GREMLIN Database
Q97WZ3 - Third ORF in transposon ISC1913
UniProt: Q97WZ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 410 (346)
Sequences: 4581 (2987)
Seq/√Len: 160.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
244_D248_K5.2991.00
326_P359_V4.2751.00
306_A313_V3.6641.00
270_P276_H3.1831.00
299_K315_L2.9791.00
189_V298_M2.9531.00
266_L302_I2.9431.00
265_V368_A2.9101.00
297_S301_A2.7251.00
251_K255_K2.7201.00
339_G342_P2.7071.00
3_R308_E2.6061.00
150_A162_F2.5521.00
320_Y323_T2.3601.00
324_V331_N2.3521.00
303_I315_L2.3511.00
208_T288_L2.3321.00
297_S300_N2.3301.00
254_V306_A2.3091.00
316_V364_L2.2641.00
298_M302_I2.2291.00
247_R304_E2.1951.00
367_R370_D2.1561.00
247_R301_A2.1441.00
38_L95_K2.1411.00
147_A167_K2.1191.00
264_I306_A2.1061.00
321_T364_L2.0951.00
346_V353_K2.0911.00
207_I241_K2.0241.00
229_V233_L2.0241.00
266_L313_V2.0131.00
35_N39_S2.0081.00
20_K154_L1.9841.00
283_D287_R1.9721.00
214_R229_V1.9471.00
12_D15_T1.9401.00
33_A72_C1.9041.00
323_T333_V1.8981.00
323_T338_G1.8951.00
278_I291_Y1.8761.00
325_C328_H1.8221.00
303_I307_R1.8171.00
328_H350_G1.8111.00
34_I75_A1.8001.00
189_V245_I1.7951.00
328_H347_C1.7951.00
343_R356_R1.7891.00
243_V297_S1.7811.00
247_R250_A1.7771.00
250_A301_A1.7711.00
262_S311_V1.7671.00
227_R230_R1.7561.00
284_K287_R1.7531.00
247_R305_K1.7431.00
21_E62_D1.7241.00
246_R301_A1.7151.00
20_K160_V1.7011.00
347_C350_G1.6981.00
8_R159_V1.6961.00
325_C347_C1.6851.00
327_I352_E1.6521.00
43_T46_T1.6341.00
182_V190_S1.6331.00
345_G354_W1.6251.00
86_K93_T1.6131.00
266_L299_K1.5921.00
325_C350_G1.5781.00
246_R297_S1.5781.00
217_A221_G1.5551.00
266_L315_L1.5441.00
224_T227_R1.5391.00
17_S21_E1.5191.00
268_D315_L1.5161.00
19_L160_V1.5051.00
191_V358_V1.4931.00
4_T163_Y1.4841.00
332_I338_G1.4771.00
188_S191_V1.4691.00
338_G342_P1.4341.00
362_Y366_R1.4321.00
344_V353_K1.4191.00
16_Y20_K1.4101.00
330_A348_E1.3901.00
76_S80_D1.3871.00
267_E318_P1.3811.00
250_A304_E1.3801.00
179_F365_A1.3801.00
214_R217_A1.3771.00
340_D343_R1.3681.00
345_G352_E1.3661.00
222_K226_D1.3621.00
33_A75_A1.3571.00
214_R236_L1.3511.00
218_I230_R1.3451.00
23_E160_V1.3441.00
221_G229_V1.3411.00
250_A305_K1.3381.00
332_I345_G1.3151.00
218_I229_V1.2971.00
42_T47_R1.2741.00
44_S47_R1.2631.00
70_T73_E1.2601.00
79_L95_K1.2581.00
303_I313_V1.2411.00
85_L93_T1.2341.00
332_I348_E1.2211.00
43_T47_R1.2151.00
192_L196_K1.2071.00
332_I337_D1.1961.00
81_S93_T1.1921.00
179_F263_A1.1911.00
197_P355_H1.1851.00
290_I295_F1.1841.00
270_P318_P1.1801.00
180_I192_L1.1781.00
277_M283_D1.1691.00
250_A298_M1.1511.00
339_G343_R1.1501.00
226_D230_R1.1491.00
54_K57_R1.1491.00
80_D84_K1.1491.00
77_E81_S1.1471.00
251_K309_F1.1431.00
184_L295_F1.1411.00
196_K252_L1.1391.00
278_I283_D1.1391.00
193_I361_L1.1371.00
316_V367_R1.1361.00
326_P362_Y1.1321.00
326_P354_W1.1271.00
254_V309_F1.1251.00
137_W140_Y1.1241.00
13_Y16_Y1.1161.00
26_Y71_A1.1151.00
358_V362_Y1.1001.00
277_M287_R1.1001.00
211_Y233_L1.0991.00
230_R234_K1.0951.00
191_V197_P1.0951.00
210_G214_R1.0951.00
301_A304_E1.0941.00
153_R163_Y1.0760.99
81_S86_K1.0740.99
324_V367_R1.0740.99
57_R68_I1.0720.99
243_V301_A1.0700.99
108_H111_K1.0660.99
321_T367_R1.0620.99
11_V15_T1.0510.99
354_W362_Y1.0500.99
30_L71_A1.0490.99
186_E293_S1.0360.99
340_D356_R1.0330.99
182_V192_L1.0290.99
276_H283_D1.0270.99
218_I233_L1.0230.99
181_P365_A1.0230.99
215_R219_T1.0190.99
125_R133_P1.0180.99
28_E32_D1.0100.99
339_G356_R1.0090.99
155_M159_V1.0060.99
64_P67_Y1.0050.99
74_D151_R1.0020.99
207_I238_E1.0010.99
246_R298_M1.0000.99
38_L79_L1.0000.99
176_P262_S0.9960.99
136_F140_Y0.9920.99
66_H70_T0.9910.99
118_S127_L0.9910.99
316_V368_A0.9880.99
179_F369_G0.9860.99
81_S85_L0.9810.99
50_A53_Y0.9790.99
250_A302_I0.9790.99
85_L94_E0.9770.99
271_R296_S0.9730.99
330_A349_K0.9730.99
326_P352_E0.9730.99
11_V19_L0.9730.99
184_L299_K0.9690.99
255_K309_F0.9670.99
46_T50_A0.9610.99
239_R243_V0.9610.99
246_R250_A0.9530.99
323_T331_N0.9530.99
254_V311_V0.9490.99
263_A312_P0.9490.99
103_I107_D0.9470.99
6_K155_M0.9430.99
338_G345_G0.9410.99
305_K308_E0.9380.98
300_N303_I0.9380.98
212_E215_R0.9320.98
54_K72_C0.9310.98
55_T59_K0.9310.98
36_Y40_N0.9300.98
57_R60_H0.9280.98
268_D318_P0.9250.98
354_W358_V0.9210.98
343_R355_H0.9160.98
213_Y217_A0.9150.98
7_L162_F0.9100.98
283_D286_L0.9090.98
102_T106_D0.9080.98
276_H287_R0.9060.98
211_Y215_R0.9060.98
326_P366_R0.9050.98
49_K53_Y0.9050.98
34_I79_L0.8970.98
254_V264_I0.8940.98
113_N116_T0.8930.98
279_K283_D0.8920.98
197_P358_V0.8910.98
45_F49_K0.8900.98
342_P356_R0.8900.98
265_V364_L0.8890.98
107_D111_K0.8890.98
30_L75_A0.8770.98
188_S199_L0.8760.98
318_P321_T0.8760.98
42_T45_F0.8760.98
69_Y73_E0.8750.98
237_R241_K0.8700.98
5_V166_F0.8670.97
203_N241_K0.8620.97
82_F95_K0.8600.97
106_D112_F0.8560.97
113_N117_I0.8520.97
342_P345_G0.8500.97
203_N207_I0.8500.97
37_G76_S0.8470.97
32_D36_Y0.8460.97
81_S84_K0.8460.97
74_D111_K0.8450.97
190_S249_L0.8390.97
271_R295_F0.8370.97
24_K27_R0.8350.97
184_L190_S0.8340.97
217_A220_T0.8330.97
359_V363_N0.8290.97
296_S300_N0.8290.97
72_C76_S0.8280.97
286_L290_I0.8280.97
188_S197_P0.8280.97
327_I362_Y0.8270.97
214_R233_L0.8270.97
128_I131_T0.8260.97
253_I264_I0.8260.97
211_Y219_T0.8250.97
179_F265_V0.8220.97
24_K28_E0.8210.96
306_A311_V0.8190.96
344_V354_W0.8190.96
332_I339_G0.8170.96
128_I134_K0.8150.96
246_R294_A0.8150.96
360_A363_N0.8150.96
212_E216_K0.8140.96
180_I193_I0.8140.96
36_Y51_G0.8140.96
66_H113_N0.8140.96
103_I106_D0.8140.96
333_V337_D0.8140.96
198_L249_L0.8120.96
320_Y367_R0.8090.96
50_A54_K0.8090.96
178_A262_S0.8050.96
314_V368_A0.8040.96
148_S165_I0.8040.96
37_G79_L0.8030.96
358_V361_L0.7970.96
223_S226_D0.7960.96
215_R233_L0.7950.96
66_H69_Y0.7950.96
269_L318_P0.7940.96
63_L66_H0.7930.96
79_L83_E0.7880.96
337_D342_P0.7870.96
43_T48_I0.7860.96
151_R163_Y0.7850.95
218_I221_G0.7830.95
70_T74_D0.7780.95
16_Y160_V0.7770.95
229_V232_K0.7750.95
52_V72_C0.7750.95
362_Y365_A0.7740.95
114_L118_S0.7740.95
9_V162_F0.7740.95
326_P360_A0.7730.95
180_I264_I0.7720.95
211_Y238_E0.7680.95
106_D110_W0.7680.95
252_L260_S0.7680.95
82_F96_P0.7670.95
131_T134_K0.7650.95
187_N191_V0.7620.95
338_G356_R0.7600.95
107_D110_W0.7600.95
225_K228_E0.7580.95
136_F139_Y0.7570.95
177_K262_S0.7550.94
323_T339_G0.7520.94
249_L252_L0.7510.94
25_E63_L0.7480.94
129_S134_K0.7470.94
263_A314_V0.7440.94
130_P134_K0.7420.94
29_V71_A0.7410.94
221_G225_K0.7370.94
30_L78_R0.7370.94
120_S123_R0.7340.94
49_K73_E0.7330.94
268_D299_K0.7330.94
53_Y56_E0.7310.93
245_I249_L0.7300.93
251_K305_K0.7290.93
53_Y57_R0.7290.93
44_S48_I0.7280.93
324_V363_N0.7270.93
183_D357_D0.7250.93
22_V26_Y0.7230.93
25_E28_E0.7230.93
79_L82_F0.7200.93
145_R167_K0.7190.93
122_K125_R0.7180.93
141_N144_W0.7180.93
128_I132_F0.7140.93
19_L23_E0.7140.93
75_A79_L0.7130.93
238_E292_R0.7120.93
367_R371_V0.7100.92
154_L160_V0.7090.92
71_A75_A0.7080.92
323_T337_D0.7070.92
207_I211_Y0.7060.92
186_E289_R0.7050.92
152_F162_F0.7050.92
13_Y17_S0.7050.92
264_I302_I0.7020.92
207_I237_R0.7010.92
102_T107_D0.7010.92
43_T52_V0.6990.92
117_I120_S0.6990.92
82_F85_L0.6980.92
330_A333_V0.6980.92
226_D229_V0.6970.92
265_V314_V0.6950.92
54_K58_E0.6950.92
200_L293_S0.6930.91
49_K52_V0.6920.91
278_I287_R0.6900.91
227_R231_R0.6890.91
128_I152_F0.6880.91
8_R161_E0.6870.91
175_E178_A0.6850.91
21_E25_E0.6830.91
36_Y39_S0.6830.91
144_W166_F0.6820.91
49_K72_C0.6820.91
18_A22_V0.6810.91
302_I313_V0.6800.91
63_L68_I0.6770.91
45_F48_I0.6750.90
123_R129_S0.6740.90
200_L203_N0.6740.90
189_V250_A0.6730.90
138_R142_T0.6700.90
22_V63_L0.6650.90
18_A21_E0.6650.90
222_K225_K0.6640.90
46_T49_K0.6640.90
242_K292_R0.6620.90
255_K263_A0.6620.90
338_G343_R0.6620.90
190_S198_L0.6620.90
345_G356_R0.6600.89
320_Y331_N0.6600.89
277_M284_K0.6580.89
138_R141_N0.6580.89
41_K79_L0.6550.89
204_T207_I0.6540.89
246_R249_L0.6530.89
191_V198_L0.6510.89
36_Y56_E0.6500.89
222_K227_R0.6490.89
53_Y58_E0.6490.89
33_A56_E0.6490.89
323_T332_I0.6480.89
40_N44_S0.6450.88
320_Y324_V0.6440.88
185_N191_V0.6400.88
322_S338_G0.6400.88
126_I129_S0.6400.88
333_V338_G0.6400.88
109_L112_F0.6400.88
216_K220_T0.6380.88
368_A372_S0.6350.88
22_V64_P0.6340.87
284_K291_Y0.6330.87
225_K232_K0.6330.87
173_P176_P0.6300.87
54_K60_H0.6270.87
265_V365_A0.6270.87
106_D109_L0.6270.87
243_V247_R0.6250.87
219_T233_L0.6240.87
330_A345_G0.6240.87
189_V293_S0.6220.86
6_K153_R0.6220.86
265_V367_R0.6220.86
271_R290_I0.6200.86
178_A261_R0.6200.86
35_N38_L0.6190.86
45_F73_E0.6170.86
317_N320_Y0.6170.86
322_S339_G0.6150.86
42_T46_T0.6090.85
340_D355_H0.6080.85
35_N98_V0.6050.85
113_N118_S0.6040.85
178_A194_N0.6030.85
201_E245_I0.6010.85
205_K288_L0.6000.84
14_S17_S0.5980.84
155_M161_E0.5980.84
181_P265_V0.5980.84
159_V240_N0.5960.84
366_R371_V0.5960.84
51_G54_K0.5960.84
102_T109_L0.5960.84
214_R232_K0.5960.84
193_I358_V0.5950.84
119_I128_I0.5940.84
4_T153_R0.5940.84
327_I354_W0.5930.84
129_S135_I0.5910.84
29_V68_I0.5900.83
190_S298_M0.5890.83
123_R128_I0.5870.83
238_E242_K0.5860.83
230_R236_L0.5860.83
324_V345_G0.5840.83
107_D112_F0.5840.83
340_D344_V0.5830.83
53_Y69_Y0.5820.83
37_G40_N0.5820.83
304_E308_E0.5810.83
122_K129_S0.5800.82
41_K82_F0.5780.82
332_I342_P0.5770.82
306_A309_F0.5730.82
183_D322_S0.5710.81
346_V352_E0.5690.81
41_K83_E0.5680.81
51_G55_T0.5670.81
324_V329_G0.5660.81
240_N243_V0.5630.81
173_P311_V0.5610.80
117_I129_S0.5610.80
212_E219_T0.5590.80
126_I162_F0.5590.80
120_S127_L0.5590.80
189_V246_R0.5580.80
11_V16_Y0.5580.80
205_K289_R0.5570.80
68_I71_A0.5550.80
354_W359_V0.5550.80
369_G372_S0.5530.79
364_L367_R0.5520.79
204_T208_T0.5510.79
286_L289_R0.5490.79
218_I226_D0.5460.78
248_K251_K0.5450.78
328_H332_I0.5440.78
4_T165_I0.5430.78
220_T229_V0.5410.78
110_W114_L0.5410.78
187_N343_R0.5410.78
49_K56_E0.5410.78
6_K163_Y0.5400.78
72_C75_A0.5400.78
127_L133_P0.5400.78
66_H115_D0.5400.78
70_T111_K0.5390.78
301_A305_K0.5370.77
36_Y52_V0.5370.77
216_K219_T0.5370.77
83_E86_K0.5350.77
42_T48_I0.5310.77
215_R220_T0.5300.76
332_I356_R0.5290.76
212_E288_L0.5280.76
6_K243_V0.5280.76
116_T129_S0.5220.75
127_L130_P0.5220.75
276_H279_K0.5210.75
53_Y60_H0.5210.75
233_L236_L0.5200.75
198_L245_I0.5190.75
206_K209_L0.5190.75
296_S299_K0.5190.75
14_S18_A0.5180.75
204_T288_L0.5180.75
52_V69_Y0.5160.75
283_D290_I0.5150.74
205_K208_T0.5120.74
147_A165_I0.5110.74
116_T119_I0.5100.74
366_R369_G0.5090.74
139_Y142_T0.5090.74
230_R233_L0.5080.73
181_P361_L0.5070.73
106_D111_K0.5050.73
322_S332_I0.5020.73
207_I236_L0.5020.73
202_T211_Y0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.3122 89 0.942 Contact Map
1vhxA 2 0.3293 88.4 0.943 Contact Map
1qypA 1 0.1195 86.5 0.945 Contact Map
3j20Y 1 0.122 86.3 0.945 Contact Map
4aybP 1 0.1073 84.4 0.946 Contact Map
1vq8Z 1 0.178 84.1 0.946 Contact Map
1vd4A 1 0.1439 82.6 0.947 Contact Map
1ffkW 1 0.1756 82.1 0.948 Contact Map
2k4xA 1 0.1341 80.9 0.948 Contact Map
1iv0A 1 0.2317 78.2 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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