GREMLIN Database
Y1976 - UPF0145 protein SSO1976
UniProt: Q97WY4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 114 (103)
Sequences: 1582 (964)
Seq/√Len: 95.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_N110_V3.9201.00
25_K109_V3.6751.00
82_N109_V3.2541.00
10_V87_V3.1051.00
23_E109_V2.7861.00
12_N86_N2.5571.00
17_P24_I2.3471.00
19_Y110_V2.1151.00
30_G72_M2.0691.00
69_L89_F1.9191.00
89_F103_A1.8921.00
62_E66_L1.8891.00
70_Q73_V1.8871.00
21_I85_V1.7561.00
74_D77_K1.6971.00
16_S110_V1.6731.00
76_A81_A1.6371.00
47_R56_E1.6201.00
38_L49_L1.5841.00
10_V73_V1.5591.00
53_E58_V1.5391.00
33_V99_D1.5121.00
81_A107_A1.5061.00
11_T16_S1.4711.00
62_E75_N1.4281.00
53_E71_R1.4230.99
34_R67_Q1.4140.99
70_Q74_D1.3890.99
34_R60_L1.3230.99
35_S48_S1.3100.99
28_V79_L1.2970.99
22_V109_V1.2860.99
75_N78_A1.2650.99
43_I56_E1.2650.99
69_L103_A1.2640.99
17_P20_K1.2280.98
16_S19_Y1.2030.98
41_N57_Y1.1820.98
14_E86_N1.1810.98
28_V72_M1.1570.98
40_K56_E1.1430.98
29_V75_N1.1060.97
66_L70_Q1.1060.97
25_K82_N1.0970.97
67_Q70_Q1.0950.97
37_G40_K1.0860.97
14_E85_V1.0800.97
69_L73_V1.0800.97
74_D78_A1.0670.96
22_V110_V1.0620.96
36_R63_Q1.0390.96
35_S54_I1.0060.95
72_M84_V0.9780.94
21_I110_V0.9480.93
42_I46_L0.9480.93
44_A61_A0.9440.93
89_F102_I0.9430.93
37_G43_I0.9380.93
15_Q20_K0.9310.92
60_L63_Q0.9300.92
32_T67_Q0.9290.92
11_T24_I0.9130.92
36_R60_L0.9100.92
40_K60_L0.8850.90
30_G68_A0.8840.90
73_V84_V0.8820.90
64_A99_D0.8710.90
64_A101_I0.8550.89
13_G85_V0.8530.89
72_M103_A0.8340.88
31_I90_D0.8230.87
73_V77_K0.8160.86
27_L87_V0.8110.86
11_T17_P0.8080.86
26_G83_A0.8050.86
88_R104_Y0.7860.84
38_L42_I0.7810.84
20_K109_V0.7660.83
85_V108_V0.7570.82
44_A54_I0.7570.82
90_D98_M0.7560.82
75_N79_L0.7480.81
15_Q86_N0.7470.81
59_E63_Q0.7450.81
47_R55_K0.7400.81
48_S95_S0.7370.80
33_V100_E0.7340.80
8_V73_V0.7290.80
47_R60_L0.7160.78
71_R104_Y0.7140.78
43_I48_S0.7120.78
92_N98_M0.7110.78
63_Q67_Q0.7030.77
94_L97_A0.6990.77
83_A110_V0.6960.76
68_A103_A0.6930.76
48_S54_I0.6910.76
100_E104_Y0.6820.75
43_I50_L0.6700.74
11_T15_Q0.6700.74
47_R50_L0.6670.73
37_G41_N0.6620.73
72_M87_V0.6600.72
8_V16_S0.6590.72
35_S61_A0.6560.72
91_S104_Y0.6450.71
39_G43_I0.6450.71
15_Q85_V0.6390.70
12_N87_V0.6330.69
90_D102_I0.6300.69
37_G42_I0.6230.68
20_K23_E0.6190.68
56_E62_E0.6130.67
57_Y94_L0.6100.67
61_A99_D0.6080.66
37_G56_E0.6040.66
22_V82_N0.5990.65
56_E59_E0.5970.65
13_G24_I0.5930.64
31_I61_A0.5920.64
13_G17_P0.5900.64
62_E65_R0.5860.63
65_R93_E0.5800.63
11_T27_L0.5780.62
43_I55_K0.5780.62
13_G18_G0.5640.60
43_I46_L0.5580.60
58_V71_R0.5580.60
31_I91_S0.5560.59
13_G86_N0.5550.59
9_L16_S0.5530.59
91_S102_I0.5490.58
16_S108_V0.5480.58
23_E70_Q0.5430.58
16_S80_G0.5390.57
14_E17_P0.5390.57
57_Y98_M0.5380.57
26_G79_L0.5340.56
32_T71_R0.5340.56
92_N102_I0.5320.56
91_S101_I0.5300.56
13_G16_S0.5280.56
29_V102_I0.5270.55
92_N100_E0.5270.55
12_N15_Q0.5260.55
12_N21_I0.5260.55
17_P33_V0.5190.54
31_I102_I0.5130.53
47_R54_I0.5060.52
60_L67_Q0.5040.52
21_I66_L0.5010.52
30_G65_R0.5010.52
10_V69_L0.5000.52
14_E88_R0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1y2iA 3 0.9298 100 0.128 Contact Map
1vr4A 3 0.9035 100 0.167 Contact Map
3qkbA 3 0.7895 99.9 0.33 Contact Map
2jz7A 3 0.6754 99.9 0.445 Contact Map
2y1bA 1 0.7368 99 0.682 Contact Map
4o5fA 2 0.9737 9.8 0.933 Contact Map
1x6vB 2 0.9825 9 0.934 Contact Map
3ox4A 2 0.9912 8.5 0.935 Contact Map
3zdrA 2 1 8.1 0.935 Contact Map
5b8hA 2 0.9649 8 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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