GREMLIN Database
Q97X22 - Glutamate dehydrogenase
UniProt: Q97X22 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 434 (383)
Sequences: 5248 (2418)
Seq/√Len: 123.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
247_L252_A4.2691.00
301_I323_K3.4271.00
233_I244_A3.3761.00
232_I304_C3.2591.00
53_E81_S3.1041.00
215_A330_V3.0781.00
304_C326_A3.0421.00
277_E281_R3.0251.00
271_D274_K2.9501.00
303_D325_K2.8241.00
147_Q177_E2.7541.00
343_D347_Q2.5451.00
119_Y367_Y2.5151.00
129_D132_K2.4631.00
217_E220_N2.4191.00
256_G299_L2.3911.00
346_K411_D2.3811.00
136_K140_D2.3801.00
217_E393_T2.3131.00
244_A257_V2.3051.00
224_G229_S2.3041.00
164_I312_V2.2291.00
57_Q98_Q2.2201.00
230_R253_K2.2161.00
345_I350_I2.1971.00
231_V252_A2.1841.00
402_F406_K2.1711.00
64_G70_R2.1571.00
112_N363_V2.1221.00
167_N170_T2.1181.00
245_K249_E2.1101.00
231_V247_L2.1021.00
79_H105_S2.0941.00
211_V332_G2.0811.00
147_Q180_K2.0491.00
411_D414_T2.0331.00
318_K340_D2.0101.00
221_K400_Y1.9991.00
401_D405_R1.9961.00
61_Q144_K1.9691.00
337_L345_I1.9561.00
422_D426_K1.9161.00
383_E387_L1.9071.00
90_V174_F1.9061.00
221_K404_K1.9041.00
202_V381_D1.8871.00
330_V358_A1.8821.00
316_I337_L1.8801.00
213_T216_R1.8691.00
230_R251_G1.8611.00
257_V275_A1.8561.00
396_F400_Y1.8411.00
321_A344_V1.8391.00
276_L280_Q1.8211.00
128_V133_L1.8041.00
217_E397_N1.7841.00
226_I252_A1.7601.00
216_R389_I1.7441.00
214_I358_A1.7341.00
225_G228_G1.7171.00
196_E426_K1.7131.00
221_K396_F1.7031.00
77_S105_S1.6951.00
353_I358_A1.6731.00
83_L116_L1.6641.00
232_I256_G1.6571.00
309_P333_A1.6521.00
404_K409_D1.6351.00
146_I174_F1.6321.00
44_D68_K1.6281.00
267_E292_K1.6191.00
65_S134_T1.6011.00
317_N320_N1.5981.00
344_V348_S1.5891.00
402_F422_D1.5731.00
260_I279_V1.5691.00
150_H182_T1.5611.00
74_G145_Y1.5461.00
139_E143_R1.5391.00
316_I324_V1.5141.00
261_G284_S1.5111.00
245_K276_L1.5061.00
90_V145_Y1.5041.00
333_A336_P1.5011.00
212_A250_M1.4881.00
97_T100_E1.4861.00
300_L307_L1.4751.00
134_T137_E1.4701.00
55_V102_I1.4671.00
410_Q418_A1.4621.00
177_E180_K1.4411.00
211_V330_V1.4401.00
263_G294_V1.4271.00
143_R177_E1.4141.00
231_V308_I1.4121.00
255_I304_C1.3971.00
168_P204_L1.3881.00
114_L357_L1.3881.00
256_G302_S1.3831.00
243_T308_I1.3731.00
221_K397_N1.3711.00
47_E50_S1.3691.00
135_L169_Q1.3551.00
239_V332_G1.3471.00
144_K147_Q1.3431.00
216_R250_M1.3421.00
381_D385_K1.3391.00
213_T385_K1.3291.00
318_K344_V1.3081.00
86_Y122_G1.3071.00
213_T389_I1.3061.00
396_F412_L1.3031.00
330_V353_I1.3021.00
81_S86_Y1.2931.00
218_A353_I1.2911.00
51_Q73_V1.2901.00
248_S273_N1.2861.00
405_R422_D1.2861.00
218_A328_L1.2851.00
316_I345_I1.2801.00
247_L254_I1.2731.00
63_R136_K1.2701.00
322_P344_V1.2671.00
278_V282_T1.2671.00
390_D394_N1.2661.00
394_N398_T1.2621.00
196_E430_A1.2611.00
172_A194_P1.2571.00
55_V98_Q1.2511.00
232_I302_S1.2491.00
128_V141_L1.2400.99
373_N378_I1.2310.99
397_N401_D1.2250.99
215_A306_I1.2230.99
79_H109_T1.2180.99
60_I144_K1.2070.99
224_G327_K1.2030.99
274_K288_Y1.2000.99
406_K418_A1.1980.99
243_T310_A1.1980.99
212_A247_L1.1980.99
219_A226_I1.1930.99
222_F327_K1.1930.99
133_L141_L1.1870.99
173_W176_D1.1850.99
283_G287_N1.1850.99
357_L399_L1.1820.99
75_W127_R1.1800.99
356_I417_M1.1770.99
295_T298_E1.1750.99
307_L324_V1.1750.99
143_R176_D1.1750.99
263_G296_N1.1740.99
232_I255_I1.1700.99
93_S312_V1.1700.99
230_R267_E1.1690.99
231_V306_I1.1680.99
109_T424_V1.1680.99
255_I265_I1.1670.99
110_W356_I1.1670.99
216_R220_N1.1610.99
124_G145_Y1.1580.99
219_A306_I1.1490.99
328_L351_V1.1460.99
157_V183_G1.1400.99
115_L364_V1.1400.99
231_V254_I1.1390.99
230_R305_D1.1380.99
144_K148_L1.1360.99
402_F419_L1.1360.99
318_K322_P1.1310.99
150_H181_I1.1260.99
149_I152_Y1.1260.99
110_W424_V1.1250.99
386_K390_D1.1080.99
380_S390_D1.1070.99
58_V149_I1.1020.99
77_S98_Q1.0960.99
115_L360_A1.0920.99
211_V308_I1.0890.99
342_D413_R1.0880.99
216_R226_I1.0860.99
382_E386_K1.0790.99
80_N428_M1.0740.98
218_A330_V1.0730.98
272_V276_L1.0720.98
215_A308_I1.0710.98
426_K429_K1.0670.98
389_I393_T1.0590.98
73_V127_R1.0550.98
56_I152_Y1.0550.98
204_L242_F1.0550.98
344_V347_Q1.0490.98
342_D346_K1.0470.98
248_S272_V1.0470.98
222_F351_V1.0370.98
297_E301_I1.0360.98
298_E301_I1.0320.98
241_S276_L1.0290.98
266_N274_K1.0280.98
319_F322_P1.0220.98
94_P129_D1.0140.98
410_Q415_V1.0060.98
230_R303_D1.0030.98
44_D47_E1.0020.98
380_S383_E1.0010.98
194_P197_L0.9950.98
211_V310_A0.9930.97
265_I302_S0.9870.97
275_A288_Y0.9860.97
253_K268_N0.9830.97
274_K277_E0.9820.97
264_V275_A0.9790.97
209_L246_F0.9770.97
266_N288_Y0.9730.97
402_F418_A0.9720.97
92_Y142_S0.9710.97
144_K180_K0.9590.97
61_Q71_T0.9570.97
64_G72_F0.9560.97
329_I345_I0.9540.97
92_Y166_T0.9530.97
211_V215_A0.9500.97
177_E181_I0.9490.97
45_T429_K0.9480.97
197_L430_A0.9480.97
58_V74_G0.9460.97
47_E70_R0.9410.97
308_I330_V0.9410.97
95_N100_E0.9380.96
142_S146_I0.9320.96
57_Q73_V0.9310.96
278_V287_N0.9300.96
147_Q181_I0.9300.96
243_T247_L0.9290.96
116_L391_R0.9270.96
166_T171_M0.9170.96
286_V290_E0.9070.96
209_L385_K0.9070.96
175_L185_V0.9060.96
307_L315_V0.9040.96
241_S280_Q0.9010.96
265_I292_K0.9010.96
278_V288_Y0.9000.96
55_V101_V0.8930.95
248_S271_D0.8900.95
82_A424_V0.8860.95
244_A275_A0.8830.95
99_E102_I0.8830.95
247_L308_I0.8810.95
55_V77_S0.8780.95
364_V368_V0.8780.95
421_V424_V0.8770.95
264_V285_V0.8750.95
101_V105_S0.8730.95
276_L279_V0.8730.95
242_F245_K0.8710.95
123_K334_N0.8680.95
329_I337_L0.8670.95
244_A254_I0.8600.94
131_K279_V0.8540.94
63_R70_R0.8540.94
410_Q414_T0.8510.94
130_P137_E0.8490.94
324_V329_I0.8440.94
214_I399_L0.8430.94
49_L110_W0.8430.94
105_S109_T0.8410.94
343_D346_K0.8390.94
83_L120_G0.8360.93
93_S164_I0.8320.93
270_I275_A0.8300.93
244_A272_V0.8290.93
259_D262_G0.8280.93
146_I190_F0.8270.93
322_P348_S0.8240.93
151_N183_G0.8200.93
146_I177_E0.8180.93
156_N374_K0.8170.93
233_I252_A0.8160.93
211_V243_T0.8130.92
316_I355_D0.8130.92
70_R132_K0.8120.92
215_A328_L0.8110.92
278_V289_P0.8070.92
296_N299_L0.8030.92
337_L341_A0.8020.92
236_F257_V0.7990.92
385_K389_I0.7990.92
92_Y126_I0.7950.92
360_A364_V0.7930.91
226_I231_V0.7910.91
298_E320_N0.7880.91
171_M174_F0.7870.91
131_K260_I0.7870.91
308_I332_G0.7830.91
259_D279_V0.7800.91
275_A279_V0.7800.91
200_I379_I0.7790.91
259_D284_S0.7750.91
305_D327_K0.7750.91
262_G286_V0.7720.90
371_A377_G0.7710.90
54_R78_Q0.7700.90
363_V366_S0.7680.90
171_M197_L0.7670.90
284_S287_N0.7670.90
329_I341_A0.7620.90
248_S254_I0.7620.90
256_G263_G0.7590.90
426_K430_A0.7580.90
111_K334_N0.7570.89
403_H410_Q0.7570.89
403_H406_K0.7550.89
297_E319_F0.7540.89
83_L113_S0.7530.89
263_G301_I0.7530.89
218_A351_V0.7520.89
420_A424_V0.7440.89
262_G285_V0.7410.88
403_H412_L0.7380.88
364_V392_M0.7370.88
406_K422_D0.7350.88
277_E280_Q0.7340.88
90_V160_P0.7320.88
208_G243_T0.7320.88
339_A342_D0.7310.88
116_L394_N0.7310.88
153_L174_F0.7310.88
219_A328_L0.7300.88
400_Y404_K0.7260.87
174_F190_F0.7250.87
326_A350_I0.7230.87
96_V125_G0.7220.87
351_V412_L0.7150.87
326_A329_I0.7150.87
409_D414_T0.7140.87
337_L352_V0.7120.86
123_K207_T0.7070.86
233_I257_V0.7070.86
316_I329_I0.7050.86
216_R393_T0.7020.86
57_Q75_W0.7020.86
287_N293_K0.6970.85
148_L181_I0.6970.85
222_F328_L0.6970.85
236_F272_V0.6960.85
211_V358_A0.6960.85
317_N323_K0.6950.85
282_T287_N0.6950.85
372_N379_I0.6910.85
165_N239_V0.6900.85
324_V345_I0.6900.85
148_L151_N0.6880.84
255_I302_S0.6860.84
242_F246_F0.6860.84
221_K401_D0.6860.84
142_S174_F0.6830.84
219_A224_G0.6820.84
107_I335_G0.6810.84
207_T359_N0.6780.84
115_L395_A0.6780.84
285_V288_Y0.6770.84
413_R417_M0.6760.83
364_V391_R0.6750.83
64_G68_K0.6750.83
329_I350_I0.6740.83
62_I72_F0.6740.83
130_P133_L0.6740.83
345_I352_V0.6730.83
366_S369_E0.6730.83
282_T285_V0.6730.83
236_F333_A0.6720.83
200_I384_A0.6720.83
391_R394_N0.6710.83
263_G299_L0.6710.83
247_L306_I0.6710.83
214_I357_L0.6700.83
316_I321_A0.6680.83
236_F275_A0.6660.83
56_I149_I0.6660.83
232_I326_A0.6650.82
310_A332_G0.6650.82
214_I330_V0.6650.82
303_D326_A0.6630.82
352_V355_D0.6620.82
278_V283_G0.6610.82
239_V260_I0.6600.82
161_A363_V0.6590.82
418_A421_V0.6580.82
288_Y291_G0.6570.82
45_T48_A0.6560.82
233_I247_L0.6540.81
126_I145_Y0.6540.81
316_I352_V0.6530.81
332_G358_A0.6510.81
421_V425_V0.6510.81
306_I328_L0.6500.81
162_P203_R0.6500.81
261_G286_V0.6490.81
263_G302_S0.6490.81
400_Y412_L0.6480.81
206_S238_N0.6470.81
419_L423_R0.6450.80
266_N291_G0.6450.80
114_L398_T0.6440.80
101_V125_G0.6440.80
87_K363_V0.6440.80
77_S122_G0.6440.80
217_E221_K0.6420.80
301_I320_N0.6400.80
203_R366_S0.6400.80
169_Q172_A0.6380.80
317_N337_L0.6380.80
406_K410_Q0.6370.80
174_F177_E0.6370.80
317_N338_T0.6360.80
144_K177_E0.6350.79
386_K389_I0.6350.79
142_S170_T0.6340.79
224_G305_D0.6340.79
294_V302_S0.6330.79
281_R287_N0.6310.79
232_I263_G0.6300.79
68_K71_T0.6280.79
246_F385_K0.6280.79
83_L423_R0.6270.79
292_K295_T0.6270.79
156_N376_G0.6270.79
243_T332_G0.6260.78
191_T366_S0.6260.78
103_A335_G0.6250.78
398_T401_D0.6250.78
111_K123_K0.6240.78
342_D352_V0.6230.78
353_I412_L0.6220.78
367_Y371_A0.6220.78
365_G384_A0.6190.78
352_V413_R0.6190.78
72_F128_V0.6180.78
75_W98_Q0.6180.78
240_G259_D0.6160.77
171_M190_F0.6150.77
208_G239_V0.6140.77
400_Y403_H0.6090.77
230_R265_I0.6060.76
65_S140_D0.6060.76
155_S186_D0.6060.76
206_S388_I0.6060.76
140_D143_R0.6050.76
70_R133_L0.6040.76
203_R238_N0.6030.76
236_F309_P0.6030.76
337_L342_D0.6030.76
393_T397_N0.6020.76
82_A428_M0.5970.75
46_L50_S0.5950.75
275_A285_V0.5950.75
321_A345_I0.5940.75
133_L137_E0.5940.75
326_A345_I0.5940.75
207_T362_G0.5930.75
241_S272_V0.5920.75
205_Y242_F0.5910.74
228_G251_G0.5870.74
394_N397_N0.5860.74
119_Y370_W0.5830.73
82_A427_A0.5830.73
402_F410_Q0.5830.73
169_Q173_W0.5790.73
106_M110_W0.5780.73
116_L398_T0.5780.73
216_R227_E0.5770.73
126_I166_T0.5770.73
195_Y201_G0.5760.73
78_Q86_Y0.5750.72
387_L390_D0.5730.72
207_T238_N0.5720.72
207_T210_G0.5720.72
161_A203_R0.5710.72
234_Q315_V0.5710.72
75_W145_Y0.5710.72
402_F415_V0.5700.72
211_V239_V0.5700.72
141_L149_I0.5700.72
221_K351_V0.5690.72
135_L139_E0.5680.72
218_A396_F0.5680.72
398_T419_L0.5670.71
155_S184_E0.5660.71
90_V124_G0.5650.71
179_I186_D0.5640.71
162_P171_M0.5640.71
44_D49_L0.5630.71
212_A243_T0.5630.71
232_I303_D0.5610.71
291_G295_T0.5600.70
218_A400_Y0.5590.70
75_W144_K0.5580.70
388_I392_M0.5580.70
309_P316_I0.5570.70
175_L179_I0.5570.70
123_K359_N0.5560.70
59_K71_T0.5560.70
312_V315_V0.5540.70
78_Q157_V0.5520.69
275_A293_K0.5520.69
279_V293_K0.5520.69
225_G229_S0.5510.69
74_G144_K0.5500.69
371_A375_S0.5500.69
45_T425_V0.5500.69
209_L245_K0.5500.69
262_G293_K0.5490.69
321_A329_I0.5490.69
123_K161_A0.5490.69
245_K273_N0.5480.69
316_I344_V0.5450.68
137_E140_D0.5440.68
318_K345_I0.5420.68
198_G369_E0.5420.68
361_G365_G0.5410.68
377_G383_E0.5400.68
313_E335_G0.5400.68
193_K369_E0.5390.68
82_A109_T0.5380.67
151_N181_I0.5370.67
402_F405_R0.5360.67
277_E283_G0.5350.67
220_N393_T0.5340.67
162_P238_N0.5330.67
139_E173_W0.5330.67
403_H409_D0.5330.67
200_I365_G0.5320.67
183_G186_D0.5310.66
182_T186_D0.5310.66
286_V293_K0.5300.66
209_L389_I0.5300.66
239_V359_N0.5300.66
303_D327_K0.5290.66
279_V285_V0.5280.66
297_E320_N0.5280.66
93_S260_I0.5270.66
141_L146_I0.5260.66
152_Y157_V0.5250.66
63_R69_L0.5230.65
138_L282_T0.5230.65
117_L424_V0.5220.65
365_G368_V0.5220.65
132_K135_L0.5200.65
113_S420_A0.5190.65
214_I396_F0.5190.65
87_K203_R0.5190.65
406_K409_D0.5170.64
138_L142_S0.5170.64
249_E273_N0.5140.64
266_N290_E0.5140.64
215_A332_G0.5140.64
114_L395_A0.5140.64
236_F285_V0.5140.64
200_I372_N0.5110.63
48_A428_M0.5100.63
87_K366_S0.5090.63
214_I353_I0.5080.63
322_P347_Q0.5080.63
307_L329_I0.5060.63
162_P166_T0.5060.63
212_A215_A0.5060.63
212_A246_F0.5050.63
261_G293_K0.5040.62
398_T402_F0.5020.62
349_G409_D0.5000.62
203_R365_G0.5000.62
342_D345_I0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r3jA 5 0.9977 100 0.102 Contact Map
4fccA 5 0.9885 100 0.105 Contact Map
2bmaA 5 0.9931 100 0.106 Contact Map
2yfqA 5 0.9009 100 0.11 Contact Map
4xgiA 6 0.9562 100 0.111 Contact Map
1bgvA 5 1 100 0.111 Contact Map
2tmgA 5 0.9378 100 0.123 Contact Map
1v9lA 4 0.9493 100 0.126 Contact Map
3mw9A 5 0.9631 100 0.129 Contact Map
3k92A 5 0.9631 100 0.129 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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