GREMLIN Database
Q97WZ5 - Transposase ISC1190
UniProt: Q97WZ5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 316 (308)
Sequences: 4632 (3515)
Seq/√Len: 200.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_G99_V4.3821.00
125_I176_E2.8981.00
195_L311_P2.7781.00
18_Y92_A2.7341.00
226_F299_A2.7111.00
163_A185_E2.6091.00
281_H284_R2.5551.00
76_L95_L2.4181.00
167_F178_R2.4071.00
124_S127_R2.2811.00
214_V226_F2.2721.00
170_E178_R2.2221.00
47_G95_L2.1891.00
221_S225_R2.1851.00
275_K279_E2.1741.00
230_C256_L2.1651.00
78_K81_D2.1301.00
118_W122_T2.1091.00
210_I302_T2.0831.00
198_T311_P2.0761.00
46_V66_Y2.0701.00
87_S236_V2.0481.00
14_K25_E2.0181.00
174_R178_R1.9801.00
248_I292_T1.9651.00
296_R300_V1.9301.00
125_I179_K1.9271.00
8_I36_I1.9081.00
238_S243_V1.8951.00
124_S131_R1.8841.00
126_A130_N1.8421.00
195_L305_V1.8371.00
146_S149_N1.8241.00
222_D225_R1.8141.00
230_C299_A1.8021.00
202_I207_G1.7961.00
118_W183_E1.7811.00
171_E174_R1.7771.00
199_I302_T1.7741.00
183_E186_L1.7541.00
6_A19_F1.7491.00
8_I15_L1.7401.00
232_L295_A1.7031.00
45_K69_R1.6901.00
220_F229_Y1.6891.00
119_D258_R1.6601.00
116_S213_R1.6551.00
310_K313_D1.6321.00
48_I68_V1.6291.00
185_E188_D1.6261.00
124_S171_E1.6261.00
132_L172_L1.6231.00
196_I302_T1.6091.00
121_V179_K1.6081.00
77_K80_K1.5971.00
171_E178_R1.5941.00
280_E284_R1.5781.00
143_D146_S1.5691.00
274_I294_C1.5671.00
305_V311_P1.5601.00
8_I58_L1.5481.00
97_E101_S1.5481.00
206_L259_A1.5411.00
143_D153_V1.5351.00
304_A308_Y1.5331.00
285_L289_K1.5191.00
60_K109_S1.5131.00
29_D32_G1.5121.00
13_D241_K1.5101.00
209_I259_A1.4981.00
279_E283_G1.4921.00
197_F204_K1.4891.00
146_S151_E1.4851.00
122_T125_I1.4811.00
274_I301_I1.4681.00
262_L265_L1.4651.00
199_I305_V1.4641.00
150_L153_V1.4491.00
195_L198_T1.4361.00
61_Y64_N1.4341.00
17_V36_I1.4341.00
147_K151_E1.4091.00
11_S16_I1.3891.00
170_E177_G1.3821.00
149_N152_E1.3721.00
24_Y39_I1.3711.00
125_I172_L1.3711.00
125_I129_K1.3691.00
278_Y294_C1.3681.00
153_V156_G1.3671.00
154_L157_G1.3631.00
16_I25_E1.3611.00
48_I59_A1.3561.00
268_I278_Y1.3551.00
282_K288_K1.3471.00
146_S157_G1.3471.00
190_V197_F1.3461.00
18_Y93_K1.3451.00
85_K236_V1.3441.00
118_W205_T1.3371.00
277_F297_K1.3141.00
146_S150_L1.3101.00
170_E174_R1.3091.00
122_T179_K1.3051.00
119_D255_V1.2941.00
264_A298_L1.2931.00
150_L157_G1.2921.00
286_K289_K1.2891.00
47_G71_I1.2881.00
264_A295_A1.2831.00
124_S128_V1.2701.00
258_R262_L1.2661.00
132_L165_V1.2561.00
40_L46_V1.2431.00
278_Y290_L1.2431.00
180_R183_E1.2361.00
303_W307_Y1.2231.00
145_L153_V1.2231.00
227_V233_D1.2191.00
188_D192_K1.2171.00
128_V131_R1.1911.00
167_F181_E1.1811.00
11_S14_K1.1811.00
199_I298_L1.1781.00
183_E187_E1.1761.00
33_Y57_N1.1761.00
264_A294_C1.1711.00
27_T32_G1.1711.00
169_L173_E1.1671.00
213_R253_D1.1671.00
272_P276_R1.1671.00
172_L176_E1.1661.00
120_F131_R1.1551.00
206_L263_A1.1541.00
261_Y295_A1.1441.00
45_K67_D1.1321.00
150_L154_L1.1261.00
46_V62_L1.1241.00
227_V296_R1.1241.00
10_V15_L1.1171.00
117_Q121_V1.1161.00
202_I206_L1.1161.00
8_I17_V1.1151.00
7_G96_A1.1141.00
149_N153_V1.1121.00
127_R130_N1.1101.00
178_R181_E1.1001.00
16_I23_L1.0981.00
187_E204_K1.0971.00
282_K287_G1.0931.00
33_Y61_Y1.0891.00
146_S155_R1.0871.00
281_H290_L1.0821.00
6_A17_V1.0801.00
146_S153_V1.0771.00
23_L93_K1.0731.00
176_E180_R1.0611.00
301_I305_V1.0581.00
261_Y292_T1.0561.00
6_A46_V1.0561.00
196_I207_G1.0561.00
202_I302_T1.0521.00
277_F281_H1.0471.00
74_F78_K1.0391.00
263_A298_L1.0361.00
71_I76_L1.0361.00
55_H70_I1.0361.00
153_V157_G1.0331.00
146_S156_G1.0271.00
37_R61_Y1.0231.00
145_L148_K1.0191.00
80_K94_K1.0151.00
105_G108_T1.0141.00
282_K290_L1.0131.00
304_A307_Y1.0071.00
277_F294_C1.0071.00
123_R127_R1.0001.00
305_V310_K0.9921.00
151_E155_R0.9911.00
6_A40_L0.9891.00
146_S154_L0.9861.00
261_Y265_L0.9851.00
145_L150_L0.9811.00
277_F293_A0.9811.00
115_T255_V0.9811.00
118_W179_K0.9771.00
264_A291_I0.9751.00
26_F39_I0.9680.99
148_K152_E0.9670.99
145_L154_L0.9660.99
248_I257_R0.9620.99
114_L182_I0.9510.99
93_K97_E0.9480.99
17_V39_I0.9480.99
146_S152_E0.9440.99
167_F185_E0.9420.99
26_F32_G0.9410.99
59_A68_V0.9360.99
32_G35_E0.9290.99
149_N157_G0.9230.99
196_I306_L0.9220.99
128_V132_L0.9120.99
38_K41_P0.9100.99
5_V99_V0.9050.99
143_D156_G0.9020.99
86_K91_D0.9000.99
149_N156_G0.8900.99
277_F280_E0.8880.99
5_V100_V0.8840.99
147_K154_L0.8820.99
265_L268_I0.8740.99
250_K257_R0.8730.99
110_D158_D0.8720.99
12_K137_V0.8690.99
174_R177_G0.8680.99
260_F299_A0.8680.99
63_N103_C0.8670.99
217_V306_L0.8660.99
117_Q164_E0.8660.99
59_A70_I0.8650.99
202_I298_L0.8510.99
185_E189_F0.8360.98
147_K155_R0.8310.98
50_S73_P0.8310.98
147_K150_L0.8290.98
143_D147_K0.8290.98
145_L149_N0.8290.98
84_G228_A0.8280.98
281_H286_K0.8280.98
36_I40_L0.8270.98
151_E156_G0.8260.98
274_I298_L0.8240.98
112_R213_R0.8230.98
186_L190_V0.8220.98
148_K151_E0.8180.98
144_S155_R0.8110.98
115_T208_C0.8080.98
214_V217_V0.8070.98
69_R99_V0.8050.98
58_L62_L0.8050.98
95_L98_L0.8000.98
177_G181_E0.7990.98
152_E156_G0.7960.98
292_T295_A0.7950.98
161_V164_E0.7940.98
150_L156_G0.7920.98
17_V26_F0.7920.98
288_K291_I0.7880.98
197_F207_G0.7880.98
222_D303_W0.7850.98
10_V48_I0.7840.98
122_T126_A0.7810.98
73_P213_R0.7800.98
281_H285_L0.7780.98
190_V193_D0.7760.98
145_L152_E0.7750.97
265_L288_K0.7740.97
239_S243_V0.7740.97
164_E167_F0.7730.97
145_L156_G0.7710.97
213_R255_V0.7650.97
273_V312_F0.7640.97
115_T209_I0.7580.97
32_G36_I0.7580.97
51_T54_Y0.7560.97
11_S15_L0.7490.97
16_I89_K0.7480.97
238_S244_V0.7480.97
121_V182_I0.7450.97
159_S185_E0.7450.97
144_S156_G0.7450.97
115_T186_L0.7440.97
151_E154_L0.7420.97
175_L178_R0.7410.97
168_L171_E0.7380.97
43_G67_D0.7360.97
187_E191_S0.7340.97
276_R280_E0.7330.96
45_K99_V0.7330.96
15_L28_N0.7290.96
235_V249_S0.7290.96
167_F171_E0.7260.96
149_N154_L0.7250.96
30_K34_E0.7250.96
117_Q167_F0.7210.96
143_D149_N0.7170.96
37_R41_P0.7160.96
145_L157_G0.7140.96
31_R35_E0.7120.96
6_A44_C0.7110.96
302_T305_V0.7110.96
267_A274_I0.7060.96
117_Q182_I0.7000.95
229_Y253_D0.6990.95
40_L62_L0.6990.95
115_T212_A0.6970.95
225_R228_A0.6970.95
233_D250_K0.6960.95
281_H293_A0.6960.95
144_S150_L0.6940.95
15_L26_F0.6920.95
7_G92_A0.6920.95
252_G257_R0.6920.95
265_L295_A0.6900.95
147_K153_V0.6890.95
147_K157_G0.6870.95
50_S70_I0.6860.95
72_N75_I0.6860.95
236_V243_V0.6860.95
18_Y23_L0.6850.95
195_L309_N0.6850.95
163_A174_R0.6830.95
163_A167_F0.6810.95
181_E185_E0.6810.95
280_E283_G0.6800.95
270_V275_K0.6770.95
84_G251_K0.6760.95
32_G39_I0.6750.94
163_A166_R0.6740.94
129_K172_L0.6720.94
183_E190_V0.6720.94
143_D151_E0.6700.94
128_V172_L0.6700.94
162_L166_R0.6630.94
145_L151_E0.6630.94
147_K152_E0.6620.94
71_I98_L0.6620.94
210_I256_L0.6610.94
286_K290_L0.6580.94
175_L179_K0.6570.94
79_F98_L0.6530.93
15_L58_L0.6510.93
107_T192_K0.6500.93
176_E179_K0.6490.93
85_K90_N0.6480.93
233_D236_V0.6470.93
265_L291_I0.6470.93
272_P275_K0.6460.93
148_K155_R0.6450.93
144_S154_L0.6430.93
119_D123_R0.6420.93
120_F124_S0.6420.93
116_S255_V0.6410.93
109_S113_E0.6400.93
88_D239_S0.6380.93
199_I202_I0.6380.93
186_L208_C0.6370.93
177_G180_R0.6350.92
59_A103_C0.6350.92
282_K289_K0.6340.92
202_I210_I0.6340.92
262_L266_T0.6320.92
160_I185_E0.6320.92
144_S147_K0.6310.92
128_V175_L0.6290.92
268_I282_K0.6280.92
34_E38_K0.6270.92
190_V208_C0.6250.92
43_G66_Y0.6240.92
278_Y282_K0.6240.92
193_D197_F0.6220.92
105_G109_S0.6220.92
173_E177_G0.6200.92
268_I291_I0.6160.91
76_L98_L0.6130.91
216_D219_R0.6120.91
107_T110_D0.6090.91
121_V175_L0.6080.91
7_G62_L0.6070.91
233_D249_S0.6060.91
209_I213_R0.6050.91
74_F251_K0.6050.91
33_Y39_I0.6050.91
160_I163_A0.6040.91
76_L94_K0.5990.90
37_R66_Y0.5980.90
144_S149_N0.5970.90
132_L169_L0.5930.90
79_F101_S0.5920.90
182_I186_L0.5910.90
144_S157_G0.5850.89
268_I294_C0.5850.89
125_I175_L0.5830.89
145_L155_R0.5820.89
235_V246_R0.5820.89
143_D150_L0.5810.89
10_V54_Y0.5810.89
171_E175_L0.5800.89
48_I70_I0.5780.89
166_R170_E0.5770.88
53_V137_V0.5770.88
300_V303_W0.5760.88
130_N134_R0.5750.88
114_L185_E0.5750.88
184_K188_D0.5720.88
265_L269_K0.5720.88
248_I252_G0.5710.88
28_N33_Y0.5680.88
87_S238_S0.5680.88
276_R279_E0.5670.88
128_V168_L0.5660.87
188_D191_S0.5640.87
131_R134_R0.5630.87
119_D209_I0.5620.87
128_V171_E0.5610.87
228_A233_D0.5600.87
34_E37_R0.5600.87
121_V178_R0.5600.87
18_Y96_A0.5600.87
237_E246_R0.5590.87
116_S253_D0.5570.87
205_T209_I0.5530.86
167_F170_E0.5510.86
259_A263_A0.5510.86
117_Q131_R0.5480.86
258_R261_Y0.5480.86
143_D157_G0.5470.86
74_F84_G0.5460.86
6_A62_L0.5460.86
143_D152_E0.5440.85
26_F33_Y0.5430.85
214_V230_C0.5430.85
260_F295_A0.5420.85
144_S148_K0.5410.85
202_I263_A0.5390.85
120_F164_E0.5390.85
233_D257_R0.5380.85
307_Y310_K0.5370.85
150_L155_R0.5360.85
215_G219_R0.5350.84
223_K300_V0.5340.84
278_Y291_I0.5320.84
227_V300_V0.5310.84
301_I304_A0.5300.84
223_K303_W0.5300.84
35_E39_I0.5290.84
48_I95_L0.5270.84
35_E38_K0.5240.83
121_V125_I0.5240.83
271_N275_K0.5240.83
271_N276_R0.5210.83
279_E282_K0.5200.83
122_T183_E0.5190.83
41_P66_Y0.5190.83
152_E155_R0.5180.82
151_E157_G0.5160.82
47_G76_L0.5160.82
217_V303_W0.5140.82
266_T270_V0.5140.82
271_N312_F0.5120.82
249_S257_R0.5120.82
131_R168_L0.5110.82
126_A129_K0.5100.82
31_R39_I0.5100.82
117_Q128_V0.5080.81
11_S240_G0.5050.81
97_E100_V0.5030.81
77_K81_D0.5020.81
71_I95_L0.5020.81
111_A186_L0.5020.81
248_I293_A0.5020.81
173_E176_E0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hjrA 2 0.3323 92.4 0.934 Contact Map
4ep4A 2 0.3418 90.2 0.937 Contact Map
3c1yA 5 0.7532 88.8 0.939 Contact Map
1keaA 2 0.5981 86.9 0.941 Contact Map
4ofaA 1 0.4304 85.9 0.941 Contact Map
1nu0A 1 0.3133 84.6 0.943 Contact Map
3fhfA 1 0.6108 84.4 0.943 Contact Map
2a1jB 2 0.2437 82.6 0.944 Contact Map
1pu6A 1 0.5886 81 0.945 Contact Map
1z00A 1 0.2595 77.6 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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