GREMLIN Database
Q97WZ6 - First ORF in transposon ISC1913
UniProt: Q97WZ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 132 (124)
Sequences: 493 (365)
Seq/√Len: 32.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_A81_L4.3651.00
59_A125_N4.2701.00
10_A14_L2.8841.00
85_A127_S2.7601.00
98_D109_G2.6431.00
8_K12_Q2.3550.99
21_L42_I2.3510.99
16_I24_W2.2970.99
5_L10_A2.2330.99
20_T24_W2.2020.99
61_I81_L2.2010.99
80_Y129_K2.0710.98
119_G122_R2.0340.98
19_S22_L1.9380.97
25_I40_Y1.8870.97
84_Y88_K1.8080.96
78_I97_K1.7720.95
116_L122_R1.7050.94
78_I95_V1.6920.94
96_L109_G1.6560.93
113_L123_Y1.6300.93
117_V126_L1.6300.93
117_V123_Y1.5840.92
58_R116_L1.5650.91
6_R37_G1.5580.91
19_S27_E1.5460.91
94_E116_L1.5050.90
70_Q73_D1.4740.89
25_I30_I1.4410.87
43_P46_E1.4350.87
61_I95_V1.4210.87
34_T40_Y1.4190.87
7_P22_L1.3790.85
117_V128_M1.3580.84
66_S70_Q1.3450.83
5_L41_R1.3060.82
61_I85_A1.3040.81
98_D129_K1.2980.81
25_I32_V1.2640.79
73_D76_R1.2230.77
30_I33_V1.1830.75
90_Y93_V1.1750.74
60_V123_Y1.1720.74
59_A127_S1.1390.72
20_T23_R1.1290.71
25_I42_I1.1260.71
6_R41_R1.1190.70
67_S76_R1.1070.70
98_D105_T1.0990.69
29_K36_E1.0760.67
84_Y89_G1.0760.67
90_Y125_N1.0710.67
22_L39_K1.0550.66
61_I92_V1.0540.66
75_E79_N1.0500.65
79_N82_T1.0420.65
29_K37_G1.0330.64
114_F118_E1.0300.64
23_R26_R1.0270.64
10_A47_I1.0220.63
14_L21_L1.0160.63
42_I46_E1.0000.62
11_C16_I0.9980.61
30_I46_E0.9950.61
80_Y98_D0.9890.61
45_S76_R0.9630.59
79_N83_N0.9550.58
33_V41_R0.9420.57
22_L42_I0.9410.57
101_S105_T0.9380.57
73_D129_K0.9060.54
96_L113_L0.8990.53
5_L44_Y0.8960.53
47_I126_L0.8920.53
10_A30_I0.8870.52
31_K46_E0.8770.52
7_P32_V0.8760.51
70_Q76_R0.8760.51
18_Y22_L0.8700.51
87_A127_S0.8640.50
46_E49_K0.8590.50
7_P11_C0.8410.49
105_T126_L0.8370.48
10_A41_R0.8360.48
82_T95_V0.8350.48
68_A71_R0.8250.47
22_L25_I0.8230.47
10_A21_L0.8190.47
93_V110_L0.8150.46
5_L13_L0.8030.45
84_Y125_N0.8020.45
59_A100_A0.8000.45
13_L97_K0.7950.45
98_D101_S0.7920.44
42_I47_I0.7880.44
41_R84_Y0.7860.44
75_E78_I0.7850.44
32_V42_I0.7830.44
99_I107_R0.7810.44
18_Y40_Y0.7800.44
7_P18_Y0.7730.43
29_K115_K0.7710.43
26_R108_K0.7700.43
104_N113_L0.7660.42
62_Y74_L0.7610.42
67_S108_K0.7530.41
14_L98_D0.7530.41
17_S23_R0.7410.40
11_C21_L0.7350.40
115_K123_Y0.7270.39
33_V46_E0.7270.39
39_K42_I0.7230.39
53_K122_R0.7110.38
100_A104_N0.7090.38
93_V127_S0.7070.38
65_V70_Q0.7050.38
33_V39_K0.7050.38
11_C15_S0.6990.37
22_L34_T0.6960.37
70_Q108_K0.6920.37
5_L16_I0.6900.36
63_A101_S0.6880.36
72_E112_K0.6850.36
45_S48_K0.6800.36
96_L126_L0.6780.35
5_L14_L0.6760.35
67_S100_A0.6750.35
37_G120_S0.6740.35
90_Y110_L0.6660.35
69_D129_K0.6640.34
22_L40_Y0.6620.34
59_A94_E0.6570.34
16_I114_F0.6520.33
7_P21_L0.6510.33
12_Q15_S0.6490.33
33_V43_P0.6370.32
55_E58_R0.6340.32
16_I41_R0.6340.32
114_F122_R0.6240.31
85_A92_V0.6230.31
5_L51_L0.6210.31
40_Y47_I0.6190.31
8_K37_G0.6180.31
89_G112_K0.6140.31
38_G97_K0.6140.31
16_I19_S0.6060.30
76_R79_N0.6030.30
51_L115_K0.6000.30
102_G110_L0.5980.30
48_K95_V0.5980.30
16_I23_R0.5910.29
67_S70_Q0.5870.29
88_K111_L0.5820.29
21_L25_I0.5810.28
99_I108_K0.5790.28
78_I114_F0.5790.28
6_R39_K0.5750.28
12_Q79_N0.5740.28
93_V107_R0.5720.28
76_R110_L0.5700.28
60_V113_L0.5660.27
7_P24_W0.5640.27
11_C18_Y0.5630.27
82_T86_T0.5620.27
11_C48_K0.5620.27
83_N91_K0.5600.27
5_L43_P0.5560.27
31_K50_Y0.5540.27
17_S30_I0.5540.27
109_G128_M0.5510.26
80_Y85_A0.5500.26
90_Y127_S0.5490.26
34_T39_K0.5480.26
22_L117_V0.5400.26
69_D126_L0.5310.25
8_K28_G0.5280.25
51_L97_K0.5240.25
12_Q104_N0.5220.25
6_R9_E0.5160.24
53_K124_K0.5140.24
60_V94_E0.5070.24
25_I34_T0.5040.24
74_L101_S0.5040.24
68_A99_I0.5020.23
89_G92_V0.5020.23
23_R32_V0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lhkA 2 0.5682 99.7 0.654 Contact Map
2mhcA 1 0.6061 99.6 0.671 Contact Map
3ilxA 2 0.5303 99.6 0.672 Contact Map
3bvpA 4 0.5682 99.6 0.678 Contact Map
3guvA 2 0.5758 99.6 0.681 Contact Map
3whpA 1 0.4545 99.5 0.686 Contact Map
3g13A 2 0.5985 99.5 0.688 Contact Map
4bqqA 2 0.553 99.5 0.696 Contact Map
2gm5A 4 0.4773 99.3 0.728 Contact Map
1gdtA 2 0.5076 99.2 0.735 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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