CAS6B - SULSO - GREMLIN Contacts

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CAS6B - CRISPR-associated endoribonuclease Cas6 2

UniProt:	Q97WV8	Sequences: MPLIFKIGYNVIPLQDVILPTPSSKVLKYLIQSGKLIPSLKDLITSRDKYKPIFISHLGFNQRRIFQTNGNLKTITKGSRLSSIIAFSTQANVLSEVADEGIFETVYGKFHIMIESIEIVEVEKLKEEVEKHMNDNIRVRFVSPTLLSSKVLLPPSLSERYKKIHAGYSTLPSVGLIVAYAYNVYCNLIGKKEVEVRAFKFGILSNALSRIIGYDLHPVTVAIGEDSKGNLRKARGVMGWIEFDIPDERLKRRALNYLLTSSYLGIGRSRGIGFGEIRLEFRKIEEKEG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	289 (246)
Sequences:	209 (184)
Seq/√Len:	11.8

SULSO - CAS6B CAS6A Q97YC0 Q97YE5 Q97YB0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
177_I	243_F	4.384	1.00
54_F	86_A	4.197	1.00
125_L	128_E	3.561	0.98
110_F	114_I	3.326	0.98
168_Y	268_R	3.192	0.97
9_Y	85_I	3.056	0.96
107_Y	114_I	2.990	0.95
107_Y	110_F	2.866	0.94
266_I	277_I	2.793	0.93
24_S	57_H	2.565	0.90
127_E	130_E	2.520	0.89
103_F	107_Y	2.438	0.87
81_L	89_T	2.358	0.85
56_S	276_E	2.346	0.85
112_I	115_E	2.268	0.83
184_V	270_R	2.261	0.83
11_V	58_L	2.200	0.81
16_D	77_K	2.138	0.79
181_A	266_I	2.108	0.78
108_G	114_I	2.105	0.78
124_K	128_E	2.019	0.75
28_K	32_Q	2.012	0.74
84_I	243_F	2.012	0.74
141_F	145_T	1.966	0.72
267_G	273_G	1.938	0.71
267_G	275_G	1.938	0.71
239_G	273_G	1.938	0.71
239_G	275_G	1.938	0.71
239_G	267_G	1.938	0.71
58_L	78_G	1.916	0.70
34_G	41_K	1.878	0.69
269_S	272_I	1.874	0.69
45_T	147_L	1.868	0.68
127_E	131_K	1.815	0.66
181_A	264_L	1.671	0.59
104_E	110_F	1.661	0.59
103_F	110_F	1.655	0.59
104_E	109_K	1.637	0.58
110_F	117_I	1.634	0.58
245_I	254_A	1.629	0.57
185_Y	189_I	1.622	0.57
28_K	31_I	1.618	0.57
25_K	28_K	1.612	0.57
268_R	272_I	1.608	0.56
112_I	217_H	1.606	0.56
180_Y	185_Y	1.605	0.56
106_V	110_F	1.589	0.55
103_F	109_K	1.576	0.55
220_T	272_I	1.556	0.54
108_G	112_I	1.555	0.54
258_L	270_R	1.542	0.53
9_Y	83_S	1.530	0.53
176_L	243_F	1.522	0.52
12_I	71_N	1.467	0.49
28_K	270_R	1.457	0.49
18_I	21_T	1.447	0.48
202_G	264_L	1.440	0.48
88_S	257_Y	1.421	0.47
205_S	210_R	1.420	0.47
54_F	278_R	1.415	0.47
45_T	270_R	1.411	0.47
183_N	204_L	1.403	0.46
144_P	275_G	1.401	0.46
144_P	267_G	1.401	0.46
144_P	239_G	1.401	0.46
144_P	273_G	1.401	0.46
62_Q	65_I	1.387	0.45
86_A	276_E	1.375	0.45
115_E	120_V	1.316	0.42
86_A	261_S	1.309	0.42
212_I	218_P	1.293	0.41
138_R	242_E	1.292	0.41
78_G	139_V	1.292	0.41
110_F	115_E	1.274	0.40
72_L	77_K	1.272	0.40
13_P	16_D	1.265	0.40
169_S	173_S	1.262	0.39
56_S	83_S	1.258	0.39
118_E	121_E	1.255	0.39
45_T	257_Y	1.252	0.39
147_L	218_P	1.243	0.38
145_T	237_V	1.220	0.37
12_I	18_I	1.212	0.37
264_L	270_R	1.207	0.37
112_I	122_V	1.176	0.35
169_S	174_V	1.164	0.35
12_I	113_M	1.163	0.35
24_S	28_K	1.162	0.35
17_V	85_I	1.146	0.34
104_E	112_I	1.143	0.34
265_G	270_R	1.127	0.33
221_V	227_S	1.126	0.33
17_V	86_A	1.099	0.32
51_K	109_K	1.087	0.31
34_G	38_P	1.085	0.31
270_R	277_I	1.083	0.31
181_A	260_T	1.076	0.31
65_I	77_K	1.074	0.31
28_K	53_I	1.074	0.31
54_F	88_S	1.070	0.31
77_K	123_E	1.065	0.30
112_I	118_E	1.064	0.30
24_S	32_Q	1.063	0.30
85_I	110_F	1.058	0.30
141_F	172_P	1.056	0.30
12_I	99_D	1.051	0.30
137_I	209_S	1.042	0.30
239_G	265_G	1.029	0.29
265_G	273_G	1.029	0.29
265_G	275_G	1.029	0.29
27_L	31_I	1.026	0.29
132_H	143_S	1.021	0.29
105_T	119_I	1.021	0.29
109_K	120_V	1.019	0.29
179_A	266_I	1.014	0.28
139_V	258_L	1.014	0.28
100_E	108_G	1.007	0.28
185_Y	257_Y	1.004	0.28
176_L	226_D	1.003	0.28
26_V	143_S	1.003	0.28
108_G	143_S	0.991	0.27
213_G	216_L	0.990	0.27
32_Q	184_V	0.988	0.27
172_P	239_G	0.987	0.27
172_P	267_G	0.987	0.27
172_P	273_G	0.987	0.27
172_P	275_G	0.987	0.27
28_K	272_I	0.980	0.27
147_L	220_T	0.976	0.27
46_S	141_F	0.970	0.27
226_D	233_K	0.963	0.26
143_S	236_G	0.957	0.26
97_V	182_Y	0.954	0.26
31_I	186_C	0.953	0.26
37_I	225_E	0.952	0.26
26_V	75_I	0.949	0.26
103_F	114_I	0.946	0.26
262_S	265_G	0.945	0.26
140_R	146_L	0.945	0.26
187_N	243_F	0.944	0.26
46_S	227_S	0.944	0.26
146_L	269_S	0.943	0.26
195_E	205_S	0.941	0.26
41_K	245_I	0.941	0.26
137_I	201_F	0.939	0.25
87_F	242_E	0.936	0.25
116_S	196_V	0.928	0.25
170_T	270_R	0.923	0.25
256_N	270_R	0.914	0.25
265_G	269_S	0.912	0.24
184_V	269_S	0.909	0.24
20_P	95_S	0.905	0.24
185_Y	263_Y	0.904	0.24
270_R	274_F	0.904	0.24
72_L	111_H	0.902	0.24
117_I	127_E	0.901	0.24
43_L	46_S	0.891	0.24
147_L	269_S	0.888	0.24
108_G	115_E	0.887	0.24
185_Y	260_T	0.879	0.23
203_I	218_P	0.876	0.23
38_P	41_K	0.876	0.23
42_D	63_R	0.876	0.23
93_V	103_F	0.871	0.23
117_I	120_V	0.868	0.23
51_K	265_G	0.863	0.23
13_P	17_V	0.862	0.23
114_I	121_E	0.860	0.23
108_G	121_E	0.856	0.22
87_F	200_K	0.850	0.22
28_K	181_A	0.850	0.22
29_Y	56_S	0.849	0.22
103_F	108_G	0.849	0.22
53_I	271_G	0.845	0.22
171_L	243_F	0.835	0.22
262_S	276_E	0.833	0.22
93_V	100_E	0.832	0.22
98_A	241_I	0.831	0.22
85_I	102_I	0.827	0.21
10_N	13_P	0.827	0.21
124_K	129_V	0.827	0.21
33_S	188_L	0.826	0.21
107_Y	115_E	0.824	0.21
168_Y	272_I	0.814	0.21
206_N	211_I	0.812	0.21
168_Y	269_S	0.811	0.21
243_F	261_S	0.811	0.21
211_I	227_S	0.809	0.21
220_T	235_R	0.807	0.21
35_K	132_H	0.803	0.21
81_L	96_E	0.800	0.21
45_T	88_S	0.799	0.21
116_S	120_V	0.795	0.20
184_V	260_T	0.795	0.20
39_S	110_F	0.786	0.20
38_P	176_L	0.786	0.20
88_S	185_Y	0.785	0.20
236_G	263_Y	0.780	0.20
106_V	112_I	0.779	0.20
83_S	279_L	0.779	0.20
19_L	252_R	0.777	0.20
263_Y	270_R	0.774	0.20
39_S	139_V	0.773	0.20
109_K	115_E	0.772	0.20
85_I	221_V	0.771	0.20
114_I	120_V	0.764	0.19
8_G	84_I	0.762	0.19
208_L	212_I	0.762	0.19
95_S	243_F	0.761	0.19
39_S	143_S	0.761	0.19
98_A	117_I	0.760	0.19
225_E	233_K	0.760	0.19
207_A	212_I	0.754	0.19
103_F	115_E	0.753	0.19
28_K	265_G	0.751	0.19
248_E	256_N	0.747	0.19
40_L	163_K	0.746	0.19
77_K	91_A	0.746	0.19
106_V	115_E	0.744	0.19
163_K	209_S	0.743	0.19
63_R	143_S	0.741	0.19
30_L	51_K	0.741	0.19
53_I	97_V	0.737	0.19
9_Y	54_F	0.735	0.19
23_S	108_G	0.732	0.18
29_Y	32_Q	0.722	0.18
16_D	76_T	0.719	0.18
177_I	195_E	0.715	0.18
10_N	113_M	0.714	0.18
95_S	103_F	0.712	0.18
104_E	120_V	0.711	0.18
213_G	218_P	0.710	0.18
202_G	205_S	0.708	0.18
103_F	120_V	0.706	0.18
44_I	271_G	0.706	0.18
186_C	189_I	0.705	0.18
30_L	188_L	0.704	0.18
44_I	53_I	0.704	0.18
211_I	218_P	0.704	0.18
40_L	268_R	0.700	0.18
264_L	277_I	0.699	0.17
14_L	91_A	0.696	0.17
87_F	142_V	0.694	0.17
17_V	21_T	0.690	0.17
67_Q	73_K	0.685	0.17
115_E	122_V	0.684	0.17
88_S	139_V	0.684	0.17
34_G	37_I	0.679	0.17
83_S	97_V	0.678	0.17
140_R	169_S	0.676	0.17
175_G	235_R	0.674	0.17
10_N	17_V	0.672	0.17
116_S	121_E	0.669	0.17
24_S	55_I	0.667	0.17
62_Q	119_I	0.661	0.16
8_G	278_R	0.661	0.16
40_L	178_V	0.660	0.16
31_I	259_L	0.660	0.16
180_Y	186_C	0.656	0.16
7_I	189_I	0.655	0.16
21_T	24_S	0.651	0.16
60_F	190_G	0.649	0.16
101_G	104_E	0.646	0.16
36_L	99_D	0.646	0.16
13_P	278_R	0.644	0.16
265_G	268_R	0.635	0.16
104_E	278_R	0.634	0.16
19_L	113_M	0.634	0.16
54_F	213_G	0.632	0.16
216_L	241_I	0.627	0.16
123_E	238_M	0.625	0.15
28_K	45_T	0.624	0.15
55_I	165_H	0.623	0.15
88_S	180_Y	0.622	0.15
87_F	97_V	0.621	0.15
201_F	264_L	0.620	0.15
104_E	107_Y	0.616	0.15
206_N	209_S	0.616	0.15
107_Y	112_I	0.615	0.15
223_I	227_S	0.614	0.15
56_S	178_V	0.612	0.15
220_T	227_S	0.610	0.15
118_E	122_V	0.610	0.15
20_P	224_G	0.609	0.15
102_I	121_E	0.609	0.15
23_S	57_H	0.608	0.15
185_Y	270_R	0.608	0.15
8_G	18_I	0.607	0.15
24_S	27_L	0.607	0.15
205_S	220_T	0.607	0.15
263_Y	268_R	0.605	0.15
83_S	163_K	0.600	0.15
140_R	194_V	0.600	0.15
14_L	133_M	0.600	0.15
55_I	167_G	0.598	0.15
38_P	58_L	0.597	0.15
146_L	274_F	0.597	0.15
166_A	186_C	0.597	0.15
170_T	175_G	0.596	0.15
78_G	140_R	0.593	0.15
85_I	132_H	0.592	0.15
106_V	109_K	0.591	0.15
43_L	47_R	0.590	0.15
24_S	89_T	0.590	0.15
99_D	191_K	0.590	0.15
191_K	278_R	0.587	0.15
170_T	220_T	0.586	0.14
266_I	272_I	0.584	0.14
177_I	218_P	0.583	0.14
234_A	243_F	0.582	0.14
181_A	257_Y	0.580	0.14
76_T	261_S	0.580	0.14
92_N	274_F	0.579	0.14
189_I	270_R	0.576	0.14
30_L	34_G	0.575	0.14
181_A	185_Y	0.575	0.14
9_Y	15_Q	0.571	0.14
13_P	180_Y	0.571	0.14
177_I	261_S	0.569	0.14
47_R	187_N	0.567	0.14
63_R	66_F	0.564	0.14
106_V	117_I	0.564	0.14
181_A	268_R	0.561	0.14
31_I	181_A	0.560	0.14
211_I	220_T	0.554	0.14
65_I	176_L	0.554	0.14
109_K	114_I	0.552	0.14
38_P	224_G	0.552	0.14
53_I	225_E	0.547	0.14
40_L	167_G	0.544	0.13
17_V	110_F	0.544	0.13
178_V	201_F	0.542	0.13
141_F	166_A	0.540	0.13
168_Y	274_F	0.538	0.13
15_Q	247_D	0.538	0.13
178_V	277_I	0.537	0.13
77_K	207_A	0.535	0.13
101_G	125_L	0.535	0.13
100_E	104_E	0.533	0.13
225_E	260_T	0.532	0.13
109_K	118_E	0.531	0.13
45_T	269_S	0.531	0.13
173_S	237_V	0.531	0.13
88_S	147_L	0.528	0.13
227_S	233_K	0.528	0.13
81_L	271_G	0.526	0.13
257_Y	260_T	0.526	0.13
49_K	122_V	0.526	0.13
186_C	257_Y	0.523	0.13
20_P	64_R	0.521	0.13
33_S	250_L	0.521	0.13
181_A	184_V	0.520	0.13
8_G	137_I	0.520	0.13
111_H	120_V	0.516	0.13
52_P	182_Y	0.515	0.13
251_K	254_A	0.514	0.13
135_D	254_A	0.513	0.13
52_P	132_H	0.513	0.13
22_P	176_L	0.513	0.13
28_K	147_L	0.512	0.13
29_Y	181_A	0.512	0.13
224_G	227_S	0.510	0.13
243_F	247_D	0.510	0.13
235_R	271_G	0.509	0.13
15_Q	90_Q	0.506	0.13
103_F	177_I	0.506	0.13
146_L	265_G	0.503	0.13
22_P	223_I	0.503	0.13
23_S	223_I	0.500	0.12

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4illA	2	0.9619	100	0.364	Contact Map
4c98A	2	0.7716	100	0.564	Contact Map
4c97A	1	0.7647	100	0.595	Contact Map
3i4hX	1	0.7543	99.9	0.663	Contact Map
3ufcX	1	0.8028	99.9	0.676	Contact Map
4qtsA	1	0.5398	41.4	0.954	Contact Map
1wicA	1	0.4602	12.6	0.964	Contact Map
4w8zA	1	0.5087	10.5	0.966	Contact Map
4l6uA	1	0.4913	8.2	0.967	Contact Map
1mspA	3	0.4118	4.6	0.971	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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