GREMLIN Database
Q97X18 - Antibiotic ABC transporter ATP binding protein
UniProt: Q97X18 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (231)
Sequences: 99480 (57700)
Seq/√Len: 3796.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_E197_R3.4981.00
15_I18_D3.0731.00
74_A147_S3.0451.00
3_V23_E3.0291.00
6_S19_N3.0041.00
30_V199_F2.8911.00
5_S57_E2.8761.00
197_R209_S2.7951.00
31_S195_S2.7371.00
57_E64_N2.7251.00
120_Y123_S2.6591.00
25_K28_E2.5801.00
10_K15_I2.5051.00
3_V59_Q2.4481.00
211_T214_D2.3411.00
18_D205_K2.3271.00
210_G214_D2.3241.00
8_V55_K2.2201.00
8_V15_I2.2111.00
9_K46_I2.2031.00
5_S59_Q2.1881.00
8_V19_N2.1111.00
199_F209_S2.0631.00
199_F206_I2.0491.00
107_E145_N1.9921.00
4_V7_I1.9721.00
61_L147_S1.9691.00
110_R114_F1.9051.00
26_K147_S1.8651.00
91_R95_E1.8601.00
145_N179_V1.7561.00
90_G128_Y1.7321.00
109_K121_A1.7231.00
91_R105_K1.7181.00
105_K109_K1.7051.00
44_I150_I1.6881.00
44_I184_T1.6661.00
171_N193_K1.6651.00
91_R121_A1.6621.00
192_K213_E1.6581.00
95_E108_V1.6511.00
107_E110_R1.5761.00
185_S191_V1.5711.00
11_Y42_T1.5451.00
113_E118_E1.5451.00
11_Y16_A1.5161.00
91_R122_N1.5111.00
22_L199_F1.5091.00
64_N67_R1.5081.00
123_S127_K1.4901.00
6_S21_S1.4801.00
9_K51_M1.4631.00
9_K54_D1.4361.00
210_G215_M1.4271.00
28_E196_D1.4081.00
94_L112_L1.4051.00
4_V22_L1.3871.00
24_V30_V1.3741.00
114_F172_K1.3721.00
8_V18_D1.3451.00
10_K54_D1.3441.00
219_F223_Q1.3361.00
30_V209_S1.3291.00
91_R108_V1.3251.00
111_V143_L1.3161.00
95_E105_K1.3161.00
61_L74_A1.3131.00
7_I53_P1.2741.00
49_T52_K1.2671.00
202_Y207_V1.2571.00
25_K197_R1.2561.00
112_L121_A1.2561.00
109_K113_E1.2531.00
91_R109_K1.2361.00
59_Q64_N1.2311.00
31_S191_V1.2281.00
214_D218_E1.2271.00
20_I43_L1.2271.00
29_F174_K1.2181.00
111_V115_V1.2061.00
22_L43_L1.2001.00
89_T92_Q1.1991.00
221_G224_V1.1991.00
30_V197_R1.1871.00
208_F218_E1.1861.00
87_F92_Q1.1711.00
4_V47_L1.1631.00
63_E68_N1.1581.00
106_S110_R1.1521.00
17_L46_I1.1421.00
5_S23_E1.1411.00
48_L77_Y1.1411.00
212_V222_I1.1401.00
151_M181_I1.1181.00
167_R190_D1.1041.00
46_I53_P1.0961.00
223_Q227_E1.0941.00
10_K13_N1.0911.00
93_V140_E1.0871.00
32_L43_L1.0861.00
164_L168_E1.0821.00
174_K181_I1.0751.00
29_F195_S1.0681.00
111_V139_A1.0521.00
76_G146_P1.0511.00
158_I166_T1.0501.00
80_E130_K1.0461.00
120_Y128_Y1.0441.00
207_V221_G1.0391.00
43_L201_I1.0331.00
213_E217_K1.0201.00
149_L179_V1.0201.00
112_L117_M1.0111.00
116_E165_K1.0091.00
92_Q95_E1.0061.00
163_S187_E1.0041.00
222_I225_I1.0021.00
110_R113_E1.0001.00
29_F181_I0.9981.00
26_K61_L0.9961.00
88_L92_Q0.9911.00
5_S21_S0.9901.00
94_L143_L0.9901.00
29_F183_M0.9861.00
107_E111_V0.9831.00
45_R51_M0.9831.00
163_S190_D0.9651.00
98_A107_E0.9621.00
47_L182_L0.9591.00
98_A102_G0.9591.00
171_N174_K0.9561.00
32_L182_L0.9551.00
4_V43_L0.9481.00
115_V139_A0.9431.00
169_L172_K0.9421.00
101_R144_G0.9371.00
6_S55_K0.9361.00
208_F220_L0.9331.00
208_F219_F0.9311.00
35_P202_Y0.9291.00
70_R73_K0.9251.00
9_K42_T0.9221.00
198_I212_V0.9201.00
214_D217_K0.9161.00
128_Y136_I0.9141.00
78_V151_M0.9141.00
89_T122_N0.9031.00
125_I136_I0.9031.00
76_G141_S0.8971.00
149_L181_I0.8851.00
105_K108_V0.8841.00
63_E74_A0.8831.00
98_A143_L0.8801.00
4_V58_V0.8711.00
52_K66_F0.8621.00
106_S109_K0.8551.00
32_L199_F0.8551.00
94_L108_V0.8541.00
174_K196_D0.8521.00
153_E186_H0.8491.00
48_L150_I0.8381.00
90_G136_I0.8371.00
167_R193_K0.8361.00
118_E121_A0.8351.00
151_M170_L0.8331.00
98_A103_V0.8331.00
10_K16_A0.8241.00
95_E99_K0.8241.00
104_D107_E0.8231.00
120_Y132_M0.8211.00
78_V141_S0.8191.00
89_T124_P0.8181.00
78_V138_I0.8111.00
46_I58_V0.8061.00
38_A201_I0.8051.00
84_Y133_V0.8011.00
170_L181_I0.7951.00
26_K178_N0.7941.00
19_N205_K0.7871.00
124_P127_K0.7871.00
10_K18_D0.7831.00
7_I46_I0.7831.00
168_E171_N0.7771.00
222_I226_V0.7741.00
212_V216_I0.7721.00
30_V182_L0.7691.00
57_E66_F0.7681.00
53_P66_F0.7681.00
147_S179_V0.7611.00
17_L20_I0.7611.00
150_I182_L0.7591.00
29_F171_N0.7591.00
206_I209_S0.7591.00
2_I148_I0.7581.00
20_I206_I0.7551.00
51_M54_D0.7471.00
192_K212_V0.7471.00
183_M195_S0.7401.00
165_K168_E0.7401.00
88_L93_V0.7371.00
46_I51_M0.7371.00
221_G225_I0.7371.00
87_F126_I0.7341.00
24_V182_L0.7331.00
111_V142_L0.7331.00
19_N55_K0.7311.00
24_V180_S0.7281.00
168_E172_K0.7271.00
97_S140_E0.7251.00
110_R145_N0.7221.00
155_N166_T0.7221.00
25_K180_S0.7211.00
89_T93_V0.7201.00
111_V114_F0.7181.00
29_F194_L0.7141.00
63_E70_R0.7131.00
130_K135_R0.7091.00
128_Y132_M0.7081.00
64_N68_N0.7071.00
202_Y226_V0.7061.00
208_F215_M0.7051.00
225_I229_D0.7031.00
83_N133_V0.7021.00
70_R74_A0.7021.00
109_K112_L0.7011.00
93_V125_I0.7001.00
45_R50_L0.6921.00
192_K216_I0.6901.00
109_K118_E0.6881.00
173_L179_V0.6871.00
28_E209_S0.6851.00
116_E172_K0.6841.00
108_V111_V0.6821.00
202_Y221_G0.6811.00
17_L43_L0.6781.00
71_I75_I0.6781.00
33_I200_M0.6741.00
33_I191_V0.6721.00
82_P137_A0.6691.00
226_V230_E0.6681.00
200_M215_M0.6651.00
2_I47_L0.6631.00
47_L58_V0.6631.00
175_R178_N0.6611.00
171_N194_L0.6601.00
6_S9_K0.6591.00
219_F222_I0.6591.00
36_N162_F0.6591.00
122_N125_I0.6571.00
168_E193_K0.6511.00
148_I180_S0.6491.00
15_I19_N0.6461.00
33_I188_L0.6451.00
113_E119_N0.6441.00
59_Q62_G0.6371.00
76_G144_G0.6361.00
88_L96_L0.6311.00
188_L216_I0.6311.00
224_V228_T0.6311.00
171_N175_R0.6301.00
75_I148_I0.6301.00
23_E209_S0.6281.00
105_K121_A0.6271.00
61_L148_I0.6241.00
46_I54_D0.6191.00
195_S198_I0.6141.00
219_F224_V0.6101.00
36_N153_E0.6081.00
202_Y205_K0.6001.00
103_V107_E0.6001.00
208_F223_Q0.5981.00
9_K17_L0.5961.00
91_R118_E0.5921.00
15_I55_K0.5901.00
2_I60_I0.5891.00
185_S190_D0.5861.00
24_V148_I0.5851.00
191_V195_S0.5831.00
10_K55_K0.5811.00
109_K117_M0.5781.00
226_V229_D0.5781.00
190_D194_L0.5761.00
11_Y51_M0.5751.00
200_M219_F0.5741.00
85_P93_V0.5731.00
108_V112_L0.5681.00
230_E233_N0.5671.00
129_S132_M0.5671.00
16_A42_T0.5661.00
48_L75_I0.5641.00
12_G15_I0.5621.00
174_K179_V0.5621.00
215_M224_V0.5611.00
57_E67_R0.5611.00
79_Q82_P0.5591.00
224_V227_E0.5591.00
106_S113_E0.5581.00
109_K119_N0.5571.00
41_T45_R0.5561.00
155_N190_D0.5551.00
60_I148_I0.5541.00
81_I133_V0.5541.00
69_K72_F0.5531.00
162_F165_K0.5531.00
97_S144_G0.5531.00
10_K14_K0.5521.00
3_V62_G0.5491.00
148_I182_L0.5481.00
60_I74_A0.5471.00
82_P133_V0.5471.00
191_V198_I0.5441.00
60_I71_I0.5401.00
218_E221_G0.5361.00
86_P133_V0.5361.00
27_G180_S0.5341.00
18_D203_K0.5341.00
86_P126_I0.5331.00
189_E193_K0.5321.00
63_E67_R0.5301.00
68_N71_I0.5301.00
14_K203_K0.5271.00
219_F227_E0.5271.00
142_L179_V0.5261.00
26_K180_S0.5251.00
220_L225_I0.5231.00
197_R211_T0.5201.00
29_F196_D0.5201.00
96_L100_I0.5191.00
112_L115_V0.5171.00
9_K16_A0.5161.00
32_L201_I0.5151.00
117_M120_Y0.5151.00
47_L150_I0.5151.00
195_S212_V0.5121.00
135_R162_F0.5111.00
97_S100_I0.5091.00
134_Q157_G0.5081.00
49_T66_F0.5071.00
183_M194_L0.5071.00
138_I166_T0.5061.00
115_V169_L0.5051.00
4_V46_I0.5051.00
65_P71_I0.5051.00
3_V21_S0.5041.00
230_E234_A0.5031.00
38_A203_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yerA 2 0.9057 100 0.133 Contact Map
3tuiC 2 1 100 0.176 Contact Map
3d31A 2 0.9966 100 0.189 Contact Map
1z47A 2 0.9865 100 0.193 Contact Map
1v43A 2 0.9596 100 0.194 Contact Map
2yyzA 1 0.9966 100 0.195 Contact Map
2it1A 1 0.9966 100 0.196 Contact Map
4rvcA 4 0.7879 100 0.199 Contact Map
4u00A 1 0.7811 100 0.2 Contact Map
3rlfA 2 1 100 0.201 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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