GREMLIN Database
THIC2 - Phosphomethylpyrimidine synthase 2
UniProt: Q97X14 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 433 (418)
Sequences: 1095 (407)
Seq/√Len: 19.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
381_E394_Y3.7181.00
103_D150_K3.7171.00
61_T359_K3.3701.00
382_N385_S3.2521.00
251_V255_L3.2411.00
54_P59_L3.2381.00
33_R39_I3.1020.99
251_V263_V3.0660.99
145_L209_Y2.9820.99
275_A279_K2.9560.99
180_I417_M2.9300.99
343_E392_R2.9270.99
83_V93_L2.8820.99
297_P354_A2.8680.99
34_I41_L2.8250.99
19_I54_P2.8210.99
214_F221_I2.7290.98
180_I231_A2.6960.98
14_D17_R2.6190.98
25_I30_V2.5760.98
145_L210_V2.5550.98
28_E31_R2.5430.98
152_L219_A2.5190.97
148_V203_Y2.5020.97
212_E257_K2.4270.97
12_I31_R2.4220.97
149_E153_K2.3810.96
103_D124_Q2.3500.96
107_R154_D2.3130.96
313_A324_L2.2930.95
5_D215_K2.2900.95
370_E382_N2.2380.95
75_D78_M2.1970.94
19_I41_L2.1950.94
30_V39_I2.1850.94
300_V367_W2.1780.94
182_I191_A2.1730.94
349_R367_W2.1540.94
13_T16_M2.1260.93
38_K57_K2.1220.93
353_H368_D2.1010.93
271_L314_A2.0990.93
65_V345_A2.0860.92
29_K33_R2.0590.92
17_R21_K2.0400.92
278_V319_S2.0360.91
22_L51_K2.0270.91
27_V31_R2.0260.91
149_E216_E2.0110.91
119_T156_V1.9950.91
252_K286_G1.9880.90
302_A308_A1.9390.89
208_D253_S1.9370.89
215_K257_K1.9330.89
101_D104_A1.9190.89
271_L315_I1.9170.89
236_H277_D1.9070.89
81_Q338_V1.8860.88
38_K287_G1.8760.88
148_V210_V1.8520.87
179_I369_D1.8280.86
3_I16_M1.8270.86
81_Q84_K1.8170.86
124_Q128_E1.7980.85
161_I221_I1.7950.85
365_R369_D1.7880.85
30_V33_R1.7860.85
179_I233_G1.7560.84
255_L286_G1.7450.84
152_L159_M1.7200.83
39_I59_L1.7200.83
215_K258_G1.7120.82
87_N114_D1.6850.81
33_R38_K1.6750.81
17_R27_V1.6490.80
5_D258_G1.6380.79
272_N360_L1.6350.79
199_S205_K1.5960.77
211_L221_I1.5920.77
273_E283_K1.5880.77
309_S327_L1.5870.77
373_Y377_K1.5750.77
167_K198_N1.5600.76
161_I210_V1.5550.76
4_I40_M1.5530.75
263_V281_M1.5500.75
326_Y341_V1.5490.75
395_Q399_Q1.5380.75
40_M220_V1.5310.74
374_Y382_N1.5300.74
61_T361_G1.5140.74
213_M219_A1.5020.73
3_I13_T1.4970.73
43_R50_R1.4880.72
12_I27_V1.4780.72
281_M290_Y1.4770.72
32_N36_E1.4670.71
370_E386_K1.4630.71
382_N386_K1.4610.71
223_L247_T1.4580.71
277_D290_Y1.4550.71
141_E206_N1.4520.70
236_H290_Y1.4510.70
204_R249_R1.4510.70
342_E346_I1.4480.70
379_D382_N1.4480.70
281_M285_T1.4380.70
67_I83_V1.4340.69
179_I231_A1.4170.68
9_R258_G1.4120.68
66_N160_T1.4100.68
244_L290_Y1.4020.68
41_L54_P1.3990.67
65_V86_A1.3860.67
84_K112_A1.3830.66
83_V113_S1.3630.65
92_T116_P1.3570.65
313_A348_Y1.3440.64
206_N209_Y1.3440.64
30_V34_I1.3390.64
4_I255_L1.3340.64
42_I55_I1.3240.63
339_K343_E1.3040.62
232_T357_V1.3010.62
65_V93_L1.2990.61
342_E392_R1.2960.61
110_I151_H1.2890.61
88_K391_Q1.2860.61
168_D200_E1.2830.60
171_I175_K1.2810.60
246_E249_R1.2810.60
141_E205_K1.2710.60
372_S417_M1.2690.60
158_F323_L1.2660.59
255_L263_V1.2590.59
231_A372_S1.2580.59
58_G322_D1.2470.58
16_M30_V1.2430.58
149_E209_Y1.2390.58
317_S355_G1.2310.57
6_E11_Q1.2290.57
63_V345_A1.2270.57
86_A345_A1.2270.57
151_H159_M1.2260.57
400_F409_T1.2250.57
211_L259_V1.2250.57
207_W223_L1.2250.57
298_I301_G1.2240.57
80_L83_V1.2220.57
275_A319_S1.2220.57
236_H241_I1.2210.57
272_N365_R1.2170.56
241_I280_L1.2110.56
369_D373_Y1.2080.56
169_L246_E1.2010.55
87_N113_S1.1970.55
40_M262_M1.1930.55
57_K287_G1.1920.55
168_D171_I1.1860.54
64_N70_S1.1810.54
282_K322_D1.1760.54
19_I34_I1.1720.53
363_K366_K1.1530.52
7_A13_T1.1500.52
102_L105_I1.1500.52
318_A359_K1.1450.52
221_I263_V1.1390.51
29_K39_I1.1330.51
100_G105_I1.1300.51
167_K194_M1.1240.50
255_L288_V1.1180.50
235_A273_E1.1170.50
307_I347_A1.1140.50
144_L148_V1.1090.49
211_L257_K1.1090.49
120_V293_L1.1080.49
324_L348_Y1.1070.49
103_D154_D1.1050.49
113_S117_V1.1010.49
418_M422_D1.0960.49
4_I251_V1.0860.48
172_R242_G1.0830.48
142_D145_L1.0820.48
225_D229_P1.0790.47
245_L284_L1.0790.47
46_K217_Y1.0770.47
85_V89_W1.0770.47
292_V316_S1.0680.47
392_R395_Q1.0620.46
18_A51_K1.0610.46
180_I372_S1.0560.46
278_V321_V1.0520.46
106_R154_D1.0510.46
148_V159_M1.0510.46
141_E145_L1.0500.46
300_V353_H1.0460.45
16_M31_R1.0430.45
109_I117_V1.0380.45
64_N264_E1.0320.44
64_N120_V1.0320.44
253_S257_K1.0290.44
60_T349_R1.0280.44
188_D416_P1.0260.44
346_I349_R1.0260.44
381_E385_S1.0250.44
209_Y216_E1.0230.44
25_I29_K1.0180.44
370_E373_Y1.0180.44
55_I116_P1.0160.43
280_L290_Y1.0160.43
151_H154_D1.0120.43
309_S348_Y1.0020.43
300_V368_D1.0000.42
406_K421_M1.0000.42
89_W345_A0.9960.42
315_I319_S0.9950.42
3_I218_D0.9920.42
134_S138_Y0.9920.42
53_V91_D0.9880.42
26_P29_K0.9870.42
238_E252_K0.9850.41
264_E293_L0.9780.41
67_I93_L0.9760.41
120_V264_E0.9750.41
61_T356_D0.9740.41
224_G264_E0.9740.41
172_R249_R0.9710.41
245_L280_L0.9670.40
251_V286_G0.9640.40
34_I54_P0.9620.40
47_Y52_L0.9540.40
64_N293_L0.9530.39
211_L214_F0.9440.39
285_T290_Y0.9440.39
168_D242_G0.9430.39
243_E295_P0.9420.39
406_K418_M0.9420.39
164_G247_T0.9410.39
270_P273_E0.9390.39
387_L390_P0.9370.38
16_M41_L0.9360.38
334_G400_F0.9360.38
91_D349_R0.9350.38
274_I315_I0.9330.38
164_G223_L0.9310.38
87_N115_L0.9240.38
146_N149_E0.9240.38
142_D209_Y0.9220.38
391_Q395_Q0.9160.37
30_V59_L0.9150.37
34_I40_M0.9130.37
89_W342_E0.9130.37
117_V272_N0.9110.37
40_M255_L0.9090.37
70_S224_G0.9060.37
296_L309_S0.9060.37
392_R396_V0.9050.37
63_V117_V0.9040.36
61_T318_A0.9040.36
323_L348_Y0.9020.36
108_D111_K0.9020.36
224_G293_L0.9010.36
247_T263_V0.9000.36
254_A261_V0.8950.36
58_G282_K0.8930.36
84_K88_K0.8900.36
202_P316_S0.8850.35
380_W410_M0.8850.35
146_N150_K0.8840.35
53_V116_P0.8810.35
384_I393_A0.8780.35
179_I373_Y0.8770.35
185_R293_L0.8770.35
271_L274_I0.8750.35
251_V354_A0.8730.35
337_T399_Q0.8600.34
18_A21_K0.8560.34
139_F197_N0.8550.34
161_I203_Y0.8550.34
7_A35_S0.8540.34
160_T291_Y0.8510.33
16_M35_S0.8500.33
64_N224_G0.8490.33
244_L281_M0.8480.33
163_A273_E0.8480.33
165_I226_A0.8470.33
70_S264_E0.8470.33
176_S238_E0.8440.33
65_V83_V0.8410.33
148_V161_I0.8410.33
39_I58_G0.8390.33
144_L203_Y0.8380.33
409_T424_V0.8360.32
120_V291_Y0.8310.32
191_A420_A0.8300.32
152_L213_M0.8280.32
70_S293_L0.8220.32
7_A16_M0.8210.32
301_G350_I0.8210.32
109_I355_G0.8200.32
236_H273_E0.8180.31
161_I166_T0.8160.31
160_T293_L0.8160.31
33_R58_G0.8150.31
4_I258_G0.8140.31
298_I368_D0.8110.31
179_I372_S0.8070.31
397_Y407_A0.8050.31
397_Y406_K0.8010.31
317_S361_G0.7990.30
176_S286_G0.7990.30
163_A221_I0.7990.30
144_L147_T0.7970.30
160_T235_A0.7960.30
244_L277_D0.7940.30
244_L280_L0.7910.30
142_D198_N0.7900.30
181_P189_M0.7890.30
70_S120_V0.7890.30
80_L113_S0.7860.30
36_E287_G0.7840.30
120_V224_G0.7820.30
159_M214_F0.7800.29
276_W279_K0.7790.29
95_D229_P0.7770.29
48_P111_K0.7750.29
12_I28_E0.7750.29
346_I350_I0.7720.29
308_A327_L0.7700.29
39_I54_P0.7660.29
141_E209_Y0.7650.29
143_E151_H0.7620.28
343_E347_A0.7610.28
66_N224_G0.7600.28
334_G396_V0.7540.28
277_D291_Y0.7530.28
76_L104_A0.7520.28
188_D419_W0.7500.28
95_D225_D0.7490.28
133_K138_Y0.7480.28
397_Y400_F0.7430.27
171_I324_L0.7410.27
219_A385_S0.7410.27
67_I136_G0.7400.27
231_A355_G0.7350.27
66_N182_I0.7340.27
208_D257_K0.7330.27
36_E57_K0.7310.27
378_L407_A0.7310.27
92_T323_L0.7290.27
90_G341_V0.7280.27
204_R207_W0.7280.27
91_D188_D0.7270.27
272_N279_K0.7240.26
69_T98_T0.7220.26
388_I391_Q0.7210.26
185_R264_E0.7200.26
22_L53_V0.7170.26
165_I209_Y0.7150.26
135_G138_Y0.7140.26
145_L149_E0.7130.26
240_Q292_V0.7120.26
107_R338_V0.7110.26
367_W388_I0.7110.26
163_A250_L0.7040.25
139_F143_E0.7040.25
85_V338_V0.7000.25
64_N69_T0.7000.25
160_T182_I0.6960.25
160_T225_D0.6930.25
80_L84_K0.6870.25
334_G383_M0.6840.25
85_V88_K0.6830.24
120_V185_R0.6820.24
8_K258_G0.6810.24
93_L115_L0.6810.24
207_W221_I0.6800.24
174_L195_I0.6790.24
338_V345_A0.6760.24
232_T372_S0.6750.24
209_Y212_E0.6730.24
119_T227_L0.6720.24
180_I190_I0.6720.24
214_F259_V0.6720.24
161_I214_F0.6720.24
315_I318_A0.6700.24
53_V92_T0.6690.24
151_H181_P0.6650.24
154_D217_Y0.6610.23
55_I394_Y0.6600.23
159_M219_A0.6580.23
159_M166_T0.6550.23
12_I16_M0.6550.23
241_I244_L0.6550.23
31_R35_S0.6540.23
276_W283_K0.6540.23
79_E82_K0.6510.23
32_N216_E0.6500.23
114_D157_A0.6490.23
311_I314_A0.6490.23
165_I169_L0.6480.23
313_A371_V0.6470.23
94_M293_L0.6460.23
248_A285_T0.6460.23
7_A10_G0.6450.23
371_V387_L0.6400.22
242_G371_V0.6400.22
388_I393_A0.6400.22
63_V258_G0.6400.22
160_T185_R0.6380.22
273_E276_W0.6370.22
248_A288_V0.6360.22
5_D9_R0.6340.22
191_A424_V0.6330.22
396_V400_F0.6330.22
88_K349_R0.6330.22
378_L417_M0.6330.22
95_D119_T0.6310.22
240_Q244_L0.6300.22
355_G360_L0.6280.22
165_I227_L0.6280.22
315_I346_I0.6270.22
164_G226_A0.6270.22
44_N157_A0.6270.22
212_E215_K0.6270.22
13_T41_L0.6260.22
2_G5_D0.6250.22
157_A220_V0.6240.22
59_L317_S0.6230.22
42_I220_V0.6230.22
337_T401_G0.6220.22
119_T147_T0.6210.22
190_I210_V0.6210.22
271_L319_S0.6210.22
214_F219_A0.6200.22
144_L202_P0.6180.21
3_I7_A0.6180.21
207_W247_T0.6150.21
163_A292_V0.6140.21
309_S406_K0.6140.21
358_V386_K0.6130.21
15_E18_A0.6120.21
172_R245_L0.6120.21
90_G409_T0.6110.21
405_V409_T0.6100.21
137_A192_G0.6100.21
26_P32_N0.6100.21
101_D128_E0.6090.21
271_L360_L0.6090.21
366_K370_E0.6080.21
408_C411_C0.6080.21
137_A196_H0.6070.21
99_G102_L0.6070.21
172_R246_E0.6060.21
264_E291_Y0.6050.21
247_T288_V0.6040.21
42_I53_V0.6040.21
94_M118_G0.6040.21
252_K302_A0.6020.21
145_L226_A0.6020.21
339_K342_E0.6020.21
394_Y398_T0.6010.21
145_L206_N0.6010.21
47_Y50_R0.5990.21
231_A383_M0.5960.21
238_E245_L0.5960.21
99_G189_M0.5940.20
87_N112_A0.5940.20
95_D156_V0.5930.20
33_R57_K0.5930.20
110_I117_V0.5910.20
66_N70_S0.5900.20
107_R111_K0.5890.20
408_C415_C0.5890.20
411_C415_C0.5890.20
113_S188_D0.5880.20
124_Q147_T0.5880.20
235_A291_Y0.5870.20
397_Y409_T0.5870.20
24_G27_V0.5860.20
226_A288_V0.5850.20
11_Q359_K0.5840.20
189_M372_S0.5840.20
207_W278_V0.5830.20
238_E249_R0.5830.20
34_I263_V0.5830.20
17_R300_V0.5830.20
229_P316_S0.5820.20
367_W372_S0.5820.20
269_V280_L0.5820.20
64_N185_R0.5800.20
236_H280_L0.5800.20
145_L262_M0.5800.20
120_V160_T0.5790.20
182_I224_G0.5790.20
98_T224_G0.5790.20
166_T239_F0.5780.20
55_I122_V0.5780.20
251_V355_G0.5780.20
374_Y386_K0.5770.20
125_I318_A0.5760.20
148_V163_A0.5760.20
314_A318_A0.5760.20
71_S337_T0.5750.20
153_K171_I0.5750.20
150_K154_D0.5730.20
77_D81_Q0.5720.20
185_R291_Y0.5720.20
207_W254_A0.5720.20
205_K209_Y0.5720.20
98_T226_A0.5710.20
95_D292_V0.5700.19
377_K421_M0.5670.19
77_D111_K0.5670.19
77_D108_D0.5670.19
403_P407_A0.5660.19
300_V349_R0.5660.19
193_W197_N0.5660.19
164_G210_V0.5660.19
69_T335_L0.5650.19
9_R256_Q0.5650.19
118_G293_L0.5650.19
251_V281_M0.5640.19
77_D84_K0.5640.19
6_E9_R0.5640.19
137_A181_P0.5630.19
124_Q383_M0.5610.19
98_T419_W0.5600.19
247_T295_P0.5600.19
108_D112_A0.5600.19
141_E199_S0.5600.19
278_V292_V0.5600.19
313_A323_L0.5590.19
25_I366_K0.5580.19
202_P292_V0.5580.19
64_N291_Y0.5580.19
5_D257_K0.5540.19
173_A238_E0.5540.19
159_M210_V0.5540.19
164_G277_D0.5520.19
174_L238_E0.5510.19
126_F189_M0.5510.19
166_T407_A0.5500.19
160_T164_G0.5490.19
124_Q132_K0.5490.19
4_I34_I0.5490.19
69_T102_L0.5470.19
346_I392_R0.5470.19
92_T158_F0.5460.19
24_G362_R0.5460.19
302_A333_L0.5440.18
44_N47_Y0.5440.18
378_L420_A0.5430.18
137_A189_M0.5420.18
195_I337_T0.5420.18
55_I110_I0.5420.18
240_Q326_Y0.5410.18
181_P191_A0.5400.18
156_V232_T0.5400.18
367_W386_K0.5390.18
202_P379_D0.5390.18
85_V345_A0.5390.18
251_V261_V0.5380.18
182_I189_M0.5370.18
124_Q181_P0.5360.18
273_E277_D0.5360.18
198_N349_R0.5350.18
147_T343_E0.5350.18
174_L400_F0.5340.18
102_L124_Q0.5340.18
4_I8_K0.5330.18
64_N335_L0.5320.18
302_A371_V0.5320.18
217_Y357_V0.5310.18
158_F348_Y0.5310.18
49_S63_V0.5300.18
26_P30_V0.5300.18
53_V115_L0.5300.18
18_A22_L0.5290.18
142_D210_V0.5290.18
7_A31_R0.5290.18
57_K61_T0.5280.18
66_N120_V0.5280.18
390_P393_A0.5280.18
245_L282_K0.5270.18
259_V284_L0.5270.18
160_T229_P0.5270.18
60_T314_A0.5270.18
118_G266_P0.5260.18
172_R239_F0.5260.18
107_R128_E0.5250.18
99_G124_Q0.5250.18
160_T224_G0.5250.18
17_R26_P0.5250.18
142_D153_K0.5240.18
242_G246_E0.5220.18
74_V78_M0.5210.18
263_V400_F0.5200.18
120_V335_L0.5200.18
103_D107_R0.5190.17
65_V89_W0.5190.17
31_R399_Q0.5180.17
168_D241_I0.5170.17
80_L112_A0.5170.17
396_V399_Q0.5170.17
339_K391_Q0.5160.17
157_A297_P0.5160.17
95_D313_A0.5150.17
231_A354_A0.5150.17
126_F137_A0.5150.17
29_K38_K0.5130.17
14_D31_R0.5120.17
313_A355_G0.5120.17
167_K390_P0.5120.17
371_V383_M0.5110.17
302_A309_S0.5090.17
104_A108_D0.5090.17
110_I314_A0.5090.17
271_L318_A0.5080.17
161_I194_M0.5080.17
95_D353_H0.5060.17
399_Q416_P0.5030.17
12_I84_K0.5020.17
414_Y419_W0.5020.17
12_I30_V0.5010.17
235_A270_P0.5010.17
247_T360_L0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4s28A 2 0.9838 100 0.039 Contact Map
3epoA 2 0.8984 100 0.039 Contact Map
1eyeA 2 0.4896 94.5 0.972 Contact Map
4muzA 2 0.4642 93.9 0.972 Contact Map
1aj0A 1 0.5612 93.4 0.973 Contact Map
2h9aB 1 0.5566 93 0.973 Contact Map
2dqwA 2 0.5012 92.9 0.973 Contact Map
4djdD 1 0.5612 91.8 0.974 Contact Map
2czdA 2 0.4596 91.7 0.974 Contact Map
3f4wA 2 0.4688 90.5 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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