GREMLIN Database
Q97X15 - Uncharacterized protein
UniProt: Q97X15 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 387 (323)
Sequences: 10517 (9082)
Seq/√Len: 505.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
224_S258_L4.4471.00
220_L223_Q4.0241.00
25_K54_E3.9941.00
305_Y347_R3.4031.00
302_P347_R3.1821.00
24_I51_A3.1601.00
291_E299_T2.8171.00
46_S50_V2.6321.00
221_P245_D2.6061.00
48_V152_I2.5311.00
296_I299_T2.5171.00
225_R244_I2.5171.00
37_L213_K2.4851.00
50_V53_K2.4661.00
182_V186_T2.4481.00
52_V152_I2.3871.00
312_L319_G2.3841.00
305_Y348_L2.3261.00
38_G42_I2.3191.00
314_R375_I2.2441.00
320_E323_E2.1991.00
228_L262_G2.1671.00
302_P305_Y2.1511.00
131_I135_I2.1141.00
224_S248_V2.0821.00
21_I50_V2.0481.00
48_V186_T2.0281.00
131_I134_I2.0141.00
24_I34_I1.9911.00
18_E223_Q1.9911.00
61_S147_K1.9901.00
223_Q226_E1.9901.00
14_L50_V1.9791.00
22_E26_D1.9721.00
295_F299_T1.9661.00
48_V188_S1.9481.00
355_E363_Y1.9331.00
292_A296_I1.9201.00
306_S310_L1.8461.00
292_A299_T1.8451.00
160_A163_N1.8211.00
50_V54_E1.8131.00
37_L215_T1.7971.00
16_D223_Q1.7711.00
181_T186_T1.7661.00
36_V48_V1.7481.00
221_P248_V1.7481.00
221_P225_R1.7311.00
154_D188_S1.7121.00
14_L46_S1.7121.00
128_G132_T1.6781.00
308_V344_I1.6761.00
292_A295_F1.6581.00
279_E282_E1.5911.00
29_A58_I1.5801.00
28_I55_I1.5711.00
156_A187_G1.5661.00
247_A258_L1.5651.00
294_N299_T1.5651.00
49_N64_L1.5641.00
309_I348_L1.5521.00
260_L263_S1.5521.00
357_R363_Y1.5471.00
229_E244_I1.5331.00
27_S34_I1.5301.00
246_E250_R1.5231.00
240_D243_V1.5211.00
295_F298_S1.5191.00
159_L168_P1.5191.00
25_K51_A1.5151.00
304_R344_I1.5101.00
20_E214_I1.5061.00
23_M212_R1.4941.00
55_I60_V1.4921.00
182_V188_S1.4811.00
133_Y137_E1.4751.00
246_E249_K1.4701.00
291_E294_N1.4261.00
15_Y230_K1.4221.00
321_L325_V1.4121.00
19_K22_E1.4021.00
291_E296_I1.3841.00
245_D249_K1.3771.00
225_R241_E1.3751.00
83_L87_E1.3621.00
336_I341_V1.3521.00
278_D282_E1.3451.00
278_D281_I1.3401.00
66_R69_D1.3371.00
288_V291_E1.3281.00
19_K23_M1.3271.00
42_I255_P1.3201.00
137_E140_S1.3111.00
318_K361_E1.3041.00
39_M42_I1.3001.00
13_D46_S1.2931.00
315_L319_G1.2811.00
227_F258_L1.2781.00
349_V354_I1.2771.00
46_S259_T1.2721.00
293_R297_F1.2681.00
221_P249_K1.2681.00
24_I47_V1.2661.00
173_D177_N1.2661.00
47_V216_L1.2651.00
21_I51_A1.2641.00
310_L378_A1.2631.00
130_D133_Y1.2601.00
312_L364_L1.2551.00
60_V150_V1.2461.00
346_N350_E1.2411.00
219_F223_Q1.2391.00
353_F370_N1.2361.00
312_L354_I1.2351.00
325_V338_E1.2311.00
319_G362_Y1.2271.00
251_L261_F1.2211.00
337_P340_R1.2181.00
226_E230_K1.2141.00
349_V356_R1.2111.00
80_L163_N1.2091.00
277_I280_I1.2001.00
18_E22_E1.1901.00
40_R155_E1.1891.00
131_I136_R1.1861.00
170_I174_V1.1801.00
225_R229_E1.1651.00
128_G134_I1.1641.00
250_R372_K1.1641.00
308_V328_S1.1621.00
251_L258_L1.1581.00
134_I139_D1.1541.00
347_R351_F1.1501.00
305_Y351_F1.1501.00
368_E372_K1.1411.00
36_V216_L1.1381.00
20_E217_G1.1221.00
225_R245_D1.1191.00
371_R375_I1.1031.00
226_E229_E1.0941.00
13_D230_K1.0891.00
23_M27_S1.0821.00
135_I139_D1.0811.00
51_A55_I1.0771.00
36_V214_I1.0761.00
154_D157_Q1.0761.00
220_L224_S1.0711.00
181_T187_G1.0701.00
136_R139_D1.0681.00
304_R340_R1.0641.00
104_L107_N1.0621.00
293_R376_L1.0621.00
294_N298_S1.0621.00
308_V324_I1.0561.00
28_I150_V1.0551.00
48_V52_V1.0541.00
293_R296_I1.0531.00
181_T188_S1.0521.00
301_S305_Y1.0521.00
372_K376_L1.0471.00
325_V341_V1.0331.00
132_T173_D1.0321.00
182_V187_G1.0191.00
42_I254_I1.0111.00
172_H176_D1.0081.00
202_Y205_P1.0061.00
132_T136_R1.0041.00
328_S336_I0.9991.00
135_I138_M0.9921.00
313_D375_I0.9881.00
20_E47_V0.9871.00
67_I70_S0.9861.00
45_T49_N0.9851.00
256_G367_D0.9841.00
27_S212_R0.9821.00
368_E371_R0.9791.00
287_E291_E0.9791.00
289_R299_T0.9781.00
25_K29_A0.9761.00
204_E207_F0.9751.00
18_E226_E0.9731.00
61_S64_L0.9721.00
291_E295_F0.9711.00
308_V341_V0.9701.00
33_W175_Y0.9701.00
25_K55_I0.9691.00
288_V299_T0.9691.00
132_T139_D0.9681.00
80_L83_L0.9601.00
23_M26_D0.9551.00
345_L362_Y0.9541.00
311_A328_S0.9521.00
293_R299_T0.9471.00
80_L170_I0.9461.00
161_K169_S0.9451.00
23_M214_I0.9361.00
319_G324_I0.9361.00
128_G131_I0.9361.00
336_I340_R0.9351.00
52_V150_V0.9341.00
222_E225_R0.9331.00
130_D134_I0.9191.00
28_I60_V0.9151.00
304_R307_A0.9151.00
100_K103_K0.9041.00
65_M83_L0.9001.00
307_A310_L0.8991.00
36_V47_V0.8901.00
133_Y136_R0.8881.00
321_L342_Y0.8861.00
22_E25_K0.8861.00
355_E366_Q0.8831.00
349_V362_Y0.8771.00
25_K58_I0.8771.00
129_T133_Y0.8761.00
39_M218_R0.8741.00
244_I248_V0.8721.00
85_I89_N0.8711.00
288_V296_I0.8701.00
129_T132_T0.8701.00
219_F227_F0.8631.00
269_A272_G0.8581.00
37_L189_M0.8521.00
285_I288_V0.8521.00
21_I54_E0.8521.00
184_I187_G0.8511.00
231_G262_G0.8481.00
52_V62_I0.8461.00
356_R362_Y0.8431.00
309_I313_D0.8381.00
102_A106_S0.8381.00
184_I188_S0.8361.00
297_F377_A0.8361.00
293_R298_S0.8361.00
241_E245_D0.8331.00
100_K106_S0.8291.00
202_Y206_F0.8271.00
20_E23_M0.8251.00
228_L244_I0.8251.00
308_V345_L0.8241.00
101_V109_L0.8231.00
128_G135_I0.8221.00
354_I364_L0.8211.00
290_N294_N0.8191.00
20_E216_L0.8191.00
288_V298_S0.8161.00
228_L247_A0.8141.00
28_I51_A0.8111.00
289_R292_A0.8081.00
366_Q370_N0.7911.00
346_N349_V0.7891.00
303_L306_S0.7851.00
231_G259_T0.7841.00
81_I85_I0.7841.00
79_V83_L0.7821.00
152_I188_S0.7791.00
256_G260_L0.7771.00
57_A60_V0.7761.00
313_D364_L0.7751.00
169_S172_H0.7721.00
156_A159_L0.7711.00
81_I87_E0.7701.00
44_K256_G0.7691.00
88_I92_I0.7641.00
59_K63_N0.7601.00
108_I111_V0.7581.00
224_S262_G0.7581.00
21_I25_K0.7561.00
128_G139_D0.7541.00
45_T154_D0.7521.00
139_D142_A0.7491.00
79_V163_N0.7491.00
33_W185_F0.7461.00
252_D368_E0.7451.00
336_I344_I0.7441.00
130_D137_E0.7441.00
55_I150_V0.7441.00
42_I216_L0.7431.00
62_I65_M0.7431.00
320_E361_E0.7371.00
83_L151_I0.7351.00
15_Y223_Q0.7331.00
228_L231_G0.7321.00
72_K75_Y0.7291.00
132_T137_E0.7251.00
75_Y78_H0.7231.00
248_V251_L0.7231.00
291_E298_S0.7221.00
340_R343_E0.7221.00
131_I138_M0.7201.00
228_L258_L0.7171.00
106_S110_G0.7131.00
248_V253_G0.7121.00
64_L67_I0.7121.00
79_V82_S0.7111.00
173_D176_D0.7111.00
178_C181_T0.7111.00
218_R252_D0.7101.00
61_S149_L0.7081.00
107_N110_G0.7061.00
128_G137_E0.7051.00
129_T134_I0.7041.00
203_T207_F0.7031.00
311_A327_V0.7021.00
35_A187_G0.7021.00
137_E141_I0.7001.00
288_V292_A0.6991.00
40_R190_V0.6991.00
224_S253_G0.6991.00
325_V328_S0.6991.00
180_N187_G0.6981.00
181_T184_I0.6931.00
25_K28_I0.6921.00
227_F259_T0.6921.00
218_R251_L0.6901.00
247_A261_F0.6871.00
305_Y344_I0.6851.00
52_V56_G0.6811.00
52_V64_L0.6811.00
103_K106_S0.6801.00
46_S49_N0.6781.00
321_L341_V0.6761.00
105_L112_E0.6741.00
289_R293_R0.6741.00
182_V185_F0.6741.00
316_G371_R0.6731.00
138_M141_I0.6721.00
42_I218_R0.6691.00
132_T135_I0.6671.00
287_E293_R0.6661.00
66_R154_D0.6651.00
35_A211_I0.6631.00
310_L377_A0.6601.00
130_D139_D0.6601.00
182_V189_M0.6601.00
77_K162_V0.6591.00
309_I353_F0.6571.00
27_S214_I0.6571.00
201_E204_E0.6561.00
58_I62_I0.6531.00
272_G276_R0.6511.00
48_V154_D0.6491.00
76_P79_V0.6481.00
134_I138_M0.6451.00
60_V63_N0.6421.00
345_L354_I0.6411.00
290_N295_F0.6381.00
150_V184_I0.6371.00
319_G327_V0.6361.00
324_I341_V0.6341.00
277_I281_I0.6331.00
101_V104_L0.6311.00
286_N289_R0.6301.00
37_L191_K0.6301.00
254_I259_T0.6281.00
319_G364_L0.6271.00
271_M276_R0.6261.00
225_R248_V0.6261.00
128_G169_S0.6251.00
183_I187_G0.6251.00
309_I374_L0.6141.00
155_E158_E0.6131.00
55_I59_K0.6111.00
59_K62_I0.6101.00
243_V246_E0.6091.00
56_G59_K0.6091.00
101_V105_L0.6070.99
136_R140_S0.6070.99
317_G368_E0.6060.99
348_L354_I0.6060.99
103_K108_I0.6050.99
288_V295_F0.6030.99
344_I347_R0.6030.99
221_P251_L0.6020.99
67_I79_V0.6020.99
322_H326_K0.5990.99
67_I159_L0.5990.99
34_I214_I0.5970.99
185_F188_S0.5960.99
304_R336_I0.5950.99
130_D135_I0.5950.99
49_N52_V0.5940.99
232_F239_V0.5930.99
82_S86_E0.5920.99
264_E268_S0.5900.99
229_E238_K0.5900.99
100_K104_L0.5860.99
15_Y226_E0.5850.99
104_L108_I0.5840.99
370_N373_G0.5830.99
298_S351_F0.5770.99
81_I84_L0.5770.99
280_I283_K0.5760.99
154_D187_G0.5760.99
134_I137_E0.5760.99
100_K108_I0.5750.99
127_R130_D0.5750.99
102_A107_N0.5740.99
40_R367_D0.5740.99
289_R295_F0.5730.99
256_G259_T0.5720.99
342_Y346_N0.5710.99
285_I289_R0.5710.99
16_D220_L0.5700.99
357_R361_E0.5670.99
315_L327_V0.5650.99
352_D366_Q0.5650.99
83_L86_E0.5650.99
128_G136_R0.5620.99
292_A298_S0.5620.99
148_Q182_V0.5590.99
136_R177_N0.5590.99
289_R294_N0.5580.99
254_I257_W0.5580.99
40_R157_Q0.5580.99
75_Y80_L0.5570.99
288_V293_R0.5570.99
324_I327_V0.5540.99
41_R188_S0.5540.99
78_H82_S0.5520.99
288_V294_N0.5510.99
309_I364_L0.5460.99
156_A185_F0.5450.99
168_P196_T0.5450.99
76_P80_L0.5450.99
51_A150_V0.5440.99
312_L316_G0.5440.99
189_M196_T0.5440.99
105_L108_I0.5440.99
245_D248_V0.5440.99
41_R155_E0.5430.99
54_E58_I0.5420.99
103_K111_V0.5400.99
65_M153_L0.5400.99
108_I112_E0.5400.99
168_P172_H0.5370.99
26_D29_A0.5350.99
79_V159_L0.5330.99
310_L313_D0.5320.99
130_D142_A0.5320.99
169_S173_D0.5310.99
101_V106_S0.5310.99
142_A149_L0.5300.99
63_N149_L0.5300.99
51_A186_T0.5290.99
201_E206_F0.5280.99
308_V312_L0.5280.99
186_T190_V0.5270.99
180_N183_I0.5260.99
228_L232_F0.5260.99
328_S335_N0.5260.99
208_G212_R0.5250.99
348_L351_F0.5240.99
340_R344_I0.5240.99
103_K110_G0.5230.99
338_E341_V0.5230.99
259_T263_S0.5220.98
374_L377_A0.5210.98
104_L111_V0.5210.98
155_E187_G0.5200.98
129_T135_I0.5200.98
323_E327_V0.5170.98
154_D368_E0.5170.98
345_L349_V0.5140.98
28_I182_V0.5120.98
301_S309_I0.5120.98
57_A61_S0.5120.98
106_S109_L0.5110.98
351_F355_E0.5110.98
310_L374_L0.5100.98
44_K367_D0.5090.98
201_E207_F0.5080.98
14_L223_Q0.5080.98
243_V265_Y0.5080.98
224_S247_A0.5070.98
136_R173_D0.5050.98
315_L323_E0.5050.98
294_N297_F0.5040.98
260_L299_T0.5030.98
14_L18_E0.5020.98
34_I184_I0.5010.98
33_W211_I0.5010.98
77_K80_L0.5000.98
252_D317_G0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fnaA 1 0.8941 100 0.416 Contact Map
2qenA 1 0.8915 100 0.43 Contact Map
1z6tA 1 0.8191 100 0.546 Contact Map
2a5yB 2 0.832 100 0.58 Contact Map
3sfzA 1 0.8191 99.9 0.604 Contact Map
1w5sA 1 0.876 99.9 0.619 Contact Map
1fnnA 1 0.8605 99.9 0.627 Contact Map
1vt4I 4 0.8088 99.9 0.641 Contact Map
2qbyA 1 0.8553 99.9 0.643 Contact Map
3pfiA 3 0.7261 99.9 0.65 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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