GREMLIN Database
Q97WY6 - Uncharacterized protein
UniProt: Q97WY6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 382 (343)
Sequences: 4686 (3036)
Seq/√Len: 163.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
249_D253_K5.1991.00
329_P356_I4.4171.00
276_K280_K4.1791.00
309_A316_V3.5671.00
272_L305_I3.1341.00
271_K365_G3.0441.00
302_Q318_F2.9351.00
189_V301_L2.9331.00
256_K260_D2.8501.00
300_R304_W2.8121.00
323_Y326_V2.4841.00
306_S318_F2.4071.00
152_A163_L2.3951.00
327_S334_R2.3931.00
300_R303_Y2.3401.00
259_V309_A2.3011.00
319_V361_L2.2931.00
208_V291_D2.2681.00
301_L305_I2.2271.00
270_I309_A2.2141.00
252_R307_W2.2031.00
282_V294_Y2.1751.00
252_R304_W2.1381.00
364_R367_L2.1381.00
328_C331_C2.1281.00
331_C347_C2.1221.00
150_K168_E2.1031.00
324_S361_L2.0751.00
272_L316_V1.9991.00
344_K350_E1.9981.00
341_R353_R1.9911.00
39_F43_E1.9791.00
331_C345_C1.9371.00
24_L156_I1.9301.00
214_L232_I1.9291.00
248_E300_R1.9281.00
16_K19_L1.9251.00
286_S290_R1.9251.00
268_N314_M1.8981.00
54_L58_H1.8731.00
37_T80_Y1.8711.00
287_K290_R1.8711.00
326_V336_V1.8691.00
252_R308_Q1.8471.00
38_L83_A1.8471.00
232_I236_V1.8401.00
255_G304_W1.8381.00
328_C347_C1.8151.00
252_R255_G1.8101.00
24_L161_A1.7891.00
25_V70_N1.7651.00
189_V250_F1.7411.00
328_C345_C1.7371.00
251_A304_W1.7291.00
343_F351_N1.7241.00
124_V163_L1.6911.00
306_S310_K1.6861.00
55_S58_H1.6711.00
272_L318_F1.6671.00
12_T160_K1.6561.00
330_K349_Y1.6091.00
182_V190_V1.5841.00
338_V341_R1.5741.00
207_E246_I1.5731.00
227_R230_K1.5721.00
54_L81_R1.5721.00
217_R221_K1.5701.00
62_Y65_L1.5641.00
225_R229_N1.5611.00
251_A300_R1.5551.00
23_L161_A1.5401.00
272_L302_Q1.5391.00
274_S318_F1.5341.00
55_S59_E1.5331.00
273_E321_P1.5321.00
255_G307_W1.4871.00
230_K233_L1.4831.00
93_N96_R1.4581.00
335_M343_F1.4571.00
179_S362_N1.4431.00
62_Y66_R1.4141.00
21_E25_V1.4071.00
192_G196_K1.3941.00
191_V355_V1.3921.00
8_A164_K1.3901.00
343_F349_Y1.3841.00
342_W350_E1.3831.00
125_R131_E1.3671.00
241_L245_R1.3621.00
20_S24_L1.3441.00
93_N97_G1.3411.00
218_L233_L1.3401.00
74_K111_P1.3391.00
306_S316_V1.3351.00
37_T83_A1.3351.00
160_K241_L1.3291.00
359_M363_G1.3171.00
59_E62_Y1.3081.00
221_K232_I1.3031.00
84_L88_K1.2991.00
180_I192_G1.2841.00
255_G308_Q1.2841.00
255_G301_L1.2831.00
329_P359_M1.2701.00
89_G96_R1.2661.00
27_V161_A1.2541.00
259_V312_R1.2521.00
74_K113_A1.2441.00
158_D241_L1.2331.00
61_L80_Y1.2281.00
188_E191_V1.2261.00
61_L65_L1.2211.00
329_P351_N1.2201.00
92_N96_R1.2131.00
53_V56_K1.2121.00
293_L298_Y1.2031.00
182_V192_G1.2001.00
110_T126_I1.1991.00
30_Y79_C1.1961.00
218_L221_K1.1791.00
82_E109_L1.1761.00
123_T131_E1.1751.00
58_H80_Y1.1751.00
338_V353_R1.1701.00
214_L239_F1.1691.00
78_D81_R1.1581.00
85_A89_G1.1571.00
58_H81_R1.1411.00
179_S269_V1.1401.00
176_P268_N1.1371.00
17_I20_S1.1351.00
184_I298_Y1.1261.00
340_H353_R1.1221.00
251_A301_L1.1211.00
82_E153_R1.1161.00
251_A255_G1.1141.00
355_V359_M1.1131.00
326_V334_R1.1111.00
308_Q311_K1.1091.00
217_R220_K1.1021.00
34_L79_C1.0991.00
41_L57_V1.0901.00
181_A362_N1.0891.00
88_K92_N1.0851.00
15_M19_L1.0841.00
40_W60_A1.0831.00
304_W307_W1.0791.00
276_K321_P1.0770.99
255_G305_I1.0740.99
219_L223_P1.0730.99
42_K46_P1.0670.99
329_P349_Y1.0600.99
126_I154_L1.0540.99
248_E304_W1.0450.99
327_S364_R1.0410.99
229_N233_L1.0390.99
54_L80_Y1.0360.99
134_I137_Y1.0350.99
337_E340_H1.0350.99
341_R352_D1.0330.99
89_G93_N1.0300.99
259_V270_I1.0290.99
319_V364_R1.0200.99
186_M296_M1.0190.99
155_V164_K1.0160.99
197_N352_D1.0060.99
205_L208_V1.0050.99
72_P75_V0.9980.99
343_F353_R0.9980.99
244_R248_E0.9950.99
184_I302_Q0.9910.99
212_K216_E0.9900.99
9_I167_F0.9810.99
256_K312_R0.9790.99
207_E243_A0.9750.99
321_P324_S0.9630.99
260_D312_R0.9590.99
210_H214_L0.9530.99
74_K78_D0.9490.99
259_V314_M0.9490.99
212_K215_A0.9480.99
28_N31_V0.9470.99
108_W112_R0.9470.99
319_V365_G0.9460.99
211_W236_V0.9460.99
73_S113_A0.9450.99
351_N359_M0.9450.99
15_M23_L0.9340.99
34_L83_A0.9300.99
324_S364_R0.9300.99
329_P357_A0.9280.98
38_L87_Y0.9270.98
215_A219_L0.9160.98
211_W219_L0.9150.98
333_K346_S0.9110.98
351_N355_V0.9110.98
282_V286_S0.9080.98
214_L217_R0.9070.98
89_G97_G0.9040.98
337_E343_F0.9040.98
257_W266_G0.9020.98
214_L236_V0.9010.98
323_Y334_R0.9000.98
274_S321_P0.9000.98
32_K36_F0.8990.98
239_F243_A0.8990.98
116_N125_R0.8980.98
42_K87_Y0.8980.98
58_H62_Y0.8950.98
39_F102_V0.8920.98
119_F122_M0.8910.98
89_G92_N0.8900.98
271_K361_L0.8900.98
90_W100_P0.8860.98
340_H343_F0.8840.98
269_V315_T0.8830.98
118_D125_R0.8830.98
188_E199_V0.8820.98
222_Y225_R0.8820.98
193_K358_I0.8810.98
303_Y306_S0.8780.98
258_V270_I0.8760.98
286_S289_F0.8730.98
34_L86_T0.8680.98
153_R164_K0.8680.98
309_A314_M0.8630.98
235_R238_S0.8620.98
282_V290_R0.8610.98
179_S366_S0.8590.97
40_W44_N0.8590.97
11_A163_L0.8570.97
20_S161_A0.8560.97
193_K355_V0.8540.97
116_N119_F0.8540.97
356_I360_N0.8530.97
74_K112_R0.8530.97
286_S294_Y0.8530.97
357_A360_N0.8530.97
342_W351_N0.8530.97
180_I270_I0.8520.97
191_V197_N0.8500.97
61_L77_E0.8480.97
200_R203_T0.8450.97
179_S271_K0.8430.97
129_V132_L0.8420.97
93_N98_R0.8420.97
108_W111_P0.8410.97
42_K99_F0.8390.97
37_T57_V0.8380.97
333_K343_F0.8370.97
36_F40_W0.8360.97
156_I161_A0.8350.97
277_N299_R0.8350.97
77_E81_R0.8310.97
299_R303_Y0.8310.97
242_K246_I0.8270.97
289_F293_L0.8250.97
218_L232_I0.8240.97
114_S117_V0.8240.97
329_P363_G0.8160.97
269_V317_E0.8140.97
188_E197_N0.8140.97
28_N32_K0.8130.97
203_T246_I0.8120.96
355_V358_I0.8090.96
180_I267_V0.8060.96
274_S302_Q0.8050.96
41_L84_L0.8030.96
65_L76_A0.8030.96
54_L57_V0.7980.96
256_K308_Q0.7960.96
154_L163_L0.7960.96
213_S217_R0.7930.96
211_W215_A0.7920.96
48_P51_K0.7920.96
78_D111_P0.7900.96
178_E268_N0.7880.96
359_M362_N0.7880.96
186_M292_K0.7860.96
184_I190_V0.7840.96
219_L222_Y0.7830.96
114_S127_V0.7830.96
275_L321_P0.7820.96
177_K268_N0.7820.96
251_A297_Q0.7800.96
147_W167_F0.7800.96
23_L27_V0.7770.95
71_L74_K0.7770.95
44_N48_P0.7740.95
44_N52_G0.7710.95
40_W43_E0.7690.95
330_K359_M0.7680.95
78_D82_E0.7640.95
187_A191_V0.7640.95
285_L289_F0.7600.95
250_F254_V0.7590.95
92_N97_G0.7590.95
151_E166_V0.7580.95
183_D354_D0.7530.95
323_Y364_R0.7510.95
338_V352_D0.7510.95
74_K77_E0.7510.95
186_M282_V0.7500.95
12_T162_F0.7460.94
185_N191_V0.7460.94
277_N281_S0.7450.94
190_V254_V0.7430.94
214_L221_K0.7430.94
254_V257_W0.7420.94
196_K257_W0.7370.94
43_E47_N0.7370.94
271_K317_E0.7360.94
335_M340_H0.7350.94
202_P205_L0.7330.94
115_Y119_F0.7320.94
178_E267_V0.7310.94
22_P26_L0.7280.94
226_W229_N0.7280.94
270_I305_I0.7280.94
215_A236_V0.7260.94
211_W243_A0.7250.94
194_D267_V0.7230.93
45_V87_Y0.7210.93
78_D109_L0.7200.93
109_L151_E0.7170.93
40_W57_V0.7150.93
137_Y141_L0.7120.93
26_L30_Y0.7120.93
60_A64_K0.7100.93
193_K197_N0.7070.93
18_A21_E0.7060.93
17_I21_E0.7050.93
118_D121_A0.7040.92
29_N32_K0.7030.92
73_S114_S0.7020.92
79_C83_A0.7010.92
108_W115_Y0.7000.92
204_R207_E0.7000.92
41_L87_Y0.7000.92
287_K294_Y0.6990.92
218_L236_V0.6980.92
327_S360_N0.6970.92
87_Y91_Y0.6970.92
29_N69_Y0.6960.92
90_W93_N0.6950.92
317_E365_G0.6940.92
326_V335_M0.6940.92
216_E219_L0.6930.92
247_M295_L0.6930.92
219_L236_V0.6930.92
189_V296_M0.6920.92
335_M353_R0.6910.92
33_A79_C0.6900.92
233_L237_R0.6880.92
86_T100_P0.6870.92
307_W311_K0.6870.92
87_Y90_W0.6860.92
80_Y83_A0.6860.92
109_L153_R0.6830.91
215_A218_L0.6830.91
180_I193_K0.6800.91
45_V49_E0.6800.91
267_V314_M0.6790.91
175_E178_E0.6780.91
225_R230_K0.6750.91
137_Y140_N0.6740.91
215_A240_H0.6740.91
32_K69_Y0.6740.91
160_K245_R0.6640.90
26_L110_T0.6630.90
230_K234_Y0.6620.90
200_R296_M0.6590.90
211_W240_H0.6560.90
83_A87_Y0.6550.90
243_A295_L0.6520.89
192_G258_V0.6510.89
351_N356_I0.6500.89
13_V163_L0.6490.89
271_K362_N0.6470.89
198_Y250_F0.6460.89
197_N355_V0.6430.89
280_K321_P0.6420.89
189_V255_G0.6360.88
26_L72_P0.6360.88
183_D325_S0.6340.88
221_K228_E0.6340.88
217_R232_I0.6310.88
10_R155_V0.6310.88
240_H247_M0.6300.88
304_W308_Q0.6300.88
51_K57_V0.6270.87
338_V342_W0.6260.87
80_Y84_L0.6240.87
190_V301_L0.6240.87
181_A271_K0.6230.87
25_V29_N0.6220.87
150_K166_V0.6210.87
228_E231_R0.6210.87
110_T113_A0.6190.87
183_D273_E0.6170.87
248_E252_R0.6160.86
260_D269_V0.6150.86
29_N71_L0.6150.86
115_Y149_M0.6140.86
39_F42_K0.6140.86
210_H217_R0.6100.86
74_K114_S0.6080.86
171_E310_K0.6050.86
322_S326_V0.6050.86
115_Y152_A0.6050.86
124_V152_A0.6010.85
123_T133_S0.6000.85
10_R164_K0.5950.85
45_V90_W0.5940.84
333_K337_E0.5930.84
11_A139_R0.5930.84
93_N99_F0.5920.84
229_N232_I0.5910.84
37_T61_L0.5910.84
73_S111_P0.5870.84
181_A193_K0.5860.84
245_R248_E0.5860.84
58_H65_L0.5850.84
327_S343_F0.5850.84
187_A341_R0.5850.84
76_A79_C0.5850.84
71_L76_A0.5840.83
216_E220_K0.5830.83
222_Y229_N0.5790.83
330_K351_N0.5780.83
111_P115_Y0.5780.83
281_S293_L0.5760.83
22_P25_V0.5750.83
112_R115_Y0.5730.82
245_R249_D0.5720.82
305_I316_V0.5720.82
41_L44_N0.5710.82
107_V110_T0.5690.82
8_A166_V0.5690.82
14_S135_L0.5680.82
53_V58_H0.5680.82
36_F64_K0.5680.82
26_L71_L0.5670.82
251_A254_V0.5650.81
337_E353_R0.5650.81
229_N236_V0.5610.81
57_V60_A0.5600.81
113_A116_N0.5590.81
286_S293_L0.5580.81
289_F292_K0.5560.80
280_K293_L0.5560.80
361_L364_R0.5540.80
309_A312_R0.5540.80
110_T115_Y0.5540.80
323_Y327_S0.5530.80
334_R337_E0.5520.80
214_L219_L0.5520.80
335_M351_N0.5520.80
33_A76_A0.5510.80
340_H352_D0.5500.80
204_R208_V0.5500.80
11_A140_N0.5490.80
271_K364_R0.5480.79
56_K59_E0.5470.79
15_M132_L0.5460.79
109_L115_Y0.5460.79
107_V115_Y0.5450.79
34_L38_L0.5450.79
52_G57_V0.5440.79
109_L112_R0.5440.79
62_Y80_Y0.5420.79
110_T114_S0.5400.78
297_Q300_R0.5400.78
243_A247_M0.5390.78
50_E56_K0.5380.78
240_H244_R0.5360.78
62_Y67_E0.5350.78
181_A358_I0.5330.78
15_M20_S0.5330.78
41_L45_V0.5300.77
189_V251_A0.5300.77
157_R241_L0.5290.77
107_V111_P0.5280.77
44_N50_E0.5280.77
63_E66_R0.5280.77
212_K217_R0.5280.77
30_Y108_W0.5270.77
327_S332_G0.5270.77
122_M125_R0.5250.77
52_G58_H0.5240.76
349_Y356_I0.5240.76
127_V132_L0.5210.76
253_K256_K0.5200.76
45_V91_Y0.5190.76
185_N188_E0.5160.75
198_Y254_V0.5150.75
181_A273_E0.5150.75
344_K349_Y0.5140.75
58_H77_E0.5140.75
215_A223_P0.5130.75
90_W99_F0.5130.75
31_V106_T0.5130.75
30_Y34_L0.5100.74
198_Y257_W0.5090.74
352_D357_A0.5090.74
254_V301_L0.5090.74
201_I204_R0.5080.74
324_S360_N0.5080.74
25_V28_N0.5060.74
302_Q306_S0.5050.74
23_L108_W0.5040.74
51_K84_L0.5020.73
111_P114_S0.5010.73
91_Y100_P0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.3403 95.6 0.923 Contact Map
1vhxA 2 0.3586 94.8 0.926 Contact Map
1iv0A 1 0.2539 93.5 0.931 Contact Map
1qypA 1 0.1126 72.9 0.948 Contact Map
4aybP 1 0.1047 58.1 0.953 Contact Map
2k4xA 1 0.1361 53.7 0.954 Contact Map
1ffkW 1 0.1832 50.6 0.955 Contact Map
1gh9A 1 0.1859 48 0.956 Contact Map
4c2mI 1 0.1649 43.5 0.957 Contact Map
4ep4A 2 0.4188 42 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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