D160_S0.5000.79
147_K155_R0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hjrA 2 0.3312 93.8 0.93 Contact Map
4ep4A 2 0.3407 90 0.937 Contact Map
1nu0A 1 0.3123 85.2 0.942 Contact Map
2a1jB 2 0.2429 82.9 0.943 Contact Map
3fhfA 1 0.612 80.8 0.945 Contact Map
3psiA 1 0.8297 78.8 0.946 Contact Map
2a1jA 1 0.1861 78.2 0.946 Contact Map
1z00A 1 0.2587 76.3 0.947 Contact Map
1ornA 1 0.6151 75.7 0.947 Contact Map
1kftA 1 0.1703 73.2 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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