GREMLIN Database
Q97WY7 - Second ORF in transposon ISC1190
UniProt: Q97WY7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 159 (149)
Sequences: 4811 (3525)
Seq/√Len: 288.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_F142_A2.5111.00
124_H127_R2.4311.00
41_T154_P2.3221.00
38_L154_P2.2871.00
17_R21_R2.2581.00
10_F21_R2.2421.00
13_E21_R2.1481.00
73_C99_L2.1051.00
14_E17_R2.0821.00
53_I145_T2.0711.00
57_V69_F2.0661.00
91_I135_T2.0541.00
15_L19_E2.0511.00
64_S68_R2.0481.00
125_K131_K2.0211.00
118_K122_E1.9971.00
139_R143_V1.9001.00
81_S86_V1.8831.00
65_D68_R1.7591.00
75_L138_A1.7481.00
52_I102_A1.7101.00
14_E21_R1.7051.00
128_L132_K1.6971.00
73_C142_A1.6931.00
38_L148_V1.6721.00
117_I137_C1.6711.00
63_F72_Y1.6431.00
105_L108_L1.6231.00
40_F47_K1.5811.00
42_I145_T1.5711.00
153_K156_D1.5611.00
70_V76_D1.5481.00
12_L16_E1.5471.00
123_D127_R1.5421.00
49_L102_A1.5371.00
147_A151_Y1.5241.00
28_E31_N1.5071.00
120_F140_K1.5051.00
45_I50_G1.5011.00
19_E22_K1.4521.00
22_K26_E1.4441.00
39_I145_T1.4281.00
129_K132_K1.4181.00
104_Y138_A1.4111.00
146_W150_Y1.4041.00
38_L41_T1.4011.00
56_R96_D1.3951.00
30_E47_K1.3951.00
148_V154_P1.3821.00
117_I144_I1.3781.00
121_Y137_C1.3781.00
122_E126_G1.3621.00
70_V139_R1.3621.00
49_L106_A1.3341.00
42_I148_V1.3131.00
23_R26_E1.3031.00
111_I121_Y1.2681.00
42_I141_L1.2291.00
107_A137_C1.2291.00
120_F124_H1.2101.00
101_R105_L1.1781.00
10_F14_E1.1631.00
33_V40_F1.1611.00
144_I148_V1.1561.00
23_R27_K1.1491.00
21_R24_E1.1361.00
107_A138_A1.1301.00
121_Y133_L1.1261.00
107_A141_L1.1241.00
115_L119_R1.1171.00
17_R20_G1.1151.00
120_F137_C1.1131.00
60_V149_L1.1101.00
124_H133_L1.1031.00
104_Y135_T1.0841.00
14_E18_L1.0781.00
106_A141_L1.0701.00
104_Y108_L1.0691.00
13_E17_R1.0671.00
26_E30_E1.0461.00
56_R98_V1.0361.00
120_F123_D1.0301.00
82_S86_V1.0261.00
10_F24_E1.0161.00
147_A150_Y0.9921.00
125_K130_G0.9861.00
10_F28_E0.9841.00
107_A134_I0.9801.00
57_V60_V0.9781.00
125_K133_L0.9661.00
40_F50_G0.9481.00
131_K134_I0.9461.00
103_F142_A0.9421.00
31_N35_K0.9381.00
19_E23_R0.9371.00
39_I149_L0.9341.00
13_E20_G0.9301.00
124_H129_K0.9181.00
28_E32_V0.9161.00
67_K139_R0.9121.00
108_L111_I0.9021.00
119_R123_D0.8791.00
108_L131_K0.8781.00
45_I145_T0.8771.00
27_K31_N0.8631.00
79_V86_V0.8631.00
115_L118_K0.8611.00
45_I49_L0.8591.00
33_V36_D0.8591.00
18_L22_K0.8501.00
30_E34_S0.8421.00
129_K133_L0.8261.00
110_A117_I0.8201.00
124_H128_L0.8151.00
20_G24_E0.8070.99
39_I50_G0.8050.99
68_R71_A0.7970.99
26_E29_L0.7950.99
78_V92_S0.7920.99
72_Y96_D0.7910.99
123_D126_G0.7880.99
93_K100_R0.7870.99
135_T138_A0.7870.99
117_I141_L0.7830.99
91_I100_R0.7820.99
120_F136_A0.7810.99
81_S87_V0.7790.99
53_I99_L0.7640.99
65_D146_W0.7610.99
108_L134_I0.7610.99
75_L139_R0.7570.99
116_V155_F0.7530.99
76_D92_S0.7380.99
27_K30_E0.7320.99
80_E85_S0.7310.99
76_D79_V0.7260.99
52_I56_R0.7210.99
66_K143_V0.7210.99
70_V143_V0.7170.99
25_I28_E0.7160.99
76_D100_R0.7140.99
45_I141_L0.7130.99
76_D93_K0.7130.99
38_L152_N0.7050.99
11_L14_E0.7040.99
16_E19_E0.7030.99
148_V153_K0.7010.99
71_A76_D0.7000.99
111_I125_K0.6980.99
124_H136_A0.6950.98
119_R122_E0.6950.98
91_I136_A0.6850.98
95_G100_R0.6810.98
113_V118_K0.6750.98
143_V146_W0.6700.98
24_E27_K0.6660.98
45_I53_I0.6610.98
61_R150_Y0.6580.98
20_G23_R0.6510.98
24_E28_E0.6460.98
48_T52_I0.6430.98
145_T148_V0.6430.98
108_L138_A0.6380.97
78_V89_R0.6360.97
101_R104_Y0.6320.97
60_V146_W0.6270.97
74_G100_R0.6240.97
144_I147_A0.6240.97
9_R12_L0.6210.97
18_L21_R0.6210.97
42_I45_I0.6160.97
125_K128_L0.6140.97
102_A106_A0.6060.96
10_F13_E0.6020.96
66_K146_W0.6020.96
15_L18_L0.6000.96
36_D50_G0.5990.96
121_Y125_K0.5960.96
76_D94_K0.5950.96
57_V73_C0.5870.96
105_L109_T0.5810.95
106_A138_A0.5780.95
109_T113_V0.5780.95
122_E125_K0.5750.95
84_K87_V0.5710.95
36_D40_F0.5690.95
79_V88_S0.5690.95
44_G109_T0.5690.95
111_I131_K0.5690.95
15_L22_K0.5670.95
36_D51_C0.5660.95
111_I134_I0.5610.95
15_L26_E0.5580.94
108_L112_K0.5570.94
23_R31_N0.5540.94
103_F138_A0.5480.94
16_E20_G0.5460.94
105_L131_K0.5460.94
100_R135_T0.5430.94
92_S95_G0.5420.94
66_K70_V0.5380.93
92_S100_R0.5330.93
52_I98_V0.5310.93
81_S85_S0.5310.93
133_L137_C0.5300.93
13_E24_E0.5280.93
15_L27_K0.5270.93
85_S88_S0.5260.93
51_C98_V0.5250.92
103_F145_T0.5230.92
73_C96_D0.5200.92
106_A110_A0.5200.92
116_V144_I0.5140.92
70_V75_L0.5110.91
47_K51_C0.5090.91
140_K143_V0.5080.91
15_L23_R0.5050.91
59_D62_R0.5050.91
38_L42_I0.5050.91
18_L34_S0.5040.91
41_T148_V0.5030.91
70_V79_V0.5020.91
105_L138_A0.5010.91
114_N118_K0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1keaA 2 0.8302 89.1 0.888 Contact Map
3c65A 1 0.1258 88.9 0.888 Contact Map
3fhfA 1 0.761 88 0.89 Contact Map
1pu6A 1 0.7547 87.2 0.891 Contact Map
2i5hA 1 0.6226 86.5 0.893 Contact Map
3n0uA 1 0.7736 85.5 0.894 Contact Map
4ofaA 1 0.522 85 0.895 Contact Map
2a1jB 2 0.4843 85 0.895 Contact Map
2nrtA 1 0.5409 83.4 0.897 Contact Map
2bgwA 2 0.5786 81.5 0.899 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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