GREMLIN Database
Q97X10 - Uncharacterized protein
UniProt: Q97X10 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 150 (138)
Sequences: 207 (158)
Seq/√Len: 13.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_K77_D3.7380.99
32_E41_K3.4890.99
29_K83_E3.3990.99
107_Q147_L2.9690.97
6_S90_V2.9410.97
11_A15_E2.8590.96
32_E79_L2.7550.95
81_D84_R2.6480.94
31_G108_I2.6100.93
22_E90_V2.5620.93
125_E130_E2.3450.89
32_E77_D2.1640.84
7_L21_Y2.0190.80
75_S81_D1.9980.79
79_L126_M1.9010.75
10_M31_G1.7720.70
75_S84_R1.7530.69
10_M30_A1.7220.68
132_K139_G1.7160.67
70_L85_L1.7110.67
117_Y126_M1.6630.65
111_A147_L1.6510.64
100_N141_T1.6460.64
124_V133_Y1.6460.64
9_A12_K1.6400.64
51_T108_I1.5930.61
55_S91_A1.5770.60
102_K108_I1.5760.60
50_K53_D1.5480.59
33_S144_K1.5250.58
24_I128_N1.5100.57
70_L73_D1.4840.56
77_D80_K1.4620.54
141_T145_I1.4470.54
123_W145_I1.4130.52
88_L92_T1.4010.51
102_K106_N1.3880.51
140_K144_K1.3240.47
105_E108_I1.3090.46
95_E131_G1.2900.45
129_L146_L1.2770.45
14_A34_K1.2330.42
123_W146_L1.2270.42
58_E65_G1.2260.42
25_L31_G1.2110.41
67_Y109_R1.2050.41
53_D66_K1.1810.40
27_A76_Q1.1730.39
14_A20_I1.1490.38
50_K67_Y1.1380.38
93_F120_L1.1080.36
38_R135_G1.1070.36
129_L145_I1.0950.35
45_A120_L1.0840.35
116_G128_N1.0820.35
76_Q109_R1.0720.34
137_K145_I1.0460.33
34_K55_S1.0440.33
115_W124_V1.0380.33
11_A25_L1.0300.32
26_R29_K1.0190.32
20_I135_G1.0070.31
55_S132_K1.0040.31
127_N132_K1.0010.31
110_Q118_N0.9880.30
108_I120_L0.9870.30
106_N138_I0.9850.30
18_G48_V0.9820.30
70_L92_T0.9790.30
143_L147_L0.9750.30
97_E101_V0.9640.29
107_Q143_L0.9520.29
122_T126_M0.9500.29
41_K50_K0.9290.28
31_G96_E0.9160.27
87_D118_N0.9110.27
79_L123_W0.9060.27
73_D129_L0.9050.27
98_M101_V0.8980.27
119_D122_T0.8950.26
96_E134_T0.8930.26
47_I102_K0.8860.26
75_S79_L0.8790.26
75_S119_D0.8790.26
22_E87_D0.8790.26
7_L65_G0.8780.26
52_V80_K0.8760.26
53_D104_Y0.8730.25
65_G78_P0.8680.25
93_F130_E0.8670.25
26_R30_A0.8640.25
127_N139_G0.8630.25
30_A122_T0.8570.25
13_E30_A0.8530.25
25_L126_M0.8460.24
125_E133_Y0.8460.24
18_G53_D0.8440.24
20_I45_A0.8420.24
54_K65_G0.8380.24
104_Y147_L0.8370.24
51_T79_L0.8250.24
116_G130_E0.8200.23
91_A132_K0.8180.23
6_S32_E0.8170.23
13_E114_K0.8160.23
10_M13_E0.8130.23
29_K79_L0.8070.23
56_E102_K0.7970.23
66_K123_W0.7820.22
5_H8_E0.7790.22
98_M102_K0.7780.22
19_K94_I0.7770.22
96_E139_G0.7750.22
68_V113_N0.7730.22
55_S58_E0.7680.21
92_T127_N0.7640.21
139_G143_L0.7610.21
112_L129_L0.7590.21
34_K139_G0.7530.21
63_I68_V0.7510.21
7_L45_A0.7500.21
110_Q113_N0.7500.21
98_M142_V0.7470.21
7_L92_T0.7450.21
43_S70_L0.7360.20
30_A76_Q0.7360.20
80_K113_N0.7320.20
18_G22_E0.7180.20
69_D108_I0.7160.20
56_E127_N0.7130.20
24_I55_S0.7110.20
71_R130_E0.7100.19
41_K73_D0.7020.19
45_A126_M0.6990.19
9_A106_N0.6980.19
91_A131_G0.6970.19
21_Y68_V0.6920.19
96_E100_N0.6910.19
118_N125_E0.6860.19
54_K75_S0.6860.19
6_S86_L0.6690.18
15_E77_D0.6670.18
79_L87_D0.6660.18
18_G50_K0.6660.18
111_A146_L0.6550.18
8_E12_K0.6550.18
58_E127_N0.6520.18
38_R141_T0.6400.17
118_N122_T0.6390.17
50_K117_Y0.6370.17
6_S64_V0.6350.17
114_K122_T0.6330.17
113_N144_K0.6330.17
29_K32_E0.6320.17
19_K22_E0.6280.17
105_E136_D0.6230.17
137_K141_T0.6210.17
46_I86_L0.6210.17
56_E131_G0.6210.17
94_I121_R0.6200.17
100_N114_K0.6160.17
94_I143_L0.6150.16
55_S65_G0.6100.16
20_I115_W0.6000.16
24_I112_L0.5970.16
89_W127_N0.5930.16
6_S14_A0.5900.16
114_K118_N0.5860.16
100_N136_D0.5850.16
126_M133_Y0.5780.15
26_R107_Q0.5780.15
141_T146_L0.5770.15
14_A18_G0.5750.15
108_I124_V0.5740.15
12_K15_E0.5690.15
130_E133_Y0.5680.15
34_K127_N0.5670.15
9_A19_K0.5570.15
69_D72_V0.5560.15
99_V134_T0.5530.15
8_E11_A0.5520.15
18_G25_L0.5500.15
100_N145_I0.5450.15
14_A90_V0.5450.15
56_E132_K0.5420.14
7_L54_K0.5410.14
24_I58_E0.5360.14
21_Y46_I0.5340.14
51_T94_I0.5330.14
17_K138_I0.5290.14
86_L133_Y0.5290.14
25_L46_I0.5290.14
6_S123_W0.5280.14
22_E109_R0.5280.14
10_M20_I0.5280.14
54_K91_A0.5280.14
106_N109_R0.5240.14
77_D137_K0.5190.14
6_S15_E0.5180.14
10_M137_K0.5180.14
34_K58_E0.5160.14
24_I34_K0.5080.14
12_K29_K0.5030.13
58_E128_N0.5020.13
25_L86_L0.5020.13
63_I119_D0.5010.13
8_E15_E0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2imhA 2 0.6533 100 0.568 Contact Map
1vjzA 1 0.4467 22.7 0.95 Contact Map
3ix3A 2 0.3933 10 0.957 Contact Map
4fetB 1 0 9.8 0.958 Contact Map
2d1zA 1 0.4667 8.2 0.959 Contact Map
2jugA 2 0.3267 7.2 0.96 Contact Map
3aofA 1 0.5133 6.1 0.961 Contact Map
3aeyA 2 0.5467 5.8 0.962 Contact Map
4cgrA 2 0.5533 5.6 0.962 Contact Map
3bkhA 1 0.5133 5.5 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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