GREMLIN Database
Q97WV4 - N-methyl hydantoinase A (HuyA-2)
UniProt: Q97WV4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 644 (618)
Sequences: 3066 (2087)
Seq/√Len: 84.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_Y167_T6.2011.00
135_E166_K5.2691.00
139_E173_K4.6951.00
124_N128_E4.4881.00
168_K180_I4.3731.00
121_E129_I4.2651.00
385_K389_L4.0291.00
120_D137_E3.9371.00
83_K120_D3.8831.00
588_K597_N3.7791.00
138_V167_T3.6621.00
393_S397_D3.6291.00
139_E174_Y3.2211.00
168_K172_K3.2091.00
86_R118_E3.1121.00
166_K169_E3.0331.00
78_A145_I3.0301.00
495_E510_R3.0071.00
153_S194_T2.9871.00
636_D640_I2.9761.00
330_W342_I2.9281.00
35_R39_E2.9221.00
498_L564_A2.9141.00
143_S174_Y2.8811.00
586_I597_N2.8431.00
82_T121_E2.8221.00
135_E170_V2.7551.00
142_V171_L2.6741.00
98_R101_D2.6641.00
78_A117_I2.6631.00
491_F510_R2.6251.00
168_K183_E2.6061.00
79_L194_T2.5261.00
432_S455_R2.5231.00
71_N202_A2.4701.00
124_N130_L2.4681.00
139_E170_V2.4631.00
134_D137_E2.4491.00
392_L405_A2.4111.00
76_R114_E2.4071.00
535_R539_E2.4011.00
449_D631_W2.3741.00
329_I405_A2.3581.00
481_K493_E2.3321.00
179_S197_T2.2731.00
32_T61_L2.2491.00
120_D131_K2.2311.00
591_I598_T2.2051.00
161_P165_L2.1081.00
384_Y387_K2.1041.00
43_N47_G2.0971.00
495_E499_I2.0851.00
589_V598_T2.0651.00
602_V605_K2.0561.00
541_K544_A2.0361.00
152_V180_I2.0251.00
16_F44_V2.0071.00
590_L595_W2.0051.00
67_L275_T1.9921.00
591_I629_P1.9841.00
133_V167_T1.9781.00
351_I387_K1.9711.00
152_V171_L1.9701.00
354_N384_Y1.9511.00
151_A197_T1.9491.00
607_P610_F1.9351.00
115_L147_A1.9201.00
123_V163_N1.9181.00
611_E632_K1.9001.00
123_V129_I1.8961.00
635_V641_M1.8831.00
613_R632_K1.8821.00
268_S279_G1.8791.00
386_E389_L1.8711.00
166_K170_V1.8441.00
588_K595_W1.8431.00
76_R148_E1.8421.00
263_E455_R1.8341.00
387_K391_G1.8321.00
611_E634_L1.8091.00
70_E342_I1.8031.00
261_L266_L1.8031.00
507_Y566_R1.7971.00
133_V163_N1.7951.00
150_V171_L1.7881.00
137_E141_K1.7881.00
28_I47_G1.7711.00
508_F564_A1.7711.00
543_L549_V1.7591.00
347_D355_K1.7391.00
80_L119_V1.7301.00
165_L183_E1.7191.00
165_L169_E1.7041.00
367_L372_L1.7021.00
170_V174_Y1.7001.00
368_V388_A1.6901.00
366_N443_H1.6791.00
169_E173_K1.6771.00
332_D338_R1.6751.00
120_D134_D1.6721.00
368_V392_L1.6721.00
533_E537_V1.6621.00
152_V168_K1.6561.00
152_V167_T1.6551.00
75_P148_E1.6531.00
395_L401_V1.6391.00
133_V166_K1.6351.00
603_R620_E1.6351.00
445_L628_K1.6341.00
69_Q309_Y1.6311.00
539_E549_V1.6281.00
136_I139_E1.6081.00
16_F48_L1.5991.00
90_E116_R1.5941.00
328_I361_T1.5911.00
78_A141_K1.5891.00
481_K490_D1.5851.00
432_S457_I1.5761.00
5_V45_I1.5741.00
479_A498_L1.5671.00
89_I198_V1.5641.00
410_N443_H1.5621.00
389_L393_S1.5541.00
267_I417_I1.5491.00
165_L182_S1.5481.00
20_S24_E1.5461.00
481_K497_K1.5421.00
32_T40_V1.5411.00
628_K631_W1.5391.00
93_R192_E1.5391.00
625_I641_M1.5371.00
252_A470_L1.5341.00
275_T320_E1.5301.00
69_Q202_A1.5271.00
135_E139_E1.5251.00
330_W338_R1.5231.00
30_F43_N1.5130.99
277_K320_E1.4940.99
177_Y204_M1.4870.99
617_I626_V1.4850.99
612_I633_A1.4830.99
388_A392_L1.4800.99
500_E504_K1.4760.99
575_P637_D1.4740.99
395_L398_P1.4680.99
34_P346_A1.4500.99
119_V138_V1.4440.99
243_V313_F1.4390.99
584_K602_V1.4380.99
121_E131_K1.4360.99
247_E277_K1.4350.99
627_V633_A1.4330.99
142_V167_T1.4170.99
535_R555_I1.4130.99
587_R619_E1.4020.99
403_K593_D1.3940.99
387_K390_E1.3930.99
57_H210_Y1.3920.99
476_R563_F1.3880.99
138_V141_K1.3870.99
618_I633_A1.3870.99
247_E275_T1.3860.99
512_A560_I1.3860.99
157_S182_S1.3850.99
435_A441_P1.3730.99
479_A501_R1.3680.99
334_A338_R1.3680.99
123_V160_N1.3630.99
140_E143_S1.3610.99
189_R522_E1.3610.99
403_K407_D1.3560.99
492_K496_N1.3540.99
492_K495_E1.3510.99
371_R406_L1.3490.99
362_I409_V1.3470.99
46_K221_D1.3460.99
376_L379_G1.3400.99
39_E43_N1.3390.99
516_Y542_H1.3390.99
496_N500_E1.3360.99
285_K509_I1.3350.99
269_F276_A1.3240.99
509_I565_I1.3200.99
583_P601_Y1.3170.99
247_E320_E1.3140.99
352_C367_L1.3130.99
398_P401_V1.3060.98
17_I464_L1.3050.98
435_A444_A1.3040.98
241_K244_Q1.2990.98
117_I145_I1.2960.98
480_R559_T1.2920.98
609_G635_V1.2900.98
598_T629_P1.2860.98
82_T129_I1.2850.98
215_Q236_N1.2800.98
394_R398_P1.2760.98
129_I132_E1.2730.98
373_G376_L1.2670.98
367_L383_L1.2590.98
508_F562_V1.2520.98
445_L631_W1.2470.98
513_D559_T1.2460.98
170_V173_K1.2460.98
83_K118_E1.2330.98
633_A641_M1.2330.98
33_N40_V1.2260.98
62_A203_L1.2250.98
211_L235_I1.2210.98
36_N39_E1.2200.98
512_A534_I1.2190.98
511_Y524_T1.2150.98
139_E143_S1.2140.98
83_K137_E1.2140.98
65_A206_I1.2130.98
77_T149_A1.2090.97
582_K605_K1.2060.97
516_Y539_E1.2060.97
257_S268_S1.2060.97
351_I358_N1.2020.97
536_K540_D1.1990.97
612_I616_A1.1950.97
20_S26_S1.1910.97
495_E508_F1.1890.97
512_A557_I1.1890.97
162_H165_L1.1840.97
329_I365_A1.1790.97
375_E585_E1.1780.97
5_V52_V1.1720.97
207_V245_L1.1700.97
35_R347_D1.1660.97
488_E492_K1.1620.97
479_A497_K1.1580.97
117_I144_K1.1530.97
515_R556_E1.1530.97
136_I140_E1.1510.97
586_I599_E1.1480.97
81_T88_V1.1400.96
407_D450_E1.1340.96
390_E393_S1.1340.96
187_E312_R1.1260.96
351_I391_G1.1250.96
603_R625_I1.1200.96
179_S200_N1.1190.96
150_V175_F1.1140.96
373_G619_E1.1140.96
254_V279_G1.1100.96
579_N582_K1.1090.96
65_A70_E1.1080.96
488_E510_R1.1070.96
490_D493_E1.1030.96
377_L381_M1.1010.96
47_G380_N1.1010.96
481_K494_L1.0990.96
181_S197_T1.0990.96
117_I141_K1.0960.95
513_D524_T1.0930.95
155_L190_E1.0910.95
537_V541_K1.0910.95
366_N410_N1.0900.95
583_P586_I1.0880.95
392_L396_G1.0800.95
373_G587_R1.0780.95
153_S181_S1.0760.95
475_W507_Y1.0750.95
344_A361_T1.0750.95
618_I641_M1.0730.95
185_A312_R1.0720.95
18_I48_L1.0650.95
161_P182_S1.0620.95
517_K554_E1.0600.95
88_V190_E1.0580.95
591_I626_V1.0570.95
38_G213_N1.0530.94
604_E621_Y1.0470.94
411_L450_E1.0450.94
600_V617_I1.0430.94
76_R147_A1.0410.94
581_N605_K1.0310.94
4_K54_E1.0300.94
608_K639_I1.0250.94
169_E172_K1.0240.94
157_S181_S1.0230.93
523_L545_T1.0210.93
537_V540_D1.0170.93
620_E625_I1.0160.93
229_S478_E1.0150.93
388_A391_G1.0150.93
366_N371_R1.0150.93
367_L385_K1.0120.93
386_E390_E1.0090.93
211_L225_I1.0070.93
80_L141_K1.0040.93
583_P605_K1.0030.93
584_K605_K1.0020.93
223_F235_I1.0010.93
513_D561_R0.9990.93
506_D566_R0.9980.93
606_L635_V0.9930.92
587_R600_V0.9910.92
148_E174_Y0.9890.92
494_L497_K0.9880.92
264_E283_N0.9840.92
7_I55_V0.9830.92
266_L434_I0.9810.92
133_V138_V0.9800.92
111_V198_V0.9760.92
41_I214_I0.9740.92
576_T579_N0.9730.92
514_V555_I0.9720.92
77_T198_V0.9720.92
246_I311_I0.9710.92
368_V389_L0.9690.92
589_V617_I0.9670.91
539_E555_I0.9650.91
590_L594_D0.9620.91
277_K306_G0.9610.91
258_A286_F0.9590.91
407_D592_E0.9580.91
497_K500_E0.9560.91
371_R446_Y0.9560.91
464_L622_S0.9520.91
16_F28_I0.9520.91
4_K53_E0.9510.91
265_N283_N0.9490.91
482_S559_T0.9470.91
542_H548_F0.9460.91
142_V174_Y0.9430.90
45_I55_V0.9420.90
491_F495_E0.9420.90
581_N610_F0.9410.90
184_V241_K0.9410.90
540_D544_A0.9360.90
66_L199_I0.9340.90
462_P623_S0.9320.90
577_F610_F0.9300.90
138_V170_V0.9290.90
119_V141_K0.9280.90
62_A245_L0.9280.90
267_I428_P0.9230.89
28_I48_L0.9210.89
265_N430_N0.9210.89
132_E166_K0.9200.89
179_S184_V0.9200.89
489_R492_K0.9190.89
80_L171_L0.9180.89
616_A627_V0.9170.89
601_Y606_L0.9160.89
271_M366_N0.9160.89
153_S197_T0.9160.89
412_E415_R0.9160.89
83_K131_K0.9160.89
231_G476_R0.9130.89
36_N213_N0.9130.89
6_A471_L0.9130.89
499_I503_K0.9110.89
78_A147_A0.9050.88
76_R115_L0.9040.88
603_R641_M0.9040.88
360_P394_R0.9020.88
410_N446_Y0.9010.88
579_N610_F0.9000.88
69_Q108_K0.9000.88
403_K590_L0.9000.88
157_S197_T0.8980.88
204_M242_S0.8970.88
119_V133_V0.8970.88
489_R493_E0.8950.88
267_I421_T0.8950.88
515_R522_E0.8950.88
200_N204_M0.8940.88
263_E432_S0.8930.88
445_L627_V0.8910.88
598_T617_I0.8900.88
477_F501_R0.8850.87
42_Q217_S0.8830.87
618_I627_V0.8820.87
260_F465_F0.8820.87
28_I44_V0.8820.87
188_P482_S0.8820.87
81_T190_E0.8800.87
142_V170_V0.8780.87
4_K19_L0.8760.87
306_G320_E0.8760.87
30_F40_V0.8740.87
63_T68_G0.8720.87
37_P61_L0.8720.87
409_V413_M0.8710.86
435_A458_I0.8700.86
474_D570_T0.8680.86
490_D560_I0.8650.86
162_H166_K0.8650.86
417_I420_V0.8650.86
261_L434_I0.8620.86
321_V416_A0.8610.86
476_R565_I0.8570.86
18_I26_S0.8560.86
80_L167_T0.8550.85
227_S244_Q0.8540.85
67_L320_E0.8530.85
354_N387_K0.8530.85
247_E318_L0.8530.85
271_M443_H0.8520.85
171_L174_Y0.8520.85
30_F47_G0.8520.85
479_A562_V0.8520.85
598_T626_V0.8510.85
493_E497_K0.8510.85
217_S220_T0.8500.85
42_Q46_K0.8490.85
390_E394_R0.8490.85
463_G623_S0.8490.85
147_A150_V0.8470.85
156_H159_I0.8450.85
578_G582_K0.8450.85
332_D335_N0.8440.85
583_P599_E0.8410.85
396_G401_V0.8410.85
196_T243_V0.8410.85
9_I37_P0.8390.84
440_G462_P0.8380.84
374_E385_K0.8370.84
208_S212_E0.8350.84
486_D489_R0.8310.84
171_L175_F0.8300.84
152_V178_I0.8290.84
462_P622_S0.8280.84
271_M409_V0.8280.84
121_E163_N0.8260.83
542_H549_V0.8250.83
360_P392_L0.8240.83
448_A456_V0.8230.83
474_D565_I0.8230.83
579_N607_P0.8220.83
516_Y550_M0.8210.83
142_V175_F0.8200.83
3_C18_I0.8190.83
468_L573_I0.8190.83
79_L116_R0.8180.83
226_M470_L0.8170.83
275_T306_G0.8150.83
80_L154_Y0.8150.83
510_R530_N0.8130.82
58_A252_A0.8120.82
462_P603_R0.8110.82
525_I541_K0.8110.82
335_N338_R0.8080.82
351_I388_A0.8070.82
268_S275_T0.8050.82
602_V621_Y0.8050.82
78_A150_V0.8040.82
582_K601_Y0.8000.81
75_P205_P0.8000.81
15_D29_K0.7980.81
575_P638_S0.7970.81
135_E169_E0.7920.81
268_S436_F0.7920.81
277_K292_Y0.7900.81
329_I392_L0.7890.81
129_I163_N0.7890.81
165_L168_K0.7880.80
140_E144_K0.7870.80
276_A320_E0.7870.80
337_L401_V0.7860.80
536_K549_V0.7850.80
322_S327_T0.7850.80
612_I618_I0.7840.80
37_P44_V0.7830.80
30_F44_V0.7830.80
391_G394_R0.7830.80
339_V408_L0.7830.80
138_V142_V0.7820.80
141_K171_L0.7810.80
448_A453_I0.7790.80
584_K619_E0.7780.80
111_V115_L0.7770.80
362_I405_A0.7750.79
375_E382_K0.7730.79
88_V194_T0.7720.79
589_V626_V0.7700.79
37_P40_V0.7700.79
601_Y610_F0.7690.79
66_L246_I0.7690.79
79_L153_S0.7690.79
92_G96_R0.7680.79
247_E306_G0.7650.78
212_E216_S0.7650.78
485_K489_R0.7610.78
486_D490_D0.7610.78
114_E147_A0.7610.78
247_E319_A0.7580.78
351_I360_P0.7570.78
271_M439_A0.7560.78
463_G603_R0.7540.77
591_I594_D0.7540.77
33_N36_N0.7530.77
143_S148_E0.7530.77
584_K601_Y0.7520.77
331_R395_L0.7510.77
491_F508_F0.7500.77
484_P488_E0.7490.77
578_G583_P0.7470.77
137_E140_E0.7460.77
601_Y612_I0.7460.77
31_L346_A0.7440.77
227_S233_V0.7420.76
509_I526_Q0.7410.76
278_A416_A0.7390.76
278_A320_E0.7380.76
135_E138_V0.7380.76
366_N436_F0.7360.76
253_G436_F0.7360.76
157_S161_P0.7330.75
187_E480_R0.7260.75
217_S221_D0.7260.75
491_F560_I0.7260.75
591_I596_V0.7250.75
19_L23_G0.7250.75
259_S472_L0.7240.75
539_E551_S0.7240.75
129_I162_H0.7210.74
58_A470_L0.7200.74
268_S466_S0.7200.74
9_I41_I0.7180.74
80_L150_V0.7180.74
5_V18_I0.7170.74
426_L431_F0.7170.74
271_M362_I0.7140.74
115_L145_I0.7140.74
78_A119_V0.7130.73
315_F320_E0.7120.73
154_Y163_N0.7120.73
143_S169_E0.7110.73
151_A179_S0.7100.73
539_E542_H0.7090.73
3_C23_G0.7050.73
148_E176_K0.7040.72
268_S277_K0.7020.72
578_G602_V0.7020.72
331_R398_P0.6980.72
533_E536_K0.6980.72
80_L145_I0.6930.71
200_N243_V0.6930.71
618_I635_V0.6930.71
70_E635_V0.6920.71
7_I41_I0.6920.71
116_R194_T0.6910.71
492_K540_D0.6900.71
171_L178_I0.6890.71
587_R617_I0.6870.71
376_L381_M0.6860.71
145_I150_V0.6860.71
247_E276_A0.6850.70
578_G607_P0.6840.70
499_I508_F0.6830.70
444_A456_V0.6830.70
392_L398_P0.6830.70
63_T251_A0.6820.70
172_K178_I0.6810.70
487_L560_I0.6780.70
141_K145_I0.6770.70
498_L508_F0.6760.69
55_V223_F0.6750.69
38_G217_S0.6740.69
616_A633_A0.6740.69
46_K49_N0.6730.69
586_I602_V0.6720.69
256_A465_F0.6720.69
593_D596_V0.6720.69
351_I396_G0.6710.69
141_K144_K0.6700.69
49_N52_V0.6660.68
494_L562_V0.6650.68
77_T151_A0.6650.68
500_E503_K0.6650.68
511_Y526_Q0.6640.68
88_V102_L0.6640.68
586_I611_E0.6640.68
215_Q219_P0.6620.68
280_V421_T0.6620.68
67_L322_S0.6620.68
392_L401_V0.6610.68
395_L544_A0.6610.68
141_K146_K0.6610.68
199_I321_V0.6550.67
278_A465_F0.6550.67
63_T320_E0.6540.67
582_K602_V0.6540.67
226_M252_A0.6510.67
45_I494_L0.6510.67
600_V619_E0.6500.66
39_E217_S0.6500.66
319_A419_L0.6500.66
579_N583_P0.6500.66
609_G634_L0.6490.66
607_P611_E0.6470.66
503_K506_D0.6440.66
351_I356_G0.6440.66
413_M443_H0.6440.66
238_A252_A0.6440.66
551_S554_E0.6430.66
151_A201_A0.6430.66
436_F466_S0.6420.65
136_I169_E0.6420.65
580_E588_K0.6420.65
474_D567_R0.6410.65
278_A321_V0.6400.65
67_L207_V0.6390.65
123_V133_V0.6380.65
448_A631_W0.6380.65
392_L395_L0.6370.65
194_T198_V0.6370.65
522_E542_H0.6370.65
279_G421_T0.6360.65
257_S266_L0.6360.65
292_Y306_G0.6340.64
119_V137_E0.6320.64
435_A456_V0.6320.64
417_I447_L0.6310.64
134_D138_V0.6310.64
41_I55_V0.6300.64
226_M466_S0.6300.64
271_M320_E0.6280.64
509_I563_F0.6280.64
124_N160_N0.6280.64
441_P462_P0.6260.64
604_E608_K0.6250.63
331_R401_V0.6240.63
385_K388_A0.6240.63
110_I202_A0.6230.63
4_K21_E0.6230.63
521_W546_Y0.6220.63
66_L308_G0.6220.63
195_S310_P0.6210.63
16_F40_V0.6210.63
384_Y389_L0.6200.63
441_P623_S0.6190.63
133_V154_Y0.6180.63
582_K585_E0.6170.62
45_I49_N0.6170.62
65_A203_L0.6160.62
371_R626_V0.6150.62
627_V631_W0.6150.62
479_A505_V0.6150.62
36_N217_S0.6140.62
483_Y490_D0.6140.62
265_N431_F0.6140.62
282_I426_L0.6140.62
136_I143_S0.6130.62
67_L334_A0.6130.62
180_I183_E0.6120.62
80_L117_I0.6120.62
62_A68_G0.6120.62
275_T305_K0.6110.62
477_F505_V0.6100.62
366_N442_Q0.6090.61
608_K637_D0.6090.61
43_N46_K0.6080.61
583_P607_P0.6070.61
331_R399_Y0.6070.61
90_E106_K0.6070.61
247_E292_Y0.6060.61
396_G399_Y0.6050.61
33_N225_I0.6040.61
292_Y320_E0.6040.61
578_G610_F0.6040.61
348_P357_G0.6040.61
167_T170_V0.6020.61
119_V167_T0.6020.61
498_L502_L0.6020.61
233_V238_A0.6010.60
371_R591_I0.5990.60
186_P520_G0.5990.60
606_L610_F0.5990.60
473_A568_R0.5990.60
10_G15_D0.5980.60
63_T276_A0.5980.60
82_T85_F0.5970.60
37_P41_I0.5970.60
458_I625_I0.5960.60
365_A402_S0.5960.60
11_G15_D0.5950.60
446_Y628_K0.5950.60
8_D15_D0.5950.60
578_G612_I0.5950.60
307_S318_L0.5940.59
400_E403_K0.5940.59
278_A420_V0.5940.59
393_S398_P0.5920.59
403_K594_D0.5920.59
216_S220_T0.5910.59
67_L247_E0.5910.59
5_V21_E0.5910.59
532_N536_K0.5910.59
585_E600_V0.5900.59
360_P388_A0.5890.59
493_E496_N0.5880.59
416_A420_V0.5880.59
527_V565_I0.5880.59
362_I443_H0.5860.58
21_E53_E0.5860.58
570_T573_I0.5860.58
449_D630_G0.5860.58
580_E583_P0.5860.58
485_K613_R0.5850.58
358_N391_G0.5830.58
526_Q537_V0.5820.58
371_R589_V0.5810.58
44_V200_N0.5800.58
581_N599_E0.5800.58
92_G106_K0.5800.58
269_F366_N0.5790.58
151_A181_S0.5780.57
269_F447_L0.5780.57
319_A420_V0.5780.57
11_G14_T0.5780.57
51_E54_E0.5770.57
463_G620_E0.5770.57
415_R423_E0.5770.57
537_V588_K0.5760.57
462_P620_E0.5750.57
251_A316_V0.5750.57
483_Y560_I0.5750.57
590_L596_V0.5750.57
132_E163_N0.5750.57
268_S320_E0.5740.57
490_D494_L0.5740.57
25_V452_G0.5740.57
276_A447_L0.5740.57
35_R355_K0.5730.57
389_L536_K0.5730.57
542_H550_M0.5730.57
96_R416_A0.5730.57
277_K307_S0.5720.57
541_K545_T0.5720.57
543_L551_S0.5720.57
34_P37_P0.5720.57
172_K212_E0.5710.57
388_A395_L0.5710.57
536_K613_R0.5710.57
66_L203_L0.5710.57
485_K496_N0.5700.56
576_T607_P0.5700.56
44_V48_L0.5700.56
238_A245_L0.5700.56
149_A204_M0.5690.56
478_E561_R0.5690.56
418_R421_T0.5690.56
394_R397_D0.5690.56
81_T153_S0.5680.56
78_A138_V0.5670.56
271_M410_N0.5660.56
603_R618_I0.5660.56
126_D130_L0.5650.56
212_E215_Q0.5640.56
540_D543_L0.5640.56
247_E251_A0.5640.56
27_T461_Y0.5640.56
50_C601_Y0.5640.56
148_E489_R0.5640.56
88_V542_H0.5630.55
180_I184_V0.5630.55
172_K183_E0.5630.55
498_L566_R0.5620.55
278_A319_A0.5620.55
408_L412_E0.5610.55
580_E605_K0.5610.55
216_S397_D0.5600.55
82_T131_K0.5600.55
474_D566_R0.5600.55
620_E623_S0.5590.55
88_V92_G0.5590.55
434_I457_I0.5580.55
366_N406_L0.5580.55
233_V470_L0.5580.55
360_P368_V0.5570.55
178_I220_T0.5570.55
326_G362_I0.5570.55
12_T15_D0.5570.55
123_V162_H0.5560.55
602_V619_E0.5560.55
24_E108_K0.5550.54
199_I307_S0.5550.54
58_A318_L0.5550.54
588_K596_V0.5550.54
8_D11_G0.5550.54
184_V197_T0.5530.54
233_V237_E0.5530.54
360_P405_A0.5520.54
505_V566_R0.5510.54
383_L452_G0.5510.54
410_N418_R0.5500.54
364_D467_A0.5490.54
573_I638_S0.5490.54
326_G343_S0.5490.54
361_T606_L0.5490.54
280_V426_L0.5480.53
276_A319_A0.5480.53
491_F512_A0.5470.53
134_D139_E0.5470.53
480_R513_D0.5460.53
585_E602_V0.5460.53
200_N238_A0.5460.53
141_K167_T0.5460.53
203_L206_I0.5460.53
470_L520_G0.5450.53
69_Q307_S0.5440.53
528_P533_E0.5440.53
577_F580_E0.5440.53
36_N361_T0.5440.53
568_R571_P0.5430.53
210_Y251_A0.5430.53
188_P522_E0.5430.53
63_T226_M0.5430.53
329_I362_I0.5420.53
149_A177_Y0.5420.53
132_E138_V0.5420.53
62_A207_V0.5410.53
580_E611_E0.5410.53
81_T116_R0.5410.53
395_L405_A0.5400.52
247_E268_S0.5400.52
143_S170_V0.5390.52
347_D351_I0.5390.52
199_I245_L0.5380.52
577_F582_K0.5380.52
578_G605_K0.5360.52
578_G581_N0.5360.52
280_V322_S0.5360.52
500_E532_N0.5360.52
514_V534_I0.5360.52
368_V402_S0.5360.52
269_F433_L0.5360.52
579_N584_K0.5350.52
99_L102_L0.5340.52
277_K318_L0.5340.52
536_K575_P0.5330.51
524_T561_R0.5320.51
78_A175_F0.5310.51
549_V575_P0.5310.51
372_L441_P0.5300.51
474_D568_R0.5300.51
483_Y487_L0.5280.51
142_V145_I0.5270.51
13_F228_S0.5270.51
225_I245_L0.5270.51
517_K523_L0.5260.51
470_L617_I0.5260.51
580_E610_F0.5260.51
413_M416_A0.5260.51
75_P209_S0.5260.51
536_K551_S0.5250.50
582_K610_F0.5240.50
275_T292_Y0.5240.50
10_G14_T0.5230.50
87_D96_R0.5230.50
612_I627_V0.5230.50
277_K315_F0.5230.50
165_L504_K0.5220.50
37_P228_S0.5220.50
583_P610_F0.5220.50
56_V232_L0.5210.50
138_V171_L0.5210.50
499_I611_E0.5210.50
528_P537_V0.5210.50
56_V470_L0.5210.50
577_F590_L0.5200.50
497_K501_R0.5200.50
557_I565_I0.5200.50
40_V48_L0.5200.50
81_T154_Y0.5200.50
468_L622_S0.5200.50
369_L402_S0.5200.50
337_L405_A0.5190.50
492_K510_R0.5190.50
485_K536_K0.5190.50
410_N431_F0.5180.50
136_I533_E0.5170.49
412_E416_A0.5170.49
68_G466_S0.5160.49
96_R371_R0.5150.49
96_R100_Y0.5150.49
576_T608_K0.5140.49
101_D411_L0.5140.49
92_G116_R0.5140.49
328_I344_A0.5140.49
211_L238_A0.5130.49
602_V612_I0.5120.49
63_T442_Q0.5120.49
100_Y116_R0.5110.49
188_P465_F0.5110.49
9_I40_V0.5110.49
320_E323_A0.5100.48
8_D12_T0.5100.48
328_I342_I0.5100.48
441_P463_G0.5090.48
568_R597_N0.5090.48
242_S307_S0.5090.48
78_A171_L0.5080.48
226_M451_I0.5080.48
470_L522_E0.5080.48
576_T581_N0.5080.48
428_P431_F0.5060.48
140_E485_K0.5060.48
532_N580_E0.5060.48
408_L411_L0.5060.48
86_R116_R0.5060.48
610_F634_L0.5060.48
34_P347_D0.5050.48
93_R428_P0.5050.48
144_K504_K0.5030.48
502_L505_V0.5030.48
165_L180_I0.5030.48
537_V544_A0.5020.47
574_S612_I0.5020.47
62_A226_M0.5020.47
94_Q470_L0.5020.47
271_M413_M0.5020.47
92_G97_P0.5020.47
228_S247_E0.5020.47
219_P236_N0.5020.47
409_V443_H0.5010.47
389_L500_E0.5010.47
503_K507_Y0.5010.47
498_L505_V0.5010.47
606_L611_E0.5010.47
132_E489_R0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cetA 2 0.4658 100 0.772 Contact Map
3hz6A 1 0.6879 100 0.876 Contact Map
3ifrA 2 0.6801 100 0.876 Contact Map
2itmA 2 0.6755 99.3 0.939 Contact Map
2zf5O 3 0.6988 99.2 0.941 Contact Map
4a2aA 1 0.5311 99.1 0.942 Contact Map
2dpnA 2 0.6941 99.1 0.943 Contact Map
3qdkA 2 0.7189 99.1 0.943 Contact Map
2d4wA 2 0.7034 99 0.945 Contact Map
2w40A 3 0.6957 99 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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