Q97X07 - SULSO - GREMLIN Contacts

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Q97X07 - Transposase ISC1190

UniProt:	Q97X07	Sequences: MEAPVAGIDVSKDKLIVYFQGKLYEFTNDKRGYEEIRKILPKGCKVGIESTGVYHVNLAKYLMGEYDVRIINPFILKKFKDFRGKKSDKNDAKKLAELVVSMCSGFTTSDARELTSQWDFVTRSIARVKNRLRRDLVLLGYRDSLSKRNLEEVLRGGDSIVLAEVRFLLEELERLKTRKREIEKELENVVSKDSLIFTIPGIGKTLGCIILARVGDVKRFSDKKRFVAYCGLDPVVESSGKSVVSRGISKKGDAVLRRAFYLAALTAIKVNPVIKRFYEEHKGRLKGKKLIVACARKLAVITWAVLYYNKPFDASE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	316 (307)
Sequences:	4342 (3277)
Seq/√Len:	187.0

SULSO - Q97X07 Q97WZ5 Q97Y59 Q97ZN4 Q97VS0 Q97WC0 Q97XK2 Q97X26 Q97UF7 Q97X12 Q97X29 Q97UQ6 Q97YE1 Q97XM7 Q97UU8 Q97Y06 Q97VB2 Q97Z62 Q97XR9 Q97WY7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
47_G	99_V	4.244	1.00
125_I	176_K	2.974	1.00
163_A	185_E	2.962	1.00
18_Y	92_A	2.827	1.00
195_L	311_P	2.726	1.00
226_F	299_A	2.642	1.00
281_H	284_R	2.563	1.00
167_F	178_R	2.534	1.00
214_V	226_F	2.420	1.00
170_E	178_R	2.344	1.00
124_S	127_R	2.284	1.00
76_L	95_L	2.203	1.00
46_V	66_Y	2.200	1.00
230_C	256_L	2.170	1.00
248_I	292_V	2.132	1.00
47_G	95_L	2.102	1.00
198_T	311_P	2.097	1.00
275_K	279_E	2.077	1.00
174_R	178_R	2.049	1.00
221_S	225_R	2.044	1.00
210_I	302_T	2.020	1.00
8_I	36_I	2.015	1.00
78_K	81_D	2.011	1.00
87_S	236_V	1.981	1.00
118_W	122_T	1.977	1.00
124_S	131_R	1.972	1.00
296_R	300_V	1.926	1.00
202_I	207_G	1.904	1.00
185_E	188_N	1.832	1.00
222_D	225_R	1.829	1.00
146_S	149_N	1.814	1.00
125_I	179_K	1.789	1.00
119_D	258_R	1.785	1.00
124_S	171_E	1.784	1.00
132_L	172_L	1.781	1.00
195_L	305_V	1.779	1.00
238_S	243_V	1.776	1.00
126_A	130_N	1.773	1.00
6_A	19_F	1.766	1.00
118_W	183_E	1.760	1.00
171_E	178_R	1.755	1.00
8_I	15_L	1.738	1.00
195_L	198_T	1.731	1.00
14_K	25_E	1.717	1.00
199_I	302_T	1.707	1.00
282_K	288_K	1.703	1.00
116_S	213_R	1.697	1.00
305_V	311_P	1.690	1.00
232_L	295_A	1.672	1.00
220_F	229_Y	1.670	1.00
196_I	302_T	1.652	1.00
121_V	179_K	1.634	1.00
125_I	172_L	1.631	1.00
206_L	259_A	1.620	1.00
77_K	80_K	1.613	1.00
280_E	284_R	1.585	1.00
230_C	299_A	1.585	1.00
122_T	179_K	1.577	1.00
45_K	69_R	1.553	1.00
304_A	308_Y	1.553	1.00
190_V	197_F	1.544	1.00
171_E	174_R	1.543	1.00
8_I	58_L	1.527	1.00
11_S	16_I	1.527	1.00
97_E	101_S	1.517	1.00
61_Y	64_G	1.514	1.00
150_L	153_V	1.506	1.00
262_L	265_L	1.500	1.00
29_D	32_G	1.493	1.00
48_I	68_V	1.483	1.00
122_T	125_I	1.462	1.00
132_L	165_V	1.449	1.00
148_R	151_E	1.442	1.00
24_Y	39_I	1.439	1.00
274_I	301_I	1.428	1.00
146_S	157_G	1.426	1.00
199_I	305_V	1.421	1.00
60_K	109_S	1.416	1.00
118_W	205_T	1.414	1.00
209_I	259_A	1.407	1.00
268_I	278_Y	1.403	1.00
278_Y	294_C	1.399	1.00
17_V	36_I	1.391	1.00
147_K	151_E	1.390	1.00
285_L	289_K	1.386	1.00
18_Y	93_K	1.366	1.00
170_E	177_T	1.366	1.00
40_L	46_V	1.364	1.00
258_R	262_L	1.362	1.00
274_I	294_C	1.360	1.00
146_S	151_E	1.355	1.00
183_E	186_L	1.343	1.00
264_A	295_A	1.330	1.00
170_E	174_R	1.323	1.00
197_F	204_K	1.321	1.00
149_N	152_E	1.305	1.00
264_A	298_L	1.303	1.00
16_I	25_E	1.299	1.00
154_L	157_G	1.296	1.00
167_F	181_E	1.296	1.00
169_L	173_E	1.294	1.00
149_N	153_V	1.286	1.00
48_I	59_A	1.285	1.00
180_R	183_E	1.281	1.00
172_L	176_K	1.270	1.00
303_W	307_Y	1.269	1.00
85_K	236_V	1.268	1.00
188_N	192_K	1.236	1.00
196_I	207_G	1.234	1.00
213_R	253_D	1.233	1.00
150_L	157_G	1.232	1.00
119_D	255_V	1.232	1.00
261_Y	295_A	1.226	1.00
286_K	289_K	1.223	1.00
123_R	127_R	1.221	1.00
227_V	296_R	1.211	1.00
277_F	297_K	1.207	1.00
27_T	32_G	1.207	1.00
279_E	283_G	1.206	1.00
120_F	131_R	1.204	1.00
150_L	154_L	1.202	1.00
272_P	276_R	1.180	1.00
248_I	257_R	1.179	1.00
45_K	67_D	1.176	1.00
13_D	241_K	1.172	1.00
7_G	96_A	1.171	1.00
8_I	17_V	1.170	1.00
146_S	150_L	1.169	1.00
153_V	157_G	1.168	1.00
37_R	61_Y	1.165	1.00
124_S	128_V	1.161	1.00
153_V	156_G	1.158	1.00
125_I	129_K	1.155	1.00
282_K	287_G	1.150	1.00
227_V	233_D	1.145	1.00
151_E	155_R	1.144	1.00
261_Y	292_V	1.144	1.00
183_E	187_E	1.136	1.00
277_F	281_H	1.136	1.00
146_S	155_R	1.132	1.00
263_A	298_L	1.131	1.00
11_S	14_K	1.123	1.00
206_L	263_A	1.122	1.00
16_I	23_L	1.121	1.00
117_Q	121_V	1.117	1.00
47_G	71_I	1.105	1.00
199_I	298_L	1.105	1.00
264_A	294_C	1.103	1.00
301_I	305_V	1.103	1.00
202_I	206_L	1.101	1.00
38_K	41_P	1.100	1.00
187_E	204_K	1.097	1.00
114_L	182_I	1.089	1.00
115_T	255_V	1.088	1.00
46_V	62_L	1.079	1.00
146_S	154_L	1.075	1.00
176_K	180_R	1.074	1.00
174_R	177_T	1.072	1.00
93_K	97_E	1.071	1.00
118_W	179_K	1.068	1.00
305_V	310_K	1.066	1.00
6_A	17_V	1.064	1.00
167_F	185_E	1.061	1.00
80_K	94_K	1.053	1.00
304_A	307_Y	1.053	1.00
278_Y	290_L	1.052	1.00
26_F	39_I	1.049	1.00
274_I	298_L	1.048	1.00
152_E	156_G	1.047	1.00
261_Y	265_L	1.044	1.00
5_V	99_V	1.042	1.00
23_L	93_K	1.030	1.00
86_K	91_D	1.029	1.00
6_A	40_L	1.023	1.00
277_F	294_C	1.022	1.00
281_H	290_L	1.021	1.00
178_R	181_E	1.019	1.00
17_V	39_I	1.019	1.00
185_E	189_V	1.012	1.00
74_F	78_K	1.007	0.99
196_I	306_L	0.999	0.99
105_G	108_T	0.991	0.99
128_V	132_L	0.989	0.99
128_V	131_R	0.986	0.99
127_R	130_N	0.984	0.99
151_E	154_L	0.984	0.99
260_F	299_A	0.982	0.99
12_K	137_V	0.982	0.99
71_I	76_L	0.980	0.99
6_A	46_V	0.978	0.99
277_F	293_A	0.978	0.99
250_K	257_R	0.976	0.99
202_I	302_T	0.975	0.99
32_G	35_E	0.968	0.99
146_S	152_E	0.965	0.99
149_N	157_G	0.965	0.99
217_V	306_L	0.957	0.99
5_V	100_V	0.956	0.99
115_T	186_L	0.951	0.99
149_N	156_G	0.949	0.99
202_I	298_L	0.942	0.99
264_A	291_I	0.941	0.99
265_L	268_I	0.936	0.99
122_T	126_A	0.934	0.99
148_R	152_E	0.933	0.99
282_K	290_L	0.932	0.99
190_V	193_D	0.931	0.99
147_K	153_V	0.929	0.99
33_Y	57_N	0.926	0.99
214_V	217_V	0.924	0.99
33_Y	61_Y	0.917	0.99
150_L	156_G	0.911	0.99
281_H	285_L	0.907	0.99
50_S	73_P	0.906	0.99
10_V	15_L	0.903	0.99
177_T	181_E	0.902	0.99
55_H	70_I	0.890	0.99
59_A	68_V	0.886	0.99
273_V	312_F	0.883	0.99
281_H	286_K	0.872	0.99
276_R	280_E	0.866	0.98
147_K	155_R	0.862	0.98
110_D	158_D	0.858	0.98
239_S	243_V	0.851	0.98
129_K	172_L	0.844	0.98
69_R	99_V	0.840	0.98
288_K	291_I	0.834	0.98
175_L	179_K	0.833	0.98
146_S	156_G	0.829	0.98
176_K	179_K	0.826	0.98
265_L	288_K	0.824	0.98
128_V	172_L	0.823	0.98
40_L	62_L	0.822	0.98
112_R	213_R	0.821	0.98
147_K	157_G	0.817	0.98
115_T	208_C	0.811	0.98
31_R	35_E	0.810	0.98
167_F	171_E	0.796	0.97
268_I	282_K	0.795	0.97
265_L	295_A	0.795	0.97
272_P	275_K	0.788	0.97
195_L	309_N	0.786	0.97
10_V	48_I	0.786	0.97
30_K	34_E	0.782	0.97
168_L	171_E	0.781	0.97
84_G	228_A	0.780	0.97
58_L	62_L	0.779	0.97
159_S	185_E	0.778	0.97
190_V	208_C	0.778	0.97
163_A	174_R	0.777	0.97
225_R	228_A	0.775	0.97
148_R	155_R	0.772	0.97
280_E	283_G	0.771	0.97
222_D	303_W	0.770	0.97
51_T	54_Y	0.769	0.97
32_G	36_I	0.766	0.97
117_Q	182_I	0.765	0.97
15_L	28_N	0.764	0.97
95_L	98_L	0.761	0.97
128_V	175_L	0.761	0.97
11_S	15_L	0.759	0.96
16_I	89_K	0.759	0.96
115_T	209_I	0.759	0.96
286_K	290_L	0.758	0.96
43_G	67_D	0.756	0.96
147_K	150_L	0.745	0.96
147_K	154_L	0.742	0.96
265_L	291_I	0.740	0.96
236_V	243_V	0.740	0.96
210_I	256_L	0.739	0.96
233_D	249_S	0.738	0.96
26_F	32_G	0.738	0.96
6_A	44_C	0.736	0.96
131_R	134_R	0.735	0.96
37_R	41_P	0.733	0.96
235_V	249_S	0.728	0.96
152_E	155_R	0.727	0.96
149_N	154_L	0.726	0.95
117_Q	164_E	0.724	0.95
84_G	251_K	0.724	0.95
302_T	305_V	0.719	0.95
88_D	239_S	0.718	0.95
117_Q	167_F	0.718	0.95
18_Y	96_A	0.717	0.95
7_G	92_A	0.715	0.95
119_D	123_R	0.713	0.95
216_D	219_R	0.713	0.95
233_D	250_K	0.711	0.95
128_V	168_L	0.710	0.95
15_L	26_F	0.710	0.95
120_F	124_S	0.708	0.95
121_V	182_I	0.707	0.95
36_I	40_L	0.706	0.95
199_I	202_I	0.705	0.95
162_L	166_R	0.705	0.95
160_I	185_E	0.704	0.95
152_E	157_G	0.701	0.95
213_R	255_V	0.701	0.95
115_T	212_A	0.699	0.94
160_I	163_A	0.695	0.94
6_A	62_L	0.694	0.94
181_E	185_E	0.693	0.94
248_I	293_A	0.691	0.94
270_V	275_K	0.690	0.94
17_V	26_F	0.690	0.94
116_S	255_V	0.688	0.94
229_Y	253_D	0.688	0.94
72_N	75_I	0.687	0.94
202_I	210_I	0.686	0.94
131_R	168_L	0.686	0.94
163_A	166_R	0.682	0.94
107_T	192_K	0.679	0.94
223_K	303_W	0.678	0.94
260_F	295_A	0.673	0.93
79_F	98_L	0.673	0.93
130_N	134_R	0.670	0.93
151_E	156_G	0.668	0.93
259_A	263_A	0.666	0.93
233_D	236_V	0.665	0.93
268_I	291_I	0.665	0.93
151_E	157_G	0.664	0.93
163_A	167_F	0.661	0.93
7_G	62_L	0.659	0.93
111_A	189_V	0.656	0.92
59_A	70_I	0.654	0.92
277_F	280_E	0.653	0.92
184_K	188_N	0.653	0.92
33_Y	58_L	0.652	0.92
183_E	205_T	0.652	0.92
292_V	295_A	0.651	0.92
10_V	54_Y	0.646	0.92
48_I	70_I	0.645	0.92
228_A	233_D	0.643	0.92
28_N	33_Y	0.640	0.91
74_F	251_K	0.639	0.91
73_P	213_R	0.637	0.91
161_V	164_E	0.637	0.91
215_G	219_R	0.633	0.91
238_S	244_V	0.629	0.91
209_I	213_R	0.628	0.91
33_Y	39_I	0.627	0.91
50_S	70_I	0.626	0.91
132_L	169_L	0.625	0.90
146_S	153_V	0.620	0.90
143_D	146_S	0.619	0.90
34_E	38_K	0.619	0.90
173_E	177_T	0.617	0.90
187_E	191_S	0.616	0.90
128_V	171_E	0.615	0.90
248_I	252_G	0.613	0.90
252_G	257_R	0.612	0.90
193_D	197_F	0.612	0.90
276_R	279_E	0.608	0.89
109_S	113_E	0.606	0.89
31_R	39_I	0.606	0.89
18_Y	23_L	0.604	0.89
122_T	183_E	0.603	0.89
300_V	303_W	0.603	0.89
116_S	253_D	0.602	0.89
289_K	293_A	0.601	0.89
224_K	296_R	0.601	0.89
103_C	106_F	0.600	0.89
235_V	246_R	0.600	0.89
84_G	235_V	0.597	0.88
25_E	28_N	0.594	0.88
71_I	98_L	0.593	0.88
53_V	137_V	0.593	0.88
121_V	175_L	0.592	0.88
45_K	99_V	0.590	0.88
188_N	191_S	0.590	0.88
105_G	109_S	0.589	0.88
111_A	186_L	0.589	0.88
210_I	226_F	0.588	0.88
307_Y	310_K	0.588	0.88
233_D	257_R	0.587	0.88
16_I	239_S	0.587	0.88
227_V	300_V	0.586	0.87
11_S	240_G	0.586	0.87
97_E	100_V	0.583	0.87
186_L	190_V	0.582	0.87
265_L	269_K	0.580	0.87
262_L	266_T	0.580	0.87
87_S	238_S	0.579	0.87
37_R	66_Y	0.579	0.87
171_E	175_L	0.578	0.87
48_I	55_H	0.577	0.87
223_K	300_V	0.576	0.87
23_L	89_K	0.575	0.86
90_N	94_K	0.573	0.86
62_L	298_L	0.572	0.86
107_T	110_D	0.572	0.86
209_I	255_V	0.571	0.86
59_A	103_C	0.570	0.86
271_N	275_K	0.570	0.86
41_P	66_Y	0.570	0.86
25_E	29_D	0.569	0.86
218_K	307_Y	0.567	0.86
175_L	178_R	0.566	0.86
26_F	33_Y	0.566	0.86
156_G	162_L	0.564	0.85
217_V	303_W	0.564	0.85
102_M	108_T	0.564	0.85
164_E	167_F	0.563	0.85
232_L	296_R	0.563	0.85
114_L	185_E	0.561	0.85
64_G	106_F	0.560	0.85
236_V	245_S	0.559	0.85
247_G	289_K	0.558	0.85
279_E	282_K	0.556	0.85
149_N	192_K	0.556	0.85
267_A	274_I	0.554	0.84
35_E	38_K	0.553	0.84
120_F	127_R	0.551	0.84
113_E	135_D	0.551	0.84
76_L	94_K	0.549	0.84
281_H	293_A	0.549	0.84
34_E	37_R	0.549	0.84
32_G	39_I	0.547	0.84
166_R	170_E	0.546	0.84
297_K	300_V	0.546	0.84
274_I	278_Y	0.546	0.84
258_R	261_Y	0.543	0.83
43_G	66_Y	0.540	0.83
125_I	175_L	0.540	0.83
17_V	40_L	0.540	0.83
257_R	292_V	0.539	0.83
260_F	302_T	0.539	0.83
227_V	299_A	0.535	0.82
268_I	294_C	0.535	0.82
189_V	192_K	0.534	0.82
202_I	263_A	0.534	0.82
197_F	207_G	0.533	0.82
38_K	42_K	0.530	0.82
85_K	90_N	0.529	0.82
190_V	207_G	0.529	0.82
271_N	276_R	0.529	0.82
167_F	170_E	0.527	0.81
102_M	219_R	0.525	0.81
15_L	58_L	0.524	0.81
237_E	246_R	0.524	0.81
227_V	236_V	0.523	0.81
267_A	298_L	0.522	0.81
278_Y	282_K	0.522	0.81
163_A	181_E	0.521	0.81
117_Q	131_R	0.520	0.81
81_D	84_G	0.517	0.80
76_L	98_L	0.514	0.80
249_S	257_R	0.512	0.79
148_R	157_G	0.510	0.79
257_R	261_Y	0.510	0.79
77_K	81_D	0.509	0.79
36_I	39_I	0.508	0.79
179_K	183_E	0.507	0.79
183_E	190_V	0.507	0.79
292_V	305_V	0.505	0.79
36_I	62_L	0.504	0.78
206_L	256_L	0.503	0.78
285_L	288_K	0.503	0.78
35_E	39_I	0.502	0.78
267_A	271_N	0.500	0.78

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1hjrA	2	0.3323	90.3	0.937	Contact Map
4ep4A	2	0.3449	89.4	0.938	Contact Map
3c1yA	5	0.7532	87.8	0.94	Contact Map
1nu0A	1	0.3133	85	0.942	Contact Map
3psiA	1	0.8323	83.7	0.943	Contact Map
2a1jB	2	0.2437	77.2	0.947	Contact Map
3psfA	1	0.8513	76.5	0.947	Contact Map
1keaA	2	0.6076	76.3	0.947	Contact Map
1z00A	1	0.2595	76.1	0.947	Contact Map
2duyA	1	0.2057	75.1	0.948	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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