CMR4 - SULSO - GREMLIN Contacts

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CMR4 - CRISPR system CMR subunit Cmr4

UniProt:	Q97WX4	Sequences: MIIMTYYTFVKPFFIKAVTHLHVSSGTSVEEEVDLPFQRDELNYPTIFASSLKGAIKSFLLKEYSNAREIIYKVLGSDENPDEASLGSFLDAVLFAIPARSIGVSGLDEAWVYVTTYELLRKVKSLLESMNTLSATQFTSLLDAINNILQESKNLIISDNAASVILNEDFYVELSNIQNEYIQSLLGDMLIENSTYNQSNQNSQSQGNHLVKPLIVLKDSIGREVINRSLIRVRRIKIKRSSKTVEEGGLWSEEYVPVNSLFFSSFLARGSKDTAYFADCILRKTRYLILGGKETIGKGIVELRWLND	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	308 (257)
Sequences:	396 (368)
Seq/√Len:	23.0

SULSO - CMR4 Q97Y36 Q97XK7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
234_R	252_S	6.487	1.00
256_V	262_F	5.758	1.00
255_Y	298_K	4.929	1.00
238_I	243_K	4.534	1.00
95_F	263_F	4.185	1.00
239_K	246_E	3.800	1.00
235_R	296_I	3.650	1.00
38_Q	48_F	3.490	1.00
97_I	226_I	3.345	1.00
77_S	83_E	3.115	1.00
94_L	260_S	2.894	0.99
37_F	262_F	2.878	0.99
243_K	294_E	2.869	0.99
251_W	296_I	2.848	0.99
237_K	246_E	2.792	0.99
109_E	112_V	2.757	0.99
167_N	174_L	2.565	0.99
17_A	21_L	2.363	0.98
58_S	294_E	2.351	0.97
174_L	177_I	2.211	0.96
75_L	85_S	2.114	0.95
253_E	293_K	2.089	0.95
164_V	167_N	2.046	0.94
117_Y	219_D	2.033	0.94
116_T	222_G	2.016	0.94
209_H	213_P	2.009	0.94
77_S	82_D	1.969	0.93
37_F	256_V	1.958	0.93
173_E	177_I	1.943	0.93
56_I	89_F	1.903	0.92
251_W	293_K	1.864	0.91
42_L	57_K	1.824	0.90
217_L	267_L	1.757	0.88
167_N	172_V	1.734	0.87
26_G	34_D	1.731	0.87
23_V	37_F	1.721	0.87
167_N	177_I	1.705	0.87
33_V	234_R	1.690	0.86
96_A	261_L	1.689	0.86
168_E	174_L	1.654	0.85
185_L	188_D	1.629	0.84
167_N	171_Y	1.612	0.83
167_N	170_F	1.607	0.83
114_V	172_V	1.597	0.83
40_D	259_N	1.596	0.83
40_D	122_K	1.583	0.82
21_L	301_V	1.566	0.81
167_N	173_E	1.555	0.81
238_I	242_S	1.553	0.81
23_V	230_L	1.530	0.80
57_K	85_S	1.524	0.79
251_W	259_N	1.521	0.79
167_N	175_S	1.506	0.79
92_A	264_S	1.495	0.78
23_V	48_F	1.494	0.78
236_I	245_V	1.493	0.78
185_L	189_M	1.483	0.78
14_F	89_F	1.470	0.77
235_R	253_E	1.465	0.77
55_A	58_S	1.463	0.77
42_L	99_A	1.459	0.76
217_L	221_I	1.445	0.76
23_V	38_Q	1.440	0.75
210_L	214_L	1.436	0.75
96_A	214_L	1.422	0.74
77_S	84_A	1.413	0.74
90_L	267_L	1.410	0.74
47_I	290_L	1.405	0.74
222_G	226_I	1.396	0.73
116_T	219_D	1.394	0.73
16_K	259_N	1.375	0.72
53_K	295_T	1.370	0.72
119_L	226_I	1.364	0.71
230_L	256_V	1.363	0.71
245_V	248_G	1.356	0.71
237_K	245_V	1.349	0.70
238_I	245_V	1.343	0.70
166_L	169_D	1.343	0.70
289_I	293_K	1.317	0.69
113_Y	255_Y	1.314	0.68
40_D	222_G	1.277	0.66
23_V	256_V	1.270	0.66
77_S	80_N	1.257	0.65
121_R	209_H	1.216	0.62
49_A	300_I	1.205	0.61
15_I	92_A	1.202	0.61
26_G	250_L	1.191	0.61
234_R	251_W	1.190	0.60
37_F	238_I	1.181	0.60
92_A	116_T	1.170	0.59
33_V	252_S	1.169	0.59
101_S	253_E	1.159	0.58
49_A	262_F	1.151	0.58
49_A	296_I	1.118	0.56
37_F	230_L	1.116	0.55
40_D	111_W	1.112	0.55
48_F	55_A	1.110	0.55
146_N	150_Q	1.105	0.55
53_K	111_W	1.077	0.53
41_E	294_E	1.069	0.52
52_L	149_L	1.055	0.51
119_L	222_G	1.039	0.50
95_F	123_V	1.034	0.50
260_S	294_E	1.033	0.50
38_Q	46_T	1.026	0.49
17_A	293_K	1.026	0.49
20_H	251_W	1.012	0.48
231_I	258_V	1.009	0.48
18_V	113_Y	1.005	0.48
96_A	210_L	0.997	0.47
20_H	258_V	0.996	0.47
113_Y	260_S	0.987	0.47
119_L	231_I	0.987	0.47
172_V	217_L	0.985	0.46
114_V	217_L	0.984	0.46
94_L	119_L	0.977	0.46
36_P	84_A	0.972	0.46
236_I	251_W	0.971	0.45
145_I	148_I	0.971	0.45
275_A	282_L	0.970	0.45
237_K	249_G	0.968	0.45
20_H	233_V	0.967	0.45
169_D	174_L	0.962	0.45
73_K	271_S	0.953	0.44
277_F	285_T	0.949	0.44
168_E	171_Y	0.940	0.43
40_D	93_V	0.936	0.43
13_F	264_S	0.936	0.43
46_T	251_W	0.930	0.43
14_F	217_L	0.926	0.42
13_F	274_T	0.926	0.42
239_K	242_S	0.926	0.42
166_L	172_V	0.924	0.42
96_A	295_T	0.922	0.42
90_L	265_S	0.919	0.42
77_S	81_P	0.918	0.42
117_Y	122_K	0.918	0.42
184_S	189_M	0.917	0.42
47_I	262_F	0.908	0.41
236_I	260_S	0.906	0.41
49_A	85_S	0.902	0.41
87_G	165_I	0.901	0.41
75_L	167_N	0.896	0.40
274_T	277_F	0.895	0.40
122_K	125_S	0.889	0.40
110_A	301_V	0.881	0.39
12_P	265_S	0.880	0.39
102_I	238_I	0.875	0.39
278_A	285_T	0.874	0.39
55_A	264_S	0.861	0.38
172_V	177_I	0.854	0.38
165_I	215_I	0.851	0.37
187_G	275_A	0.850	0.37
111_W	217_L	0.844	0.37
252_S	258_V	0.840	0.37
43_N	227_N	0.840	0.37
29_V	238_I	0.837	0.36
47_I	229_S	0.834	0.36
19_T	253_E	0.826	0.36
52_L	264_S	0.826	0.36
111_W	231_I	0.825	0.36
255_Y	293_K	0.824	0.36
44_Y	91_D	0.822	0.36
35_L	251_W	0.817	0.35
277_F	280_C	0.816	0.35
47_I	52_L	0.816	0.35
18_V	213_P	0.809	0.35
149_L	152_S	0.809	0.35
206_Q	209_H	0.804	0.34
101_S	117_Y	0.803	0.34
38_Q	53_K	0.800	0.34
19_T	96_A	0.798	0.34
167_N	239_K	0.789	0.33
97_I	230_L	0.788	0.33
222_G	231_I	0.785	0.33
33_V	111_W	0.781	0.33
87_G	268_A	0.780	0.33
163_S	208_N	0.780	0.33
99_A	225_V	0.773	0.32
164_V	184_S	0.772	0.32
88_S	267_L	0.770	0.32
26_G	33_V	0.767	0.32
119_L	230_L	0.761	0.32
113_Y	301_V	0.761	0.32
212_K	241_S	0.759	0.32
73_K	261_L	0.757	0.31
23_V	262_F	0.755	0.31
231_I	234_R	0.752	0.31
291_G	299_G	0.750	0.31
60_L	71_I	0.750	0.31
164_V	172_V	0.750	0.31
224_E	228_R	0.749	0.31
188_D	276_Y	0.744	0.31
25_S	296_I	0.740	0.30
12_P	238_I	0.737	0.30
45_P	91_D	0.733	0.30
259_N	296_I	0.730	0.30
165_I	214_L	0.729	0.30
143_D	148_I	0.727	0.30
114_V	123_V	0.724	0.30
151_E	276_Y	0.722	0.29
28_S	235_R	0.720	0.29
120_L	236_I	0.719	0.29
36_P	88_S	0.717	0.29
130_M	188_D	0.716	0.29
93_V	126_L	0.715	0.29
116_T	269_R	0.714	0.29
102_I	113_Y	0.714	0.29
20_H	40_D	0.713	0.29
169_D	172_V	0.709	0.29
34_D	250_L	0.708	0.29
176_N	216_V	0.707	0.29
233_V	296_I	0.706	0.29
74_V	277_F	0.706	0.29
273_D	285_T	0.705	0.28
255_Y	301_V	0.704	0.28
12_P	100_R	0.703	0.28
249_G	269_R	0.703	0.28
235_R	251_W	0.694	0.28
18_V	214_L	0.694	0.28
124_K	148_I	0.687	0.27
111_W	263_F	0.686	0.27
42_L	289_I	0.685	0.27
133_L	276_Y	0.685	0.27
35_L	293_K	0.683	0.27
169_D	221_I	0.682	0.27
238_I	247_E	0.681	0.27
48_F	51_S	0.676	0.27
48_F	233_V	0.676	0.27
52_L	92_A	0.675	0.27
227_N	298_K	0.675	0.27
51_S	235_R	0.674	0.27
165_I	172_V	0.674	0.27
245_V	271_S	0.674	0.27
100_R	261_L	0.672	0.27
45_P	75_L	0.669	0.26
44_Y	111_W	0.669	0.26
93_V	263_F	0.669	0.26
36_P	53_K	0.667	0.26
41_E	126_L	0.662	0.26
19_T	300_I	0.661	0.26
229_S	255_Y	0.661	0.26
226_I	231_I	0.653	0.26
52_L	290_L	0.652	0.26
33_V	100_R	0.650	0.25
133_L	188_D	0.649	0.25
46_T	71_I	0.649	0.25
17_A	301_V	0.647	0.25
90_L	266_F	0.646	0.25
230_L	262_F	0.644	0.25
275_A	281_I	0.641	0.25
96_A	250_L	0.641	0.25
77_S	269_R	0.640	0.25
47_I	51_S	0.638	0.25
221_I	235_R	0.634	0.25
142_L	145_I	0.632	0.25
225_V	228_R	0.631	0.24
44_Y	225_V	0.627	0.24
31_E	85_S	0.625	0.24
234_R	238_I	0.622	0.24
150_Q	212_K	0.622	0.24
216_V	273_D	0.619	0.24
128_E	188_D	0.617	0.24
162_A	165_I	0.612	0.23
29_V	111_W	0.611	0.23
94_L	176_N	0.611	0.23
36_P	40_D	0.609	0.23
229_S	264_S	0.608	0.23
212_K	215_I	0.608	0.23
46_T	235_R	0.607	0.23
41_E	230_L	0.606	0.23
48_F	298_K	0.606	0.23
28_S	88_S	0.605	0.23
40_D	113_Y	0.605	0.23
128_E	273_D	0.604	0.23
94_L	216_V	0.600	0.23
110_A	259_N	0.600	0.23
234_R	250_L	0.597	0.23
171_Y	177_I	0.597	0.23
235_R	293_K	0.597	0.23
44_Y	235_R	0.597	0.23
53_K	293_K	0.596	0.23
228_R	293_K	0.594	0.23
226_I	255_Y	0.593	0.23
57_K	99_A	0.592	0.23
39_R	117_Y	0.592	0.23
123_V	264_S	0.590	0.22
37_F	246_E	0.588	0.22
15_I	259_N	0.587	0.22
17_A	176_N	0.582	0.22
276_Y	286_R	0.580	0.22
144_A	147_N	0.580	0.22
27_T	289_I	0.579	0.22
127_L	131_N	0.578	0.22
144_A	149_L	0.578	0.22
53_K	235_R	0.574	0.22
150_Q	208_N	0.573	0.22
38_Q	255_Y	0.573	0.22
44_Y	119_L	0.572	0.22
208_N	278_A	0.572	0.22
161_A	286_R	0.570	0.21
147_N	272_K	0.568	0.21
237_K	248_G	0.567	0.21
21_L	245_V	0.567	0.21
74_V	116_T	0.564	0.21
109_E	117_Y	0.564	0.21
161_A	220_S	0.563	0.21
232_R	243_K	0.562	0.21
109_E	253_E	0.561	0.21
37_F	42_L	0.561	0.21
92_A	110_A	0.560	0.21
114_V	225_V	0.559	0.21
277_F	286_R	0.558	0.21
68_R	149_L	0.555	0.21
49_A	256_V	0.555	0.21
110_A	264_S	0.553	0.21
18_V	120_L	0.551	0.21
41_E	111_W	0.551	0.21
175_S	179_N	0.550	0.21
149_L	182_I	0.550	0.21
293_K	298_K	0.549	0.20
261_L	283_R	0.547	0.20
228_R	235_R	0.547	0.20
50_S	298_K	0.546	0.20
23_V	94_L	0.546	0.20
122_K	258_V	0.545	0.20
19_T	243_K	0.544	0.20
26_G	295_T	0.543	0.20
97_I	229_S	0.543	0.20
57_K	61_L	0.542	0.20
291_G	297_G	0.540	0.20
142_L	260_S	0.539	0.20
257_P	291_G	0.536	0.20
121_R	184_S	0.535	0.20
213_P	294_E	0.535	0.20
42_L	259_N	0.535	0.20
79_E	273_D	0.535	0.20
207_G	237_K	0.535	0.20
170_F	251_W	0.534	0.20
165_I	279_D	0.533	0.20
212_K	285_T	0.532	0.20
110_A	234_R	0.530	0.20
177_I	283_R	0.530	0.20
214_L	285_T	0.530	0.20
37_F	215_I	0.529	0.20
43_N	248_G	0.529	0.20
55_A	90_L	0.529	0.20
80_N	83_E	0.528	0.20
174_L	179_N	0.528	0.20
48_F	255_Y	0.528	0.20
238_I	294_E	0.527	0.20
77_S	244_T	0.525	0.19
51_S	218_K	0.522	0.19
94_L	262_F	0.521	0.19
278_A	283_R	0.521	0.19
168_E	177_I	0.520	0.19
47_I	265_S	0.519	0.19
231_I	255_Y	0.518	0.19
237_K	247_E	0.518	0.19
12_P	243_K	0.517	0.19
49_A	288_L	0.516	0.19
40_D	231_I	0.514	0.19
87_G	210_L	0.514	0.19
46_T	234_R	0.513	0.19
236_I	249_G	0.513	0.19
125_S	298_K	0.513	0.19
164_V	176_N	0.513	0.19
269_R	294_E	0.512	0.19
60_L	75_L	0.512	0.19
72_Y	260_S	0.511	0.19
222_G	289_I	0.508	0.19
40_D	50_S	0.506	0.19
255_Y	258_V	0.506	0.19
82_D	220_S	0.505	0.19
110_A	231_I	0.505	0.19
131_N	283_R	0.505	0.19
76_G	98_P	0.505	0.19
230_L	258_V	0.505	0.19
162_A	176_N	0.505	0.19
116_T	120_L	0.504	0.19
100_R	229_S	0.503	0.18
111_W	259_N	0.502	0.18
152_S	189_M	0.501	0.18
186_L	208_N	0.500	0.18
38_Q	55_A	0.500	0.18
222_G	233_V	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3x1lC	3	0.9221	100	0.312	Contact Map
4w8wA	1	0.8247	100	0.34	Contact Map
4qtsC	1	0.4416	100	0.703	Contact Map
4n0lA	1	0.6591	99.9	0.743	Contact Map
4w8vA	1	0.6039	99.8	0.789	Contact Map
3x1lH	1	0.5097	99.8	0.792	Contact Map
4qtsA	1	0.6071	98.1	0.904	Contact Map
3x1lB	1	0.6753	97.2	0.919	Contact Map
4l6uA	1	0.487	59.7	0.959	Contact Map
4txdA	1	0.7208	25.7	0.967	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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