GREMLIN Database
Q97X07 - Transposase ISC1190
UniProt: Q97X07 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 316 (307)
Sequences: 4342 (3277)
Seq/√Len: 187.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_G99_V4.2441.00
125_I176_K2.9741.00
163_A185_E2.9621.00
18_Y92_A2.8271.00
195_L311_P2.7261.00
226_F299_A2.6421.00
281_H284_R2.5631.00
167_F178_R2.5341.00
214_V226_F2.4201.00
170_E178_R2.3441.00
124_S127_R2.2841.00
76_L95_L2.2031.00
46_V66_Y2.2001.00
230_C256_L2.1701.00
248_I292_V2.1321.00
47_G95_L2.1021.00
198_T311_P2.0971.00
275_K279_E2.0771.00
174_R178_R2.0491.00
221_S225_R2.0441.00
210_I302_T2.0201.00
8_I36_I2.0151.00
78_K81_D2.0111.00
87_S236_V1.9811.00
118_W122_T1.9771.00
124_S131_R1.9721.00
296_R300_V1.9261.00
202_I207_G1.9041.00
185_E188_N1.8321.00
222_D225_R1.8291.00
146_S149_N1.8141.00
125_I179_K1.7891.00
119_D258_R1.7851.00
124_S171_E1.7841.00
132_L172_L1.7811.00
195_L305_V1.7791.00
238_S243_V1.7761.00
126_A130_N1.7731.00
6_A19_F1.7661.00
118_W183_E1.7601.00
171_E178_R1.7551.00
8_I15_L1.7381.00
195_L198_T1.7311.00
14_K25_E1.7171.00
199_I302_T1.7071.00
282_K288_K1.7031.00
116_S213_R1.6971.00
305_V311_P1.6901.00
232_L295_A1.6721.00
220_F229_Y1.6701.00
196_I302_T1.6521.00
121_V179_K1.6341.00
125_I172_L1.6311.00
206_L259_A1.6201.00
77_K80_K1.6131.00
280_E284_R1.5851.00
230_C299_A1.5851.00
122_T179_K1.5771.00
45_K69_R1.5531.00
304_A308_Y1.5531.00
190_V197_F1.5441.00
171_E174_R1.5431.00
8_I58_L1.5271.00
11_S16_I1.5271.00
97_E101_S1.5171.00
61_Y64_G1.5141.00
150_L153_V1.5061.00
262_L265_L1.5001.00
29_D32_G1.4931.00
48_I68_V1.4831.00
122_T125_I1.4621.00
132_L165_V1.4491.00
148_R151_E1.4421.00
24_Y39_I1.4391.00
274_I301_I1.4281.00
146_S157_G1.4261.00
199_I305_V1.4211.00
60_K109_S1.4161.00
118_W205_T1.4141.00
209_I259_A1.4071.00
268_I278_Y1.4031.00
278_Y294_C1.3991.00
17_V36_I1.3911.00
147_K151_E1.3901.00
285_L289_K1.3861.00
18_Y93_K1.3661.00
170_E177_T1.3661.00
40_L46_V1.3641.00
258_R262_L1.3621.00
274_I294_C1.3601.00
146_S151_E1.3551.00
183_E186_L1.3431.00
264_A295_A1.3301.00
170_E174_R1.3231.00
197_F204_K1.3211.00
149_N152_E1.3051.00
264_A298_L1.3031.00
16_I25_E1.2991.00
154_L157_G1.2961.00
167_F181_E1.2961.00
169_L173_E1.2941.00
149_N153_V1.2861.00
48_I59_A1.2851.00
180_R183_E1.2811.00
172_L176_K1.2701.00
303_W307_Y1.2691.00
85_K236_V1.2681.00
188_N192_K1.2361.00
196_I207_G1.2341.00
213_R253_D1.2331.00
150_L157_G1.2321.00
119_D255_V1.2321.00
261_Y295_A1.2261.00
286_K289_K1.2231.00
123_R127_R1.2211.00
227_V296_R1.2111.00
277_F297_K1.2071.00
27_T32_G1.2071.00
279_E283_G1.2061.00
120_F131_R1.2041.00
150_L154_L1.2021.00
272_P276_R1.1801.00
248_I257_R1.1791.00
45_K67_D1.1761.00
13_D241_K1.1721.00
7_G96_A1.1711.00
8_I17_V1.1701.00
146_S150_L1.1691.00
153_V157_G1.1681.00
37_R61_Y1.1651.00
124_S128_V1.1611.00
153_V156_G1.1581.00
125_I129_K1.1551.00
282_K287_G1.1501.00
227_V233_D1.1451.00
151_E155_R1.1441.00
261_Y292_V1.1441.00
183_E187_E1.1361.00
277_F281_H1.1361.00
146_S155_R1.1321.00
263_A298_L1.1311.00
11_S14_K1.1231.00
206_L263_A1.1221.00
16_I23_L1.1211.00
117_Q121_V1.1171.00
47_G71_I1.1051.00
199_I298_L1.1051.00
264_A294_C1.1031.00
301_I305_V1.1031.00
202_I206_L1.1011.00
38_K41_P1.1001.00
187_E204_K1.0971.00
114_L182_I1.0891.00
115_T255_V1.0881.00
46_V62_L1.0791.00
146_S154_L1.0751.00
176_K180_R1.0741.00
174_R177_T1.0721.00
93_K97_E1.0711.00
118_W179_K1.0681.00
305_V310_K1.0661.00
6_A17_V1.0641.00
167_F185_E1.0611.00
80_K94_K1.0531.00
304_A307_Y1.0531.00
278_Y290_L1.0521.00
26_F39_I1.0491.00
274_I298_L1.0481.00
152_E156_G1.0471.00
261_Y265_L1.0441.00
5_V99_V1.0421.00
23_L93_K1.0301.00
86_K91_D1.0291.00
6_A40_L1.0231.00
277_F294_C1.0221.00
281_H290_L1.0211.00
178_R181_E1.0191.00
17_V39_I1.0191.00
185_E189_V1.0121.00
74_F78_K1.0070.99
196_I306_L0.9990.99
105_G108_T0.9910.99
128_V132_L0.9890.99
128_V131_R0.9860.99
127_R130_N0.9840.99
151_E154_L0.9840.99
260_F299_A0.9820.99
12_K137_V0.9820.99
71_I76_L0.9800.99
6_A46_V0.9780.99
277_F293_A0.9780.99
250_K257_R0.9760.99
202_I302_T0.9750.99
32_G35_E0.9680.99
146_S152_E0.9650.99
149_N157_G0.9650.99
217_V306_L0.9570.99
5_V100_V0.9560.99
115_T186_L0.9510.99
149_N156_G0.9490.99
202_I298_L0.9420.99
264_A291_I0.9410.99
265_L268_I0.9360.99
122_T126_A0.9340.99
148_R152_E0.9330.99
282_K290_L0.9320.99
190_V193_D0.9310.99
147_K153_V0.9290.99
33_Y57_N0.9260.99
214_V217_V0.9240.99
33_Y61_Y0.9170.99
150_L156_G0.9110.99
281_H285_L0.9070.99
50_S73_P0.9060.99
10_V15_L0.9030.99
177_T181_E0.9020.99
55_H70_I0.8900.99
59_A68_V0.8860.99
273_V312_F0.8830.99
281_H286_K0.8720.99
276_R280_E0.8660.98
147_K155_R0.8620.98
110_D158_D0.8580.98
239_S243_V0.8510.98
129_K172_L0.8440.98
69_R99_V0.8400.98
288_K291_I0.8340.98
175_L179_K0.8330.98
146_S156_G0.8290.98
176_K179_K0.8260.98
265_L288_K0.8240.98
128_V172_L0.8230.98
40_L62_L0.8220.98
112_R213_R0.8210.98
147_K157_G0.8170.98
115_T208_C0.8110.98
31_R35_E0.8100.98
167_F171_E0.7960.97
268_I282_K0.7950.97
265_L295_A0.7950.97
272_P275_K0.7880.97
195_L309_N0.7860.97
10_V48_I0.7860.97
30_K34_E0.7820.97
168_L171_E0.7810.97
84_G228_A0.7800.97
58_L62_L0.7790.97
159_S185_E0.7780.97
190_V208_C0.7780.97
163_A174_R0.7770.97
225_R228_A0.7750.97
148_R155_R0.7720.97
280_E283_G0.7710.97
222_D303_W0.7700.97
51_T54_Y0.7690.97
32_G36_I0.7660.97
117_Q182_I0.7650.97
15_L28_N0.7640.97
95_L98_L0.7610.97
128_V175_L0.7610.97
11_S15_L0.7590.96
16_I89_K0.7590.96
115_T209_I0.7590.96
286_K290_L0.7580.96
43_G67_D0.7560.96
147_K150_L0.7450.96
147_K154_L0.7420.96
265_L291_I0.7400.96
236_V243_V0.7400.96
210_I256_L0.7390.96
233_D249_S0.7380.96
26_F32_G0.7380.96
6_A44_C0.7360.96
131_R134_R0.7350.96
37_R41_P0.7330.96
235_V249_S0.7280.96
152_E155_R0.7270.96
149_N154_L0.7260.95
117_Q164_E0.7240.95
84_G251_K0.7240.95
302_T305_V0.7190.95
88_D239_S0.7180.95
117_Q167_F0.7180.95
18_Y96_A0.7170.95
7_G92_A0.7150.95
119_D123_R0.7130.95
216_D219_R0.7130.95
233_D250_K0.7110.95
128_V168_L0.7100.95
15_L26_F0.7100.95
120_F124_S0.7080.95
121_V182_I0.7070.95
36_I40_L0.7060.95
199_I202_I0.7050.95
162_L166_R0.7050.95
160_I185_E0.7040.95
152_E157_G0.7010.95
213_R255_V0.7010.95
115_T212_A0.6990.94
160_I163_A0.6950.94
6_A62_L0.6940.94
181_E185_E0.6930.94
248_I293_A0.6910.94
270_V275_K0.6900.94
17_V26_F0.6900.94
116_S255_V0.6880.94
229_Y253_D0.6880.94
72_N75_I0.6870.94
202_I210_I0.6860.94
131_R168_L0.6860.94
163_A166_R0.6820.94
107_T192_K0.6790.94
223_K303_W0.6780.94
260_F295_A0.6730.93
79_F98_L0.6730.93
130_N134_R0.6700.93
151_E156_G0.6680.93
259_A263_A0.6660.93
233_D236_V0.6650.93
268_I291_I0.6650.93
151_E157_G0.6640.93
163_A167_F0.6610.93
7_G62_L0.6590.93
111_A189_V0.6560.92
59_A70_I0.6540.92
277_F280_E0.6530.92
184_K188_N0.6530.92
33_Y58_L0.6520.92
183_E205_T0.6520.92
292_V295_A0.6510.92
10_V54_Y0.6460.92
48_I70_I0.6450.92
228_A233_D0.6430.92
28_N33_Y0.6400.91
74_F251_K0.6390.91
73_P213_R0.6370.91
161_V164_E0.6370.91
215_G219_R0.6330.91
238_S244_V0.6290.91
209_I213_R0.6280.91
33_Y39_I0.6270.91
50_S70_I0.6260.91
132_L169_L0.6250.90
146_S153_V0.6200.90
143_D146_S0.6190.90
34_E38_K0.6190.90
173_E177_T0.6170.90
187_E191_S0.6160.90
128_V171_E0.6150.90
248_I252_G0.6130.90
252_G257_R0.6120.90
193_D197_F0.6120.90
276_R279_E0.6080.89
109_S113_E0.6060.89
31_R39_I0.6060.89
18_Y23_L0.6040.89
122_T183_E0.6030.89
300_V303_W0.6030.89
116_S253_D0.6020.89
289_K293_A0.6010.89
224_K296_R0.6010.89
103_C106_F0.6000.89
235_V246_R0.6000.89
84_G235_V0.5970.88
25_E28_N0.5940.88
71_I98_L0.5930.88
53_V137_V0.5930.88
121_V175_L0.5920.88
45_K99_V0.5900.88
188_N191_S0.5900.88
105_G109_S0.5890.88
111_A186_L0.5890.88
210_I226_F0.5880.88
307_Y310_K0.5880.88
233_D257_R0.5870.88
16_I239_S0.5870.88
227_V300_V0.5860.87
11_S240_G0.5860.87
97_E100_V0.5830.87
186_L190_V0.5820.87
265_L269_K0.5800.87
262_L266_T0.5800.87
87_S238_S0.5790.87
37_R66_Y0.5790.87
171_E175_L0.5780.87
48_I55_H0.5770.87
223_K300_V0.5760.87
23_L89_K0.5750.86
90_N94_K0.5730.86
62_L298_L0.5720.86
107_T110_D0.5720.86
209_I255_V0.5710.86
59_A103_C0.5700.86
271_N275_K0.5700.86
41_P66_Y0.5700.86
25_E29_D0.5690.86
218_K307_Y0.5670.86
175_L178_R0.5660.86
26_F33_Y0.5660.86
156_G162_L0.5640.85
217_V303_W0.5640.85
102_M108_T0.5640.85
164_E167_F0.5630.85
232_L296_R0.5630.85
114_L185_E0.5610.85
64_G106_F0.5600.85
236_V245_S0.5590.85
247_G289_K0.5580.85
279_E282_K0.5560.85
149_N192_K0.5560.85
267_A274_I0.5540.84
35_E38_K0.5530.84
120_F127_R0.5510.84
113_E135_D0.5510.84
76_L94_K0.5490.84
281_H293_A0.5490.84
34_E37_R0.5490.84
32_G39_I0.5470.84
166_R170_E0.5460.84
297_K300_V0.5460.84
274_I278_Y0.5460.84
258_R261_Y0.5430.83
43_G66_Y0.5400.83
125_I175_L0.5400.83
17_V40_L0.5400.83
257_R292_V0.5390.83
260_F302_T0.5390.83
227_V299_A0.5350.82
268_I294_C0.5350.82
189_V192_K0.5340.82
202_I263_A0.5340.82
197_F207_G0.5330.82
38_K42_K0.5300.82
85_K90_N0.5290.82
190_V207_G0.5290.82
271_N276_R0.5290.82
167_F170_E0.5270.81
102_M219_R0.5250.81
15_L58_L0.5240.81
237_E246_R0.5240.81
227_V236_V0.5230.81
267_A298_L0.5220.81
278_Y282_K0.5220.81
163_A181_E0.5210.81
117_Q131_R0.5200.81
81_D84_G0.5170.80
76_L98_L0.5140.80
249_S257_R0.5120.79
148_R157_G0.5100.79
257_R261_Y0.5100.79
77_K81_D0.5090.79
36_I39_I0.5080.79
179_K183_E0.5070.79
183_E190_V0.5070.79
292_V305_V0.5050.79
36_I62_L0.5040.78
206_L256_L0.5030.78
285_L288_K0.5030.78
35_E39_I0.5020.78
267_A271_N0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hjrA 2 0.3323 90.3 0.937 Contact Map
4ep4A 2 0.3449 89.4 0.938 Contact Map
3c1yA 5 0.7532 87.8 0.94 Contact Map
1nu0A 1 0.3133 85 0.942 Contact Map
3psiA 1 0.8323 83.7 0.943 Contact Map
2a1jB 2 0.2437 77.2 0.947 Contact Map
3psfA 1 0.8513 76.5 0.947 Contact Map
1keaA 2 0.6076 76.3 0.947 Contact Map
1z00A 1 0.2595 76.1 0.947 Contact Map
2duyA 1 0.2057 75.1 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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