GREMLIN Database
Q97X12 - Transposase ISC1229
UniProt: Q97X12 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 357 (313)
Sequences: 3850 (2901)
Seq/√Len: 164.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
156_E211_A3.2501.00
323_H326_R2.9641.00
198_E220_R2.9051.00
202_L213_N2.8971.00
256_V268_F2.7241.00
205_E213_N2.7151.00
268_F341_A2.7061.00
78_V131_V2.6971.00
163_L207_I2.4161.00
237_V353_P2.4101.00
272_C298_L2.4011.00
77_I98_V2.3441.00
155_I162_R2.3011.00
155_I158_K2.2721.00
240_T353_P2.2071.00
209_I213_N2.2031.00
78_V127_L2.2001.00
290_I334_V2.1961.00
185_A188_D2.1941.00
263_P267_S2.1921.00
149_Y218_Q2.1921.00
51_T69_I2.1891.00
252_I344_V2.1691.00
317_L321_E2.1331.00
156_E214_L2.1011.00
244_V249_A2.0661.00
108_L127_L2.0011.00
185_A189_F1.9981.00
155_I206_E1.9631.00
206_E213_N1.9481.00
220_R223_E1.9481.00
238_L344_V1.9121.00
152_L214_L1.9031.00
186_K189_F1.8971.00
338_R342_R1.8961.00
119_T278_V1.8921.00
153_K214_L1.8611.00
328_K331_K1.8441.00
264_K267_S1.8381.00
163_L200_T1.8001.00
225_R239_L1.7991.00
280_R285_V1.7991.00
150_L300_S1.7891.00
157_T161_N1.7831.00
42_I49_L1.7781.00
149_Y153_K1.7691.00
147_T255_V1.7401.00
274_L337_A1.7371.00
262_F271_Y1.7221.00
248_A301_L1.7041.00
62_S65_G1.6941.00
237_V240_T1.6901.00
45_S50_I1.6711.00
241_I347_V1.6631.00
92_Y95_E1.6631.00
48_H58_R1.6581.00
251_V301_L1.6531.00
177_S180_R1.6361.00
241_I344_V1.6281.00
352_R355_E1.6121.00
233_P351_N1.6101.00
205_E212_K1.5961.00
156_E207_I1.5951.00
215_L218_Q1.5911.00
202_L216_E1.5781.00
272_C341_A1.5691.00
300_S304_F1.5681.00
304_F307_M1.5681.00
327_L331_K1.5671.00
322_T326_R1.5591.00
320_Y336_L1.5551.00
204_L208_K1.5311.00
153_K156_E1.5281.00
206_E209_I1.5091.00
237_V347_V1.5081.00
345_W349_Y1.5021.00
186_K190_T1.5001.00
346_S350_N1.4921.00
316_L343_V1.4211.00
238_L249_A1.4141.00
184_L189_F1.4121.00
306_A340_L1.3881.00
347_V353_P1.3821.00
205_E209_I1.3771.00
324_K330_K1.3761.00
234_Q348_W1.3751.00
42_I51_T1.3701.00
76_T101_L1.3701.00
269_V338_R1.3441.00
92_Y96_R1.3441.00
310_Y320_Y1.3431.00
50_I58_R1.3301.00
91_Q140_N1.3291.00
154_D158_K1.3241.00
146_V221_L1.3231.00
207_I211_A1.3071.00
187_G190_T1.3061.00
45_S48_H1.3031.00
41_G128_E1.3011.00
42_I89_P1.2971.00
182_E186_K1.2911.00
305_L340_L1.2761.00
77_I93_F1.2711.00
324_K329_G1.2661.00
79_L100_V1.2601.00
76_T99_R1.2551.00
303_Y337_A1.2461.00
241_I340_L1.2441.00
65_G68_E1.2371.00
319_F323_H1.2291.00
220_R224_V1.2241.00
151_F162_R1.2241.00
222_K246_R1.2221.00
255_V295_N1.2191.00
40_I73_K1.2181.00
306_A337_A1.2121.00
155_I159_Y1.2061.00
209_I212_K1.1831.00
234_Q351_N1.1791.00
252_I298_L1.1781.00
346_S349_Y1.1751.00
150_L297_Y1.1701.00
146_V297_Y1.1691.00
148_L152_L1.1601.00
319_F335_A1.1461.00
314_P318_K1.1441.00
174_D184_L1.1421.00
316_L336_L1.1421.00
61_N69_I1.1421.00
57_R72_M1.1391.00
218_Q222_K1.1311.00
184_L187_G1.1241.00
248_A305_L1.1201.00
239_L246_R1.1181.00
319_F339_K1.1181.00
303_Y334_V1.1181.00
347_V352_R1.1151.00
184_L188_D1.1141.00
244_V344_V1.1121.00
177_S185_A1.1091.00
117_K278_V1.1071.00
183_K187_G1.1041.00
175_K180_R1.1031.00
202_L220_R1.1021.00
323_H328_K1.1011.00
145_L217_T1.1001.00
182_E185_A1.0991.00
225_R235_D1.0941.00
173_N177_S1.0941.00
259_V348_W1.0931.00
181_L184_L1.0791.00
238_L348_W1.0791.00
181_L185_A1.0750.99
323_H327_L1.0740.99
281_S285_V1.0720.99
178_K182_E1.0700.99
343_V347_V1.0670.99
149_Y214_L1.0630.99
47_D283_K1.0620.99
158_K161_N1.0550.99
73_K77_I1.0480.99
180_R184_L1.0480.99
78_V103_V1.0460.99
233_P237_V1.0400.99
125_E129_N1.0380.99
159_Y163_L1.0260.99
323_H332_L1.0230.99
42_I66_Y1.0200.99
180_R183_K1.0190.99
232_V253_I1.0130.99
269_V275_D1.0110.99
149_Y247_L1.0110.99
195_Y199_Y1.0090.99
159_Y203_V1.0050.99
60_E65_G1.0010.99
302_F341_A1.0010.99
185_A190_T0.9950.99
109_S112_K0.9920.99
303_Y307_M0.9910.99
211_A215_L0.9870.99
319_F336_L0.9870.99
118_K123_D0.9860.99
59_Y72_M0.9860.99
307_M330_K0.9820.99
316_L340_L0.9800.99
321_E325_D0.9790.99
213_N216_E0.9790.99
234_Q237_V0.9780.99
264_K345_W0.9770.99
70_L93_F0.9760.99
40_I51_T0.9740.99
244_V248_A0.9670.99
153_K157_T0.9660.99
193_E196_Q0.9580.99
79_L90_S0.9510.99
292_K299_R0.9480.99
314_P317_L0.9440.99
86_A102_Q0.9430.99
212_K216_E0.9420.99
56_V125_E0.9360.99
70_L96_R0.9250.98
195_Y198_E0.9250.98
81_P105_P0.9210.98
150_L154_D0.9130.98
267_S270_A0.9100.98
307_M310_Y0.9100.98
70_L98_V0.9090.98
168_F171_S0.9080.98
177_S181_L0.9060.98
306_A333_Y0.9030.98
225_R250_G0.8980.98
192_E197_L0.8940.98
160_K207_I0.8900.98
159_Y206_E0.8880.98
41_G124_A0.8850.98
306_A336_L0.8770.98
141_P193_E0.8720.98
148_L217_T0.8560.97
159_Y210_L0.8550.97
172_D177_S0.8520.97
244_V340_L0.8510.97
143_K255_V0.8470.97
40_I75_C0.8440.97
208_K212_K0.8440.97
104_S107_V0.8430.97
181_L187_G0.8380.97
241_I244_V0.8380.97
182_E190_T0.8370.97
64_K68_E0.8360.97
310_Y333_Y0.8350.97
168_F172_D0.8340.97
40_I77_I0.8280.97
156_E160_K0.8270.97
45_S282_G0.8220.97
152_L217_T0.8200.97
184_L190_T0.8200.97
109_S113_E0.8150.97
82_T85_Y0.8110.96
103_V108_L0.8090.96
146_V250_G0.8080.96
290_I299_R0.8070.96
172_D175_K0.8060.96
258_D261_R0.8050.96
44_V79_L0.8030.96
169_L175_K0.8020.96
182_E189_F0.8020.96
148_L202_L0.8010.96
40_I93_F0.8000.96
61_N66_Y0.8000.96
194_L198_E0.7980.96
181_L188_D0.7930.96
51_T59_Y0.7880.96
330_K333_Y0.7860.96
294_G299_R0.7850.96
120_D281_S0.7850.96
211_A214_L0.7830.96
183_K186_K0.7830.96
277_V291_S0.7820.96
256_V259_V0.7820.96
210_L214_L0.7810.96
192_E195_Y0.7790.96
159_Y207_I0.7750.95
255_V297_Y0.7740.95
68_E71_K0.7730.95
178_K185_A0.7690.95
181_L189_F0.7660.95
307_M333_Y0.7640.95
63_K67_E0.7590.95
160_K178_K0.7560.95
251_V297_Y0.7550.95
290_I335_A0.7530.95
328_K332_L0.7530.95
89_P93_F0.7530.95
275_D291_S0.7520.95
90_S100_V0.7520.95
180_R189_F0.7510.95
270_A275_D0.7500.95
176_V180_R0.7490.95
179_D183_K0.7480.94
176_V184_L0.7470.94
322_T325_D0.7470.94
133_K261_R0.7460.94
192_E196_Q0.7450.94
177_S190_T0.7430.94
152_L210_L0.7410.94
302_F337_A0.7400.94
146_V251_V0.7360.94
218_Q221_L0.7350.94
274_L302_F0.7300.94
191_Q197_L0.7260.94
318_K322_T0.7260.94
172_D176_V0.7250.94
201_P205_E0.7240.93
244_V305_L0.7210.93
153_K218_Q0.7210.93
90_S134_A0.7200.93
174_D177_S0.7190.93
105_P255_V0.7180.93
51_T72_M0.7160.93
278_V285_V0.7150.93
194_L220_R0.7140.93
180_R187_G0.7130.93
50_I121_F0.7110.93
196_Q199_Y0.7100.93
65_G69_I0.7080.93
223_E231_Q0.7020.92
265_P345_W0.6980.92
106_N293_R0.6970.92
324_K332_L0.6970.92
182_E187_G0.6960.92
168_F173_N0.6960.92
152_L213_N0.6920.92
156_E210_L0.6760.91
307_M337_A0.6710.91
59_Y65_G0.6700.91
202_L206_E0.6690.90
222_K239_L0.6660.90
275_D278_V0.6610.90
315_T354_Y0.6610.90
177_S189_F0.6600.90
147_T297_Y0.6600.90
159_Y162_R0.6590.90
252_I268_F0.6580.90
71_K96_R0.6570.90
169_L173_N0.6560.90
142_L221_L0.6560.90
42_I69_I0.6560.90
67_E92_Y0.6540.89
57_R68_E0.6520.89
319_F322_T0.6510.89
41_G93_F0.6510.89
269_V342_R0.6510.89
52_S55_R0.6500.89
173_N176_V0.6480.89
216_E220_R0.6460.89
45_S49_L0.6410.89
66_Y93_F0.6410.89
180_R186_K0.6360.88
308_R312_R0.6360.88
174_D188_D0.6340.88
144_E166_A0.6340.88
302_F344_V0.6330.88
161_N165_R0.6320.88
116_G293_R0.6320.88
171_S175_K0.6300.88
146_V254_G0.6300.88
50_I281_S0.6280.88
162_R203_V0.6280.88
275_D299_R0.6280.88
171_S177_S0.6280.88
226_R246_R0.6260.87
170_V173_N0.6260.87
171_S174_D0.6240.87
342_R345_W0.6160.87
331_K335_A0.6160.87
163_L204_L0.6090.86
49_L59_Y0.6090.86
260_R349_Y0.6080.86
70_L74_P0.6080.86
49_L61_N0.6060.86
142_L224_V0.6050.86
201_P216_E0.6030.85
234_Q253_I0.6020.85
251_V255_V0.6010.85
198_E202_L0.6000.85
198_E201_P0.6000.85
291_S299_R0.6000.85
222_K226_R0.5990.85
223_E226_R0.5990.85
339_K342_R0.5980.85
45_S89_P0.5970.85
136_E139_Y0.5970.85
127_L130_M0.5970.85
301_L305_L0.5960.85
145_L220_R0.5950.85
241_I343_V0.5920.84
67_E71_K0.5910.84
175_K186_K0.5890.84
169_L177_S0.5870.84
232_V344_V0.5800.83
310_Y324_K0.5800.83
175_K178_K0.5800.83
218_Q246_R0.5790.83
214_L218_Q0.5750.83
265_P342_R0.5740.82
237_V351_N0.5720.82
178_K188_D0.5710.82
151_F155_I0.5710.82
269_V278_V0.5690.82
147_T295_N0.5670.82
70_L92_Y0.5670.82
79_L127_L0.5670.82
195_Y220_R0.5670.82
101_L131_V0.5640.81
205_E216_E0.5640.81
206_E210_L0.5630.81
122_Y126_K0.5630.81
218_Q247_L0.5630.81
313_N317_L0.5630.81
65_G72_M0.5630.81
193_E197_L0.5630.81
349_Y352_R0.5620.81
273_G299_R0.5600.81
327_L330_K0.5580.81
136_E140_N0.5580.81
320_Y332_L0.5570.81
217_T221_L0.5560.80
307_M311_S0.5540.80
297_Y300_S0.5540.80
75_C98_V0.5530.80
105_P108_L0.5510.80
66_Y88_K0.5490.80
129_N132_D0.5480.79
278_V287_S0.5470.79
176_V187_G0.5460.79
103_V113_E0.5440.79
68_E72_M0.5440.79
116_G277_V0.5440.79
138_D141_P0.5440.79
42_I79_L0.5430.79
323_H335_A0.5430.79
93_F340_L0.5430.79
94_K134_A0.5420.79
119_T279_E0.5420.79
309_S313_N0.5390.78
266_E338_R0.5390.78
57_R69_I0.5370.78
151_F158_K0.5350.78
37_V75_C0.5350.78
180_R185_A0.5350.78
197_L201_P0.5330.78
78_V108_L0.5320.77
112_K126_K0.5310.77
90_S102_Q0.5300.77
44_V85_Y0.5300.77
151_F154_D0.5290.77
275_D292_K0.5280.77
195_Y223_E0.5270.77
79_L86_A0.5260.77
163_L203_V0.5250.77
89_P305_L0.5250.77
177_S184_L0.5240.76
161_N164_K0.5230.76
47_D184_L0.5230.76
309_S340_L0.5180.76
313_N354_Y0.5180.76
172_D187_G0.5180.76
199_Y217_T0.5170.75
274_L338_R0.5170.75
168_F176_V0.5160.75
94_K298_L0.5150.75
139_Y142_L0.5110.75
174_D187_G0.5110.75
46_K283_K0.5110.75
313_N318_K0.5090.74
162_R165_R0.5090.74
277_V288_R0.5080.74
238_L244_V0.5070.74
149_Y221_L0.5070.74
86_A90_S0.5060.74
324_K327_L0.5060.74
191_Q198_E0.5050.74
286_V289_G0.5030.73
235_D253_I0.5030.73
148_L203_V0.5030.73
112_K257_G0.5000.73
140_N144_E0.5000.73
171_S184_L0.5000.73
109_S114_F0.5000.73
103_V130_M0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hjrA 2 0.2885 86.2 0.947 Contact Map
1keaA 2 0.5546 84.9 0.948 Contact Map
3fhfA 1 0.5742 84.3 0.948 Contact Map
3n0uA 1 0.5658 83.1 0.949 Contact Map
2a1jB 2 0.2157 81.1 0.95 Contact Map
1z00B 1 0.2073 80.4 0.95 Contact Map
1z00A 1 0.2297 80.3 0.95 Contact Map
1pu6A 1 0.5378 79.9 0.951 Contact Map
2a1jA 1 0.1653 78 0.952 Contact Map
2duyA 1 0.1821 77.1 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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