GREMLIN Database
Q97WW7 - Uncharacterized protein
UniProt: Q97WW7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 328 (286)
Sequences: 14536 (11109)
Seq/√Len: 656.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_R19_E3.6721.00
4_R17_E3.3481.00
25_I320_M2.8381.00
196_R238_L2.7251.00
314_P318_D2.3701.00
20_F24_S2.3681.00
119_V123_E2.3311.00
294_E298_D2.3251.00
7_I10_F2.2831.00
202_I206_L2.2481.00
105_I109_D2.2371.00
24_S306_Q2.2351.00
59_I62_G2.2341.00
23_V309_A2.2201.00
169_V172_F2.2011.00
99_L102_K2.1461.00
288_L296_L2.0971.00
235_N239_H2.0901.00
6_K17_E2.0781.00
188_P192_D2.0341.00
6_K19_E2.0161.00
291_K294_E1.9641.00
301_R319_F1.9581.00
58_F61_W1.9081.00
121_R124_N1.8811.00
293_I313_S1.8751.00
149_N153_T1.8341.00
8_K15_D1.7861.00
175_V178_I1.7651.00
92_Y97_N1.7551.00
199_V203_S1.7341.00
297_V316_I1.7161.00
12_S36_N1.7091.00
6_K15_D1.6791.00
123_E126_E1.6751.00
77_I81_I1.6661.00
226_L230_F1.6441.00
104_E108_F1.6421.00
99_L103_K1.6361.00
161_F165_F1.6301.00
60_R64_Y1.6231.00
99_L104_E1.6151.00
89_D92_Y1.6101.00
155_P159_L1.6051.00
31_G258_P1.5941.00
198_L202_I1.5761.00
66_N69_F1.5541.00
174_I178_I1.5421.00
91_H94_I1.5281.00
118_N121_R1.5241.00
101_I104_E1.5191.00
13_Y16_S1.5051.00
159_L163_T1.5051.00
123_E127_M1.5021.00
59_I63_D1.4971.00
27_V317_I1.4941.00
58_F63_D1.4891.00
117_G121_R1.4881.00
61_W64_Y1.4851.00
195_G199_V1.4851.00
119_V122_Y1.4731.00
92_Y95_S1.4701.00
103_K107_N1.4421.00
154_L158_L1.4301.00
101_I105_I1.4251.00
95_S98_K1.4211.00
104_E109_D1.4151.00
94_I97_N1.4081.00
159_L165_F1.4071.00
79_F83_G1.3951.00
192_D251_I1.3941.00
155_P165_F1.3941.00
102_K109_D1.3921.00
121_R125_K1.3881.00
100_Q104_E1.3601.00
228_P232_E1.3571.00
114_E117_G1.3571.00
93_E97_N1.3541.00
223_N228_P1.3451.00
42_S47_L1.3391.00
60_R63_D1.3331.00
118_N124_N1.3331.00
118_N123_E1.3251.00
91_H95_S1.3201.00
182_P186_T1.3191.00
7_I13_Y1.3051.00
174_I177_Q1.3041.00
199_V238_L1.3021.00
124_N127_M1.3011.00
116_R123_E1.2861.00
224_I228_P1.2851.00
116_R119_V1.2771.00
117_G123_E1.2681.00
117_G122_Y1.2671.00
105_I108_F1.2661.00
122_Y127_M1.2661.00
178_I182_P1.2621.00
158_L161_F1.2571.00
116_R122_Y1.2551.00
93_E96_L1.2541.00
103_K109_D1.2531.00
223_N226_L1.2511.00
67_V71_Q1.2491.00
101_I109_D1.2381.00
78_S81_I1.2371.00
89_D93_E1.2291.00
101_I106_I1.2181.00
118_N122_Y1.2131.00
166_L169_V1.2071.00
176_P180_V1.2051.00
195_G202_I1.2021.00
72_D75_L1.2011.00
223_N230_F1.1941.00
155_P158_L1.1891.00
196_R243_K1.1861.00
294_E319_F1.1821.00
119_V124_N1.1761.00
107_N110_S1.1731.00
102_K110_S1.1641.00
58_F62_G1.1571.00
116_R127_M1.1541.00
194_N197_G1.1531.00
176_P182_P1.1511.00
102_K105_I1.1481.00
26_V308_I1.1481.00
90_Y93_E1.1431.00
200_K203_S1.1321.00
173_R176_P1.1251.00
129_I132_N1.1181.00
143_P146_I1.1151.00
61_W65_K1.1111.00
116_R124_N1.1091.00
158_L165_F1.1011.00
121_R126_E1.0971.00
103_K106_I1.0871.00
297_V319_F1.0861.00
62_G65_K1.0791.00
121_R127_M1.0761.00
102_K106_I1.0701.00
117_G126_E1.0691.00
222_N228_P1.0671.00
165_F172_F1.0581.00
59_I64_Y1.0571.00
119_V125_K1.0571.00
200_K204_N1.0451.00
124_N128_T1.0401.00
66_N70_M1.0381.00
145_I149_N1.0341.00
181_S185_F1.0271.00
197_G200_K1.0251.00
11_K66_N1.0131.00
119_V127_M1.0131.00
184_H187_F1.0131.00
105_I110_S1.0101.00
145_I148_Y1.0041.00
122_Y126_E1.0041.00
117_G124_N1.0031.00
173_R177_Q0.9991.00
143_P149_N0.9981.00
178_I181_S0.9981.00
154_L159_L0.9971.00
298_D301_R0.9941.00
147_A152_F0.9921.00
82_D85_Y0.9921.00
118_N127_M0.9911.00
114_E118_N0.9891.00
223_N227_R0.9891.00
83_G87_G0.9841.00
177_Q180_V0.9811.00
278_T308_I0.9751.00
146_I150_L0.9651.00
42_S46_Q0.9641.00
160_N163_T0.9631.00
114_E122_Y0.9571.00
67_V70_M0.9551.00
85_Y88_K0.9491.00
116_R125_K0.9491.00
90_Y94_I0.9471.00
202_I205_N0.9461.00
165_F169_V0.9441.00
195_G201_V0.9441.00
199_V202_I0.9351.00
119_V126_E0.9341.00
300_M307_F0.9331.00
103_K108_F0.9321.00
239_H302_Y0.9211.00
294_E315_L0.9201.00
10_F13_Y0.9181.00
143_P147_A0.9181.00
300_M309_A0.9091.00
100_Q103_K0.9091.00
89_D95_S0.9081.00
154_L165_F0.9061.00
8_K17_E0.9031.00
188_P191_L0.9011.00
59_I65_K0.8941.00
173_R178_I0.8921.00
311_T317_I0.8901.00
222_N226_L0.8901.00
237_R241_I0.8901.00
116_R121_R0.8871.00
79_F82_D0.8871.00
279_I307_F0.8861.00
8_K19_E0.8841.00
298_D302_Y0.8781.00
91_H96_L0.8771.00
99_L109_D0.8771.00
107_N111_Y0.8761.00
72_D76_D0.8741.00
77_I82_D0.8741.00
77_I80_E0.8711.00
154_L157_E0.8691.00
44_L308_I0.8691.00
115_R121_R0.8681.00
189_E192_D0.8671.00
106_I109_D0.8631.00
69_F72_D0.8631.00
177_Q181_S0.8541.00
99_L105_I0.8471.00
158_L162_M0.8441.00
81_I85_Y0.8401.00
195_G198_L0.8351.00
102_K108_F0.8351.00
160_N164_N0.8341.00
41_F280_I0.8321.00
315_L318_D0.8311.00
145_I150_L0.8261.00
80_E83_G0.8221.00
99_L108_F0.8201.00
10_F40_A0.8191.00
162_M166_L0.8181.00
73_E76_D0.8161.00
239_H242_E0.8131.00
190_A198_L0.8081.00
69_F74_N0.8071.00
227_R231_T0.8071.00
117_G125_K0.8061.00
180_V184_H0.8051.00
176_P183_V0.8041.00
79_F85_Y0.8031.00
188_P202_I0.8031.00
43_F47_L0.8031.00
115_R124_N0.8021.00
131_D135_V0.8001.00
176_P185_F0.8001.00
97_N191_L0.7981.00
155_P166_L0.7971.00
156_P159_L0.7921.00
120_I125_K0.7911.00
163_T167_N0.7891.00
102_K107_N0.7881.00
161_F164_N0.7881.00
279_I305_S0.7851.00
282_D285_E0.7841.00
104_E110_S0.7831.00
192_D195_G0.7811.00
118_N126_E0.7801.00
182_P187_F0.7801.00
238_L242_E0.7781.00
114_E123_E0.7771.00
90_Y97_N0.7751.00
70_M73_E0.7741.00
114_E119_V0.7731.00
122_Y125_K0.7721.00
238_L243_K0.7711.00
9_N15_D0.7671.00
199_V206_L0.7661.00
80_E84_E0.7651.00
179_A185_F0.7621.00
84_E87_G0.7611.00
163_T166_L0.7571.00
100_Q105_I0.7571.00
281_I300_M0.7531.00
173_R181_S0.7531.00
114_E121_R0.7531.00
20_F308_I0.7521.00
199_V235_N0.7471.00
135_V142_Q0.7451.00
203_S206_L0.7421.00
71_Q76_D0.7411.00
162_M165_F0.7401.00
115_R118_N0.7361.00
177_Q184_H0.7321.00
101_I108_F0.7321.00
166_L171_V0.7311.00
176_P181_S0.7291.00
99_L110_S0.7261.00
174_I181_S0.7241.00
276_M305_S0.7231.00
68_V75_L0.7231.00
120_I123_E0.7201.00
149_N152_F0.7201.00
103_K110_S0.7191.00
29_P32_S0.7191.00
75_L79_F0.7161.00
92_Y98_K0.7091.00
189_E193_E0.7081.00
195_G206_L0.7061.00
165_F168_D0.7051.00
193_E197_G0.7051.00
173_R183_V0.7041.00
83_G86_K0.7021.00
181_S184_H0.7011.00
77_I85_Y0.6991.00
163_T169_V0.6971.00
58_F65_K0.6961.00
147_A151_N0.6931.00
178_I183_V0.6911.00
67_V75_L0.6911.00
89_D97_N0.6821.00
80_E85_Y0.6781.00
143_P153_T0.6781.00
227_R230_F0.6761.00
92_Y96_L0.6741.00
190_A202_I0.6731.00
222_N225_S0.6711.00
43_F49_R0.6701.00
155_P161_F0.6701.00
191_L195_G0.6691.00
43_F46_Q0.6681.00
244_S248_K0.6671.00
143_P148_Y0.6661.00
120_I127_M0.6661.00
114_E124_N0.6631.00
179_A183_V0.6611.00
174_I182_P0.6601.00
147_A150_L0.6601.00
164_N167_N0.6591.00
31_G261_F0.6551.00
161_F168_D0.6531.00
175_V186_T0.6501.00
285_E313_S0.6501.00
45_K49_R0.6461.00
222_N230_F0.6461.00
194_N201_V0.6431.00
115_R122_Y0.6421.00
176_P179_A0.6401.00
159_L166_L0.6371.00
156_P165_F0.6371.00
167_N170_G0.6351.00
180_V186_T0.6351.00
183_V187_F0.6341.00
179_A182_P0.6281.00
129_I133_L0.6271.00
175_V182_P0.6251.00
90_Y96_L0.6231.00
192_D196_R0.6231.00
174_I186_T0.6221.00
203_S231_T0.6201.00
81_I84_E0.6201.00
121_R128_T0.6181.00
285_E316_I0.6181.00
275_K304_D0.6181.00
118_N125_K0.6171.00
221_E224_I0.6161.00
145_I152_F0.6131.00
298_D319_F0.6101.00
7_I40_A0.6101.00
81_I86_K0.6091.00
79_F86_K0.6041.00
178_I185_F0.6031.00
99_L106_I0.6021.00
178_I186_T0.6001.00
158_L169_V0.5981.00
115_R123_E0.5981.00
173_R186_T0.5961.00
119_V128_T0.5951.00
224_I232_E0.5861.00
174_I180_V0.5861.00
26_V40_A0.5841.00
290_L314_P0.5831.00
21_E24_S0.5831.00
100_Q110_S0.5821.00
45_K48_I0.5811.00
93_E98_K0.5811.00
182_P185_F0.5811.00
47_L51_L0.5811.00
181_S186_T0.5801.00
201_V204_N0.5801.00
176_P184_H0.5781.00
150_L153_T0.5771.00
155_P162_M0.5771.00
71_Q75_L0.5741.00
259_D287_S0.5711.00
197_G201_V0.5711.00
277_S305_S0.5681.00
194_N202_I0.5671.00
77_I83_G0.5661.00
82_D86_K0.5651.00
99_L107_N0.5651.00
148_Y152_F0.5621.00
91_H97_N0.5561.00
158_L166_L0.5551.00
106_I110_S0.5551.00
148_Y151_N0.5531.00
183_V186_T0.5521.00
194_N206_L0.5511.00
147_A153_T0.5501.00
175_V181_S0.5471.00
163_T168_D0.5451.00
125_K128_T0.5451.00
155_P172_F0.5411.00
89_D94_I0.5411.00
122_Y128_T0.5401.00
263_K287_S0.5381.00
254_P262_I0.5361.00
173_R185_F0.5351.00
293_I297_V0.5331.00
196_R199_V0.5270.99
159_L162_M0.5250.99
301_R321_D0.5220.99
173_R179_A0.5200.99
174_I183_V0.5200.99
114_E127_M0.5200.99
154_L161_F0.5190.99
90_Y98_K0.5180.99
117_G128_T0.5170.99
25_I309_A0.5170.99
116_R120_I0.5150.99
31_G257_V0.5140.99
175_V180_V0.5140.99
66_N71_Q0.5100.99
190_A193_E0.5070.99
159_L172_F0.5060.99
164_N168_D0.5040.99
75_L81_I0.5040.99
131_D134_S0.5030.99
156_P166_L0.5010.99
295_R298_D0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3auyA 2 0.936 100 0.467 Contact Map
4ad8A 1 0.9207 100 0.476 Contact Map
3qktA 2 0.9055 100 0.479 Contact Map
4i99A 2 0.8628 100 0.481 Contact Map
1w1wA 2 0.7988 100 0.487 Contact Map
3zgxA 2 0.8262 100 0.493 Contact Map
4abyA 1 0.8902 100 0.498 Contact Map
3qf7A 2 0.9207 100 0.505 Contact Map
4ux3A 1 0.9207 100 0.518 Contact Map
1e69A 1 0.7287 100 0.525 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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