Q97X15 - SULSO - GREMLIN Contacts

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Q97X15 - Uncharacterized protein

UniProt:	Q97X15	Sequences: MLFNTRPKEDRKDLYDREKEIEMIKDSIARGEWIAVLGMRRIGKTSVVNVAVKEIGAIKVSINLMRIHDSRKKQYPKHVLISLLIEEINEAIKNYTILGKVAKLLSNILGVEEIQTNKVRAKLTKIRGTDITYIIREMDSIARDNKKQLVIILDEAQELAKVNGLDFPSIFHDVYDNCKNTVIIFTGSMVKLIEKTLKNIEYTEPFFGRYIRKITLGRFLPEQSREFLEKGFEEEGIKVDESVIDEAVKRLDGIPGWLTLFGSEYTFSAKMGTKPRIDEIIEKAINEVRNEARNFIFSTQSPLRYSAVILALDRLGGKGELHEIVKVSSTILNENIPEPRVYEILNRLVEFDFIERREDNEYYLHQDEPNRKGLILAAKDSPASYSI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	387 (323)
Sequences:	10517 (9082)
Seq/√Len:	505.4

ECOLI - MALT
BACSU - GUTR
SULSO - Q97X15 Q97Y08 Q97VA4 Q7LX94 Q7LX62 Q97X37

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
224_S	258_L	4.447	1.00
220_L	223_Q	4.024	1.00
25_K	54_E	3.994	1.00
305_Y	347_R	3.403	1.00
302_P	347_R	3.182	1.00
24_I	51_A	3.160	1.00
291_E	299_T	2.817	1.00
46_S	50_V	2.632	1.00
221_P	245_D	2.606	1.00
48_V	152_I	2.531	1.00
296_I	299_T	2.517	1.00
225_R	244_I	2.517	1.00
37_L	213_K	2.485	1.00
50_V	53_K	2.466	1.00
182_V	186_T	2.448	1.00
52_V	152_I	2.387	1.00
312_L	319_G	2.384	1.00
305_Y	348_L	2.326	1.00
38_G	42_I	2.319	1.00
314_R	375_I	2.244	1.00
320_E	323_E	2.199	1.00
228_L	262_G	2.167	1.00
302_P	305_Y	2.151	1.00
131_I	135_I	2.114	1.00
224_S	248_V	2.082	1.00
21_I	50_V	2.048	1.00
48_V	186_T	2.028	1.00
131_I	134_I	2.014	1.00
24_I	34_I	1.991	1.00
18_E	223_Q	1.991	1.00
61_S	147_K	1.990	1.00
223_Q	226_E	1.990	1.00
14_L	50_V	1.979	1.00
22_E	26_D	1.972	1.00
295_F	299_T	1.966	1.00
48_V	188_S	1.948	1.00
355_E	363_Y	1.933	1.00
292_A	296_I	1.920	1.00
306_S	310_L	1.846	1.00
292_A	299_T	1.845	1.00
160_A	163_N	1.821	1.00
50_V	54_E	1.813	1.00
37_L	215_T	1.797	1.00
16_D	223_Q	1.771	1.00
181_T	186_T	1.766	1.00
36_V	48_V	1.748	1.00
221_P	248_V	1.748	1.00
221_P	225_R	1.731	1.00
154_D	188_S	1.712	1.00
14_L	46_S	1.712	1.00
128_G	132_T	1.678	1.00
308_V	344_I	1.676	1.00
292_A	295_F	1.658	1.00
279_E	282_E	1.591	1.00
29_A	58_I	1.580	1.00
28_I	55_I	1.571	1.00
156_A	187_G	1.566	1.00
247_A	258_L	1.565	1.00
294_N	299_T	1.565	1.00
49_N	64_L	1.564	1.00
309_I	348_L	1.552	1.00
260_L	263_S	1.552	1.00
357_R	363_Y	1.547	1.00
229_E	244_I	1.533	1.00
27_S	34_I	1.530	1.00
246_E	250_R	1.523	1.00
240_D	243_V	1.521	1.00
295_F	298_S	1.519	1.00
159_L	168_P	1.519	1.00
25_K	51_A	1.515	1.00
304_R	344_I	1.510	1.00
20_E	214_I	1.506	1.00
23_M	212_R	1.494	1.00
55_I	60_V	1.492	1.00
182_V	188_S	1.481	1.00
133_Y	137_E	1.475	1.00
246_E	249_K	1.470	1.00
291_E	294_N	1.426	1.00
15_Y	230_K	1.422	1.00
321_L	325_V	1.412	1.00
19_K	22_E	1.402	1.00
291_E	296_I	1.384	1.00
245_D	249_K	1.377	1.00
225_R	241_E	1.375	1.00
83_L	87_E	1.362	1.00
336_I	341_V	1.352	1.00
278_D	282_E	1.345	1.00
278_D	281_I	1.340	1.00
66_R	69_D	1.337	1.00
288_V	291_E	1.328	1.00
19_K	23_M	1.327	1.00
42_I	255_P	1.320	1.00
137_E	140_S	1.311	1.00
318_K	361_E	1.304	1.00
39_M	42_I	1.300	1.00
13_D	46_S	1.293	1.00
315_L	319_G	1.281	1.00
227_F	258_L	1.278	1.00
349_V	354_I	1.277	1.00
46_S	259_T	1.272	1.00
293_R	297_F	1.268	1.00
221_P	249_K	1.268	1.00
24_I	47_V	1.266	1.00
173_D	177_N	1.266	1.00
47_V	216_L	1.265	1.00
21_I	51_A	1.264	1.00
310_L	378_A	1.263	1.00
130_D	133_Y	1.260	1.00
312_L	364_L	1.255	1.00
60_V	150_V	1.246	1.00
346_N	350_E	1.241	1.00
219_F	223_Q	1.239	1.00
353_F	370_N	1.236	1.00
312_L	354_I	1.235	1.00
325_V	338_E	1.231	1.00
319_G	362_Y	1.227	1.00
251_L	261_F	1.221	1.00
337_P	340_R	1.218	1.00
226_E	230_K	1.214	1.00
349_V	356_R	1.211	1.00
80_L	163_N	1.209	1.00
277_I	280_I	1.200	1.00
18_E	22_E	1.190	1.00
40_R	155_E	1.189	1.00
131_I	136_R	1.186	1.00
170_I	174_V	1.180	1.00
225_R	229_E	1.165	1.00
128_G	134_I	1.164	1.00
250_R	372_K	1.164	1.00
308_V	328_S	1.162	1.00
251_L	258_L	1.158	1.00
134_I	139_D	1.154	1.00
347_R	351_F	1.150	1.00
305_Y	351_F	1.150	1.00
368_E	372_K	1.141	1.00
36_V	216_L	1.138	1.00
20_E	217_G	1.122	1.00
225_R	245_D	1.119	1.00
371_R	375_I	1.103	1.00
226_E	229_E	1.094	1.00
13_D	230_K	1.089	1.00
23_M	27_S	1.082	1.00
135_I	139_D	1.081	1.00
51_A	55_I	1.077	1.00
36_V	214_I	1.076	1.00
154_D	157_Q	1.076	1.00
220_L	224_S	1.071	1.00
181_T	187_G	1.070	1.00
136_R	139_D	1.068	1.00
304_R	340_R	1.064	1.00
104_L	107_N	1.062	1.00
293_R	376_L	1.062	1.00
294_N	298_S	1.062	1.00
308_V	324_I	1.056	1.00
28_I	150_V	1.055	1.00
48_V	52_V	1.054	1.00
293_R	296_I	1.053	1.00
181_T	188_S	1.052	1.00
301_S	305_Y	1.052	1.00
372_K	376_L	1.047	1.00
325_V	341_V	1.033	1.00
132_T	173_D	1.032	1.00
182_V	187_G	1.019	1.00
42_I	254_I	1.011	1.00
172_H	176_D	1.008	1.00
202_Y	205_P	1.006	1.00
132_T	136_R	1.004	1.00
328_S	336_I	0.999	1.00
135_I	138_M	0.992	1.00
313_D	375_I	0.988	1.00
20_E	47_V	0.987	1.00
67_I	70_S	0.986	1.00
45_T	49_N	0.985	1.00
256_G	367_D	0.984	1.00
27_S	212_R	0.982	1.00
368_E	371_R	0.979	1.00
287_E	291_E	0.979	1.00
289_R	299_T	0.978	1.00
25_K	29_A	0.976	1.00
204_E	207_F	0.975	1.00
18_E	226_E	0.973	1.00
61_S	64_L	0.972	1.00
291_E	295_F	0.971	1.00
308_V	341_V	0.970	1.00
33_W	175_Y	0.970	1.00
25_K	55_I	0.969	1.00
288_V	299_T	0.969	1.00
132_T	139_D	0.968	1.00
80_L	83_L	0.960	1.00
23_M	26_D	0.955	1.00
345_L	362_Y	0.954	1.00
311_A	328_S	0.952	1.00
293_R	299_T	0.947	1.00
80_L	170_I	0.946	1.00
161_K	169_S	0.945	1.00
23_M	214_I	0.936	1.00
319_G	324_I	0.936	1.00
128_G	131_I	0.936	1.00
336_I	340_R	0.935	1.00
52_V	150_V	0.934	1.00
222_E	225_R	0.933	1.00
130_D	134_I	0.919	1.00
28_I	60_V	0.915	1.00
304_R	307_A	0.915	1.00
100_K	103_K	0.904	1.00
65_M	83_L	0.900	1.00
307_A	310_L	0.899	1.00
36_V	47_V	0.890	1.00
133_Y	136_R	0.888	1.00
321_L	342_Y	0.886	1.00
22_E	25_K	0.886	1.00
355_E	366_Q	0.883	1.00
349_V	362_Y	0.877	1.00
25_K	58_I	0.877	1.00
129_T	133_Y	0.876	1.00
39_M	218_R	0.874	1.00
244_I	248_V	0.872	1.00
85_I	89_N	0.871	1.00
288_V	296_I	0.870	1.00
129_T	132_T	0.870	1.00
219_F	227_F	0.863	1.00
269_A	272_G	0.858	1.00
37_L	189_M	0.852	1.00
285_I	288_V	0.852	1.00
21_I	54_E	0.852	1.00
184_I	187_G	0.851	1.00
231_G	262_G	0.848	1.00
52_V	62_I	0.846	1.00
356_R	362_Y	0.843	1.00
309_I	313_D	0.838	1.00
102_A	106_S	0.838	1.00
184_I	188_S	0.836	1.00
297_F	377_A	0.836	1.00
293_R	298_S	0.836	1.00
241_E	245_D	0.833	1.00
100_K	106_S	0.829	1.00
202_Y	206_F	0.827	1.00
20_E	23_M	0.825	1.00
228_L	244_I	0.825	1.00
308_V	345_L	0.824	1.00
101_V	109_L	0.823	1.00
128_G	135_I	0.822	1.00
354_I	364_L	0.821	1.00
290_N	294_N	0.819	1.00
20_E	216_L	0.819	1.00
288_V	298_S	0.816	1.00
228_L	247_A	0.814	1.00
28_I	51_A	0.811	1.00
289_R	292_A	0.808	1.00
366_Q	370_N	0.791	1.00
346_N	349_V	0.789	1.00
303_L	306_S	0.785	1.00
231_G	259_T	0.784	1.00
81_I	85_I	0.784	1.00
79_V	83_L	0.782	1.00
152_I	188_S	0.779	1.00
256_G	260_L	0.777	1.00
57_A	60_V	0.776	1.00
313_D	364_L	0.775	1.00
169_S	172_H	0.772	1.00
156_A	159_L	0.771	1.00
81_I	87_E	0.770	1.00
44_K	256_G	0.769	1.00
88_I	92_I	0.764	1.00
59_K	63_N	0.760	1.00
108_I	111_V	0.758	1.00
224_S	262_G	0.758	1.00
21_I	25_K	0.756	1.00
128_G	139_D	0.754	1.00
45_T	154_D	0.752	1.00
139_D	142_A	0.749	1.00
79_V	163_N	0.749	1.00
33_W	185_F	0.746	1.00
252_D	368_E	0.745	1.00
336_I	344_I	0.744	1.00
130_D	137_E	0.744	1.00
55_I	150_V	0.744	1.00
42_I	216_L	0.743	1.00
62_I	65_M	0.743	1.00
320_E	361_E	0.737	1.00
83_L	151_I	0.735	1.00
15_Y	223_Q	0.733	1.00
228_L	231_G	0.732	1.00
72_K	75_Y	0.729	1.00
132_T	137_E	0.725	1.00
75_Y	78_H	0.723	1.00
248_V	251_L	0.723	1.00
291_E	298_S	0.722	1.00
340_R	343_E	0.722	1.00
131_I	138_M	0.720	1.00
228_L	258_L	0.717	1.00
106_S	110_G	0.713	1.00
248_V	253_G	0.712	1.00
64_L	67_I	0.712	1.00
79_V	82_S	0.711	1.00
173_D	176_D	0.711	1.00
178_C	181_T	0.711	1.00
218_R	252_D	0.710	1.00
61_S	149_L	0.708	1.00
107_N	110_G	0.706	1.00
128_G	137_E	0.705	1.00
129_T	134_I	0.704	1.00
203_T	207_F	0.703	1.00
311_A	327_V	0.702	1.00
35_A	187_G	0.702	1.00
137_E	141_I	0.700	1.00
288_V	292_A	0.699	1.00
40_R	190_V	0.699	1.00
224_S	253_G	0.699	1.00
325_V	328_S	0.699	1.00
180_N	187_G	0.698	1.00
181_T	184_I	0.693	1.00
25_K	28_I	0.692	1.00
227_F	259_T	0.692	1.00
218_R	251_L	0.690	1.00
247_A	261_F	0.687	1.00
305_Y	344_I	0.685	1.00
52_V	56_G	0.681	1.00
52_V	64_L	0.681	1.00
103_K	106_S	0.680	1.00
46_S	49_N	0.678	1.00
321_L	341_V	0.676	1.00
105_L	112_E	0.674	1.00
289_R	293_R	0.674	1.00
182_V	185_F	0.674	1.00
316_G	371_R	0.673	1.00
138_M	141_I	0.672	1.00
42_I	218_R	0.669	1.00
132_T	135_I	0.667	1.00
287_E	293_R	0.666	1.00
66_R	154_D	0.665	1.00
35_A	211_I	0.663	1.00
310_L	377_A	0.660	1.00
130_D	139_D	0.660	1.00
182_V	189_M	0.660	1.00
77_K	162_V	0.659	1.00
309_I	353_F	0.657	1.00
27_S	214_I	0.657	1.00
201_E	204_E	0.656	1.00
58_I	62_I	0.653	1.00
272_G	276_R	0.651	1.00
48_V	154_D	0.649	1.00
76_P	79_V	0.648	1.00
134_I	138_M	0.645	1.00
60_V	63_N	0.642	1.00
345_L	354_I	0.641	1.00
290_N	295_F	0.638	1.00
150_V	184_I	0.637	1.00
319_G	327_V	0.636	1.00
324_I	341_V	0.634	1.00
277_I	281_I	0.633	1.00
101_V	104_L	0.631	1.00
286_N	289_R	0.630	1.00
37_L	191_K	0.630	1.00
254_I	259_T	0.628	1.00
319_G	364_L	0.627	1.00
271_M	276_R	0.626	1.00
225_R	248_V	0.626	1.00
128_G	169_S	0.625	1.00
183_I	187_G	0.625	1.00
309_I	374_L	0.614	1.00
155_E	158_E	0.613	1.00
55_I	59_K	0.611	1.00
59_K	62_I	0.610	1.00
243_V	246_E	0.609	1.00
56_G	59_K	0.609	1.00
101_V	105_L	0.607	0.99
136_R	140_S	0.607	0.99
317_G	368_E	0.606	0.99
348_L	354_I	0.606	0.99
103_K	108_I	0.605	0.99
288_V	295_F	0.603	0.99
344_I	347_R	0.603	0.99
221_P	251_L	0.602	0.99
67_I	79_V	0.602	0.99
322_H	326_K	0.599	0.99
67_I	159_L	0.599	0.99
34_I	214_I	0.597	0.99
185_F	188_S	0.596	0.99
304_R	336_I	0.595	0.99
130_D	135_I	0.595	0.99
49_N	52_V	0.594	0.99
232_F	239_V	0.593	0.99
82_S	86_E	0.592	0.99
264_E	268_S	0.590	0.99
229_E	238_K	0.590	0.99
100_K	104_L	0.586	0.99
15_Y	226_E	0.585	0.99
104_L	108_I	0.584	0.99
370_N	373_G	0.583	0.99
298_S	351_F	0.577	0.99
81_I	84_L	0.577	0.99
280_I	283_K	0.576	0.99
154_D	187_G	0.576	0.99
134_I	137_E	0.576	0.99
100_K	108_I	0.575	0.99
127_R	130_D	0.575	0.99
102_A	107_N	0.574	0.99
40_R	367_D	0.574	0.99
289_R	295_F	0.573	0.99
256_G	259_T	0.572	0.99
342_Y	346_N	0.571	0.99
285_I	289_R	0.571	0.99
16_D	220_L	0.570	0.99
357_R	361_E	0.567	0.99
315_L	327_V	0.565	0.99
352_D	366_Q	0.565	0.99
83_L	86_E	0.565	0.99
128_G	136_R	0.562	0.99
292_A	298_S	0.562	0.99
148_Q	182_V	0.559	0.99
136_R	177_N	0.559	0.99
289_R	294_N	0.558	0.99
254_I	257_W	0.558	0.99
40_R	157_Q	0.558	0.99
75_Y	80_L	0.557	0.99
288_V	293_R	0.557	0.99
324_I	327_V	0.554	0.99
41_R	188_S	0.554	0.99
78_H	82_S	0.552	0.99
288_V	294_N	0.551	0.99
309_I	364_L	0.546	0.99
156_A	185_F	0.545	0.99
168_P	196_T	0.545	0.99
76_P	80_L	0.545	0.99
51_A	150_V	0.544	0.99
312_L	316_G	0.544	0.99
189_M	196_T	0.544	0.99
105_L	108_I	0.544	0.99
245_D	248_V	0.544	0.99
41_R	155_E	0.543	0.99
54_E	58_I	0.542	0.99
103_K	111_V	0.540	0.99
65_M	153_L	0.540	0.99
108_I	112_E	0.540	0.99
168_P	172_H	0.537	0.99
26_D	29_A	0.535	0.99
79_V	159_L	0.533	0.99
310_L	313_D	0.532	0.99
130_D	142_A	0.532	0.99
169_S	173_D	0.531	0.99
101_V	106_S	0.531	0.99
142_A	149_L	0.530	0.99
63_N	149_L	0.530	0.99
51_A	186_T	0.529	0.99
201_E	206_F	0.528	0.99
308_V	312_L	0.528	0.99
186_T	190_V	0.527	0.99
180_N	183_I	0.526	0.99
228_L	232_F	0.526	0.99
328_S	335_N	0.526	0.99
208_G	212_R	0.525	0.99
348_L	351_F	0.524	0.99
340_R	344_I	0.524	0.99
103_K	110_G	0.523	0.99
338_E	341_V	0.523	0.99
259_T	263_S	0.522	0.98
374_L	377_A	0.521	0.98
104_L	111_V	0.521	0.98
155_E	187_G	0.520	0.98
129_T	135_I	0.520	0.98
323_E	327_V	0.517	0.98
154_D	368_E	0.517	0.98
345_L	349_V	0.514	0.98
28_I	182_V	0.512	0.98
301_S	309_I	0.512	0.98
57_A	61_S	0.512	0.98
106_S	109_L	0.511	0.98
351_F	355_E	0.511	0.98
310_L	374_L	0.510	0.98
44_K	367_D	0.509	0.98
201_E	207_F	0.508	0.98
14_L	223_Q	0.508	0.98
243_V	265_Y	0.508	0.98
224_S	247_A	0.507	0.98
136_R	173_D	0.505	0.98
315_L	323_E	0.505	0.98
294_N	297_F	0.504	0.98
260_L	299_T	0.503	0.98
14_L	18_E	0.502	0.98
34_I	184_I	0.501	0.98
33_W	211_I	0.501	0.98
77_K	80_L	0.500	0.98
252_D	317_G	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2fnaA	1	0.8941	100	0.416	Contact Map
2qenA	1	0.8915	100	0.43	Contact Map
1z6tA	1	0.8191	100	0.546	Contact Map
2a5yB	2	0.832	100	0.58	Contact Map
3sfzA	1	0.8191	99.9	0.604	Contact Map
1w5sA	1	0.876	99.9	0.619	Contact Map
1fnnA	1	0.8605	99.9	0.627	Contact Map
1vt4I	4	0.8088	99.9	0.641	Contact Map
2qbyA	1	0.8553	99.9	0.643	Contact Map
3pfiA	3	0.7261	99.9	0.65	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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