GREMLIN Database
Q97WW6 - First ORF in transposon ISC1225
UniProt: Q97WW6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 290 (271)
Sequences: 193 (130)
Seq/√Len: 7.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_T245_Y4.9720.99
77_I128_V4.0520.97
147_L244_S3.9020.97
149_A168_A3.1180.89
142_I166_I3.0970.89
41_R262_F2.8970.85
265_L269_L2.8410.84
92_S98_S2.7900.83
56_L60_R2.7010.81
80_T91_G2.6790.80
80_T249_K2.6750.80
12_V20_C2.5780.77
221_T257_S2.4440.73
91_G257_S2.3820.71
112_L245_Y2.3640.70
135_V145_I2.2730.67
142_I245_Y2.2590.67
243_T246_R2.2480.66
224_D236_K2.2210.65
152_Y243_T2.1730.64
148_D238_R2.1460.63
135_V165_Y2.1310.62
263_R277_Y2.0330.58
238_R242_E2.0300.58
58_R156_V2.0190.58
221_T239_G2.0020.57
81_T100_N1.9700.56
245_Y255_T1.9350.54
44_V97_N1.9040.53
251_F274_Y1.8750.52
79_W142_I1.8650.51
104_T114_A1.8610.51
249_K274_Y1.8120.49
84_W275_I1.7980.49
267_F274_Y1.7550.47
221_T274_Y1.7220.46
15_T21_L1.7200.46
18_P27_E1.6860.44
110_V246_R1.6720.44
78_D242_E1.6630.43
128_V131_L1.6550.43
152_Y169_V1.6520.43
19_A150_G1.6470.43
140_F145_I1.6060.41
16_L20_C1.6040.41
158_N230_V1.5950.41
78_D148_D1.5740.40
102_A131_L1.5710.40
25_S101_Y1.5590.39
29_K33_Y1.5510.39
14_K28_N1.5400.38
230_V276_P1.5200.38
122_M166_I1.4870.36
262_F266_I1.4850.36
142_I248_I1.4530.35
20_C29_K1.4490.35
42_N186_T1.4470.35
15_T19_A1.4440.35
221_T249_K1.4260.34
103_T268_V1.4180.34
252_L264_T1.4090.34
50_E118_Q1.4080.34
145_I225_L1.3780.32
104_T135_V1.3700.32
248_I267_F1.3700.32
144_L250_A1.3680.32
26_V132_V1.3610.32
86_G152_Y1.3460.31
20_C40_V1.3390.31
245_Y256_G1.3380.31
75_L135_V1.3340.31
112_L271_L1.3310.31
102_A165_Y1.3150.30
20_C27_E1.3100.30
156_V243_T1.3060.30
12_V18_P1.3050.30
148_D242_E1.2890.29
78_D238_R1.2850.29
96_G175_K1.2850.29
128_V222_N1.2850.29
278_S281_R1.2750.29
129_K196_Q1.2630.28
243_T247_N1.2590.28
129_K257_S1.2580.28
108_G158_N1.2540.28
16_L25_S1.2450.28
77_I222_N1.2440.28
131_L222_N1.2370.28
15_T26_V1.2350.28
142_I183_D1.2330.27
17_I31_R1.2210.27
109_K143_R1.2100.27
131_L135_V1.2010.26
78_D234_Y1.2010.26
96_G142_I1.1990.26
234_Y241_I1.1990.26
13_A19_A1.1960.26
243_T279_R1.1940.26
165_Y184_Y1.1920.26
89_V128_V1.1880.26
131_L165_Y1.1850.26
89_V114_A1.1820.26
258_T265_L1.1720.26
273_L284_E1.1620.25
257_S267_F1.1620.25
165_Y216_Y1.1620.25
222_N267_F1.1520.25
89_V276_P1.1510.25
249_K267_F1.1480.25
203_V261_V1.1450.25
230_V235_N1.1310.24
93_S244_S1.1280.24
265_L273_L1.1240.24
131_L248_I1.1200.24
104_T275_I1.1110.24
256_G268_V1.1050.24
80_T257_S1.1000.23
53_E57_E1.0990.23
111_L173_D1.0990.23
56_L122_M1.0940.23
43_Y259_K1.0890.23
27_E41_R1.0890.23
150_G276_P1.0820.23
35_V103_T1.0820.23
110_V143_R1.0780.23
194_D229_E1.0730.23
16_L21_L1.0690.22
221_T269_L1.0620.22
154_V181_D1.0570.22
31_R40_V1.0540.22
96_G160_I1.0500.22
219_R265_L1.0500.22
129_K189_K1.0430.22
91_G117_P1.0260.21
257_S274_Y1.0230.21
239_G257_S1.0210.21
38_Q167_V1.0200.21
99_W251_F1.0190.21
147_L239_G1.0180.21
76_S156_V1.0170.21
131_L274_Y1.0170.21
46_K275_I1.0060.21
160_I184_Y0.9980.21
76_S91_G0.9970.21
102_A127_I0.9950.20
254_F275_I0.9860.20
147_L152_Y0.9860.20
81_T150_G0.9850.20
37_P40_V0.9830.20
40_V152_Y0.9820.20
12_V16_L0.9800.20
225_L246_R0.9800.20
152_Y170_P0.9760.20
146_T168_A0.9730.20
86_G258_T0.9730.20
50_E224_D0.9680.20
160_I163_F0.9670.20
235_N275_I0.9670.20
84_W107_K0.9630.20
71_K141_K0.9610.20
110_V169_V0.9540.19
9_V13_A0.9540.19
10_E253_P0.9520.19
128_V135_V0.9520.19
84_W258_T0.9480.19
144_L166_I0.9460.19
126_E149_A0.9450.19
15_T44_V0.9380.19
12_V19_A0.9380.19
18_P21_L0.9350.19
99_W200_R0.9340.19
257_S263_R0.9330.19
157_L165_Y0.9330.19
57_E89_V0.9300.19
101_Y192_R0.9290.19
280_G283_G0.9240.19
271_L274_Y0.9230.19
235_N240_P0.9170.18
98_S239_G0.9160.18
259_K272_V0.9100.18
160_I196_Q0.9080.18
273_L277_Y0.9010.18
234_Y242_E0.8970.18
79_W118_Q0.8960.18
236_K261_V0.8840.18
183_D259_K0.8810.18
45_E202_L0.8780.18
261_V279_R0.8750.17
80_T248_I0.8720.17
103_T142_I0.8640.17
186_T226_S0.8620.17
186_T202_L0.8560.17
59_A149_A0.8560.17
166_I235_N0.8540.17
77_I156_V0.8520.17
101_Y234_Y0.8510.17
101_Y173_D0.8500.17
12_V40_V0.8460.17
151_F255_T0.8360.17
137_A244_S0.8340.17
39_T249_K0.8320.16
181_D226_S0.8270.16
131_L245_Y0.8220.16
249_K257_S0.8220.16
253_P266_I0.8180.16
238_R241_I0.8170.16
240_P270_A0.8080.16
101_Y282_W0.8040.16
129_K228_R0.8010.16
25_S29_K0.7980.16
165_Y222_N0.7970.16
80_T110_V0.7970.16
118_Q146_T0.7950.16
115_F124_K0.7940.16
24_N208_K0.7940.16
221_T251_F0.7910.16
139_G265_L0.7900.16
67_L70_V0.7900.16
136_M166_I0.7840.15
113_L131_L0.7810.15
203_V244_S0.7790.15
78_D151_F0.7790.15
143_R239_G0.7770.15
142_I224_D0.7770.15
80_T165_Y0.7720.15
48_G52_I0.7710.15
28_N58_R0.7630.15
29_K127_I0.7580.15
119_V132_V0.7560.15
17_I46_K0.7540.15
50_E66_V0.7530.15
44_V176_V0.7460.15
144_L163_F0.7460.15
50_E119_V0.7430.15
21_L24_N0.7420.15
92_S253_P0.7410.15
92_S95_K0.7340.14
140_F185_K0.7340.14
242_E263_R0.7330.14
91_G249_K0.7330.14
77_I102_A0.7310.14
135_V140_F0.7300.14
148_D234_Y0.7290.14
35_V86_G0.7290.14
157_L160_I0.7280.14
93_S147_L0.7230.14
44_V114_A0.7220.14
97_N275_I0.7180.14
59_A236_K0.7160.14
274_Y281_R0.7140.14
39_T122_M0.7140.14
135_V222_N0.7140.14
96_G157_L0.7060.14
51_V178_E0.7060.14
157_L167_V0.7030.14
118_Q128_V0.7030.14
103_T241_I0.7000.14
97_N235_N0.6970.14
243_T276_P0.6960.14
78_D241_I0.6920.14
97_N112_L0.6900.14
108_G137_A0.6860.13
111_L189_K0.6840.13
113_L120_N0.6840.13
37_P234_Y0.6840.13
86_G111_L0.6770.13
165_Y259_K0.6740.13
19_A96_G0.6720.13
57_E60_R0.6700.13
90_K130_V0.6690.13
158_N235_N0.6680.13
219_R239_G0.6670.13
20_C25_S0.6630.13
31_R152_Y0.6630.13
185_K224_D0.6600.13
20_C91_G0.6580.13
108_G201_L0.6580.13
59_A64_L0.6550.13
19_A166_I0.6550.13
167_V223_L0.6510.13
19_A25_S0.6500.13
99_W245_Y0.6480.13
21_L25_S0.6480.13
222_N248_I0.6480.13
41_R90_K0.6480.13
88_P260_F0.6460.13
89_V205_S0.6460.13
105_K245_Y0.6460.13
265_L281_R0.6460.13
128_V165_Y0.6380.13
137_A152_Y0.6370.13
77_I255_T0.6370.13
263_R275_I0.6360.13
114_A215_V0.6340.13
119_V276_P0.6330.12
29_K240_P0.6330.12
17_I165_Y0.6310.12
75_L224_D0.6300.12
114_A132_V0.6270.12
132_V148_D0.6260.12
91_G221_T0.6260.12
29_K132_V0.6230.12
166_I196_Q0.6220.12
131_L225_L0.6210.12
173_D246_R0.6180.12
16_L26_V0.6160.12
74_D146_T0.6160.12
121_G228_R0.6150.12
163_F225_L0.6120.12
59_A173_D0.6080.12
61_K92_S0.6080.12
186_T189_K0.6070.12
53_E265_L0.6050.12
111_L197_V0.6040.12
265_L271_L0.6010.12
101_Y149_A0.6000.12
63_S265_L0.5990.12
260_F275_I0.5960.12
240_P246_R0.5950.12
33_Y177_Y0.5950.12
183_D194_D0.5920.12
123_T153_T0.5920.12
101_Y199_F0.5900.12
86_G276_P0.5880.12
155_D161_S0.5870.12
157_L220_A0.5870.12
81_T276_P0.5870.12
156_V241_I0.5810.12
36_S169_V0.5790.12
132_V151_F0.5780.12
23_N28_N0.5780.12
20_C250_A0.5760.12
207_G221_T0.5750.11
262_F276_P0.5740.11
133_E145_I0.5710.11
95_K147_L0.5710.11
259_K277_Y0.5710.11
225_L269_L0.5690.11
202_L251_F0.5690.11
68_K106_Y0.5680.11
112_L248_I0.5670.11
85_Y100_N0.5670.11
25_S31_R0.5660.11
69_G87_K0.5640.11
109_K257_S0.5620.11
17_I223_L0.5600.11
142_I162_Q0.5600.11
102_A179_E0.5600.11
222_N257_S0.5590.11
67_L167_V0.5570.11
86_G125_D0.5540.11
186_T205_S0.5520.11
80_T266_I0.5500.11
89_V253_P0.5500.11
184_Y284_E0.5490.11
102_A216_Y0.5480.11
41_R100_N0.5450.11
222_N239_G0.5420.11
10_E139_G0.5420.11
92_S269_L0.5410.11
53_E111_L0.5400.11
100_N248_I0.5390.11
107_K229_E0.5390.11
125_D159_F0.5380.11
16_L19_A0.5350.11
260_F267_F0.5340.11
205_S225_L0.5320.11
19_A75_L0.5310.11
248_I282_W0.5310.11
204_Y262_F0.5290.11
144_L156_V0.5290.11
64_L202_L0.5280.11
102_A128_V0.5270.11
12_V21_L0.5260.11
117_P165_Y0.5250.11
26_V166_I0.5230.11
185_K201_L0.5220.11
55_L220_A0.5220.11
215_V220_A0.5210.11
83_T273_L0.5190.11
81_T98_S0.5190.11
160_I216_Y0.5190.11
67_L166_I0.5190.11
100_N146_T0.5180.11
96_G241_I0.5180.11
69_G99_W0.5180.11
20_C160_I0.5170.11
55_L265_L0.5170.11
42_N235_N0.5170.11
59_A233_L0.5160.11
247_N270_A0.5150.11
47_Q270_A0.5140.11
61_K89_V0.5140.11
158_N166_I0.5120.10
68_K265_L0.5120.10
25_S282_W0.5110.10
32_A57_E0.5100.10
9_V20_C0.5080.10
146_T253_P0.5070.10
125_D223_L0.5060.10
42_N259_K0.5060.10
42_N46_K0.5060.10
128_V273_L0.5040.10
166_I234_Y0.5010.10
10_E171_V0.5000.10
89_V252_L0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9586 99.3 0.84 Contact Map
4xb4A 1 0.4241 21 0.966 Contact Map
2m8eA 1 0.1897 16.3 0.967 Contact Map
1f6yA 2 0.7448 13.7 0.968 Contact Map
2ao9A 7 0.3586 12.4 0.969 Contact Map
2elhA 1 0.2448 11.2 0.97 Contact Map
2jn6A 1 0.2862 10.9 0.97 Contact Map
2ia0A 2 0.4931 7.7 0.972 Contact Map
2whnA 1 0.369 6.3 0.973 Contact Map
2vxzA 1 0.4759 6.3 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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