GREMLIN Database
Q97X25 - First ORF in partial transposon ISC1913
UniProt: Q97X25 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 145 (135)
Sequences: 497 (362)
Seq/√Len: 31.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_A127_S4.1511.00
63_A81_L3.8961.00
98_D109_G3.0071.00
85_A129_K2.9591.00
10_A14_L2.7841.00
105_T142_C2.4810.99
16_I24_W2.3520.99
20_T24_W2.2900.99
5_L10_A2.2860.99
110_L136_Y2.2820.99
61_I81_L2.2780.99
137_L141_T2.2700.99
80_Y131_E2.1470.98
8_K12_Q2.0540.98
113_L125_N2.0490.98
19_S22_L2.0160.98
25_I40_Y1.9100.97
103_L139_N1.8950.96
21_L42_I1.8590.96
78_I97_K1.7810.95
94_E116_L1.6820.93
84_Y88_K1.6660.93
78_I95_V1.6440.92
96_L109_G1.6410.92
6_R37_G1.5740.90
73_D76_R1.5650.90
70_Q73_D1.5200.89
129_K142_C1.4950.88
116_L124_K1.4500.86
7_P22_L1.4290.85
117_V125_N1.4260.85
61_I95_V1.4050.84
19_S27_E1.3540.82
84_Y89_G1.3450.82
10_A47_I1.3350.81
61_I85_A1.3340.81
34_T40_Y1.3270.81
117_V130_I1.3070.80
58_R116_L1.2810.78
117_V128_L1.2710.78
66_S70_Q1.2670.78
25_I32_V1.2610.77
29_K36_E1.2540.77
25_I30_I1.2390.76
59_A129_K1.1850.73
31_R46_E1.1850.73
43_P46_E1.1780.72
96_L113_L1.1440.70
105_T137_L1.1200.68
90_Y127_S1.1150.68
79_N83_N1.1110.68
105_T128_L1.1100.68
5_L41_R1.1010.67
18_Y22_L1.0960.67
6_R41_R1.0920.66
20_T23_R1.0690.65
14_L21_L1.0580.64
90_Y93_V1.0430.63
23_R26_R1.0370.62
67_S76_R1.0360.62
33_V41_R1.0350.62
70_Q76_R1.0350.62
46_E49_K1.0090.60
61_I92_V1.0040.60
98_D131_E1.0040.60
25_I42_I0.9960.59
17_S23_R0.9960.59
134_S138_R0.9850.58
29_K37_G0.9810.58
22_L42_I0.9710.57
65_V70_Q0.9620.56
10_A30_I0.9460.55
65_V74_L0.9400.55
75_E79_N0.9360.54
80_Y98_D0.9340.54
6_R9_E0.9310.54
42_I47_I0.9300.54
73_D131_E0.9290.54
98_D105_T0.9270.54
96_L128_L0.9150.53
30_I33_V0.9120.52
45_S76_R0.9060.52
103_L140_E0.9040.52
60_V125_N0.8990.51
102_G136_Y0.8950.51
75_E78_I0.8910.51
5_L44_Y0.8760.50
87_A129_K0.8750.49
110_L137_L0.8740.49
16_I23_R0.8720.49
42_I46_E0.8630.48
11_C21_L0.8530.48
39_K42_I0.8340.46
7_P32_V0.8250.45
22_L39_K0.8230.45
12_Q71_K0.8220.45
22_L25_I0.8160.45
38_G97_K0.8070.44
79_N82_T0.8040.44
7_P21_L0.8030.44
30_I46_E0.7950.43
107_R137_L0.7910.43
114_F124_K0.7900.43
67_S70_Q0.7870.42
84_Y127_S0.7850.42
25_I34_T0.7830.42
29_K115_K0.7820.42
11_C18_Y0.7810.42
99_I107_R0.7800.42
16_I19_S0.7760.41
88_K129_K0.7740.41
93_V110_L0.7700.41
10_A21_L0.7690.41
82_T95_V0.7660.41
85_A92_V0.7650.41
85_A131_E0.7630.40
99_I108_K0.7520.40
5_L16_I0.7410.39
5_L13_L0.7370.38
5_L14_L0.7340.38
19_S23_R0.7320.38
11_C16_I0.7320.38
5_L51_L0.7290.38
90_Y110_L0.7220.37
63_A97_K0.7160.37
7_P11_C0.7120.37
76_R79_N0.7100.36
26_R108_K0.7090.36
101_S105_T0.6960.35
48_K95_V0.6910.35
22_L34_T0.6900.35
133_N142_C0.6810.34
135_H138_R0.6810.34
67_S108_K0.6780.34
33_V43_P0.6760.34
37_G123_Y0.6760.34
22_L40_Y0.6690.33
63_A101_S0.6640.33
32_V42_I0.6550.32
7_P18_Y0.6550.32
41_R84_Y0.6520.32
40_Y47_I0.6460.32
132_H141_T0.6390.31
16_I114_F0.6380.31
59_A100_A0.6350.31
78_I114_F0.6340.31
66_S101_S0.6330.31
17_S22_L0.6320.31
17_S25_I0.6300.31
35_T44_Y0.6300.31
11_C15_G0.6270.30
60_V78_I0.6250.30
8_K37_G0.6250.30
68_A71_K0.6230.30
45_S48_K0.6190.30
31_R50_Y0.6120.29
32_V73_D0.6110.29
5_L141_T0.6090.29
58_R98_D0.6060.29
53_R124_K0.6060.29
89_G112_K0.6050.29
69_D131_E0.5990.29
18_Y40_Y0.5980.28
8_K28_G0.5930.28
47_I51_L0.5930.28
14_L98_D0.5930.28
82_T86_T0.5910.28
69_D76_R0.5890.28
109_G130_I0.5880.28
88_K111_L0.5870.28
114_F118_E0.5870.28
83_N112_K0.5800.27
104_N113_L0.5780.27
10_A41_R0.5770.27
28_G140_E0.5760.27
13_L97_K0.5720.27
7_P24_W0.5640.26
60_V89_G0.5580.26
67_S100_A0.5570.26
135_H140_E0.5540.26
33_V46_E0.5510.26
96_L116_L0.5500.25
58_R126_F0.5460.25
110_L117_V0.5460.25
93_V107_R0.5380.25
59_A94_E0.5380.25
16_I21_L0.5370.25
54_R75_E0.5370.25
15_G139_N0.5350.25
86_T113_L0.5280.24
6_R39_K0.5270.24
128_L137_L0.5220.24
41_R133_N0.5200.24
12_Q79_N0.5160.23
98_D101_S0.5080.23
128_L136_Y0.5050.23
11_C48_K0.5040.23
43_P93_V0.5030.23
21_L25_I0.5030.23
24_W41_R0.5010.23
102_G110_L0.5010.23
104_N138_R0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lhkA 2 0.5931 99.8 0.644 Contact Map
3ilxA 2 0.5586 99.8 0.664 Contact Map
2mhcA 1 0.6276 99.8 0.669 Contact Map
3bvpA 4 0.5931 99.8 0.671 Contact Map
3guvA 2 0.6 99.8 0.672 Contact Map
3g13A 2 0.6207 99.7 0.677 Contact Map
4bqqA 2 0.5793 99.7 0.688 Contact Map
2gm5A 4 0.5103 99.6 0.711 Contact Map
3whpA 1 0.4897 99.6 0.713 Contact Map
1gdtA 2 0.5379 99.6 0.717 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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