Q97WZ5 - SULSO - GREMLIN Contacts

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Q97WZ5 - Transposase ISC1190

UniProt:	Q97WZ5	Sequences: MEAPVAGIDVSKDKLIVYFQGKLYEFTNDKRGYEEIRKILPKGCKVGIESTGVYHVNLAKYLNNEYDVRIINPFILKKFKDFRGKKSDKNDAKKLAELVVSMCSGFTTSDARELTSQWDFVTRSIARVKNRLRRDLVLLGYRDSLSKKNLEEVLRGGDSIVLAEVRFLLEELERLEGRKREIEKELEDFVSKDSLIFTIPGIGKTLGCIILARVGDVKRFSDKKRFVAYCGLDPVVESSGKSVVSRGISKKGDAVLRRAFYLAALTAIKVNPVIKRFYEEHKGRLKGKKLITACARKLAVITWAVLYYNKPFDASE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	316 (308)
Sequences:	4632 (3515)
Seq/√Len:	200.3

SULSO - Q97WZ5 Q97X07 Q97Y59 Q97XK2 Q97WC0 Q97VS0 Q97ZN4 Q97X26 Q97UF7 Q97X12 Q97X29 Q97UQ6 Q97YE1 Q97XM7 Q97UU8 Q97Y06 Q97VB2 Q97Z62 Q97XR9 Q97WY7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
47_G	99_V	4.382	1.00
125_I	176_E	2.898	1.00
195_L	311_P	2.778	1.00
18_Y	92_A	2.734	1.00
226_F	299_A	2.711	1.00
163_A	185_E	2.609	1.00
281_H	284_R	2.555	1.00
76_L	95_L	2.418	1.00
167_F	178_R	2.407	1.00
124_S	127_R	2.281	1.00
214_V	226_F	2.272	1.00
170_E	178_R	2.222	1.00
47_G	95_L	2.189	1.00
221_S	225_R	2.185	1.00
275_K	279_E	2.174	1.00
230_C	256_L	2.165	1.00
78_K	81_D	2.130	1.00
118_W	122_T	2.109	1.00
210_I	302_T	2.083	1.00
198_T	311_P	2.076	1.00
46_V	66_Y	2.070	1.00
87_S	236_V	2.048	1.00
14_K	25_E	2.018	1.00
174_R	178_R	1.980	1.00
248_I	292_T	1.965	1.00
296_R	300_V	1.930	1.00
125_I	179_K	1.927	1.00
8_I	36_I	1.908	1.00
238_S	243_V	1.895	1.00
124_S	131_R	1.884	1.00
126_A	130_N	1.842	1.00
195_L	305_V	1.837	1.00
146_S	149_N	1.824	1.00
222_D	225_R	1.814	1.00
230_C	299_A	1.802	1.00
202_I	207_G	1.796	1.00
118_W	183_E	1.781	1.00
171_E	174_R	1.777	1.00
199_I	302_T	1.774	1.00
183_E	186_L	1.754	1.00
6_A	19_F	1.749	1.00
8_I	15_L	1.740	1.00
232_L	295_A	1.703	1.00
45_K	69_R	1.690	1.00
220_F	229_Y	1.689	1.00
119_D	258_R	1.660	1.00
116_S	213_R	1.655	1.00
310_K	313_D	1.632	1.00
48_I	68_V	1.629	1.00
185_E	188_D	1.626	1.00
124_S	171_E	1.626	1.00
132_L	172_L	1.623	1.00
196_I	302_T	1.609	1.00
121_V	179_K	1.608	1.00
77_K	80_K	1.597	1.00
171_E	178_R	1.594	1.00
280_E	284_R	1.578	1.00
143_D	146_S	1.569	1.00
274_I	294_C	1.567	1.00
305_V	311_P	1.560	1.00
8_I	58_L	1.548	1.00
97_E	101_S	1.548	1.00
206_L	259_A	1.541	1.00
143_D	153_V	1.535	1.00
304_A	308_Y	1.533	1.00
285_L	289_K	1.519	1.00
60_K	109_S	1.513	1.00
29_D	32_G	1.512	1.00
13_D	241_K	1.510	1.00
209_I	259_A	1.498	1.00
279_E	283_G	1.492	1.00
197_F	204_K	1.489	1.00
146_S	151_E	1.485	1.00
122_T	125_I	1.481	1.00
274_I	301_I	1.468	1.00
262_L	265_L	1.465	1.00
199_I	305_V	1.464	1.00
150_L	153_V	1.449	1.00
195_L	198_T	1.436	1.00
61_Y	64_N	1.434	1.00
17_V	36_I	1.434	1.00
147_K	151_E	1.409	1.00
11_S	16_I	1.389	1.00
170_E	177_G	1.382	1.00
149_N	152_E	1.372	1.00
24_Y	39_I	1.371	1.00
125_I	172_L	1.371	1.00
125_I	129_K	1.369	1.00
278_Y	294_C	1.368	1.00
153_V	156_G	1.367	1.00
154_L	157_G	1.363	1.00
16_I	25_E	1.361	1.00
48_I	59_A	1.356	1.00
268_I	278_Y	1.355	1.00
282_K	288_K	1.347	1.00
146_S	157_G	1.347	1.00
190_V	197_F	1.346	1.00
18_Y	93_K	1.345	1.00
85_K	236_V	1.344	1.00
118_W	205_T	1.337	1.00
277_F	297_K	1.314	1.00
146_S	150_L	1.310	1.00
170_E	174_R	1.309	1.00
122_T	179_K	1.305	1.00
119_D	255_V	1.294	1.00
264_A	298_L	1.293	1.00
150_L	157_G	1.292	1.00
286_K	289_K	1.289	1.00
47_G	71_I	1.288	1.00
264_A	295_A	1.283	1.00
124_S	128_V	1.270	1.00
258_R	262_L	1.266	1.00
132_L	165_V	1.256	1.00
40_L	46_V	1.243	1.00
278_Y	290_L	1.243	1.00
180_R	183_E	1.236	1.00
303_W	307_Y	1.223	1.00
145_L	153_V	1.223	1.00
227_V	233_D	1.219	1.00
188_D	192_K	1.217	1.00
128_V	131_R	1.191	1.00
167_F	181_E	1.181	1.00
11_S	14_K	1.181	1.00
199_I	298_L	1.178	1.00
183_E	187_E	1.176	1.00
33_Y	57_N	1.176	1.00
264_A	294_C	1.171	1.00
27_T	32_G	1.171	1.00
169_L	173_E	1.167	1.00
213_R	253_D	1.167	1.00
272_P	276_R	1.167	1.00
172_L	176_E	1.166	1.00
120_F	131_R	1.155	1.00
206_L	263_A	1.154	1.00
261_Y	295_A	1.144	1.00
45_K	67_D	1.132	1.00
150_L	154_L	1.126	1.00
46_V	62_L	1.124	1.00
227_V	296_R	1.124	1.00
10_V	15_L	1.117	1.00
117_Q	121_V	1.116	1.00
202_I	206_L	1.116	1.00
8_I	17_V	1.115	1.00
7_G	96_A	1.114	1.00
149_N	153_V	1.112	1.00
127_R	130_N	1.110	1.00
178_R	181_E	1.100	1.00
16_I	23_L	1.098	1.00
187_E	204_K	1.097	1.00
282_K	287_G	1.093	1.00
33_Y	61_Y	1.089	1.00
146_S	155_R	1.087	1.00
281_H	290_L	1.082	1.00
6_A	17_V	1.080	1.00
146_S	153_V	1.077	1.00
23_L	93_K	1.073	1.00
176_E	180_R	1.061	1.00
301_I	305_V	1.058	1.00
261_Y	292_T	1.056	1.00
6_A	46_V	1.056	1.00
196_I	207_G	1.056	1.00
202_I	302_T	1.052	1.00
277_F	281_H	1.047	1.00
74_F	78_K	1.039	1.00
263_A	298_L	1.036	1.00
71_I	76_L	1.036	1.00
55_H	70_I	1.036	1.00
153_V	157_G	1.033	1.00
146_S	156_G	1.027	1.00
37_R	61_Y	1.023	1.00
145_L	148_K	1.019	1.00
80_K	94_K	1.015	1.00
105_G	108_T	1.014	1.00
282_K	290_L	1.013	1.00
304_A	307_Y	1.007	1.00
277_F	294_C	1.007	1.00
123_R	127_R	1.000	1.00
305_V	310_K	0.992	1.00
151_E	155_R	0.991	1.00
6_A	40_L	0.989	1.00
146_S	154_L	0.986	1.00
261_Y	265_L	0.985	1.00
145_L	150_L	0.981	1.00
277_F	293_A	0.981	1.00
115_T	255_V	0.981	1.00
118_W	179_K	0.977	1.00
264_A	291_I	0.975	1.00
26_F	39_I	0.968	0.99
148_K	152_E	0.967	0.99
145_L	154_L	0.966	0.99
248_I	257_R	0.962	0.99
114_L	182_I	0.951	0.99
93_K	97_E	0.948	0.99
17_V	39_I	0.948	0.99
146_S	152_E	0.944	0.99
167_F	185_E	0.942	0.99
26_F	32_G	0.941	0.99
59_A	68_V	0.936	0.99
32_G	35_E	0.929	0.99
149_N	157_G	0.923	0.99
196_I	306_L	0.922	0.99
128_V	132_L	0.912	0.99
38_K	41_P	0.910	0.99
5_V	99_V	0.905	0.99
143_D	156_G	0.902	0.99
86_K	91_D	0.900	0.99
149_N	156_G	0.890	0.99
277_F	280_E	0.888	0.99
5_V	100_V	0.884	0.99
147_K	154_L	0.882	0.99
265_L	268_I	0.874	0.99
250_K	257_R	0.873	0.99
110_D	158_D	0.872	0.99
12_K	137_V	0.869	0.99
174_R	177_G	0.868	0.99
260_F	299_A	0.868	0.99
63_N	103_C	0.867	0.99
217_V	306_L	0.866	0.99
117_Q	164_E	0.866	0.99
59_A	70_I	0.865	0.99
202_I	298_L	0.851	0.99
185_E	189_F	0.836	0.98
147_K	155_R	0.831	0.98
50_S	73_P	0.831	0.98
147_K	150_L	0.829	0.98
143_D	147_K	0.829	0.98
145_L	149_N	0.829	0.98
84_G	228_A	0.828	0.98
281_H	286_K	0.828	0.98
36_I	40_L	0.827	0.98
151_E	156_G	0.826	0.98
274_I	298_L	0.824	0.98
112_R	213_R	0.823	0.98
186_L	190_V	0.822	0.98
148_K	151_E	0.818	0.98
144_S	155_R	0.811	0.98
115_T	208_C	0.808	0.98
214_V	217_V	0.807	0.98
69_R	99_V	0.805	0.98
58_L	62_L	0.805	0.98
95_L	98_L	0.800	0.98
177_G	181_E	0.799	0.98
152_E	156_G	0.796	0.98
292_T	295_A	0.795	0.98
161_V	164_E	0.794	0.98
150_L	156_G	0.792	0.98
17_V	26_F	0.792	0.98
288_K	291_I	0.788	0.98
197_F	207_G	0.788	0.98
222_D	303_W	0.785	0.98
10_V	48_I	0.784	0.98
122_T	126_A	0.781	0.98
73_P	213_R	0.780	0.98
281_H	285_L	0.778	0.98
190_V	193_D	0.776	0.98
145_L	152_E	0.775	0.97
265_L	288_K	0.774	0.97
239_S	243_V	0.774	0.97
164_E	167_F	0.773	0.97
145_L	156_G	0.771	0.97
213_R	255_V	0.765	0.97
273_V	312_F	0.764	0.97
115_T	209_I	0.758	0.97
32_G	36_I	0.758	0.97
51_T	54_Y	0.756	0.97
11_S	15_L	0.749	0.97
16_I	89_K	0.748	0.97
238_S	244_V	0.748	0.97
121_V	182_I	0.745	0.97
159_S	185_E	0.745	0.97
144_S	156_G	0.745	0.97
115_T	186_L	0.744	0.97
151_E	154_L	0.742	0.97
175_L	178_R	0.741	0.97
168_L	171_E	0.738	0.97
43_G	67_D	0.736	0.97
187_E	191_S	0.734	0.97
276_R	280_E	0.733	0.96
45_K	99_V	0.733	0.96
15_L	28_N	0.729	0.96
235_V	249_S	0.729	0.96
167_F	171_E	0.726	0.96
149_N	154_L	0.725	0.96
30_K	34_E	0.725	0.96
117_Q	167_F	0.721	0.96
143_D	149_N	0.717	0.96
37_R	41_P	0.716	0.96
145_L	157_G	0.714	0.96
31_R	35_E	0.712	0.96
6_A	44_C	0.711	0.96
302_T	305_V	0.711	0.96
267_A	274_I	0.706	0.96
117_Q	182_I	0.700	0.95
229_Y	253_D	0.699	0.95
40_L	62_L	0.699	0.95
115_T	212_A	0.697	0.95
225_R	228_A	0.697	0.95
233_D	250_K	0.696	0.95
281_H	293_A	0.696	0.95
144_S	150_L	0.694	0.95
15_L	26_F	0.692	0.95
7_G	92_A	0.692	0.95
252_G	257_R	0.692	0.95
265_L	295_A	0.690	0.95
147_K	153_V	0.689	0.95
147_K	157_G	0.687	0.95
50_S	70_I	0.686	0.95
72_N	75_I	0.686	0.95
236_V	243_V	0.686	0.95
18_Y	23_L	0.685	0.95
195_L	309_N	0.685	0.95
163_A	174_R	0.683	0.95
163_A	167_F	0.681	0.95
181_E	185_E	0.681	0.95
280_E	283_G	0.680	0.95
270_V	275_K	0.677	0.95
84_G	251_K	0.676	0.95
32_G	39_I	0.675	0.94
163_A	166_R	0.674	0.94
129_K	172_L	0.672	0.94
183_E	190_V	0.672	0.94
143_D	151_E	0.670	0.94
128_V	172_L	0.670	0.94
162_L	166_R	0.663	0.94
145_L	151_E	0.663	0.94
147_K	152_E	0.662	0.94
71_I	98_L	0.662	0.94
210_I	256_L	0.661	0.94
286_K	290_L	0.658	0.94
175_L	179_K	0.657	0.94
79_F	98_L	0.653	0.93
15_L	58_L	0.651	0.93
107_T	192_K	0.650	0.93
176_E	179_K	0.649	0.93
85_K	90_N	0.648	0.93
233_D	236_V	0.647	0.93
265_L	291_I	0.647	0.93
272_P	275_K	0.646	0.93
148_K	155_R	0.645	0.93
144_S	154_L	0.643	0.93
119_D	123_R	0.642	0.93
120_F	124_S	0.642	0.93
116_S	255_V	0.641	0.93
109_S	113_E	0.640	0.93
88_D	239_S	0.638	0.93
199_I	202_I	0.638	0.93
186_L	208_C	0.637	0.93
177_G	180_R	0.635	0.92
59_A	103_C	0.635	0.92
282_K	289_K	0.634	0.92
202_I	210_I	0.634	0.92
262_L	266_T	0.632	0.92
160_I	185_E	0.632	0.92
144_S	147_K	0.631	0.92
128_V	175_L	0.629	0.92
268_I	282_K	0.628	0.92
34_E	38_K	0.627	0.92
190_V	208_C	0.625	0.92
43_G	66_Y	0.624	0.92
278_Y	282_K	0.624	0.92
193_D	197_F	0.622	0.92
105_G	109_S	0.622	0.92
173_E	177_G	0.620	0.92
268_I	291_I	0.616	0.91
76_L	98_L	0.613	0.91
216_D	219_R	0.612	0.91
107_T	110_D	0.609	0.91
121_V	175_L	0.608	0.91
7_G	62_L	0.607	0.91
233_D	249_S	0.606	0.91
209_I	213_R	0.605	0.91
74_F	251_K	0.605	0.91
33_Y	39_I	0.605	0.91
160_I	163_A	0.604	0.91
76_L	94_K	0.599	0.90
37_R	66_Y	0.598	0.90
144_S	149_N	0.597	0.90
132_L	169_L	0.593	0.90
79_F	101_S	0.592	0.90
182_I	186_L	0.591	0.90
144_S	157_G	0.585	0.89
268_I	294_C	0.585	0.89
125_I	175_L	0.583	0.89
145_L	155_R	0.582	0.89
235_V	246_R	0.582	0.89
143_D	150_L	0.581	0.89
10_V	54_Y	0.581	0.89
171_E	175_L	0.580	0.89
48_I	70_I	0.578	0.89
166_R	170_E	0.577	0.88
53_V	137_V	0.577	0.88
300_V	303_W	0.576	0.88
130_N	134_R	0.575	0.88
114_L	185_E	0.575	0.88
184_K	188_D	0.572	0.88
265_L	269_K	0.572	0.88
248_I	252_G	0.571	0.88
28_N	33_Y	0.568	0.88
87_S	238_S	0.568	0.88
276_R	279_E	0.567	0.88
128_V	168_L	0.566	0.87
188_D	191_S	0.564	0.87
131_R	134_R	0.563	0.87
119_D	209_I	0.562	0.87
128_V	171_E	0.561	0.87
228_A	233_D	0.560	0.87
34_E	37_R	0.560	0.87
121_V	178_R	0.560	0.87
18_Y	96_A	0.560	0.87
237_E	246_R	0.559	0.87
116_S	253_D	0.557	0.87
205_T	209_I	0.553	0.86
167_F	170_E	0.551	0.86
259_A	263_A	0.551	0.86
117_Q	131_R	0.548	0.86
258_R	261_Y	0.548	0.86
143_D	157_G	0.547	0.86
74_F	84_G	0.546	0.86
6_A	62_L	0.546	0.86
143_D	152_E	0.544	0.85
26_F	33_Y	0.543	0.85
214_V	230_C	0.543	0.85
260_F	295_A	0.542	0.85
144_S	148_K	0.541	0.85
202_I	263_A	0.539	0.85
120_F	164_E	0.539	0.85
233_D	257_R	0.538	0.85
307_Y	310_K	0.537	0.85
150_L	155_R	0.536	0.85
215_G	219_R	0.535	0.84
223_K	300_V	0.534	0.84
278_Y	291_I	0.532	0.84
227_V	300_V	0.531	0.84
301_I	304_A	0.530	0.84
223_K	303_W	0.530	0.84
35_E	39_I	0.529	0.84
48_I	95_L	0.527	0.84
35_E	38_K	0.524	0.83
121_V	125_I	0.524	0.83
271_N	275_K	0.524	0.83
271_N	276_R	0.521	0.83
279_E	282_K	0.520	0.83
122_T	183_E	0.519	0.83
41_P	66_Y	0.519	0.83
152_E	155_R	0.518	0.82
151_E	157_G	0.516	0.82
47_G	76_L	0.516	0.82
217_V	303_W	0.514	0.82
266_T	270_V	0.514	0.82
271_N	312_F	0.512	0.82
249_S	257_R	0.512	0.82
131_R	168_L	0.511	0.82
126_A	129_K	0.510	0.82
31_R	39_I	0.510	0.82
117_Q	128_V	0.508	0.81
11_S	240_G	0.505	0.81
97_E	100_V	0.503	0.81
77_K	81_D	0.502	0.81
71_I	95_L	0.502	0.81
111_A	186_L	0.502	0.81
248_I	293_A	0.502	0.81
173_E	176_E	0.500	0.80

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1hjrA	2	0.3323	92.4	0.934	Contact Map
4ep4A	2	0.3418	90.2	0.937	Contact Map
3c1yA	5	0.7532	88.8	0.939	Contact Map
1keaA	2	0.5981	86.9	0.941	Contact Map
4ofaA	1	0.4304	85.9	0.941	Contact Map
1nu0A	1	0.3133	84.6	0.943	Contact Map
3fhfA	1	0.6108	84.4	0.943	Contact Map
2a1jB	2	0.2437	82.6	0.944	Contact Map
1pu6A	1	0.5886	81	0.945	Contact Map
1z00A	1	0.2595	77.6	0.947	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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