GREMLIN Database
CMR4 - CRISPR system CMR subunit Cmr4
UniProt: Q97WX4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 308 (257)
Sequences: 396 (368)
Seq/√Len: 23.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
234_R252_S6.4871.00
256_V262_F5.7581.00
255_Y298_K4.9291.00
238_I243_K4.5341.00
95_F263_F4.1851.00
239_K246_E3.8001.00
235_R296_I3.6501.00
38_Q48_F3.4901.00
97_I226_I3.3451.00
77_S83_E3.1151.00
94_L260_S2.8940.99
37_F262_F2.8780.99
243_K294_E2.8690.99
251_W296_I2.8480.99
237_K246_E2.7920.99
109_E112_V2.7570.99
167_N174_L2.5650.99
17_A21_L2.3630.98
58_S294_E2.3510.97
174_L177_I2.2110.96
75_L85_S2.1140.95
253_E293_K2.0890.95
164_V167_N2.0460.94
117_Y219_D2.0330.94
116_T222_G2.0160.94
209_H213_P2.0090.94
77_S82_D1.9690.93
37_F256_V1.9580.93
173_E177_I1.9430.93
56_I89_F1.9030.92
251_W293_K1.8640.91
42_L57_K1.8240.90
217_L267_L1.7570.88
167_N172_V1.7340.87
26_G34_D1.7310.87
23_V37_F1.7210.87
167_N177_I1.7050.87
33_V234_R1.6900.86
96_A261_L1.6890.86
168_E174_L1.6540.85
185_L188_D1.6290.84
167_N171_Y1.6120.83
167_N170_F1.6070.83
114_V172_V1.5970.83
40_D259_N1.5960.83
40_D122_K1.5830.82
21_L301_V1.5660.81
167_N173_E1.5550.81
238_I242_S1.5530.81
23_V230_L1.5300.80
57_K85_S1.5240.79
251_W259_N1.5210.79
167_N175_S1.5060.79
92_A264_S1.4950.78
23_V48_F1.4940.78
236_I245_V1.4930.78
185_L189_M1.4830.78
14_F89_F1.4700.77
235_R253_E1.4650.77
55_A58_S1.4630.77
42_L99_A1.4590.76
217_L221_I1.4450.76
23_V38_Q1.4400.75
210_L214_L1.4360.75
96_A214_L1.4220.74
77_S84_A1.4130.74
90_L267_L1.4100.74
47_I290_L1.4050.74
222_G226_I1.3960.73
116_T219_D1.3940.73
16_K259_N1.3750.72
53_K295_T1.3700.72
119_L226_I1.3640.71
230_L256_V1.3630.71
245_V248_G1.3560.71
237_K245_V1.3490.70
238_I245_V1.3430.70
166_L169_D1.3430.70
289_I293_K1.3170.69
113_Y255_Y1.3140.68
40_D222_G1.2770.66
23_V256_V1.2700.66
77_S80_N1.2570.65
121_R209_H1.2160.62
49_A300_I1.2050.61
15_I92_A1.2020.61
26_G250_L1.1910.61
234_R251_W1.1900.60
37_F238_I1.1810.60
92_A116_T1.1700.59
33_V252_S1.1690.59
101_S253_E1.1590.58
49_A262_F1.1510.58
49_A296_I1.1180.56
37_F230_L1.1160.55
40_D111_W1.1120.55
48_F55_A1.1100.55
146_N150_Q1.1050.55
53_K111_W1.0770.53
41_E294_E1.0690.52
52_L149_L1.0550.51
119_L222_G1.0390.50
95_F123_V1.0340.50
260_S294_E1.0330.50
38_Q46_T1.0260.49
17_A293_K1.0260.49
20_H251_W1.0120.48
231_I258_V1.0090.48
18_V113_Y1.0050.48
96_A210_L0.9970.47
20_H258_V0.9960.47
113_Y260_S0.9870.47
119_L231_I0.9870.47
172_V217_L0.9850.46
114_V217_L0.9840.46
94_L119_L0.9770.46
36_P84_A0.9720.46
236_I251_W0.9710.45
145_I148_I0.9710.45
275_A282_L0.9700.45
237_K249_G0.9680.45
20_H233_V0.9670.45
169_D174_L0.9620.45
73_K271_S0.9530.44
277_F285_T0.9490.44
168_E171_Y0.9400.43
40_D93_V0.9360.43
13_F264_S0.9360.43
46_T251_W0.9300.43
14_F217_L0.9260.42
13_F274_T0.9260.42
239_K242_S0.9260.42
166_L172_V0.9240.42
96_A295_T0.9220.42
90_L265_S0.9190.42
77_S81_P0.9180.42
117_Y122_K0.9180.42
184_S189_M0.9170.42
47_I262_F0.9080.41
236_I260_S0.9060.41
49_A85_S0.9020.41
87_G165_I0.9010.41
75_L167_N0.8960.40
274_T277_F0.8950.40
122_K125_S0.8890.40
110_A301_V0.8810.39
12_P265_S0.8800.39
102_I238_I0.8750.39
278_A285_T0.8740.39
55_A264_S0.8610.38
172_V177_I0.8540.38
165_I215_I0.8510.37
187_G275_A0.8500.37
111_W217_L0.8440.37
252_S258_V0.8400.37
43_N227_N0.8400.37
29_V238_I0.8370.36
47_I229_S0.8340.36
19_T253_E0.8260.36
52_L264_S0.8260.36
111_W231_I0.8250.36
255_Y293_K0.8240.36
44_Y91_D0.8220.36
35_L251_W0.8170.35
277_F280_C0.8160.35
47_I52_L0.8160.35
18_V213_P0.8090.35
149_L152_S0.8090.35
206_Q209_H0.8040.34
101_S117_Y0.8030.34
38_Q53_K0.8000.34
19_T96_A0.7980.34
167_N239_K0.7890.33
97_I230_L0.7880.33
222_G231_I0.7850.33
33_V111_W0.7810.33
87_G268_A0.7800.33
163_S208_N0.7800.33
99_A225_V0.7730.32
164_V184_S0.7720.32
88_S267_L0.7700.32
26_G33_V0.7670.32
119_L230_L0.7610.32
113_Y301_V0.7610.32
212_K241_S0.7590.32
73_K261_L0.7570.31
23_V262_F0.7550.31
231_I234_R0.7520.31
291_G299_G0.7500.31
60_L71_I0.7500.31
164_V172_V0.7500.31
224_E228_R0.7490.31
188_D276_Y0.7440.31
25_S296_I0.7400.30
12_P238_I0.7370.30
45_P91_D0.7330.30
259_N296_I0.7300.30
165_I214_L0.7290.30
143_D148_I0.7270.30
114_V123_V0.7240.30
151_E276_Y0.7220.29
28_S235_R0.7200.29
120_L236_I0.7190.29
36_P88_S0.7170.29
130_M188_D0.7160.29
93_V126_L0.7150.29
116_T269_R0.7140.29
102_I113_Y0.7140.29
20_H40_D0.7130.29
169_D172_V0.7090.29
34_D250_L0.7080.29
176_N216_V0.7070.29
233_V296_I0.7060.29
74_V277_F0.7060.29
273_D285_T0.7050.28
255_Y301_V0.7040.28
12_P100_R0.7030.28
249_G269_R0.7030.28
235_R251_W0.6940.28
18_V214_L0.6940.28
124_K148_I0.6870.27
111_W263_F0.6860.27
42_L289_I0.6850.27
133_L276_Y0.6850.27
35_L293_K0.6830.27
169_D221_I0.6820.27
238_I247_E0.6810.27
48_F51_S0.6760.27
48_F233_V0.6760.27
52_L92_A0.6750.27
227_N298_K0.6750.27
51_S235_R0.6740.27
165_I172_V0.6740.27
245_V271_S0.6740.27
100_R261_L0.6720.27
45_P75_L0.6690.26
44_Y111_W0.6690.26
93_V263_F0.6690.26
36_P53_K0.6670.26
41_E126_L0.6620.26
19_T300_I0.6610.26
229_S255_Y0.6610.26
226_I231_I0.6530.26
52_L290_L0.6520.26
33_V100_R0.6500.25
133_L188_D0.6490.25
46_T71_I0.6490.25
17_A301_V0.6470.25
90_L266_F0.6460.25
230_L262_F0.6440.25
275_A281_I0.6410.25
96_A250_L0.6410.25
77_S269_R0.6400.25
47_I51_S0.6380.25
221_I235_R0.6340.25
142_L145_I0.6320.25
225_V228_R0.6310.24
44_Y225_V0.6270.24
31_E85_S0.6250.24
234_R238_I0.6220.24
150_Q212_K0.6220.24
216_V273_D0.6190.24
128_E188_D0.6170.24
162_A165_I0.6120.23
29_V111_W0.6110.23
94_L176_N0.6110.23
36_P40_D0.6090.23
229_S264_S0.6080.23
212_K215_I0.6080.23
46_T235_R0.6070.23
41_E230_L0.6060.23
48_F298_K0.6060.23
28_S88_S0.6050.23
40_D113_Y0.6050.23
128_E273_D0.6040.23
94_L216_V0.6000.23
110_A259_N0.6000.23
234_R250_L0.5970.23
171_Y177_I0.5970.23
235_R293_K0.5970.23
44_Y235_R0.5970.23
53_K293_K0.5960.23
228_R293_K0.5940.23
226_I255_Y0.5930.23
57_K99_A0.5920.23
39_R117_Y0.5920.23
123_V264_S0.5900.22
37_F246_E0.5880.22
15_I259_N0.5870.22
17_A176_N0.5820.22
276_Y286_R0.5800.22
144_A147_N0.5800.22
27_T289_I0.5790.22
127_L131_N0.5780.22
144_A149_L0.5780.22
53_K235_R0.5740.22
150_Q208_N0.5730.22
38_Q255_Y0.5730.22
44_Y119_L0.5720.22
208_N278_A0.5720.22
161_A286_R0.5700.21
147_N272_K0.5680.21
237_K248_G0.5670.21
21_L245_V0.5670.21
74_V116_T0.5640.21
109_E117_Y0.5640.21
161_A220_S0.5630.21
232_R243_K0.5620.21
109_E253_E0.5610.21
37_F42_L0.5610.21
92_A110_A0.5600.21
114_V225_V0.5590.21
277_F286_R0.5580.21
68_R149_L0.5550.21
49_A256_V0.5550.21
110_A264_S0.5530.21
18_V120_L0.5510.21
41_E111_W0.5510.21
175_S179_N0.5500.21
149_L182_I0.5500.21
293_K298_K0.5490.20
261_L283_R0.5470.20
228_R235_R0.5470.20
50_S298_K0.5460.20
23_V94_L0.5460.20
122_K258_V0.5450.20
19_T243_K0.5440.20
26_G295_T0.5430.20
97_I229_S0.5430.20
57_K61_L0.5420.20
291_G297_G0.5400.20
142_L260_S0.5390.20
257_P291_G0.5360.20
121_R184_S0.5350.20
213_P294_E0.5350.20
42_L259_N0.5350.20
79_E273_D0.5350.20
207_G237_K0.5350.20
170_F251_W0.5340.20
165_I279_D0.5330.20
212_K285_T0.5320.20
110_A234_R0.5300.20
177_I283_R0.5300.20
214_L285_T0.5300.20
37_F215_I0.5290.20
43_N248_G0.5290.20
55_A90_L0.5290.20
80_N83_E0.5280.20
174_L179_N0.5280.20
48_F255_Y0.5280.20
238_I294_E0.5270.20
77_S244_T0.5250.19
51_S218_K0.5220.19
94_L262_F0.5210.19
278_A283_R0.5210.19
168_E177_I0.5200.19
47_I265_S0.5190.19
231_I255_Y0.5180.19
237_K247_E0.5180.19
12_P243_K0.5170.19
49_A288_L0.5160.19
40_D231_I0.5140.19
87_G210_L0.5140.19
46_T234_R0.5130.19
236_I249_G0.5130.19
125_S298_K0.5130.19
164_V176_N0.5130.19
269_R294_E0.5120.19
60_L75_L0.5120.19
72_Y260_S0.5110.19
222_G289_I0.5080.19
40_D50_S0.5060.19
255_Y258_V0.5060.19
82_D220_S0.5050.19
110_A231_I0.5050.19
131_N283_R0.5050.19
76_G98_P0.5050.19
230_L258_V0.5050.19
162_A176_N0.5050.19
116_T120_L0.5040.19
100_R229_S0.5030.18
111_W259_N0.5020.18
152_S189_M0.5010.18
186_L208_N0.5000.18
38_Q55_A0.5000.18
222_G233_V0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3x1lC 3 0.9221 100 0.312 Contact Map
4w8wA 1 0.8247 100 0.34 Contact Map
4qtsC 1 0.4416 100 0.703 Contact Map
4n0lA 1 0.6591 99.9 0.743 Contact Map
4w8vA 1 0.6039 99.8 0.789 Contact Map
3x1lH 1 0.5097 99.8 0.792 Contact Map
4qtsA 1 0.6071 98.1 0.904 Contact Map
3x1lB 1 0.6753 97.2 0.919 Contact Map
4l6uA 1 0.487 59.7 0.959 Contact Map
4txdA 1 0.7208 25.7 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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