GREMLIN Database
Q97WZ7 - Uncharacterized protein
UniProt: Q97WZ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 141 (130)
Sequences: 1063 (861)
Seq/√Len: 75.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_M135_L3.9421.00
52_K56_D3.7281.00
120_E137_K3.2121.00
70_F98_R3.0941.00
101_L128_K2.6861.00
86_T89_S2.4841.00
81_R113_I2.3901.00
31_I40_D2.3531.00
49_V85_V2.3471.00
50_A54_L2.2831.00
104_E112_L2.2071.00
90_D94_E2.1321.00
115_I138_F2.1121.00
88_A92_I2.1111.00
83_L115_I2.0481.00
115_I133_V2.0011.00
115_I135_L1.9941.00
25_V47_N1.9471.00
48_L139_L1.9131.00
72_I103_A1.8791.00
4_A26_V1.8661.00
94_E98_R1.8361.00
89_S93_E1.8341.00
51_L55_R1.7541.00
89_S92_I1.7101.00
97_I114_M1.6681.00
89_S132_L1.6661.00
28_Q44_V1.6291.00
10_G15_E1.6151.00
72_I99_S1.5540.99
135_L139_L1.5110.99
61_G77_E1.4900.99
108_R113_I1.4550.99
70_F102_K1.4240.99
113_I133_V1.4230.99
15_E18_T1.3830.99
134_P137_K1.3830.99
58_Q76_D1.3220.98
92_I119_I1.3200.98
6_R62_L1.3200.98
89_S114_M1.3150.98
122_E131_K1.3100.98
28_Q48_L1.2820.98
8_R19_F1.2530.97
41_R87_Y1.2490.97
88_A116_T1.2450.97
6_R50_A1.2410.97
5_F23_V1.2390.97
93_E97_I1.2210.97
5_F21_K1.2170.97
113_I131_K1.2090.96
83_L113_I1.1610.96
114_M132_L1.1520.95
77_E80_S1.1470.95
67_G99_S1.1410.95
116_T132_L1.0930.94
63_Y77_E1.0860.94
82_L103_A1.0750.93
86_T92_I1.0680.93
84_Q114_M1.0470.92
73_D96_E1.0470.92
52_K55_R1.0350.92
92_I99_S1.0080.91
28_Q32_S1.0040.91
25_V30_I0.9920.90
30_I34_V0.9840.90
82_L112_L0.9690.89
15_E19_F0.9680.89
81_R138_F0.9650.89
93_E114_M0.9580.89
92_I95_R0.9510.88
20_N64_Y0.9290.87
52_K115_I0.9180.86
28_Q51_L0.9140.86
12_K19_F0.9130.86
4_A51_L0.9090.86
40_D43_R0.8990.85
14_R17_L0.8910.85
82_L107_L0.8740.84
25_V31_I0.8730.83
94_E101_L0.8720.83
100_L130_I0.8590.82
9_Y63_Y0.8580.82
86_T114_M0.8560.82
11_E103_A0.8360.81
12_K15_E0.8260.80
87_Y117_Y0.8220.80
117_Y135_L0.8170.79
16_R35_A0.8060.78
103_A107_L0.7850.76
91_K94_E0.7770.76
61_G86_T0.7750.75
15_E33_R0.7680.75
45_M85_V0.7520.73
105_E129_K0.7510.73
83_L102_K0.7500.73
13_P17_L0.7480.73
20_N43_R0.7450.73
29_G32_S0.7450.73
31_I35_A0.7380.72
53_L74_F0.7160.70
7_P21_K0.7160.70
32_S37_R0.7140.69
67_G70_F0.7080.69
65_V72_I0.7070.69
93_E121_G0.7060.68
10_G75_Y0.7050.68
93_E132_L0.7030.68
107_L126_E0.7020.68
104_E128_K0.6960.67
88_A118_D0.6930.67
54_L62_L0.6900.67
105_E112_L0.6840.66
101_L112_L0.6790.65
90_D93_E0.6760.65
42_G87_Y0.6720.65
45_M117_Y0.6710.65
18_T26_V0.6680.64
69_D126_E0.6680.64
53_L76_D0.6670.64
53_L83_L0.6620.64
65_V107_L0.6610.63
122_E126_E0.6590.63
82_L105_E0.6580.63
44_V48_L0.6560.63
41_R117_Y0.6560.63
52_K57_N0.6510.62
9_Y19_F0.6470.62
98_R114_M0.6460.62
54_L57_N0.6460.62
45_M92_I0.6440.61
20_N23_V0.6410.61
127_G132_L0.6370.61
28_Q43_R0.6340.60
105_E128_K0.6340.60
22_K71_E0.6330.60
49_V135_L0.6230.59
16_R36_L0.6210.59
75_Y82_L0.6200.58
132_L138_F0.6140.58
11_E16_R0.6140.58
14_R18_T0.6130.58
7_P17_L0.5960.56
72_I112_L0.5860.54
25_V32_S0.5810.54
13_P105_E0.5810.54
13_P65_V0.5790.53
121_G126_E0.5780.53
11_E44_V0.5610.51
13_P36_L0.5580.51
106_M130_I0.5570.51
72_I82_L0.5560.51
105_E117_Y0.5550.50
69_D102_K0.5540.50
125_R128_K0.5530.50
37_R80_S0.5520.50
84_Q95_R0.5520.50
16_R33_R0.5500.50
61_G131_K0.5500.50
90_D135_L0.5460.49
64_Y103_A0.5450.49
118_D139_L0.5450.49
41_R119_I0.5450.49
10_G23_V0.5430.49
103_A112_L0.5420.49
119_I132_L0.5410.49
89_S119_I0.5410.49
5_F10_G0.5400.48
10_G65_V0.5370.48
107_L112_L0.5360.48
78_V83_L0.5320.47
37_R43_R0.5300.47
113_I117_Y0.5280.47
33_R39_K0.5270.47
32_S113_I0.5260.47
113_I138_F0.5250.47
55_R63_Y0.5190.46
101_L127_G0.5180.46
68_K102_K0.5170.46
21_K62_L0.5160.45
122_E132_L0.5150.45
114_M120_E0.5150.45
103_A106_M0.5150.45
118_D132_L0.5130.45
9_Y80_S0.5130.45
47_N51_L0.5120.45
82_L100_L0.5110.45
58_Q78_V0.5110.45
95_R116_T0.5100.45
93_E130_I0.5060.44
88_A132_L0.5040.44
13_P82_L0.5030.44
62_L139_L0.5010.44
41_R135_L0.5010.44
97_I101_L0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1y88A 5 0.7092 75.6 0.909 Contact Map
2eo0A 2 0.6738 71.6 0.912 Contact Map
1gefA 2 0.7021 60.9 0.918 Contact Map
4f0qA 4 0.9504 55.3 0.921 Contact Map
2wcwA 2 0.7163 54.9 0.921 Contact Map
1ob8A 1 0.6525 47 0.925 Contact Map
4oc8A 4 0.9645 38.6 0.928 Contact Map
1hh1A 2 0.6454 36.5 0.929 Contact Map
3fovA 2 0.6454 27.9 0.933 Contact Map
1xmxA 2 0.9858 26.8 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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