GREMLIN Database
Q97X00 - Uncharacterized protein
UniProt: Q97X00 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 288 (272)
Sequences: 1028 (750)
Seq/√Len: 45.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
241_E244_N5.1771.00
228_M232_R5.0681.00
42_I65_S4.3121.00
237_R240_A3.8411.00
212_P216_R3.4421.00
45_P63_P3.4351.00
225_I229_D3.0021.00
104_R125_F2.9311.00
96_I127_V2.8521.00
128_Q198_D2.8291.00
178_S187_A2.7261.00
24_D27_I2.5951.00
127_V133_L2.3911.00
242_Q245_A2.3561.00
157_V202_V2.3521.00
238_I243_Q2.3371.00
40_L65_S2.3091.00
216_R219_Q2.2321.00
48_R130_P2.1881.00
245_A248_V2.1631.00
176_K179_E2.1621.00
56_Q135_T2.1511.00
115_V118_E2.1131.00
126_R198_D2.0851.00
249_N252_I2.0100.99
131_A135_T1.9930.99
125_F146_D1.9610.99
193_A198_D1.9410.99
73_N76_S1.9240.99
243_Q246_A1.8400.99
163_S179_E1.8290.99
234_G240_A1.8220.99
113_D170_L1.7980.99
50_I96_I1.7860.98
8_Q78_F1.7840.98
27_I138_Q1.7810.98
242_Q246_A1.7710.98
220_L223_M1.7490.98
141_S148_D1.7480.98
12_T81_K1.7450.98
240_A243_Q1.7320.98
132_A193_A1.7080.98
276_G279_G1.7010.98
278_R281_Q1.6660.98
213_E217_I1.6650.98
224_G229_D1.6570.97
163_S167_R1.6470.97
231_V236_A1.6390.97
106_A202_V1.6370.97
61_L73_N1.6350.97
235_L239_L1.6340.97
265_N268_D1.6180.97
214_L218_I1.5760.97
28_F31_P1.5420.96
17_G25_A1.5370.96
59_A66_H1.5320.96
106_A157_V1.5300.96
137_V195_I1.5280.96
220_L230_A1.5210.96
17_G22_T1.5140.96
50_I60_D1.5050.96
13_E35_I1.4940.95
191_F201_S1.4920.95
220_L233_M1.4900.95
23_A26_I1.4850.95
126_R200_I1.4660.95
75_V79_L1.4600.95
22_T25_A1.4500.95
247_A252_I1.4390.94
159_Q181_S1.4290.94
27_I31_P1.4250.94
77_A81_K1.4070.94
51_V91_T1.4030.93
51_V61_L1.3980.93
231_V239_L1.3870.93
77_A87_L1.3840.93
10_I39_S1.3790.93
276_G280_Q1.3500.92
40_L67_N1.3450.92
277_R281_Q1.3290.91
26_I127_V1.3290.91
35_I39_S1.3010.91
240_A245_A1.3000.91
273_V281_Q1.2990.91
160_E178_S1.2890.90
45_P135_T1.2820.90
36_T39_S1.2790.90
48_R98_T1.2680.89
230_A233_M1.2540.89
129_N132_A1.2340.88
34_A90_D1.2140.87
133_L137_V1.2110.87
259_N263_I1.1950.86
167_R187_A1.1880.86
103_V122_A1.1750.85
244_N250_M1.1600.85
41_I61_L1.1520.84
238_I242_Q1.1480.84
183_A186_A1.1480.84
122_A155_P1.1480.84
191_F194_E1.1390.84
104_R123_I1.1370.84
100_R195_I1.1290.83
103_V151_H1.1230.83
52_L57_I1.1200.83
126_R136_N1.1170.82
14_K90_D1.0950.81
217_I221_R1.0950.81
104_R157_V1.0950.81
251_A255_P1.0930.81
262_T266_L1.0840.80
136_N194_E1.0830.80
52_L94_Y1.0820.80
110_Q206_R1.0810.80
216_R237_R1.0740.80
108_V112_D1.0660.79
115_V172_D1.0640.79
162_S206_R1.0580.79
54_Q65_S1.0580.79
216_R230_A1.0360.77
247_A251_A1.0240.76
163_S178_S1.0230.76
215_R218_I1.0190.76
275_I279_G1.0160.76
266_L270_L1.0100.75
243_Q248_V1.0070.75
231_V243_Q1.0060.75
11_S81_K1.0060.75
213_E219_Q1.0030.75
37_S69_Q0.9970.75
212_P215_R0.9920.74
153_I192_L0.9870.74
159_Q177_F0.9860.74
42_I95_F0.9820.73
26_I31_P0.9790.73
227_L232_R0.9660.72
39_S82_F0.9650.72
258_P265_N0.9640.72
46_T140_G0.9630.72
54_Q90_D0.9560.71
10_I83_R0.9550.71
51_V73_N0.9530.71
182_T185_T0.9530.71
25_A31_P0.9440.70
218_I221_R0.9430.70
254_V257_Y0.9410.70
267_P270_L0.9400.70
233_M240_A0.9370.70
14_K44_Q0.9320.69
273_V276_G0.9320.69
47_E108_V0.9260.69
225_I230_A0.9250.69
217_I222_D0.9250.69
240_A244_N0.9220.69
273_V280_Q0.9160.68
41_I68_I0.9110.68
18_S28_F0.9090.67
44_Q47_E0.9080.67
156_I195_I0.9070.67
108_V111_T0.9050.67
262_T275_I0.9050.67
252_I264_V0.9000.67
137_V201_S0.9000.67
234_G239_L0.9000.67
268_D274_G0.8790.65
52_L134_V0.8770.65
272_R280_Q0.8760.65
132_A135_T0.8750.65
149_L153_I0.8730.64
233_M237_R0.8680.64
268_D271_I0.8670.64
274_G279_G0.8640.64
72_G89_Y0.8620.63
257_Y263_I0.8610.63
69_Q199_L0.8580.63
242_Q248_V0.8510.62
70_T90_D0.8500.62
102_E127_V0.8480.62
270_L275_I0.8450.62
230_A234_G0.8400.61
76_S88_P0.8390.61
100_R124_Y0.8380.61
6_R9_V0.8360.61
165_L260_L0.8360.61
49_A93_V0.8350.61
272_R276_G0.8340.61
230_A240_A0.8330.61
202_V205_T0.8330.61
164_V187_A0.8330.61
161_V165_L0.8230.60
214_L217_I0.8230.60
35_I90_D0.8210.60
192_L199_L0.8200.59
13_E17_G0.8190.59
272_R277_R0.8190.59
231_V235_L0.8180.59
210_Q222_D0.8170.59
274_G281_Q0.8140.59
126_R166_N0.8120.59
230_A236_A0.8090.58
227_L242_Q0.8090.58
269_G272_R0.8080.58
29_K142_L0.8080.58
180_I202_V0.8040.58
227_L230_A0.8020.58
100_R136_N0.7980.57
12_T77_A0.7930.57
125_F150_A0.7920.57
187_A190_Q0.7910.57
160_E191_F0.7900.57
208_L222_D0.7890.56
268_D272_R0.7870.56
242_Q250_M0.7860.56
73_N89_Y0.7860.56
24_D101_H0.7760.55
263_I267_P0.7720.55
106_A159_Q0.7660.54
11_S32_K0.7660.54
24_D145_K0.7630.54
68_I79_L0.7610.54
100_R114_L0.7540.53
271_I275_I0.7520.53
96_I134_V0.7490.53
275_I278_R0.7470.52
185_T189_K0.7320.51
209_P217_I0.7290.51
246_A252_I0.7240.50
236_A243_Q0.7230.50
171_T217_I0.7230.50
134_V170_L0.7230.50
105_V173_V0.7230.50
59_A75_V0.7210.50
218_I222_D0.7210.50
221_R238_I0.7190.50
77_A84_Y0.7190.50
204_I233_M0.7180.50
88_P93_V0.7130.49
104_R150_A0.7130.49
182_T186_A0.7120.49
238_I241_E0.7120.49
147_A195_I0.7120.49
27_I96_I0.7020.48
231_V266_L0.7020.48
239_L246_A0.6990.48
33_E78_F0.6980.48
12_T42_I0.6970.48
236_A240_A0.6950.47
125_F254_V0.6950.47
144_F180_I0.6940.47
12_T90_D0.6900.47
269_G276_G0.6890.47
16_D33_E0.6880.47
13_E39_S0.6830.46
252_I255_P0.6830.46
23_A27_I0.6810.46
59_A94_Y0.6800.46
95_F262_T0.6790.46
262_T270_L0.6790.46
180_I228_M0.6780.46
14_K33_E0.6780.46
78_F83_R0.6780.46
49_A79_L0.6740.45
217_I224_G0.6710.45
84_Y88_P0.6700.45
26_I146_D0.6700.45
272_R275_I0.6700.45
90_D95_F0.6690.45
95_F173_V0.6680.45
18_S50_I0.6680.45
53_I91_T0.6600.44
12_T87_L0.6590.44
237_R241_E0.6580.44
190_Q216_R0.6540.43
265_N269_G0.6540.43
24_D125_F0.6530.43
60_D98_T0.6530.43
256_Y262_T0.6510.43
26_I46_T0.6510.43
215_R230_A0.6510.43
220_L224_G0.6490.43
162_S166_N0.6470.43
12_T15_E0.6470.43
79_L93_V0.6460.43
24_D237_R0.6450.43
243_Q263_I0.6440.42
217_I220_L0.6410.42
256_Y263_I0.6400.42
250_M254_V0.6400.42
50_I134_V0.6380.42
14_K36_T0.6380.42
188_L191_F0.6360.42
271_I274_G0.6340.41
258_P272_R0.6330.41
228_M231_V0.6330.41
76_S79_L0.6310.41
270_L281_Q0.6270.41
80_S83_R0.6230.40
106_A203_R0.6220.40
65_S71_P0.6190.40
102_E125_F0.6190.40
229_D242_Q0.6180.40
234_G242_Q0.6140.40
239_L242_Q0.6130.39
149_L182_T0.6120.39
246_A249_N0.6100.39
27_I30_Y0.6100.39
36_T91_T0.6070.39
51_V68_I0.6060.39
123_I205_T0.6050.39
60_D131_A0.6050.39
168_V180_I0.6050.39
212_P219_Q0.6030.39
249_N253_G0.6030.39
12_T17_G0.6020.38
252_I273_V0.6020.38
91_T213_E0.6010.38
180_I187_A0.6010.38
231_V234_G0.5980.38
59_A88_P0.5950.38
156_I203_R0.5950.38
29_K74_P0.5930.38
263_I268_D0.5910.37
53_I72_G0.5880.37
236_A264_V0.5880.37
262_T265_N0.5870.37
34_A77_A0.5860.37
251_A257_Y0.5850.37
258_P266_L0.5850.37
40_L88_P0.5850.37
161_V184_V0.5840.37
37_S83_R0.5830.37
259_N266_L0.5760.36
103_V257_Y0.5760.36
167_R178_S0.5760.36
170_L208_L0.5710.36
133_L188_L0.5710.36
14_K42_I0.5700.36
12_T78_F0.5700.36
254_V258_P0.5690.35
22_T26_I0.5670.35
67_N197_V0.5670.35
224_G227_L0.5670.35
159_Q203_R0.5660.35
184_V205_T0.5660.35
133_L161_V0.5620.35
217_I230_A0.5600.35
60_D199_L0.5570.34
54_Q80_S0.5550.34
264_V274_G0.5550.34
65_S77_A0.5540.34
119_Y217_I0.5540.34
118_E121_T0.5530.34
105_V137_V0.5530.34
47_E97_S0.5520.34
50_I145_K0.5510.34
63_P98_T0.5490.34
159_Q184_V0.5490.34
149_L204_I0.5460.33
76_S80_S0.5450.33
96_I264_V0.5450.33
32_K135_T0.5440.33
250_M258_P0.5440.33
194_E201_S0.5440.33
177_F181_S0.5440.33
125_F278_R0.5440.33
276_G281_Q0.5410.33
212_P237_R0.5400.33
270_L273_V0.5400.33
158_D205_T0.5370.33
240_A246_A0.5370.33
55_G74_P0.5370.33
61_L68_I0.5360.33
12_T65_S0.5360.33
23_A141_S0.5340.32
222_D225_I0.5330.32
275_I280_Q0.5300.32
59_A73_N0.5270.32
258_P268_D0.5270.32
227_L231_V0.5270.32
189_K198_D0.5270.32
66_H87_L0.5260.32
225_I232_R0.5260.32
26_I101_H0.5260.32
252_I266_L0.5250.32
73_N77_A0.5240.32
16_D29_K0.5230.31
58_V75_V0.5220.31
57_I135_T0.5190.31
13_E16_D0.5190.31
17_G155_P0.5180.31
126_R172_D0.5180.31
114_L170_L0.5170.31
47_E74_P0.5170.31
268_D275_I0.5170.31
229_D239_L0.5150.31
53_I71_P0.5140.31
8_Q161_V0.5140.31
241_E248_V0.5140.31
176_K180_I0.5140.31
122_A258_P0.5120.31
249_N280_Q0.5120.31
212_P272_R0.5100.30
69_Q137_V0.5080.30
125_F137_V0.5080.30
31_P66_H0.5050.30
44_Q95_F0.5050.30
108_V139_F0.5010.30
53_I80_S0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fvgA 2 0.3681 99.2 0.853 Contact Map
1winA 1 0.4861 99.2 0.858 Contact Map
2rpbA 1 0.3924 98.9 0.874 Contact Map
3bk6A 3 0.5625 98.8 0.877 Contact Map
2ptmA 3 0.3958 55.8 0.958 Contact Map
4b8cD 1 0.066 47.7 0.96 Contact Map
3pnaA 4 0.3542 46 0.96 Contact Map
3i54A 2 0.6979 45.9 0.96 Contact Map
3ocpA 2 0.3403 42.2 0.961 Contact Map
2gauA 2 0.6806 40.7 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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