GREMLIN Database
Q97WY1 - Transposase ISC1332
UniProt: Q97WY1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 414 (366)
Sequences: 1231 (760)
Seq/√Len: 39.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
174_K352_A4.5631.00
303_S318_L4.2221.00
173_V188_A4.1511.00
171_I221_L4.1151.00
292_V296_R4.1081.00
196_D202_F3.9751.00
282_R305_L3.9601.00
177_K186_E3.7651.00
351_L372_L3.6641.00
237_S256_H3.3041.00
255_Q329_N3.2941.00
189_I372_L3.0361.00
235_I254_S3.0031.00
290_R294_E2.7471.00
278_E305_L2.7391.00
189_I206_Y2.7221.00
271_L279_L2.6151.00
169_L232_V2.5691.00
191_I348_N2.5431.00
279_L302_L2.5001.00
132_A137_P2.4681.00
315_K319_D2.4311.00
291_N294_E2.4261.00
346_S350_T2.3811.00
178_V368_L2.3551.00
300_L318_L2.3451.00
268_M280_M2.3401.00
35_K38_V2.2841.00
298_A301_S2.2721.00
207_E223_G2.2180.99
62_V66_H2.1960.99
232_V254_S2.1940.99
168_A334_I2.1100.99
282_R306_V2.0960.99
261_T265_R2.0770.99
164_H230_S2.0510.99
349_L360_G2.0280.99
273_D276_K2.0110.99
32_K35_K1.9910.99
176_V368_L1.9780.99
153_K156_E1.9690.99
307_Q314_A1.9620.99
346_S349_L1.8990.98
35_K41_R1.8940.98
187_R365_L1.8860.98
171_I243_L1.8840.98
193_I203_V1.8800.98
279_L313_R1.8510.98
175_I188_A1.8350.98
72_F83_R1.8310.98
303_S307_Q1.8280.98
47_I60_L1.8190.98
167_L194_G1.7750.97
302_L314_A1.7610.97
132_A135_G1.7260.97
76_G81_V1.7220.97
224_L229_V1.7100.97
47_I56_R1.7060.97
263_M324_Y1.6940.97
239_D244_D1.6930.97
155_K158_K1.6830.96
169_L192_A1.6720.96
201_K346_S1.6690.96
294_E297_K1.6540.96
57_E60_L1.6460.96
196_D200_N1.6450.96
52_M65_D1.6450.96
285_D298_A1.6270.96
169_L204_L1.6000.95
263_M320_A1.5890.95
370_V374_V1.5880.95
120_S378_E1.5840.95
275_E309_F1.5830.95
114_L146_V1.5780.95
194_G204_L1.5560.95
294_E298_A1.5330.94
350_T354_F1.5320.94
235_I247_V1.5230.94
237_S243_L1.5170.94
192_A348_N1.5060.94
202_F380_N1.5020.93
218_K222_S1.4970.93
218_K249_T1.4780.93
229_V251_F1.4680.93
131_L143_M1.4430.92
388_M391_I1.4360.92
192_A220_F1.4230.91
72_F85_R1.4030.91
300_L321_A1.3860.90
166_L202_F1.3810.90
175_I186_E1.3760.90
148_E151_S1.3660.90
47_I54_E1.3630.90
56_R60_L1.3630.90
70_T85_R1.3610.89
96_P99_L1.3600.89
276_K280_M1.3530.89
384_K387_P1.3500.89
116_Q120_S1.3390.89
275_E310_S1.3380.89
290_R332_R1.3360.89
124_P143_M1.3330.88
307_Q318_L1.3150.88
49_Q56_R1.3090.88
48_L89_T1.3060.87
236_V338_L1.3010.87
71_Y103_Y1.2980.87
263_M316_R1.2870.87
191_I351_L1.2600.85
292_V325_C1.2500.85
123_T359_G1.2470.85
214_L249_T1.2470.85
53_M57_E1.2460.85
45_E56_R1.2400.85
141_I145_R1.2220.84
368_L372_L1.2220.84
54_E60_L1.2150.83
41_R44_E1.2130.83
41_R47_I1.2090.83
169_L235_I1.1990.82
303_S314_A1.1960.82
301_S304_Q1.1960.82
328_L335_R1.1950.82
267_L283_V1.1920.82
47_I53_M1.1880.82
145_R148_E1.1790.81
65_D89_T1.1750.81
54_E58_A1.1730.81
272_P275_E1.1710.81
39_S42_E1.1690.81
341_N344_S1.1670.81
239_D258_L1.1600.80
151_S370_V1.1520.80
225_V251_F1.1500.80
155_K159_S1.1400.79
347_F376_I1.1400.79
74_Y81_V1.1370.79
300_L304_Q1.1350.79
46_I53_M1.1340.79
197_L395_S1.1340.79
47_I51_A1.1290.78
75_L165_D1.1280.78
279_L314_A1.1270.78
47_I57_E1.1250.78
170_Y195_V1.1220.78
351_L376_I1.1180.78
350_T353_R1.1160.78
71_Y88_R1.1060.77
244_D258_L1.1050.77
342_N345_E1.1030.77
267_L317_L1.0910.76
176_V372_L1.0900.76
354_F375_S1.0900.76
364_S367_S1.0890.76
178_V189_I1.0740.75
41_R45_E1.0730.75
61_E64_D1.0670.74
235_I243_L1.0600.74
221_L243_L1.0540.73
353_R358_L1.0470.73
296_R322_D1.0460.73
126_Q353_R1.0420.73
237_S244_D1.0400.72
118_V355_E1.0360.72
347_F351_L1.0300.72
389_S392_R1.0260.71
244_D323_K1.0250.71
153_K377_H1.0230.71
313_R316_R1.0150.71
78_G107_S1.0150.71
214_L245_R1.0100.70
56_R59_Y1.0080.70
49_Q55_E1.0050.70
253_S322_D1.0030.70
180_I187_R1.0000.69
149_R309_F1.0000.69
191_I347_F0.9990.69
327_F337_Y0.9980.69
190_Y211_R0.9960.69
54_E57_E0.9960.69
47_I59_Y0.9890.69
53_M56_R0.9860.68
70_T291_N0.9850.68
258_L323_K0.9830.68
78_G109_D0.9750.67
248_S323_K0.9670.67
77_T105_R0.9600.66
234_V338_L0.9580.66
261_T340_T0.9540.66
299_I318_L0.9510.65
27_R30_I0.9490.65
234_V330_F0.9470.65
33_A38_V0.9440.65
55_E60_L0.9410.65
118_V124_P0.9340.64
230_S293_E0.9290.64
286_L327_F0.9290.64
176_V355_E0.9260.63
77_T82_L0.9200.63
30_I34_I0.9200.63
353_R363_P0.9190.63
381_S385_F0.9170.63
264_V289_S0.9130.62
163_P196_D0.9090.62
243_L256_H0.9070.62
124_P140_E0.9040.62
123_T168_A0.9000.61
383_W387_P0.8970.61
53_M60_L0.8970.61
316_R324_Y0.8960.61
354_F371_Y0.8930.61
292_V329_N0.8910.60
193_I343_T0.8910.60
44_E94_F0.8880.60
41_R54_E0.8870.60
362_F367_S0.8870.60
125_S140_E0.8840.60
24_E27_R0.8820.60
171_I247_V0.8820.60
59_Y64_D0.8820.60
232_V235_I0.8740.59
268_M276_K0.8720.59
261_T280_M0.8720.59
67_K80_G0.8710.59
370_V373_Y0.8660.58
45_E48_L0.8650.58
47_I61_E0.8630.58
222_S250_L0.8620.58
323_K326_S0.8620.58
45_E55_E0.8590.58
44_E47_I0.8570.57
334_I338_L0.8560.57
128_K132_A0.8550.57
109_D112_D0.8540.57
312_A347_F0.8520.57
46_I326_S0.8520.57
258_L320_A0.8510.57
152_N155_K0.8500.57
343_T346_S0.8500.57
297_K300_L0.8480.57
176_V189_I0.8420.56
64_D91_K0.8420.56
113_F131_L0.8420.56
105_R327_F0.8410.56
225_V264_V0.8410.56
44_E57_E0.8390.56
255_Q326_S0.8380.56
54_E59_Y0.8370.56
82_L221_L0.8350.55
57_E61_E0.8340.55
75_L82_L0.8320.55
44_E142_V0.8280.55
157_Y380_N0.8270.55
38_V42_E0.8250.54
143_M309_F0.8250.54
251_F274_K0.8230.54
168_A236_V0.8220.54
387_P392_R0.8200.54
348_N351_L0.8190.54
41_R53_M0.8180.54
344_S347_F0.8170.54
191_I258_L0.8160.54
304_Q308_P0.8160.54
133_A136_I0.8150.54
58_A63_E0.8130.53
171_I246_V0.8130.53
133_A251_F0.8100.53
203_V380_N0.8090.53
264_V268_M0.8070.53
387_P390_V0.7970.52
296_R318_L0.7960.52
203_V347_F0.7900.51
35_K82_L0.7900.51
57_E63_E0.7880.51
208_V369_E0.7810.50
175_I352_A0.7760.50
51_A60_L0.7750.50
349_L352_A0.7740.50
114_L138_Y0.7730.50
160_R202_F0.7730.50
138_Y165_D0.7680.49
268_M341_N0.7650.49
278_E282_R0.7650.49
35_K47_I0.7620.49
54_E63_E0.7590.48
118_V371_Y0.7590.48
315_K322_D0.7590.48
179_R363_P0.7580.48
65_D91_K0.7560.48
354_F359_G0.7560.48
30_I47_I0.7520.48
349_L359_G0.7490.48
171_I251_F0.7490.48
97_K344_S0.7480.47
255_Q330_F0.7470.47
45_E49_Q0.7470.47
364_S371_Y0.7450.47
178_V302_L0.7410.47
171_I192_A0.7380.47
201_K385_F0.7320.46
32_K143_M0.7320.46
190_Y209_R0.7320.46
392_R395_S0.7270.46
156_E297_K0.7260.45
188_A211_R0.7250.45
53_M67_K0.7230.45
391_I395_S0.7220.45
321_A325_C0.7200.45
140_E149_R0.7180.45
261_T268_M0.7180.45
201_K350_T0.7160.45
94_F98_I0.7150.44
128_K140_E0.7120.44
138_Y142_V0.7100.44
53_M59_Y0.7080.44
387_P391_I0.7060.44
30_I35_K0.7050.44
103_Y378_E0.7020.43
120_S129_A0.7000.43
253_S308_P0.7000.43
196_D220_F0.6980.43
283_V340_T0.6970.43
60_L63_E0.6970.43
200_N330_F0.6950.43
117_L385_F0.6950.43
32_K297_K0.6940.43
117_L390_V0.6930.42
99_L138_Y0.6880.42
124_P179_R0.6880.42
74_Y83_R0.6880.42
44_E49_Q0.6870.42
388_M392_R0.6850.42
174_K355_E0.6850.42
117_L295_G0.6840.42
201_K349_L0.6830.42
171_I235_I0.6800.41
142_V145_R0.6800.41
214_L240_F0.6790.41
381_S384_K0.6780.41
75_L163_P0.6760.41
177_K245_R0.6750.41
270_V312_A0.6740.41
56_R143_M0.6730.41
361_Y368_L0.6710.41
218_K250_L0.6700.40
45_E53_M0.6700.40
189_I368_L0.6680.40
168_A375_S0.6680.40
59_Y63_E0.6680.40
181_S192_A0.6620.40
59_Y62_V0.6610.40
206_Y272_P0.6590.39
30_I41_R0.6590.39
373_Y381_S0.6580.39
71_Y358_L0.6570.39
335_R339_Y0.6570.39
56_R64_D0.6550.39
77_T80_G0.6550.39
45_E70_T0.6550.39
363_P367_S0.6540.39
389_S395_S0.6520.39
75_L84_L0.6520.39
71_Y86_V0.6500.39
275_E278_E0.6490.39
213_D360_G0.6490.39
205_D220_F0.6480.39
122_M249_T0.6460.38
327_F330_F0.6450.38
26_I33_A0.6450.38
213_D306_V0.6410.38
304_Q322_D0.6390.38
130_V133_A0.6390.38
155_K366_R0.6390.38
76_G106_T0.6360.37
106_T142_V0.6340.37
60_L64_D0.6340.37
114_L154_L0.6340.37
35_K42_E0.6340.37
40_L356_E0.6340.37
289_S328_L0.6330.37
213_D241_S0.6290.37
171_I348_N0.6290.37
84_L99_L0.6270.37
279_L305_L0.6270.37
243_L295_G0.6250.37
51_A54_E0.6240.36
206_Y369_E0.6240.36
270_V316_R0.6240.36
269_R333_E0.6230.36
229_V303_S0.6220.36
34_I47_I0.6210.36
157_Y340_T0.6200.36
208_V365_L0.6200.36
98_I146_V0.6160.36
254_S315_K0.6150.36
210_D352_A0.6150.36
175_I209_R0.6150.36
266_N269_R0.6140.36
32_K186_E0.6130.36
48_L51_A0.6130.36
191_I206_Y0.6100.35
110_Y174_K0.6100.35
46_I54_E0.6070.35
375_S379_S0.6070.35
40_L94_F0.6070.35
43_I46_I0.6060.35
118_V188_A0.6050.35
83_R296_R0.6040.35
349_L358_L0.6030.35
202_F379_S0.5990.34
182_E360_G0.5990.34
162_L169_L0.5980.34
190_Y339_Y0.5980.34
180_I185_M0.5970.34
173_V363_P0.5970.34
157_Y220_F0.5960.34
71_Y140_E0.5950.34
383_W388_M0.5950.34
152_N156_E0.5950.34
260_I340_T0.5930.34
29_K47_I0.5910.34
130_V173_V0.5900.34
299_I303_S0.5900.34
94_F170_Y0.5890.34
243_L380_N0.5870.33
126_Q336_H0.5870.33
278_E281_I0.5860.33
94_F217_W0.5850.33
150_I237_S0.5850.33
124_P144_N0.5840.33
47_I63_E0.5830.33
290_R377_H0.5830.33
188_A351_L0.5820.33
274_K284_R0.5820.33
245_R248_S0.5820.33
379_S383_W0.5810.33
279_L306_V0.5800.33
120_S225_V0.5800.33
360_G371_Y0.5780.33
44_E48_L0.5780.33
124_P141_I0.5770.33
225_V230_S0.5760.33
302_L313_R0.5730.32
239_D344_S0.5720.32
104_E332_R0.5690.32
296_R300_L0.5690.32
283_V287_K0.5670.32
299_I341_N0.5670.32
92_G98_I0.5630.31
260_I327_F0.5630.31
212_E262_H0.5620.31
216_G223_G0.5610.31
84_L329_N0.5610.31
158_K293_E0.5610.31
30_I33_A0.5600.31
147_A321_A0.5600.31
248_S281_I0.5590.31
351_L354_F0.5580.31
171_I237_S0.5570.31
225_V250_L0.5560.31
346_S371_Y0.5550.31
40_L47_I0.5530.31
302_L306_V0.5520.31
66_H91_K0.5520.31
157_Y162_L0.5520.31
83_R247_V0.5510.31
31_R47_I0.5510.31
116_Q130_V0.5500.30
128_K131_L0.5490.30
187_R216_G0.5480.30
218_K246_V0.5480.30
206_Y365_L0.5480.30
267_L340_T0.5480.30
102_K157_Y0.5470.30
133_A367_S0.5460.30
214_L252_P0.5460.30
95_R102_K0.5460.30
147_A287_K0.5420.30
99_L103_Y0.5420.30
119_L335_R0.5420.30
123_T383_W0.5410.30
157_Y370_V0.5410.30
162_L166_L0.5400.30
56_R67_K0.5390.30
250_L254_S0.5380.30
330_F338_L0.5380.30
41_R60_L0.5370.29
333_E393_H0.5350.29
91_K198_E0.5350.29
30_I38_V0.5330.29
237_S247_V0.5320.29
360_G375_S0.5320.29
390_V393_H0.5320.29
90_R224_L0.5310.29
181_S395_S0.5310.29
34_I40_L0.5290.29
235_I246_V0.5280.29
348_N353_R0.5270.29
173_V240_F0.5270.29
171_I306_V0.5260.29
163_P338_L0.5260.29
154_L369_E0.5250.29
323_K367_S0.5250.29
269_R287_K0.5240.28
143_M177_K0.5230.28
239_D256_H0.5230.28
106_T368_L0.5220.28
123_T313_R0.5220.28
196_D206_Y0.5220.28
177_K195_V0.5210.28
235_I343_T0.5200.28
198_E372_L0.5200.28
154_L216_G0.5190.28
123_T126_Q0.5190.28
286_L346_S0.5180.28
123_T361_Y0.5170.28
350_T371_Y0.5170.28
194_G311_P0.5170.28
34_I314_A0.5160.28
154_L329_N0.5150.28
127_V265_R0.5150.28
68_N217_W0.5140.28
358_L371_Y0.5140.28
260_I324_Y0.5140.28
163_P366_R0.5140.28
73_R157_Y0.5140.28
125_S350_T0.5140.28
93_G367_S0.5130.28
201_K299_I0.5130.28
29_K32_K0.5130.28
271_L310_S0.5110.28
363_P371_Y0.5100.27
97_K269_R0.5090.27
86_V103_Y0.5090.27
34_I57_E0.5080.27
115_Q330_F0.5070.27
117_L122_M0.5070.27
193_I201_K0.5070.27
106_T150_I0.5050.27
39_S175_I0.5050.27
265_R341_N0.5030.27
45_E85_R0.5020.27
78_G106_T0.5020.27
72_F230_S0.5020.27
266_N322_D0.5020.27
30_I42_E0.5010.27
146_V164_H0.5010.27
229_V232_V0.5000.27
184_I361_Y0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u7bA 2 0.6884 97.6 0.939 Contact Map
1bcoA 1 0.4758 90.2 0.961 Contact Map
4fcyA 4 0.756 85.1 0.964 Contact Map
2bw3A 3 0.6522 82.1 0.965 Contact Map
1tc3C 1 0.1232 75.8 0.968 Contact Map
3frwA 2 0.2271 68.4 0.969 Contact Map
2x48A 1 0.1304 58 0.971 Contact Map
1reqA 1 0.6498 55.3 0.972 Contact Map
1jkoC 1 0.1111 55.1 0.972 Contact Map
1on0A 4 0.3454 52.6 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.012 seconds.