GREMLIN Database
Q97WZ0 - Uncharacterized protein
UniProt: Q97WZ0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 132 (121)
Sequences: 108 (94)
Seq/√Len: 8.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_A97_I3.4700.95
26_A114_Y2.7800.85
102_L113_I2.6530.82
103_V123_V2.5660.80
30_V37_G2.4660.77
18_G24_K2.3420.73
7_F37_G2.3020.72
30_V71_P2.0690.63
11_F98_V2.0420.62
103_V113_I2.0150.61
40_L105_F1.8820.55
43_N115_T1.8760.55
53_K116_T1.8100.52
82_A115_T1.7490.50
38_Y60_A1.6800.47
102_L116_T1.6450.45
12_F47_F1.5920.43
14_V19_L1.5840.43
10_G116_T1.5820.43
97_I101_F1.5800.43
6_L14_V1.5750.42
37_G71_P1.5730.42
16_F53_K1.5410.41
9_T15_Y1.5200.40
6_L40_L1.4890.39
102_L115_T1.4650.38
48_L60_A1.4320.37
7_F72_I1.4120.36
78_N108_K1.3710.34
40_L116_T1.3690.34
48_L53_K1.3680.34
27_V70_S1.3300.33
15_Y83_L1.2840.31
16_F116_T1.2640.30
97_I115_T1.2640.30
11_F19_L1.2430.30
10_G115_T1.2400.29
44_L106_A1.2290.29
45_A101_F1.2250.29
67_I88_L1.2080.28
43_N101_F1.1920.28
10_G102_L1.1900.28
10_G82_A1.1870.28
24_K87_E1.1710.27
21_E24_K1.1670.27
63_R104_A1.1620.27
45_A115_T1.1500.26
12_F45_A1.1430.26
34_K104_A1.1420.26
10_G45_A1.1350.26
43_N102_L1.1270.26
36_V73_K1.1260.26
22_E25_K1.1220.25
4_K22_E1.1060.25
51_Y63_R1.0990.25
23_A27_V1.0980.25
74_I88_L1.0980.25
35_S63_R1.0790.24
67_I114_Y1.0620.24
24_K33_G1.0440.23
7_F122_R1.0380.23
50_T118_S1.0320.23
29_E34_K1.0280.23
13_H45_A1.0150.22
92_Y105_F1.0120.22
13_H19_L1.0020.22
60_A85_A0.9920.22
42_L97_I0.9900.21
41_D103_V0.9850.21
45_A116_T0.9840.21
101_F116_T0.9800.21
51_Y113_I0.9770.21
88_L92_Y0.9710.21
16_F85_A0.9710.21
6_L105_F0.9690.21
16_F51_Y0.9670.21
31_Y103_V0.9620.21
10_G113_I0.9610.21
68_L86_G0.9460.20
5_I69_N0.9280.20
63_R100_C0.9240.20
26_A106_A0.9160.19
96_S103_V0.9040.19
82_A116_T0.9030.19
11_F115_T0.8920.19
94_N124_Y0.8910.19
47_F61_N0.8900.19
12_F102_L0.8890.19
7_F110_N0.8870.19
96_S108_K0.8840.19
96_S106_A0.8830.19
53_K102_L0.8790.18
4_K18_G0.8690.18
48_L61_N0.8630.18
51_Y98_V0.8570.18
38_Y113_I0.8540.18
38_Y109_E0.8470.18
56_G111_T0.8370.17
42_L45_A0.8230.17
121_K124_Y0.8090.17
8_D99_D0.8090.17
91_K106_A0.8060.17
101_F115_T0.7930.16
4_K36_V0.7910.16
68_L95_L0.7840.16
13_H25_K0.7840.16
17_S86_G0.7780.16
9_T121_K0.7690.16
95_L120_I0.7630.16
84_R87_E0.7620.16
10_G97_I0.7590.16
100_C105_F0.7580.16
18_G113_I0.7520.15
73_K76_S0.7500.15
94_N112_V0.7410.15
86_G100_C0.7380.15
40_L43_N0.7330.15
74_I95_L0.7330.15
11_F45_A0.7260.15
82_A102_L0.7250.15
9_T118_S0.7240.15
92_Y104_A0.7240.15
15_Y39_T0.7220.15
50_T105_F0.7100.15
90_V113_I0.7100.15
9_T116_T0.7000.14
27_V120_I0.6980.14
72_I75_V0.6950.14
8_D19_L0.6880.14
26_A29_E0.6740.14
45_A82_A0.6740.14
75_V104_A0.6680.14
27_V104_A0.6670.14
78_N81_L0.6660.14
5_I92_Y0.6650.14
78_N101_F0.6650.14
33_G38_Y0.6650.14
118_S121_K0.6630.14
42_L66_L0.6540.13
65_S83_L0.6470.13
5_I27_V0.6460.13
84_R107_E0.6420.13
26_A90_V0.6410.13
51_Y84_R0.6390.13
44_L110_N0.6370.13
9_T13_H0.6350.13
100_C122_R0.6320.13
17_S39_T0.6250.13
5_I123_V0.6250.13
61_N120_I0.6200.13
29_E95_L0.6180.13
25_K113_I0.6080.13
67_I125_K0.6060.13
83_L86_G0.6050.12
43_N116_T0.6040.12
11_F48_L0.6010.12
59_E80_E0.5920.12
81_L84_R0.5880.12
23_A120_I0.5820.12
80_E123_V0.5730.12
14_V27_V0.5710.12
102_L121_K0.5690.12
55_N66_L0.5650.12
11_F90_V0.5640.12
90_V98_V0.5630.12
90_V119_E0.5620.12
64_L113_I0.5610.12
13_H37_G0.5600.12
26_A118_S0.5470.11
18_G33_G0.5430.11
23_A28_E0.5350.11
4_K29_E0.5340.11
35_S84_R0.5310.11
31_Y86_G0.5290.11
71_P113_I0.5280.11
64_L80_E0.5260.11
62_V110_N0.5210.11
5_I39_T0.5190.11
34_K78_N0.5150.11
62_V77_T0.5070.11
86_G89_K0.5040.11
20_N50_T0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zvkA 3 0.9545 99.6 0.639 Contact Map
2h1cA 2 0.9394 99.6 0.646 Contact Map
3tndA 3 0.947 99.6 0.647 Contact Map
1w8iA 2 0.9697 99.6 0.649 Contact Map
1v96A 2 0.9394 99.6 0.651 Contact Map
1v8pA 4 0.8939 99.5 0.661 Contact Map
3h87A 3 0.9318 99.5 0.666 Contact Map
3dboB 1 0.8939 99.5 0.666 Contact Map
2fe1A 2 0.9091 99.5 0.666 Contact Map
4chgA 2 0.9318 99.4 0.691 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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