GREMLIN Database
Q97X05 - Dolichyl-phosphate mannose synthase related protein
UniProt: Q97X05 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 242 (206)
Sequences: 44939 (37719)
Seq/√Len: 2628.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_R152_L3.4721.00
11_E82_A3.2741.00
12_E40_N2.9741.00
168_N172_G2.5571.00
93_K185_I2.4931.00
8_A41_T2.4191.00
67_R71_E2.3721.00
35_F54_I2.3001.00
3_S74_F2.2331.00
42_P46_K2.2241.00
30_E51_K2.1091.00
34_V68_G2.0971.00
16_G20_E2.0841.00
5_I68_G2.0261.00
99_A181_K1.9991.00
40_N43_E1.9771.00
6_I31_I1.9651.00
65_I81_D1.9531.00
150_K178_Y1.9301.00
3_S30_E1.8941.00
55_S67_R1.8691.00
59_L63_G1.8451.00
17_R85_P1.8301.00
16_G48_F1.8251.00
35_F38_H1.8081.00
53_L71_E1.8071.00
94_I145_L1.8071.00
78_L145_L1.8001.00
97_T183_V1.7891.00
97_T181_K1.7441.00
76_R145_L1.7441.00
20_E48_F1.7321.00
42_P54_I1.7221.00
12_E44_V1.7201.00
90_E94_I1.6801.00
51_K71_E1.6791.00
42_P52_L1.6771.00
87_T188_I1.6701.00
16_G44_V1.6461.00
86_I90_E1.6381.00
33_V45_V1.6221.00
6_I18_T1.6101.00
16_G47_K1.6001.00
9_F58_R1.5931.00
61_K65_I1.5901.00
67_R70_N1.5671.00
26_L95_L1.5561.00
100_D147_N1.5481.00
8_A33_V1.5041.00
89_E93_K1.4971.00
46_K54_I1.4921.00
20_E24_S1.4881.00
53_L67_R1.4731.00
8_A11_E1.4611.00
30_E74_F1.4571.00
62_G165_F1.4411.00
192_S195_K1.4361.00
78_L91_L1.4141.00
17_R190_D1.3971.00
69_I151_V1.3941.00
92_D96_S1.3901.00
26_L29_A1.3821.00
36_D58_R1.3681.00
93_K96_S1.3631.00
65_I79_L1.3561.00
149_E153_D1.3531.00
70_N156_D1.3481.00
10_N38_H1.3431.00
78_L90_E1.3381.00
80_L86_I1.3281.00
153_D176_R1.3081.00
56_E59_L1.3061.00
77_V148_R1.2991.00
44_V48_F1.2851.00
35_F55_S1.2741.00
11_E14_R1.2691.00
153_D178_Y1.2361.00
158_L161_N1.2291.00
2_I95_L1.2211.00
144_K170_I1.2211.00
100_D178_Y1.2191.00
8_A82_A1.2161.00
72_S148_R1.2101.00
3_S72_S1.1921.00
75_Q147_N1.1781.00
150_K173_F1.1741.00
19_L31_I1.1691.00
44_V47_K1.1611.00
45_V52_L1.1571.00
35_F42_P1.1561.00
34_V64_A1.1501.00
30_E73_N1.1451.00
56_E67_R1.1421.00
2_I91_L1.1421.00
101_L180_V1.1401.00
19_L48_F1.1371.00
149_E152_L1.1351.00
69_I79_L1.1241.00
61_K165_F1.1041.00
21_K86_I1.0811.00
147_N150_K1.0721.00
94_I104_P1.0721.00
63_G159_I1.0591.00
107_K188_I1.0521.00
70_N157_E1.0521.00
43_E46_K1.0421.00
55_S64_A1.0401.00
18_T80_L1.0301.00
40_N44_V1.0151.00
3_S32_V1.0081.00
23_S49_P1.0041.00
7_P64_A1.0031.00
85_P188_I1.0031.00
78_L86_I0.9911.00
24_S88_E0.9901.00
89_E92_D0.9881.00
55_S59_L0.9861.00
100_D179_K0.9791.00
31_I50_V0.9781.00
69_I77_V0.9751.00
99_A103_I0.9651.00
23_S48_F0.9551.00
93_K183_V0.9491.00
43_E47_K0.9461.00
36_D64_A0.9361.00
51_K73_N0.9321.00
20_E23_S0.9311.00
63_G67_R0.9301.00
151_V169_L0.9281.00
101_L173_F0.9261.00
22_I80_L0.9201.00
65_I165_F0.9201.00
114_K117_F0.9191.00
99_A106_R0.9171.00
22_I31_I0.9041.00
56_E63_G0.8951.00
99_A104_P0.8911.00
105_K182_E0.8891.00
206_L210_S0.8751.00
155_L158_L0.8671.00
21_K85_P0.8611.00
106_R142_G0.8591.00
192_S197_S0.8541.00
19_L33_V0.8521.00
76_R95_L0.8511.00
93_K97_T0.8401.00
42_P55_S0.8401.00
107_K186_N0.8341.00
90_E104_P0.8301.00
61_K141_A0.8281.00
61_K81_D0.8241.00
23_S50_V0.8161.00
29_A91_L0.8151.00
158_L168_N0.8091.00
36_D59_L0.8091.00
98_D179_K0.8061.00
52_L55_S0.7981.00
87_T90_E0.7911.00
4_I22_I0.7901.00
34_V67_R0.7861.00
17_R20_E0.7791.00
62_G66_K0.7791.00
29_A49_P0.7711.00
36_D60_G0.7671.00
124_I128_I0.7651.00
19_L23_S0.7641.00
4_I78_L0.7581.00
69_I72_S0.7551.00
203_V207_M0.7551.00
187_Y190_D0.7521.00
18_T21_K0.7511.00
8_A15_I0.7501.00
85_P190_D0.7481.00
59_L64_A0.7441.00
192_S196_I0.7391.00
193_D196_I0.7381.00
8_A45_V0.7381.00
97_T102_V0.7381.00
105_K108_I0.7351.00
7_P82_A0.7321.00
75_Q149_E0.7311.00
46_K55_S0.7301.00
95_L145_L0.7261.00
32_V71_E0.7231.00
141_A144_K0.7201.00
183_V186_N0.7131.00
32_V68_G0.7111.00
46_K52_L0.7101.00
6_I22_I0.7081.00
22_I86_I0.7081.00
15_I44_V0.7061.00
76_R147_N0.6981.00
111_M114_K0.6961.00
25_T92_D0.6931.00
37_G58_R0.6891.00
18_T22_I0.6881.00
100_D104_P0.6861.00
173_F178_Y0.6811.00
154_I173_F0.6811.00
64_A67_R0.6791.00
105_K184_E0.6751.00
150_K154_I0.6741.00
26_L92_D0.6721.00
7_P65_I0.6721.00
12_E16_G0.6711.00
115_R118_L0.6711.00
200_L203_V0.6701.00
146_V151_V0.6691.00
66_K70_N0.6681.00
204_I207_M0.6641.00
154_I176_R0.6621.00
90_E143_V0.6621.00
103_I106_R0.6571.00
94_I102_V0.6561.00
204_I208_F0.6531.00
142_G187_Y0.6521.00
4_I91_L0.6491.00
28_N49_P0.6491.00
146_V170_I0.6481.00
42_P45_V0.6481.00
206_L209_L0.6471.00
32_V51_K0.6441.00
72_S77_V0.6411.00
121_G124_I0.6391.00
9_F36_D0.6381.00
120_K124_I0.6371.00
7_P36_D0.6331.00
87_T107_K0.6311.00
99_A102_V0.6281.00
63_G160_I0.6261.00
169_L173_F0.6241.00
64_A81_D0.6221.00
32_V72_S0.6201.00
201_I204_I0.6191.00
84_F190_D0.6191.00
15_I82_A0.6161.00
112_P115_R0.6141.00
122_F125_I0.6131.00
66_K157_E0.6101.00
61_K64_A0.6081.00
150_K153_D0.6071.00
202_K206_L0.6041.00
126_T130_F0.6021.00
207_M211_L0.5961.00
114_K118_L0.5961.00
9_F37_G0.5951.00
94_I97_T0.5941.00
12_E43_E0.5941.00
90_E93_K0.5931.00
150_K177_H0.5891.00
203_V206_L0.5871.00
79_L146_V0.5871.00
15_I45_V0.5861.00
128_I131_P0.5861.00
36_D81_D0.5851.00
4_I29_A0.5851.00
100_D150_K0.5821.00
113_L116_K0.5771.00
111_M115_R0.5761.00
10_N41_T0.5721.00
151_V156_D0.5701.00
146_V169_L0.5671.00
12_E15_I0.5641.00
122_F126_T0.5641.00
109_V113_L0.5641.00
119_H122_F0.5631.00
167_V171_Y0.5621.00
59_L67_R0.5601.00
113_L117_F0.5591.00
146_V173_F0.5571.00
5_I34_V0.5571.00
110_G114_K0.5561.00
207_M210_S0.5551.00
12_E39_D0.5531.00
125_I128_I0.5531.00
99_A105_K0.5471.00
99_A147_N0.5471.00
61_K196_I0.5451.00
61_K79_L0.5431.00
27_P92_D0.5431.00
203_V210_S0.5411.00
94_I143_V0.5401.00
208_F211_L0.5391.00
5_I72_S0.5381.00
78_L143_V0.5381.00
6_I82_A0.5351.00
2_I145_L0.5351.00
201_I205_I0.5331.00
100_D105_K0.5291.00
6_I33_V0.5291.00
81_D165_F0.5281.00
164_L167_V0.5241.00
205_I209_L0.5221.00
79_L157_E0.5201.00
18_T83_D0.5191.00
123_I126_T0.5111.00
33_V50_V0.5101.00
194_S197_S0.5101.00
86_I91_L0.5101.00
2_I26_L0.5091.00
125_I129_L0.5091.00
21_K89_E0.5081.00
109_V112_P0.5081.00
200_L204_I0.5071.00
55_S58_R0.5071.00
135_K179_K0.5061.00
12_E41_T0.5051.00
17_R191_E0.5031.00
23_S29_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l7iA 4 0 100 0.31 Contact Map
1qg8A 1 0.8595 100 0.328 Contact Map
2z86A 2 0.9711 100 0.343 Contact Map
1xhbA 1 0.9545 100 0.345 Contact Map
3bcvA 2 0.686 100 0.345 Contact Map
2d7iA 1 1 100 0.355 Contact Map
5ajoA 1 1 100 0.359 Contact Map
4fixA 3 0.9959 100 0.362 Contact Map
2bo4A 4 0.9628 100 0.401 Contact Map
4p02A 1 0.9835 100 0.409 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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