CMR3 - SULSO - GREMLIN Contacts

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CMR3 - CRISPR system CMR subunit Cmr3

UniProt:	Q97WW9	Sequences: MMKRVLIKPLEPLMFRSQGEFEPLITGSHTAAQSLIIPRPSTIAGMLGYILFNKSSGTGDWLSDLTNLLDTIYGTFIETNGEYLFPLRMGNHLALVDQQHLINLPILLEKEYEQREKGIYELFYDKNKLFQIINHQDRIGISIDKSTRTVKEHYLYSARYLAFKKEVNYVIFIDNDAISDKINGKIVNFGGENRIAKLEVDDYKVDTSIEEEYYLTLSPILIPDEALDDLLDNISDYVTMGKVDKISLGFDIANTKRKEMLTAILEGSIVKRSIIDFIKKEINNNLLDRFTKYEKIGYNTLMNLCKLAFRKILS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	314 (280)
Sequences:	250 (234)
Seq/√Len:	14.0

SULSO - CMR3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
136_Q	162_A	5.358	1.00
90_G	213_Y	4.842	1.00
225_E	228_D	4.106	1.00
264_I	270_V	3.926	1.00
44_A	138_R	3.917	1.00
188_N	193_N	3.592	0.99
213_Y	269_I	3.527	0.99
12_P	160_Y	3.523	0.99
89_M	241_G	3.328	0.99
221_L	263_A	3.147	0.98
11_E	46_M	2.978	0.97
228_D	264_I	2.941	0.97
90_G	269_I	2.891	0.97
143_I	147_T	2.860	0.96
222_I	270_V	2.772	0.96
241_G	268_S	2.632	0.94
9_P	163_F	2.519	0.93
140_G	156_Y	2.513	0.93
132_I	140_G	2.457	0.92
141_I	156_Y	2.412	0.91
222_I	239_T	2.375	0.90
237_Y	273_S	2.242	0.87
13_L	196_A	2.221	0.87
43_I	47_L	2.216	0.87
14_M	140_G	2.145	0.85
16_R	32_A	2.104	0.84
144_D	151_K	2.029	0.81
114_Q	121_E	1.974	0.80
72_I	173_I	1.966	0.79
250_F	257_R	1.953	0.79
42_T	52_F	1.878	0.76
140_G	160_Y	1.872	0.76
20_E	192_E	1.821	0.74
19_G	194_R	1.802	0.73
222_I	238_V	1.799	0.73
39_R	246_I	1.770	0.71
238_V	272_R	1.738	0.70
45_G	297_G	1.731	0.70
116_E	120_Y	1.712	0.69
226_A	240_M	1.704	0.68
116_E	122_L	1.616	0.64
138_R	194_R	1.611	0.64
34_S	268_S	1.584	0.63
7_I	40_P	1.568	0.62
37_I	161_L	1.552	0.61
141_I	150_V	1.548	0.61
228_D	270_V	1.545	0.61
49_Y	80_N	1.542	0.60
44_A	263_A	1.528	0.60
140_G	296_I	1.493	0.58
36_I	156_Y	1.490	0.58
113_E	116_E	1.482	0.57
156_Y	163_F	1.467	0.56
185_K	198_L	1.453	0.56
15_F	162_A	1.443	0.55
40_P	90_G	1.438	0.55
99_Q	204_K	1.434	0.55
82_E	268_S	1.428	0.54
225_E	240_M	1.428	0.54
15_F	140_G	1.425	0.54
10_L	21_F	1.404	0.53
18_Q	299_N	1.402	0.53
8_K	86_P	1.382	0.52
230_L	238_V	1.381	0.52
46_M	187_V	1.340	0.50
216_T	238_V	1.339	0.50
291_T	295_K	1.328	0.49
139_I	157_S	1.327	0.49
238_V	270_V	1.327	0.49
44_A	271_K	1.305	0.48
6_L	81_G	1.300	0.47
85_F	217_L	1.297	0.47
21_F	218_S	1.266	0.46
113_E	119_I	1.252	0.45
145_K	205_V	1.242	0.44
194_R	250_F	1.241	0.44
225_E	264_I	1.238	0.44
187_V	198_L	1.222	0.43
17_S	299_N	1.221	0.43
37_I	156_Y	1.218	0.43
222_I	225_E	1.216	0.43
17_S	262_T	1.204	0.42
90_G	270_V	1.201	0.42
31_A	194_R	1.190	0.42
38_P	189_F	1.190	0.42
136_Q	152_E	1.186	0.41
20_E	143_I	1.182	0.41
225_E	242_K	1.169	0.40
16_R	44_A	1.166	0.40
115_R	122_L	1.152	0.40
15_F	76_F	1.151	0.39
87_L	139_I	1.144	0.39
11_E	265_L	1.144	0.39
74_G	218_S	1.142	0.39
249_G	258_K	1.142	0.39
225_E	270_V	1.141	0.39
146_S	234_I	1.131	0.38
262_T	298_Y	1.129	0.38
45_G	251_D	1.127	0.38
257_R	297_G	1.127	0.38
37_I	133_I	1.125	0.38
156_Y	193_N	1.119	0.38
7_I	196_A	1.117	0.38
239_T	271_K	1.113	0.38
77_I	163_F	1.112	0.37
31_A	157_S	1.112	0.37
151_K	154_Y	1.110	0.37
41_S	298_Y	1.109	0.37
217_L	253_A	1.107	0.37
43_I	169_Y	1.103	0.37
93_L	189_F	1.098	0.37
236_D	272_R	1.093	0.37
209_I	255_T	1.092	0.36
230_L	237_Y	1.087	0.36
155_L	194_R	1.085	0.36
194_R	260_M	1.079	0.36
235_S	275_I	1.077	0.36
216_T	264_I	1.073	0.36
41_S	258_K	1.069	0.35
38_P	42_T	1.066	0.35
44_A	213_Y	1.061	0.35
16_R	21_F	1.057	0.35
187_V	202_D	1.052	0.34
27_G	37_I	1.052	0.34
44_A	296_I	1.048	0.34
113_E	120_Y	1.047	0.34
226_A	270_V	1.047	0.34
20_E	299_N	1.042	0.34
220_I	270_V	1.042	0.34
19_G	260_M	1.039	0.34
46_M	156_Y	1.035	0.34
264_I	294_E	1.030	0.33
139_I	156_Y	1.022	0.33
168_N	202_D	1.010	0.32
18_Q	298_Y	1.006	0.32
246_I	263_A	1.006	0.32
135_H	159_R	1.001	0.32
138_R	213_Y	0.998	0.32
18_Q	40_P	0.996	0.32
15_F	27_G	0.994	0.32
17_S	213_Y	0.991	0.32
47_L	126_K	0.989	0.31
190_G	267_G	0.983	0.31
116_E	119_I	0.982	0.31
143_I	272_R	0.977	0.31
278_I	303_N	0.976	0.31
118_G	121_E	0.974	0.31
187_V	196_A	0.973	0.31
17_S	271_K	0.969	0.31
40_P	155_L	0.965	0.30
136_Q	156_Y	0.965	0.30
52_F	271_K	0.960	0.30
40_P	225_E	0.958	0.30
9_P	143_I	0.953	0.30
220_I	228_D	0.946	0.29
158_A	196_A	0.942	0.29
117_K	121_E	0.942	0.29
64_D	68_L	0.938	0.29
222_I	262_T	0.936	0.29
77_I	202_D	0.929	0.29
218_S	270_V	0.927	0.29
170_V	186_I	0.925	0.29
37_I	163_F	0.924	0.28
63_S	221_L	0.913	0.28
42_T	90_G	0.909	0.28
196_A	218_S	0.907	0.28
192_E	299_N	0.907	0.28
283_N	286_L	0.906	0.28
115_R	121_E	0.906	0.28
136_Q	299_N	0.899	0.27
26_T	140_G	0.898	0.27
84_L	132_I	0.894	0.27
5_V	139_I	0.893	0.27
91_N	246_I	0.891	0.27
12_P	37_I	0.891	0.27
36_I	162_A	0.890	0.27
268_S	297_G	0.885	0.27
140_G	190_G	0.879	0.27
72_I	240_M	0.864	0.26
43_I	298_Y	0.859	0.26
244_D	289_R	0.856	0.26
276_D	280_K	0.855	0.26
16_R	158_A	0.849	0.25
68_L	99_Q	0.848	0.25
12_P	162_A	0.847	0.25
216_T	277_F	0.845	0.25
18_Q	155_L	0.844	0.25
227_L	239_T	0.843	0.25
59_G	259_E	0.830	0.25
78_E	197_K	0.829	0.24
12_P	296_I	0.824	0.24
219_P	225_E	0.823	0.24
97_D	150_V	0.820	0.24
20_E	266_E	0.818	0.24
70_D	182_I	0.818	0.24
138_R	224_D	0.815	0.24
124_Y	256_K	0.814	0.24
14_M	160_Y	0.811	0.24
84_L	127_N	0.809	0.24
49_Y	92_H	0.807	0.24
237_Y	276_D	0.802	0.23
16_R	215_L	0.802	0.23
12_P	16_R	0.799	0.23
10_L	189_F	0.798	0.23
63_S	256_K	0.795	0.23
163_F	220_I	0.795	0.23
48_G	242_K	0.794	0.23
219_P	266_E	0.793	0.23
84_L	92_H	0.791	0.23
110_K	116_E	0.782	0.23
31_A	156_Y	0.782	0.23
15_F	156_Y	0.781	0.23
77_I	161_L	0.781	0.23
41_S	44_A	0.778	0.22
11_E	233_N	0.775	0.22
138_R	158_A	0.775	0.22
228_D	299_N	0.773	0.22
52_F	299_N	0.771	0.22
191_G	267_G	0.771	0.22
110_K	120_Y	0.769	0.22
17_S	222_I	0.767	0.22
50_I	193_N	0.767	0.22
86_P	297_G	0.766	0.22
43_I	194_R	0.765	0.22
40_P	219_P	0.765	0.22
73_Y	172_F	0.763	0.22
70_D	130_F	0.760	0.22
89_M	268_S	0.760	0.22
117_K	120_Y	0.759	0.22
287_L	291_T	0.758	0.22
36_I	192_E	0.757	0.22
46_M	162_A	0.754	0.22
12_P	36_I	0.751	0.21
14_M	196_A	0.751	0.21
84_L	173_I	0.748	0.21
288_D	292_K	0.745	0.21
35_L	142_S	0.745	0.21
19_G	193_N	0.744	0.21
155_L	262_T	0.740	0.21
41_S	90_G	0.738	0.21
152_E	272_R	0.737	0.21
72_I	259_E	0.737	0.21
239_T	263_A	0.736	0.21
12_P	230_L	0.724	0.21
89_M	251_D	0.721	0.20
78_E	144_D	0.720	0.20
45_G	138_R	0.720	0.20
36_I	136_Q	0.720	0.20
234_I	238_V	0.715	0.20
119_I	122_L	0.712	0.20
152_E	156_Y	0.710	0.20
158_A	259_E	0.710	0.20
16_R	270_V	0.709	0.20
246_I	268_S	0.709	0.20
45_G	194_R	0.708	0.20
233_N	236_D	0.707	0.20
5_V	298_Y	0.707	0.20
139_I	256_K	0.701	0.20
56_S	295_K	0.700	0.20
77_I	91_N	0.697	0.20
216_T	220_I	0.693	0.19
205_V	255_T	0.692	0.19
65_L	68_L	0.692	0.19
60_D	173_I	0.688	0.19
287_L	292_K	0.684	0.19
114_Q	118_G	0.682	0.19
142_S	153_H	0.681	0.19
38_P	251_D	0.681	0.19
15_F	217_L	0.679	0.19
141_I	296_I	0.676	0.19
47_L	86_P	0.675	0.19
222_I	226_A	0.669	0.19
286_L	292_K	0.664	0.18
281_E	287_L	0.663	0.18
233_N	237_Y	0.662	0.18
220_I	271_K	0.661	0.18
19_G	218_S	0.655	0.18
21_F	40_P	0.653	0.18
129_L	135_H	0.653	0.18
88_R	265_L	0.652	0.18
156_Y	263_A	0.651	0.18
235_S	298_Y	0.650	0.18
118_G	196_A	0.649	0.18
74_G	169_Y	0.649	0.18
29_H	158_A	0.648	0.18
26_T	30_T	0.646	0.18
110_K	113_E	0.646	0.18
32_A	47_L	0.645	0.18
251_D	254_N	0.642	0.18
80_N	276_D	0.641	0.18
27_G	263_A	0.640	0.18
25_I	93_L	0.639	0.18
160_Y	194_R	0.639	0.18
177_A	268_S	0.637	0.18
115_R	119_I	0.636	0.18
208_S	254_N	0.635	0.18
155_L	298_Y	0.634	0.18
92_H	218_S	0.634	0.18
83_Y	170_V	0.633	0.17
74_G	136_Q	0.632	0.17
84_L	215_L	0.632	0.17
25_I	136_Q	0.629	0.17
36_I	46_M	0.629	0.17
75_T	299_N	0.627	0.17
34_S	194_R	0.626	0.17
12_P	140_G	0.622	0.17
15_F	190_G	0.622	0.17
35_L	215_L	0.622	0.17
48_G	266_E	0.621	0.17
110_K	119_I	0.621	0.17
71_T	295_K	0.621	0.17
216_T	250_F	0.620	0.17
76_F	171_I	0.619	0.17
264_I	299_N	0.618	0.17
110_K	115_R	0.615	0.17
38_P	45_G	0.611	0.17
4_R	172_F	0.606	0.17
32_A	37_I	0.605	0.17
143_I	236_D	0.602	0.17
264_I	272_R	0.601	0.17
138_R	160_Y	0.600	0.16
39_R	192_E	0.599	0.16
195_I	262_T	0.598	0.16
216_T	229_D	0.598	0.16
64_D	67_N	0.597	0.16
114_Q	119_I	0.597	0.16
18_Q	246_I	0.597	0.16
8_K	59_G	0.596	0.16
18_Q	296_I	0.595	0.16
19_G	31_A	0.594	0.16
37_I	188_N	0.593	0.16
278_I	281_E	0.591	0.16
40_P	194_R	0.590	0.16
16_R	264_I	0.590	0.16
34_S	45_G	0.590	0.16
17_S	20_E	0.590	0.16
285_N	288_D	0.588	0.16
249_G	299_N	0.588	0.16
28_S	162_A	0.587	0.16
219_P	299_N	0.587	0.16
35_L	271_K	0.587	0.16
268_S	271_K	0.587	0.16
239_T	270_V	0.585	0.16
9_P	15_F	0.585	0.16
14_M	296_I	0.584	0.16
76_F	85_F	0.583	0.16
5_V	200_V	0.579	0.16
158_A	194_R	0.578	0.16
225_E	230_L	0.577	0.16
161_L	169_Y	0.574	0.16
36_I	148_R	0.574	0.16
226_A	238_V	0.574	0.16
94_A	253_A	0.571	0.16
200_V	255_T	0.570	0.16
14_M	157_S	0.570	0.16
42_T	269_I	0.568	0.16
47_L	125_D	0.568	0.16
138_R	157_S	0.563	0.15
21_F	270_V	0.562	0.15
140_G	270_V	0.562	0.15
52_F	133_I	0.562	0.15
205_V	282_I	0.561	0.15
49_Y	164_K	0.561	0.15
42_T	170_V	0.558	0.15
198_L	269_I	0.558	0.15
211_E	233_N	0.556	0.15
5_V	72_I	0.556	0.15
115_R	120_Y	0.556	0.15
264_I	268_S	0.556	0.15
141_I	171_I	0.553	0.15
59_G	220_I	0.553	0.15
46_M	50_I	0.553	0.15
258_K	269_I	0.553	0.15
246_I	258_K	0.553	0.15
91_N	170_V	0.552	0.15
5_V	220_I	0.550	0.15
163_F	173_I	0.550	0.15
160_Y	241_G	0.550	0.15
39_R	169_Y	0.550	0.15
165_K	269_I	0.549	0.15
17_S	246_I	0.543	0.15
204_K	211_E	0.542	0.15
131_Q	199_E	0.537	0.15
195_I	220_I	0.537	0.15
192_E	213_Y	0.537	0.15
59_G	62_L	0.537	0.15
27_G	38_P	0.536	0.15
194_R	219_P	0.536	0.15
194_R	249_G	0.534	0.15
17_S	73_Y	0.533	0.15
136_Q	271_K	0.528	0.14
58_T	84_L	0.526	0.14
39_R	263_A	0.526	0.14
161_L	187_V	0.524	0.14
76_F	234_I	0.521	0.14
48_G	88_R	0.521	0.14
205_V	264_I	0.520	0.14
21_F	32_A	0.520	0.14
44_A	74_G	0.520	0.14
220_I	264_I	0.518	0.14
128_K	144_D	0.518	0.14
138_R	297_G	0.518	0.14
263_A	270_V	0.517	0.14
130_F	209_I	0.517	0.14
68_L	124_Y	0.516	0.14
215_L	301_L	0.515	0.14
46_M	242_K	0.514	0.14
27_G	193_N	0.513	0.14
14_M	139_I	0.512	0.14
12_P	46_M	0.511	0.14
201_D	273_S	0.508	0.14
25_I	273_S	0.508	0.14
10_L	187_V	0.507	0.14
7_I	212_E	0.507	0.14
18_Q	172_F	0.505	0.14
128_K	198_L	0.505	0.14
202_D	280_K	0.503	0.14
46_M	196_A	0.503	0.14
34_S	118_G	0.501	0.14
128_K	223_P	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3x1lB	1	0.9108	100	0.411	Contact Map
4qtsA	1	0.7866	98.7	0.878	Contact Map
4w8wA	1	0.5478	97.1	0.916	Contact Map
3x1lC	3	0.6146	96.2	0.924	Contact Map
4qtsC	1	0.5032	60.7	0.955	Contact Map
4gxbA	1	0.1943	12.8	0.969	Contact Map
4mjkA	2	0.7389	7.1	0.972	Contact Map
3j61Z	1	0.1688	6	0.973	Contact Map
3j39Z	1	0.1656	5.1	0.974	Contact Map
4nawA	1	0.1688	4.8	0.974	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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