Q97X12 - SULSO - GREMLIN Contacts

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Q97X12 - Transposase ISC1229

UniProt:	Q97X12	Sequences: MVERETEAKSSGSGVTNPYHRTEHCDKIHAYRCDKEVGVIGIDVSKDHLITSRGRVRRYENSKKGYEEILKMKPCTIVLEPTGVYAIKPSQYFKERGVRVLQVSPNVLSREKEFRGKKTDFYDAEKLENMVDKAKEYDYNPLKELVTLYLFLKDIETKYKNRLKRALFLVSDNDKVSKDRLEKLAKGDFTQEELYQLEYTPLVLEEIKILAKNLLETQERLKEVRRMIEGQVPQDHVLLTIPGVGRLAAGVIIGVVGDVRRFPKPESFVAYCGLDPVVERSGKAVVSRGISKRGNKYLRSLFYFLAMRSYSRNPTLLKFYETHKDRLKGKKLYVALARKLARVVWSVWYNNRPYEPK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	357 (313)
Sequences:	3850 (2901)
Seq/√Len:	164.0

SULSO - Q97X12 Q97X29 Q97UQ6 Q97UF7 Q97WZ5 Q97X07 Q97ZN4 Q97Y59 Q97WC0 Q97X26 Q97XK2 Q97VS0 Q97YE1 Q97Y06 Q97VB2 Q97XM7 Q97UU8 Q97Z62

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
156_E	211_A	3.250	1.00
323_H	326_R	2.964	1.00
198_E	220_R	2.905	1.00
202_L	213_N	2.897	1.00
256_V	268_F	2.724	1.00
205_E	213_N	2.715	1.00
268_F	341_A	2.706	1.00
78_V	131_V	2.697	1.00
163_L	207_I	2.416	1.00
237_V	353_P	2.410	1.00
272_C	298_L	2.401	1.00
77_I	98_V	2.344	1.00
155_I	162_R	2.301	1.00
155_I	158_K	2.272	1.00
240_T	353_P	2.207	1.00
209_I	213_N	2.203	1.00
78_V	127_L	2.200	1.00
290_I	334_V	2.196	1.00
185_A	188_D	2.194	1.00
263_P	267_S	2.192	1.00
149_Y	218_Q	2.192	1.00
51_T	69_I	2.189	1.00
252_I	344_V	2.169	1.00
317_L	321_E	2.133	1.00
156_E	214_L	2.101	1.00
244_V	249_A	2.066	1.00
108_L	127_L	2.001	1.00
185_A	189_F	1.998	1.00
155_I	206_E	1.963	1.00
206_E	213_N	1.948	1.00
220_R	223_E	1.948	1.00
238_L	344_V	1.912	1.00
152_L	214_L	1.903	1.00
186_K	189_F	1.897	1.00
338_R	342_R	1.896	1.00
119_T	278_V	1.892	1.00
153_K	214_L	1.861	1.00
328_K	331_K	1.844	1.00
264_K	267_S	1.838	1.00
163_L	200_T	1.800	1.00
225_R	239_L	1.799	1.00
280_R	285_V	1.799	1.00
150_L	300_S	1.789	1.00
157_T	161_N	1.783	1.00
42_I	49_L	1.778	1.00
149_Y	153_K	1.769	1.00
147_T	255_V	1.740	1.00
274_L	337_A	1.737	1.00
262_F	271_Y	1.722	1.00
248_A	301_L	1.704	1.00
62_S	65_G	1.694	1.00
237_V	240_T	1.690	1.00
45_S	50_I	1.671	1.00
241_I	347_V	1.663	1.00
92_Y	95_E	1.663	1.00
48_H	58_R	1.658	1.00
251_V	301_L	1.653	1.00
177_S	180_R	1.636	1.00
241_I	344_V	1.628	1.00
352_R	355_E	1.612	1.00
233_P	351_N	1.610	1.00
205_E	212_K	1.596	1.00
156_E	207_I	1.595	1.00
215_L	218_Q	1.591	1.00
202_L	216_E	1.578	1.00
272_C	341_A	1.569	1.00
300_S	304_F	1.568	1.00
304_F	307_M	1.568	1.00
327_L	331_K	1.567	1.00
322_T	326_R	1.559	1.00
320_Y	336_L	1.555	1.00
204_L	208_K	1.531	1.00
153_K	156_E	1.528	1.00
206_E	209_I	1.509	1.00
237_V	347_V	1.508	1.00
345_W	349_Y	1.502	1.00
186_K	190_T	1.500	1.00
346_S	350_N	1.492	1.00
316_L	343_V	1.421	1.00
238_L	249_A	1.414	1.00
184_L	189_F	1.412	1.00
306_A	340_L	1.388	1.00
347_V	353_P	1.382	1.00
205_E	209_I	1.377	1.00
324_K	330_K	1.376	1.00
234_Q	348_W	1.375	1.00
42_I	51_T	1.370	1.00
76_T	101_L	1.370	1.00
269_V	338_R	1.344	1.00
92_Y	96_R	1.344	1.00
310_Y	320_Y	1.343	1.00
50_I	58_R	1.330	1.00
91_Q	140_N	1.329	1.00
154_D	158_K	1.324	1.00
146_V	221_L	1.323	1.00
207_I	211_A	1.307	1.00
187_G	190_T	1.306	1.00
45_S	48_H	1.303	1.00
41_G	128_E	1.301	1.00
42_I	89_P	1.297	1.00
182_E	186_K	1.291	1.00
305_L	340_L	1.276	1.00
77_I	93_F	1.271	1.00
324_K	329_G	1.266	1.00
79_L	100_V	1.260	1.00
76_T	99_R	1.255	1.00
303_Y	337_A	1.246	1.00
241_I	340_L	1.244	1.00
65_G	68_E	1.237	1.00
319_F	323_H	1.229	1.00
220_R	224_V	1.224	1.00
151_F	162_R	1.224	1.00
222_K	246_R	1.222	1.00
255_V	295_N	1.219	1.00
40_I	73_K	1.218	1.00
306_A	337_A	1.212	1.00
155_I	159_Y	1.206	1.00
209_I	212_K	1.183	1.00
234_Q	351_N	1.179	1.00
252_I	298_L	1.178	1.00
346_S	349_Y	1.175	1.00
150_L	297_Y	1.170	1.00
146_V	297_Y	1.169	1.00
148_L	152_L	1.160	1.00
319_F	335_A	1.146	1.00
314_P	318_K	1.144	1.00
174_D	184_L	1.142	1.00
316_L	336_L	1.142	1.00
61_N	69_I	1.142	1.00
57_R	72_M	1.139	1.00
218_Q	222_K	1.131	1.00
184_L	187_G	1.124	1.00
248_A	305_L	1.120	1.00
239_L	246_R	1.118	1.00
319_F	339_K	1.118	1.00
303_Y	334_V	1.118	1.00
347_V	352_R	1.115	1.00
184_L	188_D	1.114	1.00
244_V	344_V	1.112	1.00
177_S	185_A	1.109	1.00
117_K	278_V	1.107	1.00
183_K	187_G	1.104	1.00
175_K	180_R	1.103	1.00
202_L	220_R	1.102	1.00
323_H	328_K	1.101	1.00
145_L	217_T	1.100	1.00
182_E	185_A	1.099	1.00
225_R	235_D	1.094	1.00
173_N	177_S	1.094	1.00
259_V	348_W	1.093	1.00
181_L	184_L	1.079	1.00
238_L	348_W	1.079	1.00
181_L	185_A	1.075	0.99
323_H	327_L	1.074	0.99
281_S	285_V	1.072	0.99
178_K	182_E	1.070	0.99
343_V	347_V	1.067	0.99
149_Y	214_L	1.063	0.99
47_D	283_K	1.062	0.99
158_K	161_N	1.055	0.99
73_K	77_I	1.048	0.99
180_R	184_L	1.048	0.99
78_V	103_V	1.046	0.99
233_P	237_V	1.040	0.99
125_E	129_N	1.038	0.99
159_Y	163_L	1.026	0.99
323_H	332_L	1.023	0.99
42_I	66_Y	1.020	0.99
180_R	183_K	1.019	0.99
232_V	253_I	1.013	0.99
269_V	275_D	1.011	0.99
149_Y	247_L	1.011	0.99
195_Y	199_Y	1.009	0.99
159_Y	203_V	1.005	0.99
60_E	65_G	1.001	0.99
302_F	341_A	1.001	0.99
185_A	190_T	0.995	0.99
109_S	112_K	0.992	0.99
303_Y	307_M	0.991	0.99
211_A	215_L	0.987	0.99
319_F	336_L	0.987	0.99
118_K	123_D	0.986	0.99
59_Y	72_M	0.986	0.99
307_M	330_K	0.982	0.99
316_L	340_L	0.980	0.99
321_E	325_D	0.979	0.99
213_N	216_E	0.979	0.99
234_Q	237_V	0.978	0.99
264_K	345_W	0.977	0.99
70_L	93_F	0.976	0.99
40_I	51_T	0.974	0.99
244_V	248_A	0.967	0.99
153_K	157_T	0.966	0.99
193_E	196_Q	0.958	0.99
79_L	90_S	0.951	0.99
292_K	299_R	0.948	0.99
314_P	317_L	0.944	0.99
86_A	102_Q	0.943	0.99
212_K	216_E	0.942	0.99
56_V	125_E	0.936	0.99
70_L	96_R	0.925	0.98
195_Y	198_E	0.925	0.98
81_P	105_P	0.921	0.98
150_L	154_D	0.913	0.98
267_S	270_A	0.910	0.98
307_M	310_Y	0.910	0.98
70_L	98_V	0.909	0.98
168_F	171_S	0.908	0.98
177_S	181_L	0.906	0.98
306_A	333_Y	0.903	0.98
225_R	250_G	0.898	0.98
192_E	197_L	0.894	0.98
160_K	207_I	0.890	0.98
159_Y	206_E	0.888	0.98
41_G	124_A	0.885	0.98
306_A	336_L	0.877	0.98
141_P	193_E	0.872	0.98
148_L	217_T	0.856	0.97
159_Y	210_L	0.855	0.97
172_D	177_S	0.852	0.97
244_V	340_L	0.851	0.97
143_K	255_V	0.847	0.97
40_I	75_C	0.844	0.97
208_K	212_K	0.844	0.97
104_S	107_V	0.843	0.97
181_L	187_G	0.838	0.97
241_I	244_V	0.838	0.97
182_E	190_T	0.837	0.97
64_K	68_E	0.836	0.97
310_Y	333_Y	0.835	0.97
168_F	172_D	0.834	0.97
40_I	77_I	0.828	0.97
156_E	160_K	0.827	0.97
45_S	282_G	0.822	0.97
152_L	217_T	0.820	0.97
184_L	190_T	0.820	0.97
109_S	113_E	0.815	0.97
82_T	85_Y	0.811	0.96
103_V	108_L	0.809	0.96
146_V	250_G	0.808	0.96
290_I	299_R	0.807	0.96
172_D	175_K	0.806	0.96
258_D	261_R	0.805	0.96
44_V	79_L	0.803	0.96
169_L	175_K	0.802	0.96
182_E	189_F	0.802	0.96
148_L	202_L	0.801	0.96
40_I	93_F	0.800	0.96
61_N	66_Y	0.800	0.96
194_L	198_E	0.798	0.96
181_L	188_D	0.793	0.96
51_T	59_Y	0.788	0.96
330_K	333_Y	0.786	0.96
294_G	299_R	0.785	0.96
120_D	281_S	0.785	0.96
211_A	214_L	0.783	0.96
183_K	186_K	0.783	0.96
277_V	291_S	0.782	0.96
256_V	259_V	0.782	0.96
210_L	214_L	0.781	0.96
192_E	195_Y	0.779	0.96
159_Y	207_I	0.775	0.95
255_V	297_Y	0.774	0.95
68_E	71_K	0.773	0.95
178_K	185_A	0.769	0.95
181_L	189_F	0.766	0.95
307_M	333_Y	0.764	0.95
63_K	67_E	0.759	0.95
160_K	178_K	0.756	0.95
251_V	297_Y	0.755	0.95
290_I	335_A	0.753	0.95
328_K	332_L	0.753	0.95
89_P	93_F	0.753	0.95
275_D	291_S	0.752	0.95
90_S	100_V	0.752	0.95
180_R	189_F	0.751	0.95
270_A	275_D	0.750	0.95
176_V	180_R	0.749	0.95
179_D	183_K	0.748	0.94
176_V	184_L	0.747	0.94
322_T	325_D	0.747	0.94
133_K	261_R	0.746	0.94
192_E	196_Q	0.745	0.94
177_S	190_T	0.743	0.94
152_L	210_L	0.741	0.94
302_F	337_A	0.740	0.94
146_V	251_V	0.736	0.94
218_Q	221_L	0.735	0.94
274_L	302_F	0.730	0.94
191_Q	197_L	0.726	0.94
318_K	322_T	0.726	0.94
172_D	176_V	0.725	0.94
201_P	205_E	0.724	0.93
244_V	305_L	0.721	0.93
153_K	218_Q	0.721	0.93
90_S	134_A	0.720	0.93
174_D	177_S	0.719	0.93
105_P	255_V	0.718	0.93
51_T	72_M	0.716	0.93
278_V	285_V	0.715	0.93
194_L	220_R	0.714	0.93
180_R	187_G	0.713	0.93
50_I	121_F	0.711	0.93
196_Q	199_Y	0.710	0.93
65_G	69_I	0.708	0.93
223_E	231_Q	0.702	0.92
265_P	345_W	0.698	0.92
106_N	293_R	0.697	0.92
324_K	332_L	0.697	0.92
182_E	187_G	0.696	0.92
168_F	173_N	0.696	0.92
152_L	213_N	0.692	0.92
156_E	210_L	0.676	0.91
307_M	337_A	0.671	0.91
59_Y	65_G	0.670	0.91
202_L	206_E	0.669	0.90
222_K	239_L	0.666	0.90
275_D	278_V	0.661	0.90
315_T	354_Y	0.661	0.90
177_S	189_F	0.660	0.90
147_T	297_Y	0.660	0.90
159_Y	162_R	0.659	0.90
252_I	268_F	0.658	0.90
71_K	96_R	0.657	0.90
169_L	173_N	0.656	0.90
142_L	221_L	0.656	0.90
42_I	69_I	0.656	0.90
67_E	92_Y	0.654	0.89
57_R	68_E	0.652	0.89
319_F	322_T	0.651	0.89
41_G	93_F	0.651	0.89
269_V	342_R	0.651	0.89
52_S	55_R	0.650	0.89
173_N	176_V	0.648	0.89
216_E	220_R	0.646	0.89
45_S	49_L	0.641	0.89
66_Y	93_F	0.641	0.89
180_R	186_K	0.636	0.88
308_R	312_R	0.636	0.88
174_D	188_D	0.634	0.88
144_E	166_A	0.634	0.88
302_F	344_V	0.633	0.88
161_N	165_R	0.632	0.88
116_G	293_R	0.632	0.88
171_S	175_K	0.630	0.88
146_V	254_G	0.630	0.88
50_I	281_S	0.628	0.88
162_R	203_V	0.628	0.88
275_D	299_R	0.628	0.88
171_S	177_S	0.628	0.88
226_R	246_R	0.626	0.87
170_V	173_N	0.626	0.87
171_S	174_D	0.624	0.87
342_R	345_W	0.616	0.87
331_K	335_A	0.616	0.87
163_L	204_L	0.609	0.86
49_L	59_Y	0.609	0.86
260_R	349_Y	0.608	0.86
70_L	74_P	0.608	0.86
49_L	61_N	0.606	0.86
142_L	224_V	0.605	0.86
201_P	216_E	0.603	0.85
234_Q	253_I	0.602	0.85
251_V	255_V	0.601	0.85
198_E	202_L	0.600	0.85
198_E	201_P	0.600	0.85
291_S	299_R	0.600	0.85
222_K	226_R	0.599	0.85
223_E	226_R	0.599	0.85
339_K	342_R	0.598	0.85
45_S	89_P	0.597	0.85
136_E	139_Y	0.597	0.85
127_L	130_M	0.597	0.85
301_L	305_L	0.596	0.85
145_L	220_R	0.595	0.85
241_I	343_V	0.592	0.84
67_E	71_K	0.591	0.84
175_K	186_K	0.589	0.84
169_L	177_S	0.587	0.84
232_V	344_V	0.580	0.83
310_Y	324_K	0.580	0.83
175_K	178_K	0.580	0.83
218_Q	246_R	0.579	0.83
214_L	218_Q	0.575	0.83
265_P	342_R	0.574	0.82
237_V	351_N	0.572	0.82
178_K	188_D	0.571	0.82
151_F	155_I	0.571	0.82
269_V	278_V	0.569	0.82
147_T	295_N	0.567	0.82
70_L	92_Y	0.567	0.82
79_L	127_L	0.567	0.82
195_Y	220_R	0.567	0.82
101_L	131_V	0.564	0.81
205_E	216_E	0.564	0.81
206_E	210_L	0.563	0.81
122_Y	126_K	0.563	0.81
218_Q	247_L	0.563	0.81
313_N	317_L	0.563	0.81
65_G	72_M	0.563	0.81
193_E	197_L	0.563	0.81
349_Y	352_R	0.562	0.81
273_G	299_R	0.560	0.81
327_L	330_K	0.558	0.81
136_E	140_N	0.558	0.81
320_Y	332_L	0.557	0.81
217_T	221_L	0.556	0.80
307_M	311_S	0.554	0.80
297_Y	300_S	0.554	0.80
75_C	98_V	0.553	0.80
105_P	108_L	0.551	0.80
66_Y	88_K	0.549	0.80
129_N	132_D	0.548	0.79
278_V	287_S	0.547	0.79
176_V	187_G	0.546	0.79
103_V	113_E	0.544	0.79
68_E	72_M	0.544	0.79
116_G	277_V	0.544	0.79
138_D	141_P	0.544	0.79
42_I	79_L	0.543	0.79
323_H	335_A	0.543	0.79
93_F	340_L	0.543	0.79
94_K	134_A	0.542	0.79
119_T	279_E	0.542	0.79
309_S	313_N	0.539	0.78
266_E	338_R	0.539	0.78
57_R	69_I	0.537	0.78
151_F	158_K	0.535	0.78
37_V	75_C	0.535	0.78
180_R	185_A	0.535	0.78
197_L	201_P	0.533	0.78
78_V	108_L	0.532	0.77
112_K	126_K	0.531	0.77
90_S	102_Q	0.530	0.77
44_V	85_Y	0.530	0.77
151_F	154_D	0.529	0.77
275_D	292_K	0.528	0.77
195_Y	223_E	0.527	0.77
79_L	86_A	0.526	0.77
163_L	203_V	0.525	0.77
89_P	305_L	0.525	0.77
177_S	184_L	0.524	0.76
161_N	164_K	0.523	0.76
47_D	184_L	0.523	0.76
309_S	340_L	0.518	0.76
313_N	354_Y	0.518	0.76
172_D	187_G	0.518	0.76
199_Y	217_T	0.517	0.75
274_L	338_R	0.517	0.75
168_F	176_V	0.516	0.75
94_K	298_L	0.515	0.75
139_Y	142_L	0.511	0.75
174_D	187_G	0.511	0.75
46_K	283_K	0.511	0.75
313_N	318_K	0.509	0.74
162_R	165_R	0.509	0.74
277_V	288_R	0.508	0.74
238_L	244_V	0.507	0.74
149_Y	221_L	0.507	0.74
86_A	90_S	0.506	0.74
324_K	327_L	0.506	0.74
191_Q	198_E	0.505	0.74
286_V	289_G	0.503	0.73
235_D	253_I	0.503	0.73
148_L	203_V	0.503	0.73
112_K	257_G	0.500	0.73
140_N	144_E	0.500	0.73
171_S	184_L	0.500	0.73
109_S	114_F	0.500	0.73
103_V	130_M	0.500	0.73

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1hjrA	2	0.2885	86.2	0.947	Contact Map
1keaA	2	0.5546	84.9	0.948	Contact Map
3fhfA	1	0.5742	84.3	0.948	Contact Map
3n0uA	1	0.5658	83.1	0.949	Contact Map
2a1jB	2	0.2157	81.1	0.95	Contact Map
1z00B	1	0.2073	80.4	0.95	Contact Map
1z00A	1	0.2297	80.3	0.95	Contact Map
1pu6A	1	0.5378	79.9	0.951	Contact Map
2a1jA	1	0.1653	78	0.952	Contact Map
2duyA	1	0.1821	77.1	0.952	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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