GREMLIN Database
Q97WV1 - Uncharacterized protein
UniProt: Q97WV1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 123 (114)
Sequences: 106 (95)
Seq/√Len: 8.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_E114_K3.9310.98
95_G98_E2.5600.81
68_F89_W2.4950.79
9_A12_F2.4180.77
53_I56_V2.3420.75
22_K54_N2.3070.73
16_A23_G2.2890.73
13_L35_A2.2730.72
94_E100_S2.2410.71
91_L113_V2.0850.65
68_F101_L1.9430.60
51_E56_V1.9370.59
9_A44_V1.9140.58
92_H98_E1.8580.56
49_L90_T1.8110.54
55_D59_K1.7770.53
13_L117_V1.7670.52
86_K109_L1.7380.51
114_K117_V1.6770.48
47_N74_L1.6720.48
92_H95_G1.6520.47
111_E115_K1.6480.47
92_H97_H1.6390.47
56_V90_T1.4550.39
44_V50_K1.4370.38
92_H96_F1.4250.38
53_I100_S1.4160.37
67_L85_W1.4130.37
36_A87_S1.4060.37
64_S68_F1.3690.35
106_V113_V1.3530.35
8_L61_R1.3480.35
68_F94_E1.3360.34
76_S104_K1.3210.34
71_S76_S1.2950.33
49_L60_G1.2900.32
41_K62_W1.2850.32
89_W92_H1.2730.32
21_S107_K1.2720.32
8_L42_L1.2340.30
114_K118_I1.1940.29
15_E78_N1.1940.29
78_N119_F1.1870.29
89_W116_L1.1820.28
14_N54_N1.1630.28
74_L81_I1.1560.28
102_N108_K1.1370.27
75_R102_N1.1240.26
26_V64_S1.1170.26
47_N117_V1.0980.26
107_K118_I1.0940.25
16_A20_L1.0710.25
43_L85_W1.0680.25
82_L107_K1.0670.25
93_V97_H1.0530.24
39_A116_L1.0320.23
40_I69_K1.0180.23
87_S109_L0.9860.22
40_I78_N0.9830.22
90_T101_L0.9820.22
93_V98_E0.9670.21
69_K102_N0.9600.21
5_S39_A0.9560.21
5_S18_E0.9530.21
59_K74_L0.9410.21
102_N107_K0.9360.21
35_A53_I0.9290.20
25_L32_Y0.9250.20
56_V66_N0.9230.20
61_R92_H0.9130.20
31_K38_E0.9050.20
25_L75_R0.8980.20
24_D49_L0.8950.19
7_D11_K0.8930.19
5_S9_A0.8850.19
112_D116_L0.8850.19
80_E119_F0.8840.19
88_A104_K0.8760.19
55_D58_S0.8600.19
61_R67_L0.8590.19
13_L114_K0.8570.18
50_K88_A0.8410.18
68_F100_S0.8400.18
103_E117_V0.8300.18
7_D20_L0.8300.18
93_V96_F0.8250.18
29_C41_K0.8210.18
5_S100_S0.8110.17
49_L77_N0.8080.17
46_E74_L0.8030.17
23_G85_W0.8010.17
36_A85_W0.7970.17
51_E74_L0.7910.17
65_E74_L0.7880.17
26_V44_V0.7840.17
89_W97_H0.7790.17
48_N67_L0.7780.16
104_K111_E0.7590.16
5_S94_E0.7540.16
76_S108_K0.7510.16
17_E118_I0.7500.16
80_E115_K0.7460.16
36_A101_L0.7370.16
14_N40_I0.7330.15
80_E84_L0.7300.15
24_D41_K0.7180.15
78_N91_L0.7130.15
19_F45_I0.7070.15
11_K40_I0.7000.15
35_A45_I0.6970.15
19_F50_K0.6970.15
89_W95_G0.6920.15
28_A113_V0.6880.14
61_R95_G0.6850.14
68_F90_T0.6840.14
61_R97_H0.6740.14
49_L101_L0.6720.14
71_S103_E0.6680.14
56_V91_L0.6670.14
11_K36_A0.6530.14
59_K63_E0.6530.14
87_S113_V0.6470.14
36_A111_E0.6460.14
39_A69_K0.6440.14
23_G81_I0.6410.13
58_S104_K0.6380.13
43_L78_N0.6370.13
17_E51_E0.6370.13
50_K54_N0.6350.13
69_K118_I0.6350.13
24_D30_E0.6350.13
12_F37_E0.6330.13
8_L99_L0.6300.13
20_L25_L0.6280.13
14_N77_N0.6250.13
76_S81_I0.6210.13
18_E58_S0.6180.13
20_L107_K0.6180.13
45_I54_N0.6170.13
80_E94_E0.6120.13
12_F36_A0.6080.13
61_R93_V0.6070.13
67_L75_R0.6010.13
21_S113_V0.6000.13
40_I66_N0.5980.13
48_N86_K0.5970.13
35_A117_V0.5960.13
75_R83_I0.5920.13
13_L116_L0.5860.12
7_D24_D0.5790.12
43_L67_L0.5780.12
74_L116_L0.5700.12
25_L99_L0.5610.12
25_L107_K0.5610.12
93_V100_S0.5610.12
89_W98_E0.5570.12
20_L101_L0.5540.12
60_G75_R0.5420.12
50_K60_G0.5380.12
106_V114_K0.5370.12
72_K115_K0.5360.12
20_L37_E0.5360.12
11_K14_N0.5350.11
58_S76_S0.5330.11
40_I105_E0.5310.11
28_A38_E0.5180.11
13_L47_N0.5170.11
28_A31_K0.5080.11
71_S89_W0.5050.11
79_L105_E0.5030.11
44_V53_I0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jpuA 1 0.9837 100 0.275 Contact Map
2hsbA 2 0.9106 94.1 0.887 Contact Map
1wolA 1 0.9187 90.5 0.899 Contact Map
1o3uA 2 0.8618 86.7 0.905 Contact Map
3o10A 2 0.9106 84.9 0.908 Contact Map
4nqfA 2 0.9187 84.2 0.909 Contact Map
1ufbA 3 0.9106 76.9 0.915 Contact Map
1knyA 2 0.8211 22.3 0.941 Contact Map
2i7uA 2 0.3496 19.8 0.943 Contact Map
4fzpA 2 0.4146 18.9 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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