GREMLIN Database
Q97WZ8 - Uncharacterized protein
UniProt: Q97WZ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 257 (214)
Sequences: 3297 (2366)
Seq/√Len: 161.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_E158_K5.1781.00
199_R202_D4.3111.00
209_K214_A3.6961.00
144_K147_V3.3781.00
39_D159_R2.9641.00
162_V228_I2.6001.00
211_I214_A2.6001.00
44_I224_I2.4411.00
31_E34_S2.4391.00
140_E144_K2.4141.00
40_K160_V2.3971.00
193_D197_S2.3751.00
77_D129_V2.0351.00
168_H191_I2.0071.00
138_K141_I1.9951.00
219_Y223_L1.9921.00
80_L84_I1.9861.00
209_K213_E1.8881.00
91_S151_E1.8771.00
44_I149_I1.8621.00
5_I225_M1.8461.00
23_S27_K1.8401.00
22_S27_K1.7931.00
12_D16_D1.7901.00
143_R147_V1.7641.00
40_K80_L1.7561.00
41_Y126_R1.7541.00
205_K208_D1.7441.00
164_V225_M1.7421.00
185_A189_S1.7401.00
210_V214_A1.7381.00
194_I202_D1.7281.00
56_A107_E1.7281.00
63_A66_K1.7201.00
62_Y73_K1.7101.00
9_P167_D1.7091.00
59_L106_K1.6861.00
83_E87_R1.6841.00
57_V85_Y1.6681.00
31_E35_L1.6671.00
85_Y106_K1.5881.00
42_I131_L1.5871.00
83_E86_E1.5311.00
27_K30_R1.5241.00
70_I121_Y1.5241.00
58_I130_L1.5161.00
87_R151_E1.5151.00
13_E16_D1.5141.00
143_R204_M1.4941.00
39_D158_K1.4841.00
190_T194_I1.4781.00
91_S148_V1.4701.00
134_A142_L1.4571.00
82_Y86_E1.4511.00
143_R200_F1.3891.00
186_V210_V1.3621.00
146_G227_G1.3471.00
85_Y95_V1.3431.00
192_V196_K1.3371.00
141_I144_K1.3361.00
146_G228_I1.3231.00
191_I219_Y1.3071.00
66_K111_A1.3061.00
112_L116_S1.3031.00
41_Y161_G1.2911.00
43_V116_S1.2871.00
56_A96_V1.2861.00
43_V163_I1.2851.00
40_K127_R1.2841.00
62_Y75_L1.2681.00
87_R152_V1.2571.00
42_I129_V1.2551.00
23_S26_N1.2541.00
137_V141_I1.2351.00
86_E90_G1.2311.00
55_M134_A1.2201.00
79_G82_Y1.2141.00
187_Y219_Y1.2031.00
209_K212_S1.2021.00
8_A29_M1.1931.00
42_I160_V1.1901.00
84_I129_V1.1891.00
42_I84_I1.1891.00
188_D192_V1.1681.00
49_I215_K1.1491.00
78_R81_A1.1351.00
120_L128_I1.1261.00
194_I199_R1.1251.00
67_R117_S1.1241.00
17_P20_E1.1161.00
82_Y106_K1.1151.00
124_K161_G1.1021.00
77_D80_L1.1011.00
77_D158_K1.0790.99
133_P217_D1.0770.99
44_I162_V1.0700.99
175_K178_Y1.0690.99
49_I135_R1.0680.99
13_E17_P1.0610.99
134_A141_I1.0580.99
42_I162_V1.0530.99
54_H134_A1.0490.99
46_P217_D1.0460.99
55_M145_F1.0420.99
206_I211_I1.0420.99
84_I87_R1.0390.99
11_G16_D1.0360.99
182_E186_V1.0320.99
38_A126_R1.0280.99
143_R226_L1.0250.99
139_R223_L1.0210.99
180_Y185_A1.0180.99
210_V213_E1.0170.99
24_L27_K1.0140.99
174_P177_P1.0120.99
26_N30_R1.0060.99
27_K31_E1.0030.99
57_V131_L1.0010.99
116_S130_L0.9930.99
85_Y89_K0.9870.99
45_T113_D0.9830.99
190_T193_D0.9800.99
175_K179_G0.9800.99
193_D196_K0.9790.99
6_L161_G0.9670.99
63_A76_C0.9640.99
82_Y85_Y0.9520.99
131_L149_I0.9450.99
133_P220_W0.9350.98
12_D17_P0.9320.98
171_T215_K0.9300.98
80_L129_V0.9240.98
207_D212_S0.9240.98
92_G140_E0.9240.98
142_L224_I0.9160.98
8_A32_A0.9130.98
143_R223_L0.9130.98
88_A145_F0.9070.98
43_V120_L0.9040.98
57_V66_K0.8950.98
144_K148_V0.8940.98
61_Q78_R0.8930.98
200_F204_M0.8900.98
147_V230_E0.8840.98
150_G230_E0.8820.98
44_I131_L0.8800.98
12_D15_I0.8720.98
6_L32_A0.8720.98
59_L108_S0.8680.98
189_S193_D0.8650.97
41_Y120_L0.8590.97
37_K126_R0.8530.97
215_K218_S0.8460.97
72_R125_R0.8460.97
143_R227_G0.8450.97
57_V84_I0.8400.97
88_A148_V0.8400.97
177_P180_Y0.8390.97
186_V189_S0.8340.97
38_A161_G0.8300.97
140_E201_E0.8280.97
156_H159_R0.8230.97
87_R91_S0.8200.97
55_M142_L0.8180.96
53_D136_G0.8040.96
58_I63_A0.8030.96
77_D84_I0.7920.96
80_L152_V0.7880.96
8_A163_I0.7870.96
49_I217_D0.7870.96
75_L78_R0.7830.96
36_V123_L0.7810.95
24_L28_A0.7750.95
88_A93_L0.7740.95
45_T115_G0.7740.95
9_P169_A0.7740.95
57_V106_K0.7660.95
65_G112_L0.7650.95
38_A41_Y0.7630.95
137_V142_L0.7600.95
140_E204_M0.7570.95
201_E205_K0.7570.95
8_A119_P0.7460.94
30_R34_S0.7440.94
203_L226_L0.7430.94
182_E185_A0.7410.94
22_S26_N0.7360.94
89_K94_P0.7350.94
75_L127_R0.7320.94
20_E23_S0.7260.93
76_C81_A0.7260.93
139_R219_Y0.7240.93
84_I152_V0.7220.93
174_P179_G0.7200.93
54_H96_V0.7190.93
200_F226_L0.7140.93
17_P21_K0.7130.93
36_V161_G0.7120.93
68_G72_R0.7080.92
57_V65_G0.6960.92
169_A188_D0.6960.92
29_M122_F0.6920.92
112_L128_I0.6850.91
64_E110_I0.6840.91
47_H170_H0.6810.91
68_G71_K0.6810.91
147_V151_E0.6790.91
49_I133_P0.6770.91
11_G14_I0.6760.91
65_G71_K0.6710.90
48_N132_T0.6680.90
60_T63_A0.6640.90
116_S120_L0.6580.89
33_A123_L0.6570.89
191_I222_L0.6560.89
8_A123_L0.6560.89
216_P220_W0.6530.89
133_P224_I0.6490.89
174_P178_Y0.6470.89
74_Y112_L0.6400.88
144_K233_Y0.6390.88
38_A124_K0.6380.88
167_D184_A0.6380.88
46_P49_I0.6370.88
30_R122_F0.6370.88
10_H165_S0.6370.88
96_V106_K0.6330.88
16_D121_Y0.6310.87
54_H63_A0.6310.87
194_I197_S0.6290.87
230_E233_Y0.6290.87
198_E229_L0.6250.87
28_A32_A0.6240.87
181_S213_E0.6240.87
11_G15_I0.6200.86
202_D205_K0.6170.86
53_D135_R0.6150.86
29_M33_A0.6120.86
165_S170_H0.6100.86
116_S128_I0.6080.85
30_R33_A0.6070.85
9_P14_I0.6060.85
118_I121_Y0.6050.85
45_T58_I0.5980.84
50_R132_T0.5970.84
130_L133_P0.5940.84
142_L220_W0.5870.83
61_Q65_G0.5860.83
50_R56_A0.5850.83
184_A188_D0.5840.83
7_V225_M0.5820.83
187_Y190_T0.5820.83
217_D220_W0.5810.83
139_R206_I0.5800.83
198_E230_E0.5800.83
25_L188_D0.5790.83
115_G118_I0.5760.82
45_T221_Q0.5740.82
119_P122_F0.5720.82
14_I67_R0.5710.82
9_P12_D0.5680.81
6_L123_L0.5660.81
169_A184_A0.5660.81
25_L28_A0.5650.81
183_Y213_E0.5650.81
186_V190_T0.5640.81
53_D66_K0.5640.81
79_G83_E0.5620.81
225_M229_L0.5610.81
148_V152_V0.5600.80
87_R158_K0.5600.80
65_G74_Y0.5590.80
10_H47_H0.5590.80
10_H170_H0.5580.80
198_E201_E0.5560.80
143_R230_E0.5560.80
168_H188_D0.5550.80
15_I118_I0.5520.79
60_T129_V0.5510.79
14_I17_P0.5510.79
48_N130_L0.5460.79
89_K95_V0.5440.78
26_N122_F0.5440.78
39_D77_D0.5420.78
16_D118_I0.5400.78
28_A31_E0.5400.78
58_I65_G0.5380.78
151_E180_Y0.5380.78
32_A36_V0.5350.77
12_D22_S0.5350.77
16_D122_F0.5330.77
48_N110_I0.5310.77
217_D221_Q0.5290.77
96_V107_E0.5270.76
204_M223_L0.5260.76
157_R160_V0.5250.76
169_A172_H0.5230.76
41_Y124_K0.5220.76
95_V106_K0.5210.75
169_A215_K0.5180.75
60_T65_G0.5180.75
152_V156_H0.5170.75
93_L145_F0.5170.75
67_R72_R0.5160.75
25_L169_A0.5160.75
189_S192_V0.5150.75
22_S25_L0.5140.75
59_L85_Y0.5130.74
43_V128_I0.5120.74
12_D21_K0.5090.74
11_G17_P0.5090.74
61_Q66_K0.5080.74
12_D172_H0.5070.74
55_M66_K0.5070.74
59_L107_E0.5070.74
134_A137_V0.5050.73
37_K159_R0.5050.73
150_G231_S0.5050.73
53_D96_V0.5050.73
124_K159_R0.5040.73
41_Y168_H0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vsjA 1 0.9572 100 0.297 Contact Map
2pw6A 2 0.8949 100 0.314 Contact Map
3vsjB 2 0.965 100 0.328 Contact Map
1b4uB 2 0.9377 100 0.342 Contact Map
3wraA 2 0.9339 100 0.359 Contact Map
3bczA 1 0.8911 100 0.493 Contact Map
2odfA 2 0.5447 60.5 0.942 Contact Map
1t57A 5 0.6459 50 0.945 Contact Map
1vp8A 5 0.6809 48.1 0.946 Contact Map
4yhsA 1 0.9027 35 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0085 seconds.