GREMLIN Database
ILVC3 - Putative ketol-acid reductoisomerase 3
UniProt: Q97X13 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 332 (316)
Sequences: 1918 (659)
Seq/√Len: 37.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_I39_L4.5711.00
96_E101_F4.0291.00
148_V173_A3.7971.00
206_I241_I3.1541.00
17_T40_N2.9731.00
97_G121_N2.8991.00
250_M261_T2.8501.00
102_V125_V2.7911.00
150_L161_W2.7871.00
78_I86_I2.7571.00
30_Q106_A2.7091.00
174_I178_I2.6071.00
206_I234_L2.5681.00
202_L234_L2.5421.00
308_E312_Q2.5281.00
119_P122_V2.4941.00
258_Q307_W2.4761.00
139_L142_Q2.4091.00
186_E220_S2.3931.00
88_E92_A2.3531.00
52_D55_I2.3281.00
85_E89_K2.2970.99
81_E255_T2.2760.99
275_I278_D2.2680.99
269_Y272_V2.2590.99
138_D243_E2.1830.99
244_E248_N2.1290.99
264_R279_E2.1060.99
8_A174_I2.1000.99
35_R59_F2.0490.99
104_D125_V1.9940.99
267_K282_Y1.9790.98
272_V275_I1.9430.98
102_V163_Y1.9330.98
85_E297_Q1.9310.98
76_L91_I1.9230.98
34_M170_G1.8960.98
13_L166_A1.8920.98
169_K174_I1.8800.98
51_Y55_I1.8670.98
207_K310_A1.8660.98
47_K63_D1.8580.98
102_V123_D1.8550.98
45_N48_D1.8330.97
264_R291_E1.7830.97
64_I90_K1.7640.97
264_R282_Y1.7620.97
43_I59_F1.7590.97
155_D162_D1.7440.97
298_A301_P1.7220.96
23_Y57_E1.7140.96
269_Y275_I1.7090.96
65_G90_K1.7030.96
11_E14_K1.6740.96
123_D160_A1.6580.95
161_W181_I1.6490.95
220_S223_A1.6460.95
19_A67_A1.6340.95
75_F106_A1.6250.95
271_L274_E1.6210.95
5_V174_I1.6100.95
74_A101_F1.5830.94
206_I229_Y1.5780.94
131_M173_A1.5730.94
296_Q300_Y1.5720.94
62_Y70_K1.5690.94
21_I76_L1.5690.94
135_G138_D1.5560.93
109_Y289_A1.5520.93
30_Q75_F1.4890.92
121_N156_A1.4880.92
51_Y63_D1.4730.91
21_I44_G1.4710.91
42_I70_K1.4690.91
55_I60_E1.4680.91
203_F261_T1.4610.91
123_D159_K1.4570.91
60_E70_K1.4510.91
139_L144_K1.4500.91
75_F104_D1.4390.90
291_E302_V1.4370.90
202_L206_I1.4330.90
42_I62_Y1.4230.90
294_L297_Q1.4090.89
317_K321_E1.3950.89
203_F246_I1.3750.88
281_K285_D1.3670.88
17_T42_I1.3670.88
204_G273_K1.3660.88
47_K51_Y1.3600.88
263_T291_E1.3600.88
255_T300_Y1.3520.87
267_K275_I1.3480.87
68_V101_F1.3410.87
294_L298_A1.3360.87
17_T70_K1.3310.87
292_W295_E1.3260.86
68_V94_I1.3210.86
278_D282_Y1.3150.86
262_L307_W1.3110.86
264_R268_Y1.3070.86
134_E252_H1.3050.85
258_Q262_L1.3030.85
211_D273_K1.2970.85
229_Y241_I1.2920.85
263_T282_Y1.2890.85
69_K94_I1.2790.84
216_E277_K1.2770.84
206_I315_M1.2760.84
203_F250_M1.2680.84
52_D56_K1.2640.84
216_E273_K1.2620.83
292_W300_Y1.2560.83
305_R309_L1.2460.83
83_M110_N1.2420.82
303_F307_W1.2330.82
204_G207_K1.2260.82
112_A185_E1.2220.81
48_D59_F1.2130.81
136_I146_Y1.2110.81
18_I170_G1.2090.81
290_K294_L1.2060.80
68_V74_A1.2040.80
123_D156_A1.1970.80
32_N59_F1.1920.80
204_G208_A1.1880.79
8_A178_I1.1840.79
293_T298_A1.1820.79
125_V160_A1.1740.79
101_F122_V1.1740.79
46_V49_R1.1650.78
37_N140_H1.1600.78
40_N60_E1.1530.77
115_L293_T1.1520.77
262_L306_L1.1490.77
287_S291_E1.1470.77
210_F314_E1.1380.76
102_V157_S1.1370.76
292_W296_Q1.1360.76
63_D66_E1.1330.76
21_I78_I1.1040.74
229_Y315_M1.1040.74
211_D313_S1.1030.74
256_T288_F1.0970.74
123_D157_S1.0950.74
28_R252_H1.0860.73
197_T209_C1.0780.72
208_A212_V1.0730.72
243_E248_N1.0530.71
9_S12_P1.0480.70
159_K162_D1.0400.70
253_H261_T1.0400.70
110_N116_I1.0400.70
95_L122_V1.0370.69
84_K88_E1.0340.69
282_Y287_S1.0310.69
64_I68_V1.0280.69
8_A169_K1.0260.69
10_L169_K1.0230.68
275_I282_Y1.0230.68
268_Y279_E1.0150.68
45_N50_Y1.0130.68
186_E223_A1.0090.67
109_Y115_L1.0080.67
121_N154_Q1.0070.67
48_D51_Y1.0060.67
308_E311_V0.9990.67
268_Y272_V0.9950.66
306_L310_A0.9940.66
294_L305_R0.9930.66
101_F119_P0.9920.66
202_L241_I0.9910.66
94_I101_F0.9900.66
131_M146_Y0.9640.64
65_G94_I0.9640.64
198_W209_C0.9610.63
156_A160_A0.9610.63
59_F62_Y0.9530.63
270_D274_E0.9480.62
12_P166_A0.9460.62
300_Y304_Y0.9440.62
28_R134_E0.9380.62
324_K327_R0.9370.61
305_R308_E0.9350.61
104_D167_I0.9290.61
74_A119_P0.9210.60
270_D273_K0.9170.60
40_N70_K0.9170.60
50_Y61_V0.9110.59
5_V169_K0.9070.59
20_V167_I0.9050.59
263_T306_L0.9030.59
274_E277_K0.9030.59
102_V160_A0.9010.58
197_T268_Y0.8990.58
247_F311_V0.8990.58
144_K328_R0.8980.58
53_L57_E0.8960.58
204_G266_F0.8920.58
292_W303_F0.8860.57
35_R48_D0.8810.57
248_N251_V0.8810.57
118_P121_N0.8790.57
32_N57_E0.8770.56
131_M148_V0.8670.55
63_D68_V0.8650.55
300_Y303_F0.8650.55
20_V31_A0.8540.54
161_W165_K0.8520.54
46_V51_Y0.8450.54
42_I74_A0.8450.54
127_V168_A0.8430.53
95_L119_P0.8390.53
279_E282_Y0.8360.53
72_D101_F0.8340.53
21_I68_V0.8310.52
250_M310_A0.8300.52
87_Y103_L0.8220.52
114_G117_R0.8210.51
20_V34_M0.8210.51
9_S162_D0.8200.51
255_T292_W0.8160.51
302_V306_L0.8140.51
135_G242_A0.8130.51
21_I64_I0.8130.51
322_L326_L0.8040.50
84_K297_Q0.8040.50
212_V273_K0.8030.50
268_Y275_I0.8020.50
294_L309_L0.7960.49
111_V126_M0.7950.49
83_M116_I0.7900.49
302_V305_R0.7900.49
45_N61_V0.7830.48
39_L170_G0.7830.48
19_A42_I0.7830.48
109_Y188_A0.7810.48
101_F121_N0.7810.48
73_V125_V0.7790.48
97_G101_F0.7750.47
204_G250_M0.7730.47
44_G50_Y0.7680.47
271_L275_I0.7680.47
247_F316_A0.7650.47
62_Y66_E0.7640.46
282_Y291_E0.7590.46
264_R275_I0.7560.46
206_I238_A0.7520.45
139_L242_A0.7500.45
72_D96_E0.7470.45
311_V314_E0.7470.45
53_L56_K0.7470.45
294_L302_V0.7440.45
83_M105_F0.7430.45
115_L294_L0.7410.44
138_D141_K0.7400.44
229_Y246_I0.7350.44
97_G156_A0.7340.44
139_L327_R0.7320.44
148_V171_I0.7310.44
82_I86_I0.7290.43
131_M138_D0.7260.43
169_K178_I0.7240.43
12_P163_Y0.7240.43
241_I246_I0.7230.43
76_L86_I0.7210.43
246_I310_A0.7160.42
54_A61_V0.7110.42
126_M148_V0.7100.42
115_L296_Q0.7100.42
217_Y280_A0.7070.41
125_V150_L0.7040.41
32_N50_Y0.7030.41
50_Y53_L0.7030.41
294_L308_E0.7020.41
25_N134_E0.7000.41
144_K242_A0.6980.41
34_M167_I0.6970.41
134_E251_V0.6970.41
259_Y291_E0.6960.41
163_Y166_A0.6950.40
259_Y328_R0.6950.40
48_D57_E0.6940.40
282_Y285_D0.6940.40
15_G166_A0.6920.40
35_R57_E0.6900.40
317_K320_K0.6900.40
278_D281_K0.6900.40
150_L164_A0.6890.40
73_V166_A0.6890.40
109_Y293_T0.6810.39
13_L170_G0.6790.39
201_I205_A0.6780.39
28_R57_E0.6750.39
51_Y61_V0.6740.39
287_S290_K0.6740.39
113_F188_A0.6730.39
278_D287_S0.6730.39
10_L39_L0.6730.39
161_W164_A0.6700.38
144_K327_R0.6680.38
112_A153_K0.6610.38
204_G261_T0.6580.37
84_K293_T0.6570.37
41_V44_G0.6550.37
124_T154_Q0.6540.37
69_K96_E0.6510.37
303_F306_L0.6510.37
45_N51_Y0.6480.37
321_E324_K0.6480.37
149_L181_I0.6480.37
78_I82_I0.6440.36
21_I91_I0.6420.36
46_V64_I0.6410.36
131_M135_G0.6410.36
279_E291_E0.6410.36
262_L291_E0.6400.36
74_A122_V0.6390.36
197_T279_E0.6380.36
104_D163_Y0.6350.35
114_G153_K0.6350.35
197_T234_L0.6340.35
81_E258_Q0.6330.35
54_A59_F0.6310.35
155_D158_G0.6300.35
114_G299_G0.6280.35
75_F167_I0.6240.35
117_R304_Y0.6240.35
46_V82_I0.6240.35
247_F320_K0.6220.34
97_G122_V0.6200.34
16_K163_Y0.6190.34
138_D248_N0.6180.34
291_E294_L0.6180.34
139_L173_A0.6170.34
49_R52_D0.6160.34
309_L312_Q0.6160.34
81_E253_H0.6150.34
173_A328_R0.6140.34
115_L297_Q0.6130.34
312_Q317_K0.6130.34
66_E70_K0.6130.34
30_Q104_D0.6110.34
307_W311_V0.6080.33
35_R47_K0.6070.33
204_G283_I0.6060.33
135_G139_L0.6060.33
5_V10_L0.6050.33
188_A289_A0.6050.33
19_A44_G0.6050.33
193_M280_A0.6040.33
264_R278_D0.6030.33
263_T275_I0.6020.33
28_R32_N0.6020.33
125_V164_A0.6020.33
189_L284_W0.6010.33
131_M175_P0.6010.33
138_D142_Q0.6010.33
92_A119_P0.6000.33
96_E122_V0.5990.33
70_K166_A0.5990.33
291_E306_L0.5980.33
66_E69_K0.5970.32
207_K246_I0.5960.32
246_I315_M0.5920.32
64_I78_I0.5920.32
150_L223_A0.5920.32
263_T279_E0.5910.32
307_W310_A0.5910.32
148_V178_I0.5910.32
290_K302_V0.5900.32
125_V163_Y0.5900.32
135_G326_L0.5880.32
44_G48_D0.5870.32
97_G119_P0.5870.32
185_E223_A0.5870.32
287_S302_V0.5860.32
13_L70_K0.5860.32
168_A178_I0.5860.32
319_E323_Y0.5850.32
194_S199_V0.5810.31
294_L301_P0.5800.31
250_M253_H0.5790.31
68_V76_L0.5750.31
234_L241_I0.5750.31
6_L169_K0.5730.31
19_A74_A0.5730.31
270_D277_K0.5730.31
235_V239_R0.5720.31
102_V159_K0.5700.30
217_Y284_W0.5700.30
301_P304_Y0.5680.30
50_Y54_A0.5670.30
63_D90_K0.5670.30
35_R62_Y0.5670.30
259_Y264_R0.5620.30
28_R251_V0.5620.30
255_T307_W0.5620.30
19_A71_A0.5610.30
123_D163_Y0.5600.30
127_V144_K0.5590.30
189_L219_V0.5570.29
43_I62_Y0.5570.29
267_K278_D0.5550.29
32_N36_E0.5540.29
229_Y234_L0.5520.29
306_L309_L0.5520.29
163_Y290_K0.5520.29
116_I256_T0.5510.29
31_A293_T0.5450.29
139_L328_R0.5450.29
204_G211_D0.5450.29
44_G74_A0.5420.28
320_K324_K0.5410.28
297_Q302_V0.5410.28
210_F216_E0.5400.28
32_N35_R0.5370.28
106_A234_L0.5370.28
264_R306_L0.5360.28
8_A12_P0.5360.28
70_K101_F0.5350.28
141_K144_K0.5350.28
263_T278_D0.5340.28
113_F285_D0.5340.28
16_K72_D0.5290.27
20_V106_A0.5280.27
144_K176_G0.5270.27
68_V91_I0.5260.27
78_I81_E0.5260.27
115_L299_G0.5260.27
255_T303_F0.5250.27
5_V36_E0.5250.27
210_F220_S0.5230.27
273_K277_K0.5230.27
135_G328_R0.5230.27
148_V174_I0.5210.27
261_T310_A0.5210.27
255_T258_Q0.5200.27
277_K281_K0.5190.27
136_I173_A0.5190.27
125_V327_R0.5180.27
177_G226_L0.5170.27
264_R267_K0.5170.27
11_E52_D0.5150.26
253_H257_S0.5150.26
62_Y67_A0.5140.26
211_D266_F0.5140.26
113_F256_T0.5130.26
303_F310_A0.5120.26
35_R40_N0.5100.26
14_K120_K0.5100.26
21_I70_K0.5070.26
117_R162_D0.5070.26
79_P86_I0.5070.26
114_G304_Y0.5070.26
45_N55_I0.5060.26
18_I73_V0.5060.26
28_R31_A0.5060.26
35_R60_E0.5060.26
110_N188_A0.5050.26
76_L83_M0.5050.26
64_I86_I0.5050.26
78_I90_K0.5050.26
173_A234_L0.5040.26
107_S130_R0.5030.26
5_V327_R0.5030.26
159_K163_Y0.5020.26
69_K268_Y0.5020.26
317_K324_K0.5010.25
208_A270_D0.5010.25
51_Y64_I0.5000.25
53_L251_V0.5000.25
48_D52_D0.5000.25
81_E307_W0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ulkA 3 0.9639 100 0.497 Contact Map
4xdyA 2 0.9699 100 0.526 Contact Map
4xdzA 2 0.9759 100 0.528 Contact Map
4tskA 3 0.9789 100 0.55 Contact Map
3fr7A 2 0.9608 100 0.58 Contact Map
1np3A 4 0.9729 100 0.608 Contact Map
4kqwA 2 0.9729 100 0.621 Contact Map
4yt2A 2 0.9036 99.9 0.842 Contact Map
3ggoA 2 0.7922 99.6 0.88 Contact Map
2izzA 5 0.7952 99.4 0.897 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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