GREMLIN Database
Q97WW1 - ATP-dependent RNA helicase homolog
UniProt: Q97WW1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 515 (407)
Sequences: 14598 (10156)
Seq/√Len: 503.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_M98_L4.6141.00
380_T384_V3.8391.00
239_R246_L3.6501.00
68_A81_V3.6381.00
374_E378_K3.5981.00
132_T137_F3.5151.00
64_T173_I3.4811.00
28_R104_R3.4221.00
379_E384_V3.4121.00
381_V384_V3.3361.00
85_L94_L3.0911.00
55_P58_Y3.0471.00
44_L205_V3.0411.00
286_L312_L2.7251.00
36_G52_L2.6771.00
268_Y277_A2.6441.00
306_K311_K2.6181.00
241_I246_L2.6021.00
268_Y274_A2.5541.00
360_G366_P2.5301.00
241_I244_N2.5101.00
45_E70_A2.4881.00
271_R294_K2.4081.00
242_Y246_L2.3351.00
374_E377_V2.3301.00
305_N309_E2.3131.00
278_Y288_P2.2741.00
360_G364_I2.2571.00
360_G363_Y2.2541.00
250_E258_V2.2251.00
362_V366_P2.1911.00
215_L218_V2.1591.00
373_D377_V2.1061.00
302_D306_K2.0971.00
253_I256_E2.0121.00
335_S364_I2.0041.00
226_N230_V2.0041.00
212_D215_L1.9981.00
289_I306_K1.9811.00
95_Y99_K1.9641.00
239_R242_Y1.9401.00
240_K246_L1.9081.00
360_G367_F1.8851.00
242_Y245_V1.8561.00
49_S206_V1.8431.00
268_Y314_V1.8431.00
344_A362_V1.8291.00
241_I245_V1.8241.00
214_G218_V1.8101.00
380_T383_R1.8051.00
215_L219_L1.8021.00
239_R243_V1.7941.00
262_K328_D1.7831.00
360_G365_F1.7751.00
243_V248_N1.7491.00
281_L314_V1.7481.00
250_E253_I1.7351.00
239_R245_V1.7341.00
239_R244_N1.7171.00
319_I323_I1.7091.00
187_L190_G1.6901.00
235_F238_D1.6881.00
31_F62_T1.6591.00
28_R103_D1.6551.00
275_I290_L1.6411.00
97_K100_N1.6331.00
249_D253_I1.6301.00
255_E284_R1.6151.00
240_K244_N1.5991.00
213_K217_R1.5991.00
81_V171_I1.5941.00
250_E257_K1.5801.00
373_D376_E1.5571.00
218_V222_K1.5341.00
384_V388_K1.5341.00
48_H227_V1.5331.00
64_T94_L1.5251.00
362_V365_F1.5081.00
448_P451_N1.4851.00
278_Y282_K1.4811.00
64_T207_T1.4701.00
187_L191_L1.4671.00
251_I257_K1.4501.00
361_E364_I1.4501.00
362_V367_F1.4491.00
256_E259_K1.4291.00
243_V246_L1.4271.00
388_K392_E1.4271.00
255_E259_K1.4251.00
42_L46_N1.4241.00
364_I367_F1.4211.00
249_D252_S1.4201.00
315_S319_I1.4141.00
239_R248_N1.4131.00
98_L129_V1.4131.00
384_V387_L1.4121.00
363_Y366_P1.4111.00
231_N234_D1.4021.00
360_G370_K1.3881.00
242_Y248_N1.3761.00
363_Y367_F1.3751.00
326_S352_K1.3691.00
214_G217_R1.3601.00
44_L50_V1.3561.00
242_Y247_E1.3441.00
252_S284_R1.3441.00
296_S299_D1.3371.00
337_S375_R1.3251.00
240_K245_V1.3251.00
186_S190_G1.3171.00
400_Y404_I1.3081.00
360_G368_S1.3081.00
403_V406_S1.3061.00
98_L131_V1.3001.00
361_E367_F1.2981.00
362_V370_K1.2971.00
216_E219_L1.2861.00
332_T335_S1.2831.00
226_N231_N1.2831.00
194_L198_R1.2821.00
385_R388_K1.2741.00
172_V204_I1.2661.00
194_L197_L1.2611.00
177_F206_V1.2601.00
391_D394_L1.2591.00
68_A83_H1.2421.00
367_F370_K1.2411.00
39_E43_N1.2411.00
68_A173_I1.2351.00
140_N161_E1.2351.00
408_L412_L1.2321.00
192_A196_V1.2231.00
380_T385_R1.2231.00
277_A314_V1.2211.00
379_E382_E1.2181.00
262_K352_K1.2131.00
253_I257_K1.2041.00
230_V233_D1.2031.00
69_N78_G1.2021.00
39_E42_L1.2001.00
52_L207_T1.1931.00
278_Y290_L1.1901.00
426_V430_Y1.1891.00
68_A171_I1.1861.00
251_I255_E1.1841.00
407_I410_K1.1801.00
66_I69_N1.1711.00
274_A292_H1.1661.00
159_H162_F1.1591.00
403_V407_I1.1571.00
95_Y109_T1.1551.00
441_S444_L1.1521.00
183_D186_S1.1511.00
382_E385_R1.1491.00
301_I305_N1.1401.00
278_Y314_V1.1351.00
240_K361_E1.1341.00
188_G192_A1.1311.00
191_L195_E1.1311.00
381_V385_R1.1301.00
164_R167_I1.1271.00
240_K243_V1.1261.00
351_G399_D1.1231.00
332_T344_A1.1121.00
289_I303_K1.1071.00
299_D303_K1.1071.00
437_T441_S1.1061.00
362_V368_S1.1051.00
198_R201_G1.0951.00
332_T364_I1.0941.00
186_S189_A1.0931.00
80_R168_Y1.0861.00
251_I258_V1.0861.00
42_L70_A1.0841.00
439_N443_I1.0821.00
218_V221_N1.0801.00
453_V456_A1.0751.00
190_G193_A1.0721.00
189_A193_A1.0721.00
439_N442_I1.0671.00
383_R386_E1.0661.00
82_I167_I1.0651.00
250_E254_T1.0641.00
259_K286_L1.0601.00
274_A278_Y1.0601.00
381_V386_E1.0591.00
186_S193_A1.0571.00
264_V329_V1.0541.00
256_E260_E1.0531.00
432_K436_I1.0521.00
122_S125_F1.0521.00
138_I192_A1.0511.00
366_P370_K1.0491.00
398_R401_T1.0391.00
92_Q301_I1.0381.00
449_N453_V1.0311.00
212_D218_V1.0291.00
397_E403_V1.0241.00
228_K231_N1.0201.00
422_D425_K1.0191.00
273_G334_A1.0171.00
69_N102_A1.0151.00
445_G448_P1.0121.00
379_E383_R1.0121.00
96_L100_N1.0111.00
121_D125_F1.0111.00
81_V173_I1.0061.00
178_H321_A0.9991.00
327_F331_I0.9991.00
159_H164_R0.9981.00
457_I461_E0.9981.00
304_V325_T0.9931.00
244_N248_N0.9901.00
84_V132_T0.9901.00
404_I407_I0.9881.00
230_V234_D0.9861.00
84_V137_F0.9831.00
405_D408_L0.9831.00
216_E228_K0.9821.00
378_K381_V0.9801.00
362_V369_G0.9781.00
444_L447_P0.9781.00
295_F303_K0.9751.00
422_D426_V0.9751.00
411_D415_I0.9731.00
47_G203_P0.9721.00
361_E366_P0.9671.00
116_D119_Y0.9661.00
43_N46_N0.9631.00
397_E402_E0.9611.00
113_G116_D0.9591.00
62_T66_I0.9581.00
452_D456_A0.9571.00
243_V247_E0.9561.00
456_A459_L0.9561.00
267_V343_R0.9531.00
241_I247_E0.9441.00
430_Y434_C0.9381.00
71_V171_I0.9361.00
459_L462_E0.9321.00
381_V389_T0.9301.00
332_T336_P0.9271.00
371_V375_R0.9251.00
183_D190_G0.9241.00
80_R128_K0.9201.00
412_L416_D0.9181.00
218_V223_L0.9141.00
263_R310_A0.9121.00
364_I370_K0.9091.00
383_R387_L0.9011.00
455_D458_P0.8981.00
455_D459_L0.8981.00
215_L221_N0.8931.00
377_V381_V0.8901.00
391_D395_L0.8901.00
264_V331_I0.8891.00
185_K190_G0.8871.00
98_L109_T0.8861.00
458_P462_E0.8851.00
371_V374_E0.8841.00
446_F450_S0.8841.00
325_T328_D0.8801.00
117_M120_Q0.8791.00
365_F368_S0.8761.00
43_N229_V0.8751.00
456_A460_T0.8701.00
255_E258_V0.8701.00
416_D419_V0.8691.00
111_N114_A0.8671.00
227_V230_V0.8621.00
216_E220_M0.8591.00
403_V408_L0.8581.00
192_A195_E0.8581.00
399_D402_E0.8541.00
391_D396_I0.8531.00
184_G188_G0.8531.00
219_L222_K0.8501.00
244_N247_E0.8491.00
64_T67_L0.8491.00
266_L312_L0.8471.00
35_K39_E0.8461.00
220_M223_L0.8451.00
438_R442_I0.8421.00
411_D418_S0.8401.00
429_I433_I0.8401.00
113_G120_Q0.8391.00
253_I258_V0.8391.00
239_R247_E0.8381.00
183_D189_A0.8341.00
423_S427_K0.8311.00
213_K218_V0.8291.00
443_I446_F0.8231.00
448_P452_D0.8221.00
183_D187_L0.8201.00
187_L193_A0.8171.00
249_D258_V0.8161.00
380_T387_L0.8161.00
385_R389_T0.8151.00
377_V380_T0.8141.00
403_V411_D0.8101.00
457_I460_T0.8061.00
245_V248_N0.8061.00
436_I440_A0.8061.00
380_T386_E0.8051.00
422_D427_K0.8051.00
195_E201_G0.8041.00
453_V458_P0.8021.00
78_G166_L0.8011.00
413_S417_N0.8011.00
261_G264_V0.8001.00
213_K216_E0.8001.00
305_N308_N0.8001.00
426_V429_I0.7991.00
219_L223_L0.7991.00
41_L66_I0.7961.00
447_P450_S0.7951.00
85_L91_V0.7951.00
168_Y202_V0.7921.00
392_E395_L0.7901.00
187_L192_A0.7891.00
440_A443_I0.7881.00
299_D302_D0.7871.00
132_T162_F0.7861.00
415_I419_V0.7861.00
274_A290_L0.7861.00
173_I205_V0.7851.00
185_K188_G0.7831.00
194_L201_G0.7831.00
451_N455_D0.7781.00
249_D257_K0.7751.00
64_T205_V0.7711.00
364_I369_G0.7691.00
363_Y368_S0.7681.00
228_K232_A0.7681.00
441_S445_G0.7631.00
441_S447_P0.7621.00
212_D219_L0.7621.00
251_I284_R0.7581.00
83_H98_L0.7571.00
43_N227_V0.7571.00
411_D414_V0.7561.00
386_E390_I0.7541.00
49_S204_I0.7541.00
387_L391_D0.7511.00
414_V418_S0.7511.00
274_A314_V0.7511.00
40_T63_L0.7511.00
453_V457_I0.7481.00
251_I277_A0.7451.00
336_P343_R0.7441.00
270_T273_G0.7421.00
373_D378_K0.7421.00
435_S439_N0.7421.00
411_D417_N0.7401.00
36_G40_T0.7401.00
227_V231_N0.7391.00
275_I292_H0.7371.00
390_I395_L0.7361.00
404_I408_L0.7361.00
430_Y433_I0.7341.00
397_E408_L0.7331.00
188_G191_L0.7321.00
437_T440_A0.7311.00
276_E280_K0.7311.00
430_Y436_I0.7301.00
451_N454_N0.7261.00
226_N229_V0.7191.00
291_I319_I0.7171.00
379_E385_R0.7171.00
252_S256_E0.7161.00
398_R410_K0.7151.00
452_D455_D0.7121.00
399_D411_D0.7111.00
332_T343_R0.7101.00
406_S411_D0.7101.00
183_D188_G0.7091.00
168_Y171_I0.7091.00
185_K189_A0.7091.00
415_I418_S0.7051.00
442_I448_P0.7041.00
406_S410_K0.7041.00
172_V194_L0.7031.00
421_V426_V0.7021.00
384_V389_T0.7021.00
399_D408_L0.7011.00
451_N457_I0.7011.00
425_K429_I0.6991.00
397_E415_I0.6991.00
375_R378_K0.6971.00
179_L183_D0.6951.00
421_V424_K0.6931.00
422_D429_I0.6911.00
449_N452_D0.6911.00
330_L347_V0.6901.00
402_E406_S0.6881.00
433_I437_T0.6871.00
401_T405_D0.6861.00
360_G369_G0.6851.00
190_G194_L0.6801.00
453_V459_L0.6801.00
456_A462_E0.6801.00
443_I447_P0.6791.00
183_D193_A0.6781.00
410_K414_V0.6721.00
186_S191_L0.6701.00
212_D223_L0.6701.00
379_E387_L0.6691.00
434_C439_N0.6681.00
264_V312_L0.6671.00
387_L390_I0.6651.00
381_V388_K0.6641.00
454_N460_T0.6631.00
252_S255_E0.6621.00
429_I432_K0.6611.00
373_D380_T0.6591.00
430_Y437_T0.6581.00
383_R388_K0.6571.00
452_D459_L0.6561.00
401_T409_A0.6561.00
446_F449_N0.6551.00
96_L99_K0.6541.00
195_E198_R0.6541.00
377_V383_R0.6531.00
408_L416_D0.6521.00
450_S453_V0.6521.00
282_K288_P0.6491.00
421_V428_S0.6491.00
90_I322_G0.6471.00
400_Y405_D0.6471.00
280_K284_R0.6461.00
373_D384_V0.6451.00
307_I313_V0.6441.00
442_I445_G0.6441.00
112_I297_K0.6441.00
375_R379_E0.6431.00
400_Y407_I0.6411.00
412_L418_S0.6401.00
251_I280_K0.6401.00
434_C438_R0.6401.00
163_P166_L0.6381.00
302_D305_N0.6371.00
61_T94_L0.6361.00
397_E401_T0.6351.00
265_L313_V0.6351.00
422_D430_Y0.6351.00
450_S457_I0.6351.00
407_I412_L0.6351.00
47_G71_V0.6331.00
263_R326_S0.6321.00
257_K363_Y0.6321.00
242_Y361_E0.6321.00
228_K234_D0.6311.00
427_K430_Y0.6301.00
403_V412_L0.6291.00
226_N232_A0.6281.00
440_A444_L0.6271.00
223_L226_N0.6251.00
454_N457_I0.6221.00
445_G450_S0.6221.00
376_E379_E0.6201.00
423_S433_I0.6201.00
398_R403_V0.6181.00
68_A98_L0.6181.00
427_K431_E0.6171.00
240_K248_N0.6171.00
385_R390_I0.6161.00
364_I368_S0.6161.00
336_P340_L0.6151.00
426_V433_I0.6141.00
51_I211_I0.6121.00
421_V425_K0.6121.00
436_I443_I0.6111.00
382_E389_T0.6111.00
279_K282_K0.6111.00
295_F299_D0.6101.00
361_E369_G0.6101.00
384_V390_I0.6091.00
174_F181_G0.6040.99
439_N444_L0.6030.99
444_L448_P0.6020.99
431_E434_C0.6020.99
257_K260_E0.6010.99
266_L331_I0.6010.99
259_K284_R0.6000.99
442_I446_F0.5990.99
397_E406_S0.5990.99
71_V203_P0.5980.99
450_S454_N0.5980.99
51_I206_V0.5980.99
405_D409_A0.5980.99
399_D403_V0.5970.99
452_D457_I0.5970.99
374_E381_V0.5970.99
451_N456_A0.5970.99
265_L315_S0.5960.99
404_I415_I0.5950.99
404_I412_L0.5950.99
185_K192_A0.5950.99
436_I439_N0.5900.99
112_I115_Q0.5900.99
438_R441_S0.5900.99
399_D405_D0.5890.99
374_E384_V0.5860.99
443_I451_N0.5860.99
423_S426_V0.5850.99
437_T446_F0.5840.99
407_I411_D0.5840.99
390_I394_L0.5810.99
189_A192_A0.5810.99
236_K241_I0.5810.99
224_G227_V0.5800.99
439_N447_P0.5790.99
327_F330_L0.5790.99
66_I70_A0.5790.99
120_Q123_P0.5780.99
214_G221_N0.5780.99
251_I254_T0.5770.99
412_L417_N0.5770.99
453_V460_T0.5760.99
254_T257_K0.5750.99
34_R37_I0.5720.99
420_F426_V0.5720.99
184_G190_G0.5700.99
389_T392_E0.5690.99
114_A117_M0.5690.99
443_I448_P0.5680.99
403_V410_K0.5680.99
411_D416_D0.5670.99
304_V307_I0.5670.99
437_T442_I0.5660.99
457_I462_E0.5650.99
420_F429_I0.5640.99
236_K239_R0.5640.99
329_V363_Y0.5640.99
328_D331_I0.5640.99
118_D122_S0.5620.99
373_D381_V0.5610.99
95_Y131_V0.5610.99
454_N458_P0.5610.99
398_R408_L0.5610.99
377_V382_E0.5560.99
251_I333_E0.5560.99
450_S456_A0.5550.99
215_L222_K0.5540.99
433_I456_A0.5530.99
453_V461_E0.5530.99
329_V332_T0.5530.99
397_E412_L0.5530.99
191_L221_N0.5520.99
403_V414_V0.5520.99
162_F166_L0.5510.99
404_I416_D0.5500.99
158_S161_E0.5500.99
447_P452_D0.5490.99
421_V430_Y0.5480.99
404_I411_D0.5480.99
435_S438_R0.5470.99
70_A74_D0.5470.99
93_D324_D0.5470.99
213_K221_N0.5450.99
451_N459_L0.5450.99
406_S412_L0.5440.99
122_S126_M0.5440.99
440_A448_P0.5430.99
438_R444_L0.5420.99
429_I434_C0.5400.99
161_E164_R0.5370.99
440_A452_D0.5320.99
434_C441_S0.5320.99
376_E383_R0.5320.99
29_H100_N0.5290.99
458_P461_E0.5280.99
361_E365_F0.5280.99
41_L45_E0.5280.99
428_S432_K0.5270.99
399_D412_L0.5270.99
429_I441_S0.5260.99
409_A412_L0.5250.99
264_V268_Y0.5230.98
455_D462_E0.5220.98
87_Y321_A0.5220.98
405_D412_L0.5210.98
435_S440_A0.5210.98
123_P126_M0.5210.98
413_S416_D0.5190.98
433_I436_I0.5190.98
71_V168_Y0.5190.98
430_Y435_S0.5190.98
254_T266_L0.5190.98
431_E435_S0.5190.98
51_I218_V0.5190.98
397_E407_I0.5170.98
273_G276_E0.5160.98
435_S443_I0.5150.98
327_F332_T0.5130.98
183_D198_R0.5120.98
434_C437_T0.5120.98
79_S166_L0.5110.98
408_L411_D0.5110.98
376_E384_V0.5080.98
446_F452_D0.5050.98
40_T44_L0.5040.98
450_S455_D0.5040.98
215_L223_L0.5030.98
380_T388_K0.5030.98
393_N397_E0.5020.98
31_F101_Y0.5020.98
44_L67_L0.5010.98
374_E382_E0.5000.98
371_V376_E0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pxaA 1 0.7223 100 0.426 Contact Map
4ljyA 1 0.7495 100 0.426 Contact Map
4d25A 1 0.7165 100 0.435 Contact Map
4nhoA 1 0.7126 100 0.435 Contact Map
2db3A 1 0.7165 100 0.436 Contact Map
3fmpB 1 0.4136 100 0.437 Contact Map
3peyA 1 0.7204 100 0.439 Contact Map
4c9bA 1 0.7146 100 0.447 Contact Map
1xtiA 1 0.7087 100 0.447 Contact Map
4ct4B 1 0.7087 100 0.448 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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