GREMLIN Database
Q97WW3 - Uncharacterized protein
UniProt: Q97WW3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 321 (278)
Sequences: 101 (85)
Seq/√Len: 5.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_G76_S7.2411.00
177_V237_K2.9880.71
73_G115_D2.9590.70
57_Y121_G2.8210.66
84_F118_A2.6920.63
58_Q83_K2.6760.62
196_A236_G2.6580.62
73_G118_A2.6290.61
17_G52_A2.5770.59
17_G115_D2.4910.56
66_K77_S2.4790.56
61_L116_V2.4780.56
32_V77_S2.4620.55
74_N77_S2.4050.53
76_S115_D2.2500.48
15_L243_P2.2450.48
13_E83_K2.1920.46
184_Y215_K2.1750.46
76_S118_A2.1460.45
271_K275_M2.1140.44
83_K249_S2.0820.43
13_E182_A2.0810.43
46_P240_R2.0000.40
124_M186_F2.0000.40
83_K121_G1.9510.39
2_I269_Y1.8810.37
16_N236_G1.8420.35
178_E240_R1.8270.35
220_D224_K1.8150.35
274_V278_E1.7830.34
20_S142_M1.7690.33
61_L70_L1.7490.33
277_L291_V1.7010.31
55_H243_P1.6540.30
217_R220_D1.5950.28
51_E83_K1.5840.28
54_A57_Y1.5800.28
139_L157_A1.5790.28
211_L216_A1.5780.28
180_S223_I1.5670.28
46_P144_P1.5630.28
53_L142_M1.5630.28
112_M211_L1.5320.27
19_E54_A1.4790.25
137_I188_F1.4760.25
5_S147_R1.4750.25
5_S35_K1.4750.25
144_P240_R1.4690.25
69_G106_R1.4620.25
92_I101_Y1.4590.25
61_L117_I1.4460.25
17_G198_P1.4450.25
17_G141_Y1.4420.25
65_A71_P1.4380.24
112_M198_P1.4350.24
14_S237_K1.4280.24
14_S17_G1.4260.24
27_H182_A1.4240.24
72_V182_A1.4210.24
51_E121_G1.4150.24
7_R240_R1.4120.24
48_I69_G1.4100.24
19_E83_K1.4030.24
19_E26_K1.3980.23
115_D236_G1.3870.23
238_R242_L1.3860.23
92_I102_N1.3750.23
68_E224_K1.3700.23
141_Y263_P1.3680.23
76_S137_I1.3430.22
28_R263_P1.3390.22
123_F237_K1.3340.22
83_K187_S1.3240.22
13_E141_Y1.3030.21
36_T274_V1.2990.21
24_L244_S1.2990.21
131_V254_K1.2950.21
90_L203_E1.2940.21
30_A115_D1.2940.21
92_I291_V1.2920.21
62_V132_R1.2840.21
13_E19_E1.2830.21
5_S264_G1.2830.21
108_E144_P1.2820.21
141_Y178_E1.2810.21
178_E237_K1.2780.21
18_V182_A1.2780.21
126_A280_A1.2760.21
42_V244_S1.2730.21
15_L55_H1.2650.20
51_E241_F1.2480.20
166_K292_Y1.2430.20
25_T208_E1.2410.20
30_A73_G1.2090.19
197_V247_L1.2080.19
48_I293_V1.1720.19
160_H258_P1.1580.18
121_G137_I1.1510.18
79_Y226_L1.1470.18
46_P108_E1.1430.18
19_E58_Q1.1390.18
268_S292_Y1.1380.18
48_I142_M1.1380.18
28_R49_S1.1370.18
216_A256_D1.1350.18
54_A83_K1.1330.18
20_S161_V1.1330.18
126_A191_D1.1330.18
19_E52_A1.1280.18
19_E177_V1.1220.18
159_F181_S1.1100.17
18_V141_Y1.1030.17
219_V251_V1.1030.17
2_I192_E1.0970.17
31_P141_Y1.0940.17
81_F239_S1.0920.17
158_Q162_R1.0910.17
161_V173_A1.0890.17
133_R243_P1.0860.17
172_Q176_N1.0850.17
17_G236_G1.0840.17
111_V125_Y1.0820.17
215_K219_V1.0790.17
13_E54_A1.0780.17
29_T149_D1.0780.17
132_R191_D1.0740.17
27_H46_P1.0670.17
69_G288_V1.0570.16
10_V264_G1.0570.16
3_G221_S1.0540.16
161_V263_P1.0510.16
123_F162_R1.0490.16
191_D253_V1.0470.16
83_K141_Y1.0420.16
44_Y258_P1.0350.16
13_E52_A1.0340.16
79_Y260_I1.0330.16
158_Q163_F1.0300.16
136_R214_Q1.0280.16
225_A281_K1.0280.16
222_A225_A1.0260.16
16_N48_I1.0230.16
84_F225_A1.0120.16
214_Q217_R1.0110.16
141_Y177_V1.0090.16
13_E187_S1.0060.15
179_V241_F1.0000.15
95_I143_I0.9990.15
196_A223_I0.9970.15
264_G291_V0.9950.15
62_V79_Y0.9900.15
54_A185_T0.9900.15
64_I221_S0.9890.15
143_I292_Y0.9760.15
14_S284_L0.9750.15
61_L269_Y0.9750.15
260_I273_T0.9690.15
92_I147_R0.9660.15
34_L244_S0.9620.15
17_G157_A0.9600.15
66_K291_V0.9590.15
77_S120_V0.9580.15
6_G186_F0.9550.15
6_G248_M0.9450.14
181_S229_L0.9440.14
54_A141_Y0.9350.14
64_I165_N0.9330.14
27_H144_P0.9310.14
57_Y222_A0.9300.14
54_A72_V0.9290.14
69_G212_E0.9280.14
160_H184_Y0.9280.14
102_N113_L0.9200.14
16_N49_S0.9180.14
134_T177_V0.9180.14
27_H51_E0.9160.14
24_L178_E0.9150.14
134_T172_Q0.9100.14
81_F141_Y0.9090.14
141_Y240_R0.9030.14
2_I283_V0.9000.14
69_G213_R0.8980.14
47_V172_Q0.8960.14
2_I112_M0.8950.14
55_H223_I0.8950.14
76_S199_S0.8870.14
4_G268_S0.8860.14
68_E71_P0.8850.14
2_I65_A0.8810.13
49_S65_A0.8790.13
76_S104_A0.8780.13
45_V55_H0.8780.13
33_V87_D0.8770.13
73_G84_F0.8760.13
22_G119_D0.8730.13
22_G50_G0.8730.13
50_G122_G0.8730.13
50_G119_D0.8730.13
22_G122_G0.8730.13
22_G218_R0.8730.13
119_D122_G0.8730.13
50_G218_R0.8730.13
122_G218_R0.8730.13
119_D218_R0.8730.13
19_E141_Y0.8720.13
27_H178_E0.8720.13
57_Y229_L0.8720.13
131_V197_V0.8690.13
6_G250_L0.8690.13
6_G180_S0.8660.13
173_A259_F0.8650.13
54_A121_G0.8650.13
144_P178_E0.8640.13
133_R160_H0.8640.13
27_H52_A0.8590.13
48_I140_G0.8550.13
124_M127_G0.8480.13
28_R141_Y0.8480.13
164_S192_E0.8460.13
51_E58_Q0.8420.13
121_G238_R0.8350.13
30_A47_V0.8350.13
112_M255_T0.8350.13
19_E57_Y0.8330.13
215_K244_S0.8320.13
146_L260_I0.8320.13
47_V251_V0.8280.13
41_L254_K0.8280.13
239_S273_T0.8270.13
132_R237_K0.8210.13
49_S236_G0.8190.13
115_D263_P0.8190.13
65_A117_I0.8170.13
178_E244_S0.8170.13
259_F276_R0.8160.13
141_Y172_Q0.8130.12
57_Y225_A0.8130.12
3_G261_P0.8130.12
25_T175_F0.8110.12
11_N55_H0.8100.12
54_A243_P0.8090.12
52_A276_R0.8080.12
93_E293_V0.8080.12
17_G263_P0.8070.12
66_K277_L0.8040.12
16_N115_D0.8020.12
3_G28_R0.7980.12
190_L222_A0.7930.12
56_A273_T0.7920.12
61_L182_A0.7890.12
27_H240_R0.7840.12
156_E174_I0.7840.12
57_Y238_R0.7750.12
44_Y56_A0.7720.12
28_R65_A0.7720.12
8_F60_S0.7720.12
183_L211_L0.7700.12
21_I26_K0.7650.12
149_D229_L0.7550.12
57_Y81_F0.7540.12
54_A177_V0.7490.12
2_I43_R0.7480.12
46_P178_E0.7430.11
179_V238_R0.7400.11
29_T230_L0.7390.11
82_I169_K0.7380.11
81_F161_V0.7360.11
14_S177_V0.7350.11
25_T190_L0.7320.11
161_V186_F0.7300.11
126_A294_I0.7300.11
254_K281_K0.7270.11
20_S290_K0.7260.11
167_P292_Y0.7210.11
92_I127_G0.7180.11
53_L69_G0.7170.11
112_M180_S0.7110.11
13_E57_Y0.7100.11
147_R291_V0.7080.11
13_E18_V0.7080.11
173_A263_P0.7040.11
177_V238_R0.7030.11
217_R288_V0.6980.11
185_T266_D0.6970.11
72_V142_M0.6970.11
34_L42_V0.6920.11
48_I156_E0.6920.11
182_A262_E0.6910.11
143_I257_F0.6910.11
30_A76_S0.6900.11
112_M191_D0.6870.11
57_Y141_Y0.6860.11
11_N108_E0.6860.11
223_I248_M0.6850.11
14_S52_A0.6840.11
199_S263_P0.6840.11
120_V221_S0.6830.11
137_I228_S0.6820.11
106_R249_S0.6810.11
141_Y199_S0.6780.11
51_E158_Q0.6780.11
140_G266_D0.6780.11
128_S131_V0.6730.11
131_V181_S0.6710.11
115_D118_A0.6680.11
23_N184_Y0.6640.10
136_R274_V0.6580.10
135_S243_P0.6540.10
13_E27_H0.6530.10
290_K294_I0.6490.10
108_E250_L0.6450.10
14_S120_V0.6430.10
262_E276_R0.6410.10
57_Y83_K0.6410.10
35_K170_G0.6400.10
7_R48_I0.6390.10
112_M222_A0.6390.10
249_S269_Y0.6380.10
106_R143_I0.6370.10
175_F179_V0.6360.10
13_E61_L0.6350.10
18_V52_A0.6340.10
164_S175_F0.6330.10
87_D275_M0.6320.10
287_N291_V0.6310.10
134_T141_Y0.6300.10
51_E141_Y0.6300.10
30_A231_A0.6290.10
83_K182_A0.6290.10
102_N268_S0.6280.10
57_Y182_A0.6280.10
79_Y146_L0.6270.10
31_P44_Y0.6270.10
17_G47_V0.6270.10
115_D198_P0.6260.10
72_V230_L0.6220.10
134_T178_E0.6200.10
128_S275_M0.6180.10
14_S176_N0.6160.10
79_Y88_E0.6140.10
250_L294_I0.6120.10
85_S180_S0.6110.10
26_K48_I0.6110.10
194_L197_V0.6110.10
124_M229_L0.6080.10
16_N28_R0.6070.10
81_F108_E0.6070.10
53_L193_D0.6050.10
126_A264_G0.6020.10
236_G244_S0.6000.10
237_K240_R0.5940.10
69_G275_M0.5940.10
32_V214_Q0.5940.10
60_S229_L0.5910.10
174_I275_M0.5870.10
114_K150_E0.5860.10
212_E251_V0.5850.10
140_G156_E0.5850.10
7_R237_K0.5840.10
188_F226_L0.5840.10
141_Y237_K0.5840.10
195_I262_E0.5810.10
143_I181_S0.5810.10
33_V181_S0.5790.09
110_E113_L0.5780.09
66_K222_A0.5770.09
88_E226_L0.5770.09
31_P130_P0.5730.09
141_Y259_F0.5720.09
27_H61_L0.5700.09
194_L250_L0.5700.09
117_I226_L0.5690.09
211_L264_G0.5690.09
110_E288_V0.5660.09
46_P79_Y0.5640.09
83_K239_S0.5640.09
50_G133_R0.5590.09
122_G133_R0.5590.09
133_R218_R0.5590.09
22_G133_R0.5590.09
119_D133_R0.5590.09
6_G272_T0.5550.09
164_S193_D0.5550.09
45_V58_Q0.5530.09
255_T277_L0.5480.09
58_Q121_G0.5480.09
203_E212_E0.5430.09
251_V256_D0.5420.09
93_E113_L0.5420.09
93_E140_G0.5410.09
91_K295_N0.5400.09
290_K295_N0.5400.09
108_E240_R0.5390.09
275_M278_E0.5390.09
55_H83_K0.5390.09
183_L249_S0.5390.09
223_I289_A0.5380.09
32_V116_V0.5360.09
141_Y158_Q0.5350.09
95_I105_R0.5290.09
63_D244_S0.5260.09
27_H141_Y0.5260.09
106_R109_V0.5250.09
191_D230_L0.5230.09
268_S291_V0.5220.09
123_F132_R0.5220.09
137_I140_G0.5190.09
64_I228_S0.5180.09
143_I242_L0.5160.09
28_R172_Q0.5150.09
201_V253_V0.5130.09
117_I157_A0.5130.09
183_L216_A0.5110.09
83_K125_Y0.5100.09
193_D213_R0.5030.09
48_I63_D0.5000.09
27_H237_K0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ps0A 1 0.9283 100 0.302 Contact Map
4u7uE 3 0.8816 89.1 0.954 Contact Map
3k7nA 1 0.2492 26 0.972 Contact Map
2l5qA 1 0.1994 19.1 0.973 Contact Map
3k7lA 1 0.2679 16.9 0.974 Contact Map
4qtsC 1 0.5514 15.3 0.975 Contact Map
3o2pE 1 0.2679 11.9 0.976 Contact Map
4txdA 1 0.8224 11.9 0.976 Contact Map
2eroA 2 0.271 10.7 0.976 Contact Map
3wwvA 2 0.1433 10.5 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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