GREMLIN Database
CMR3 - CRISPR system CMR subunit Cmr3
UniProt: Q97WW9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 314 (280)
Sequences: 250 (234)
Seq/√Len: 14.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_Q162_A5.3581.00
90_G213_Y4.8421.00
225_E228_D4.1061.00
264_I270_V3.9261.00
44_A138_R3.9171.00
188_N193_N3.5920.99
213_Y269_I3.5270.99
12_P160_Y3.5230.99
89_M241_G3.3280.99
221_L263_A3.1470.98
11_E46_M2.9780.97
228_D264_I2.9410.97
90_G269_I2.8910.97
143_I147_T2.8600.96
222_I270_V2.7720.96
241_G268_S2.6320.94
9_P163_F2.5190.93
140_G156_Y2.5130.93
132_I140_G2.4570.92
141_I156_Y2.4120.91
222_I239_T2.3750.90
237_Y273_S2.2420.87
13_L196_A2.2210.87
43_I47_L2.2160.87
14_M140_G2.1450.85
16_R32_A2.1040.84
144_D151_K2.0290.81
114_Q121_E1.9740.80
72_I173_I1.9660.79
250_F257_R1.9530.79
42_T52_F1.8780.76
140_G160_Y1.8720.76
20_E192_E1.8210.74
19_G194_R1.8020.73
222_I238_V1.7990.73
39_R246_I1.7700.71
238_V272_R1.7380.70
45_G297_G1.7310.70
116_E120_Y1.7120.69
226_A240_M1.7040.68
116_E122_L1.6160.64
138_R194_R1.6110.64
34_S268_S1.5840.63
7_I40_P1.5680.62
37_I161_L1.5520.61
141_I150_V1.5480.61
228_D270_V1.5450.61
49_Y80_N1.5420.60
44_A263_A1.5280.60
140_G296_I1.4930.58
36_I156_Y1.4900.58
113_E116_E1.4820.57
156_Y163_F1.4670.56
185_K198_L1.4530.56
15_F162_A1.4430.55
40_P90_G1.4380.55
99_Q204_K1.4340.55
82_E268_S1.4280.54
225_E240_M1.4280.54
15_F140_G1.4250.54
10_L21_F1.4040.53
18_Q299_N1.4020.53
8_K86_P1.3820.52
230_L238_V1.3810.52
46_M187_V1.3400.50
216_T238_V1.3390.50
291_T295_K1.3280.49
139_I157_S1.3270.49
238_V270_V1.3270.49
44_A271_K1.3050.48
6_L81_G1.3000.47
85_F217_L1.2970.47
21_F218_S1.2660.46
113_E119_I1.2520.45
145_K205_V1.2420.44
194_R250_F1.2410.44
225_E264_I1.2380.44
187_V198_L1.2220.43
17_S299_N1.2210.43
37_I156_Y1.2180.43
222_I225_E1.2160.43
17_S262_T1.2040.42
90_G270_V1.2010.42
31_A194_R1.1900.42
38_P189_F1.1900.42
136_Q152_E1.1860.41
20_E143_I1.1820.41
225_E242_K1.1690.40
16_R44_A1.1660.40
115_R122_L1.1520.40
15_F76_F1.1510.39
87_L139_I1.1440.39
11_E265_L1.1440.39
74_G218_S1.1420.39
249_G258_K1.1420.39
225_E270_V1.1410.39
146_S234_I1.1310.38
262_T298_Y1.1290.38
45_G251_D1.1270.38
257_R297_G1.1270.38
37_I133_I1.1250.38
156_Y193_N1.1190.38
7_I196_A1.1170.38
239_T271_K1.1130.38
77_I163_F1.1120.37
31_A157_S1.1120.37
151_K154_Y1.1100.37
41_S298_Y1.1090.37
217_L253_A1.1070.37
43_I169_Y1.1030.37
93_L189_F1.0980.37
236_D272_R1.0930.37
209_I255_T1.0920.36
230_L237_Y1.0870.36
155_L194_R1.0850.36
194_R260_M1.0790.36
235_S275_I1.0770.36
216_T264_I1.0730.36
41_S258_K1.0690.35
38_P42_T1.0660.35
44_A213_Y1.0610.35
16_R21_F1.0570.35
187_V202_D1.0520.34
27_G37_I1.0520.34
44_A296_I1.0480.34
113_E120_Y1.0470.34
226_A270_V1.0470.34
20_E299_N1.0420.34
220_I270_V1.0420.34
19_G260_M1.0390.34
46_M156_Y1.0350.34
264_I294_E1.0300.33
139_I156_Y1.0220.33
168_N202_D1.0100.32
18_Q298_Y1.0060.32
246_I263_A1.0060.32
135_H159_R1.0010.32
138_R213_Y0.9980.32
18_Q40_P0.9960.32
15_F27_G0.9940.32
17_S213_Y0.9910.32
47_L126_K0.9890.31
190_G267_G0.9830.31
116_E119_I0.9820.31
143_I272_R0.9770.31
278_I303_N0.9760.31
118_G121_E0.9740.31
187_V196_A0.9730.31
17_S271_K0.9690.31
40_P155_L0.9650.30
136_Q156_Y0.9650.30
52_F271_K0.9600.30
40_P225_E0.9580.30
9_P143_I0.9530.30
220_I228_D0.9460.29
158_A196_A0.9420.29
117_K121_E0.9420.29
64_D68_L0.9380.29
222_I262_T0.9360.29
77_I202_D0.9290.29
218_S270_V0.9270.29
170_V186_I0.9250.29
37_I163_F0.9240.28
63_S221_L0.9130.28
42_T90_G0.9090.28
196_A218_S0.9070.28
192_E299_N0.9070.28
283_N286_L0.9060.28
115_R121_E0.9060.28
136_Q299_N0.8990.27
26_T140_G0.8980.27
84_L132_I0.8940.27
5_V139_I0.8930.27
91_N246_I0.8910.27
12_P37_I0.8910.27
36_I162_A0.8900.27
268_S297_G0.8850.27
140_G190_G0.8790.27
72_I240_M0.8640.26
43_I298_Y0.8590.26
244_D289_R0.8560.26
276_D280_K0.8550.26
16_R158_A0.8490.25
68_L99_Q0.8480.25
12_P162_A0.8470.25
216_T277_F0.8450.25
18_Q155_L0.8440.25
227_L239_T0.8430.25
59_G259_E0.8300.25
78_E197_K0.8290.24
12_P296_I0.8240.24
219_P225_E0.8230.24
97_D150_V0.8200.24
20_E266_E0.8180.24
70_D182_I0.8180.24
138_R224_D0.8150.24
124_Y256_K0.8140.24
14_M160_Y0.8110.24
84_L127_N0.8090.24
49_Y92_H0.8070.24
237_Y276_D0.8020.23
16_R215_L0.8020.23
12_P16_R0.7990.23
10_L189_F0.7980.23
63_S256_K0.7950.23
163_F220_I0.7950.23
48_G242_K0.7940.23
219_P266_E0.7930.23
84_L92_H0.7910.23
110_K116_E0.7820.23
31_A156_Y0.7820.23
15_F156_Y0.7810.23
77_I161_L0.7810.23
41_S44_A0.7780.22
11_E233_N0.7750.22
138_R158_A0.7750.22
228_D299_N0.7730.22
52_F299_N0.7710.22
191_G267_G0.7710.22
110_K120_Y0.7690.22
17_S222_I0.7670.22
50_I193_N0.7670.22
86_P297_G0.7660.22
43_I194_R0.7650.22
40_P219_P0.7650.22
73_Y172_F0.7630.22
70_D130_F0.7600.22
89_M268_S0.7600.22
117_K120_Y0.7590.22
287_L291_T0.7580.22
36_I192_E0.7570.22
46_M162_A0.7540.22
12_P36_I0.7510.21
14_M196_A0.7510.21
84_L173_I0.7480.21
288_D292_K0.7450.21
35_L142_S0.7450.21
19_G193_N0.7440.21
155_L262_T0.7400.21
41_S90_G0.7380.21
152_E272_R0.7370.21
72_I259_E0.7370.21
239_T263_A0.7360.21
12_P230_L0.7240.21
89_M251_D0.7210.20
78_E144_D0.7200.20
45_G138_R0.7200.20
36_I136_Q0.7200.20
234_I238_V0.7150.20
119_I122_L0.7120.20
152_E156_Y0.7100.20
158_A259_E0.7100.20
16_R270_V0.7090.20
246_I268_S0.7090.20
45_G194_R0.7080.20
233_N236_D0.7070.20
5_V298_Y0.7070.20
139_I256_K0.7010.20
56_S295_K0.7000.20
77_I91_N0.6970.20
216_T220_I0.6930.19
205_V255_T0.6920.19
65_L68_L0.6920.19
60_D173_I0.6880.19
287_L292_K0.6840.19
114_Q118_G0.6820.19
142_S153_H0.6810.19
38_P251_D0.6810.19
15_F217_L0.6790.19
141_I296_I0.6760.19
47_L86_P0.6750.19
222_I226_A0.6690.19
286_L292_K0.6640.18
281_E287_L0.6630.18
233_N237_Y0.6620.18
220_I271_K0.6610.18
19_G218_S0.6550.18
21_F40_P0.6530.18
129_L135_H0.6530.18
88_R265_L0.6520.18
156_Y263_A0.6510.18
235_S298_Y0.6500.18
118_G196_A0.6490.18
74_G169_Y0.6490.18
29_H158_A0.6480.18
26_T30_T0.6460.18
110_K113_E0.6460.18
32_A47_L0.6450.18
251_D254_N0.6420.18
80_N276_D0.6410.18
27_G263_A0.6400.18
25_I93_L0.6390.18
160_Y194_R0.6390.18
177_A268_S0.6370.18
115_R119_I0.6360.18
208_S254_N0.6350.18
155_L298_Y0.6340.18
92_H218_S0.6340.18
83_Y170_V0.6330.17
74_G136_Q0.6320.17
84_L215_L0.6320.17
25_I136_Q0.6290.17
36_I46_M0.6290.17
75_T299_N0.6270.17
34_S194_R0.6260.17
12_P140_G0.6220.17
15_F190_G0.6220.17
35_L215_L0.6220.17
48_G266_E0.6210.17
110_K119_I0.6210.17
71_T295_K0.6210.17
216_T250_F0.6200.17
76_F171_I0.6190.17
264_I299_N0.6180.17
110_K115_R0.6150.17
38_P45_G0.6110.17
4_R172_F0.6060.17
32_A37_I0.6050.17
143_I236_D0.6020.17
264_I272_R0.6010.17
138_R160_Y0.6000.16
39_R192_E0.5990.16
195_I262_T0.5980.16
216_T229_D0.5980.16
64_D67_N0.5970.16
114_Q119_I0.5970.16
18_Q246_I0.5970.16
8_K59_G0.5960.16
18_Q296_I0.5950.16
19_G31_A0.5940.16
37_I188_N0.5930.16
278_I281_E0.5910.16
40_P194_R0.5900.16
16_R264_I0.5900.16
34_S45_G0.5900.16
17_S20_E0.5900.16
285_N288_D0.5880.16
249_G299_N0.5880.16
28_S162_A0.5870.16
219_P299_N0.5870.16
35_L271_K0.5870.16
268_S271_K0.5870.16
239_T270_V0.5850.16
9_P15_F0.5850.16
14_M296_I0.5840.16
76_F85_F0.5830.16
5_V200_V0.5790.16
158_A194_R0.5780.16
225_E230_L0.5770.16
161_L169_Y0.5740.16
36_I148_R0.5740.16
226_A238_V0.5740.16
94_A253_A0.5710.16
200_V255_T0.5700.16
14_M157_S0.5700.16
42_T269_I0.5680.16
47_L125_D0.5680.16
138_R157_S0.5630.15
21_F270_V0.5620.15
140_G270_V0.5620.15
52_F133_I0.5620.15
205_V282_I0.5610.15
49_Y164_K0.5610.15
42_T170_V0.5580.15
198_L269_I0.5580.15
211_E233_N0.5560.15
5_V72_I0.5560.15
115_R120_Y0.5560.15
264_I268_S0.5560.15
141_I171_I0.5530.15
59_G220_I0.5530.15
46_M50_I0.5530.15
258_K269_I0.5530.15
246_I258_K0.5530.15
91_N170_V0.5520.15
5_V220_I0.5500.15
163_F173_I0.5500.15
160_Y241_G0.5500.15
39_R169_Y0.5500.15
165_K269_I0.5490.15
17_S246_I0.5430.15
204_K211_E0.5420.15
131_Q199_E0.5370.15
195_I220_I0.5370.15
192_E213_Y0.5370.15
59_G62_L0.5370.15
27_G38_P0.5360.15
194_R219_P0.5360.15
194_R249_G0.5340.15
17_S73_Y0.5330.15
136_Q271_K0.5280.14
58_T84_L0.5260.14
39_R263_A0.5260.14
161_L187_V0.5240.14
76_F234_I0.5210.14
48_G88_R0.5210.14
205_V264_I0.5200.14
21_F32_A0.5200.14
44_A74_G0.5200.14
220_I264_I0.5180.14
128_K144_D0.5180.14
138_R297_G0.5180.14
263_A270_V0.5170.14
130_F209_I0.5170.14
68_L124_Y0.5160.14
215_L301_L0.5150.14
46_M242_K0.5140.14
27_G193_N0.5130.14
14_M139_I0.5120.14
12_P46_M0.5110.14
201_D273_S0.5080.14
25_I273_S0.5080.14
10_L187_V0.5070.14
7_I212_E0.5070.14
18_Q172_F0.5050.14
128_K198_L0.5050.14
202_D280_K0.5030.14
46_M196_A0.5030.14
34_S118_G0.5010.14
128_K223_P0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3x1lB 1 0.9108 100 0.411 Contact Map
4qtsA 1 0.7866 98.7 0.878 Contact Map
4w8wA 1 0.5478 97.1 0.916 Contact Map
3x1lC 3 0.6146 96.2 0.924 Contact Map
4qtsC 1 0.5032 60.7 0.955 Contact Map
4gxbA 1 0.1943 12.8 0.969 Contact Map
4mjkA 2 0.7389 7.1 0.972 Contact Map
3j61Z 1 0.1688 6 0.973 Contact Map
3j39Z 1 0.1656 5.1 0.974 Contact Map
4nawA 1 0.1688 4.8 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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