Q97WU8 - SULSO - GREMLIN Contacts

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Q97WU8 - Protease, putative

UniProt:	Q97WU8	Sequences: MKLVVATNFDDSLLEELKKYPEVKYIFGSFKRTITGHGRAGFIIPDIKEEQFKNHISIAHSYGIKFLYTMNTNTLLGKEYDAEFIGKVMKEIDKLVSLGVDGFIIAVPFLIRLIRSEYPDLEVSASSFSRIHNVREVEEYANLGVNTIIMHEDANRDFKLLKEIASLSKTNKFDVELILNNSCLYGCPFRLTHDGISSITSMVNGVNDVWFEYPILLCATDVLNDPVNLIRSRWIRPEDIKYYEEIGINRFKIAGRNKKTEWILNVVKAFTERMYEGDLLDLVSYPQGRAATKAIQMVNGPSSYSVLTKVKIDNTKFPEDGIKFFLTNDCDTRSCKECKYCDIIAERVITIDGEPFKTDKWNIRQSYPINLIPKFKENGIKKGNQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	385 (314)
Sequences:	2305 (1515)
Seq/√Len:	85.5

ECOLI - YDCP YEGQ
BACSU - YRRO
SULSO - Q97WU8 Q97XI1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
111_I	145_V	3.957	1.00
5_V	267_V	3.741	1.00
162_K	166_S	3.287	1.00
125_A	145_V	3.191	1.00
17_L	64_I	3.143	1.00
88_V	110_L	3.092	1.00
68_Y	95_L	2.998	1.00
103_F	121_L	2.883	1.00
243_Y	251_F	2.828	1.00
48_K	51_Q	2.776	1.00
165_A	249_N	2.571	1.00
60_H	101_D	2.553	1.00
303_S	334_S	2.523	1.00
28_G	66_F	2.500	1.00
53_K	57_S	2.496	1.00
141_A	172_K	2.491	1.00
18_K	58_I	2.421	1.00
165_A	175_V	2.388	1.00
122_E	146_N	2.351	1.00
92_I	114_I	2.350	1.00
30_F	91_E	2.278	1.00
56_I	100_V	2.230	1.00
56_I	98_L	2.228	1.00
59_A	66_F	2.199	1.00
268_K	272_E	2.182	1.00
274_M	277_G	2.178	1.00
13_L	55_H	2.167	1.00
177_L	243_Y	2.135	1.00
215_I	228_N	2.088	1.00
49_E	94_K	2.031	1.00
253_I	267_V	2.011	1.00
70_M	92_I	2.003	1.00
298_V	330_C	1.983	1.00
236_R	239_D	1.976	1.00
279_L	282_L	1.948	1.00
68_Y	100_V	1.910	1.00
244_E	251_F	1.909	1.00
147_T	174_D	1.875	1.00
10_D	54_N	1.871	1.00
19_K	264_L	1.865	1.00
305_S	308_T	1.854	1.00
137_V	148_I	1.842	1.00
29_S	37_H	1.836	1.00
162_K	245_E	1.816	1.00
17_L	58_I	1.814	1.00
137_V	173_F	1.772	1.00
3_L	271_T	1.768	1.00
158_F	246_I	1.762	1.00
141_A	173_F	1.757	1.00
138_E	141_A	1.730	1.00
10_D	14_L	1.725	1.00
14_L	54_N	1.712	1.00
14_L	58_I	1.710	1.00
10_D	55_H	1.709	1.00
9_F	12_S	1.704	1.00
9_F	45_P	1.698	1.00
241_K	245_E	1.656	1.00
17_L	62_Y	1.637	1.00
298_V	305_S	1.618	1.00
324_F	328_N	1.606	1.00
58_I	62_Y	1.604	1.00
291_A	297_M	1.593	1.00
70_M	88_V	1.592	1.00
131_I	136_E	1.588	1.00
237_P	269_A	1.577	1.00
141_A	171_N	1.566	1.00
138_E	142_N	1.545	1.00
102_G	124_S	1.526	1.00
95_L	100_V	1.524	1.00
96_V	120_D	1.515	1.00
278_D	281_D	1.514	1.00
294_A	297_M	1.512	1.00
5_V	253_I	1.509	1.00
150_M	161_L	1.508	1.00
28_G	52_F	1.504	1.00
57_S	61_S	1.496	0.99
150_M	177_L	1.465	0.99
32_R	87_K	1.464	0.99
237_P	273_R	1.460	0.99
73_N	106_A	1.459	0.99
159_K	162_K	1.453	0.99
239_D	242_Y	1.427	0.99
208_D	213_Y	1.414	0.99
114_I	123_V	1.412	0.99
88_V	92_I	1.399	0.99
177_L	248_I	1.388	0.99
293_K	297_M	1.378	0.99
139_E	143_L	1.374	0.99
265_N	294_A	1.371	0.99
291_A	296_Q	1.369	0.99
154_A	164_I	1.368	0.99
93_D	118_Y	1.366	0.99
16_E	263_I	1.357	0.99
94_K	98_L	1.353	0.99
122_E	174_D	1.345	0.99
331_D	334_S	1.334	0.99
12_S	260_T	1.328	0.99
89_M	113_L	1.325	0.99
92_I	110_L	1.317	0.99
111_I	125_A	1.300	0.99
217_L	221_D	1.293	0.98
28_G	68_Y	1.292	0.98
284_S	288_G	1.290	0.98
298_V	301_P	1.281	0.98
31_K	51_Q	1.280	0.98
4_V	250_R	1.267	0.98
125_A	129_S	1.258	0.98
137_V	164_I	1.255	0.98
13_L	59_A	1.248	0.98
112_R	116_S	1.247	0.98
150_M	175_V	1.245	0.98
14_L	18_K	1.242	0.98
189_F	193_H	1.224	0.98
108_P	139_E	1.215	0.98
53_K	98_L	1.208	0.98
131_I	140_Y	1.201	0.98
123_V	145_V	1.200	0.98
3_L	266_V	1.193	0.97
175_V	248_I	1.186	0.97
131_I	137_V	1.184	0.97
332_T	335_C	1.182	0.97
165_A	172_K	1.160	0.97
85_I	113_L	1.154	0.97
285_Y	288_G	1.152	0.97
41_G	257_N	1.152	0.97
78_K	200_T	1.150	0.97
177_L	246_I	1.144	0.97
40_A	202_M	1.131	0.96
60_H	66_F	1.129	0.96
130_R	186_G	1.123	0.96
89_M	110_L	1.122	0.96
76_L	134_V	1.118	0.96
17_L	59_A	1.115	0.96
246_I	251_F	1.113	0.96
18_K	62_Y	1.112	0.96
92_I	118_Y	1.101	0.96
182_S	234_W	1.096	0.96
103_F	114_I	1.094	0.96
130_R	151_H	1.088	0.96
113_L	117_E	1.084	0.95
37_H	40_A	1.078	0.95
86_G	89_M	1.077	0.95
105_I	111_I	1.068	0.95
105_I	123_V	1.066	0.95
217_L	220_T	1.065	0.95
104_I	251_F	1.060	0.95
134_V	163_E	1.059	0.95
286_P	290_A	1.056	0.95
37_H	69_T	1.052	0.95
291_A	294_A	1.051	0.95
53_K	94_K	1.042	0.94
90_K	93_D	1.038	0.94
275_Y	279_L	1.034	0.94
74_T	88_V	1.023	0.94
89_M	93_D	1.023	0.94
111_I	123_V	1.020	0.94
13_L	26_I	1.013	0.93
269_A	291_A	1.006	0.93
323_K	326_L	1.004	0.93
96_V	121_L	1.002	0.93
115_R	146_N	1.001	0.93
154_A	160_L	1.001	0.93
306_V	310_V	1.000	0.93
114_I	118_Y	0.996	0.93
196_I	206_V	0.996	0.93
41_G	202_M	0.994	0.93
238_E	288_G	0.988	0.93
292_T	296_Q	0.980	0.92
279_L	283_V	0.979	0.92
31_K	48_K	0.975	0.92
36_G	87_K	0.973	0.92
290_A	297_M	0.971	0.92
13_L	47_I	0.964	0.92
55_H	59_A	0.963	0.92
135_R	138_E	0.959	0.91
328_N	332_T	0.955	0.91
245_E	275_Y	0.954	0.91
96_V	118_Y	0.952	0.91
243_Y	246_I	0.948	0.91
275_Y	278_D	0.945	0.91
11_D	260_T	0.942	0.91
323_K	327_T	0.938	0.91
281_D	284_S	0.938	0.91
307_L	315_T	0.933	0.90
283_V	287_Q	0.928	0.90
282_L	288_G	0.925	0.90
46_D	257_N	0.922	0.90
70_M	91_E	0.922	0.90
301_P	304_Y	0.919	0.90
37_H	72_T	0.918	0.90
279_L	284_S	0.918	0.90
50_E	53_K	0.916	0.89
104_I	149_I	0.913	0.89
125_A	140_Y	0.912	0.89
301_P	308_T	0.910	0.89
285_Y	289_R	0.899	0.89
137_V	175_V	0.895	0.88
49_E	52_F	0.891	0.88
275_Y	281_D	0.891	0.88
146_N	174_D	0.889	0.88
95_L	98_L	0.881	0.88
125_A	131_I	0.878	0.87
44_I	257_N	0.876	0.87
108_P	140_Y	0.874	0.87
161_L	246_I	0.874	0.87
163_E	166_S	0.874	0.87
28_G	47_I	0.872	0.87
322_I	325_F	0.871	0.87
93_D	117_E	0.870	0.87
332_T	336_K	0.870	0.87
161_L	164_I	0.866	0.87
129_S	140_Y	0.863	0.87
321_G	324_F	0.861	0.86
194_D	206_V	0.856	0.86
137_V	150_M	0.855	0.86
283_V	286_P	0.850	0.86
312_I	315_T	0.839	0.85
241_K	278_D	0.834	0.85
150_M	164_I	0.832	0.84
248_I	251_F	0.825	0.84
107_V	181_N	0.823	0.84
15_E	19_K	0.823	0.84
89_M	117_E	0.822	0.84
132_H	151_H	0.819	0.84
53_K	97_S	0.813	0.83
89_M	116_S	0.812	0.83
25_Y	250_R	0.807	0.83
54_N	57_S	0.807	0.83
91_E	95_L	0.802	0.82
302_S	307_L	0.798	0.82
251_F	291_A	0.797	0.82
109_F	119_P	0.796	0.82
263_I	267_V	0.793	0.81
65_K	146_N	0.791	0.81
105_I	114_I	0.790	0.81
67_L	102_G	0.789	0.81
104_I	139_E	0.787	0.81
55_H	66_F	0.787	0.81
138_E	172_K	0.786	0.81
189_F	228_N	0.783	0.81
41_G	198_S	0.782	0.81
127_S	151_H	0.780	0.80
241_K	244_E	0.778	0.80
77_G	90_K	0.774	0.80
222_V	225_D	0.773	0.80
100_V	121_L	0.771	0.80
207_N	231_R	0.770	0.80
293_K	296_Q	0.769	0.79
299_N	303_S	0.765	0.79
304_Y	311_K	0.762	0.79
231_R	296_Q	0.759	0.79
148_I	173_F	0.757	0.78
104_I	179_L	0.755	0.78
177_L	251_F	0.754	0.78
290_A	293_K	0.750	0.78
37_H	41_G	0.750	0.78
244_E	276_E	0.748	0.78
303_S	308_T	0.746	0.77
48_K	54_N	0.746	0.77
94_K	97_S	0.743	0.77
4_V	25_Y	0.742	0.77
306_V	309_K	0.742	0.77
2_K	250_R	0.742	0.77
331_D	335_C	0.741	0.77
283_V	288_G	0.741	0.77
300_G	308_T	0.738	0.77
308_T	315_T	0.736	0.76
286_P	291_A	0.734	0.76
281_D	285_Y	0.730	0.76
181_N	207_N	0.727	0.76
59_A	64_I	0.724	0.75
280_L	284_S	0.724	0.75
287_Q	290_A	0.723	0.75
157_D	160_L	0.720	0.75
89_M	118_Y	0.717	0.75
15_E	260_T	0.714	0.74
274_M	278_D	0.713	0.74
191_L	198_S	0.713	0.74
284_S	287_Q	0.710	0.74
329_D	332_T	0.707	0.74
274_M	279_L	0.704	0.73
240_I	275_Y	0.703	0.73
28_G	59_A	0.702	0.73
56_I	66_F	0.702	0.73
92_I	113_L	0.699	0.73
304_Y	315_T	0.699	0.73
118_Y	121_L	0.694	0.72
49_E	53_K	0.693	0.72
279_L	288_G	0.689	0.72
115_R	142_N	0.687	0.71
75_L	191_L	0.686	0.71
192_T	197_S	0.683	0.71
279_L	289_R	0.682	0.71
161_L	177_L	0.681	0.71
284_S	289_R	0.680	0.71
300_G	304_Y	0.680	0.71
280_L	283_V	0.680	0.71
319_E	323_K	0.679	0.70
93_D	97_S	0.678	0.70
301_P	313_D	0.675	0.70
131_I	145_V	0.674	0.70
3_L	270_F	0.673	0.70
61_S	334_S	0.671	0.70
197_S	200_T	0.670	0.69
109_F	258_K	0.668	0.69
12_S	15_E	0.667	0.69
52_F	98_L	0.667	0.69
211_F	227_V	0.666	0.69
75_L	160_L	0.665	0.69
215_I	229_L	0.663	0.69
310_V	313_D	0.663	0.69
306_V	315_T	0.662	0.69
235_I	270_F	0.662	0.69
12_S	259_K	0.659	0.68
95_L	103_F	0.659	0.68
241_K	275_Y	0.657	0.68
266_V	291_A	0.655	0.68
216_L	220_T	0.654	0.68
191_L	197_S	0.653	0.68
13_L	58_I	0.651	0.67
179_L	253_I	0.651	0.67
12_S	261_E	0.648	0.67
13_L	17_L	0.648	0.67
281_D	287_Q	0.645	0.67
301_P	307_L	0.644	0.66
87_K	90_K	0.642	0.66
96_V	119_P	0.641	0.66
52_F	56_I	0.641	0.66
66_F	157_D	0.637	0.66
13_L	66_F	0.633	0.65
302_S	334_S	0.630	0.65
134_V	138_E	0.630	0.65
286_P	289_R	0.629	0.65
137_V	141_A	0.629	0.65
15_E	18_K	0.628	0.65
136_E	140_Y	0.626	0.64
30_F	52_F	0.626	0.64
162_K	242_Y	0.621	0.64
12_S	16_E	0.619	0.63
277_G	281_D	0.615	0.63
11_D	266_V	0.615	0.63
278_D	282_L	0.614	0.63
132_H	186_G	0.613	0.63
327_T	331_D	0.613	0.63
301_P	311_K	0.610	0.62
189_F	208_D	0.609	0.62
283_V	289_R	0.606	0.62
56_I	60_H	0.605	0.62
242_Y	245_E	0.604	0.62
7_T	46_D	0.604	0.62
281_D	289_R	0.603	0.61
105_I	109_F	0.601	0.61
165_A	171_N	0.600	0.61
266_V	270_F	0.600	0.61
185_Y	208_D	0.599	0.61
72_T	75_L	0.598	0.61
308_T	311_K	0.597	0.61
303_S	311_K	0.597	0.61
290_A	294_A	0.595	0.60
317_F	321_G	0.594	0.60
298_V	311_K	0.593	0.60
2_K	25_Y	0.591	0.60
329_D	333_R	0.590	0.60
272_E	287_Q	0.590	0.60
148_I	251_F	0.590	0.60
184_L	231_R	0.590	0.60
304_Y	308_T	0.589	0.60
162_K	246_I	0.588	0.59
324_F	327_T	0.587	0.59
38_G	106_A	0.587	0.59
19_K	37_H	0.585	0.59
134_V	164_I	0.584	0.59
300_G	310_V	0.584	0.59
218_C	221_D	0.583	0.59
150_M	249_N	0.583	0.59
131_I	266_V	0.582	0.59
154_A	161_L	0.581	0.59
182_S	186_G	0.581	0.59
281_D	286_P	0.580	0.58
140_Y	145_V	0.579	0.58
100_V	103_F	0.578	0.58
30_F	46_D	0.573	0.57
165_A	248_I	0.572	0.57
185_Y	231_R	0.566	0.57
115_R	120_D	0.565	0.56
211_F	229_L	0.565	0.56
44_I	127_S	0.562	0.56
301_P	306_V	0.562	0.56
96_V	117_E	0.562	0.56
322_I	326_L	0.561	0.56
298_V	303_S	0.558	0.56
24_K	67_L	0.556	0.55
216_L	219_A	0.556	0.55
26_I	144_G	0.556	0.55
19_K	267_V	0.555	0.55
298_V	317_F	0.555	0.55
302_S	315_T	0.554	0.55
259_K	264_L	0.553	0.55
228_N	231_R	0.552	0.55
232_S	292_T	0.552	0.55
282_L	285_Y	0.550	0.54
37_H	70_M	0.549	0.54
282_L	286_P	0.548	0.54
61_S	302_S	0.548	0.54
245_E	279_L	0.548	0.54
85_I	88_V	0.547	0.54
86_G	90_K	0.546	0.54
141_A	146_N	0.545	0.54
93_D	96_V	0.544	0.54
19_K	268_K	0.541	0.53
57_S	98_L	0.541	0.53
239_D	243_Y	0.539	0.53
151_H	154_A	0.539	0.53
301_P	315_T	0.539	0.53
103_F	123_V	0.536	0.53
320_D	324_F	0.536	0.53
300_G	313_D	0.534	0.52
300_G	303_S	0.532	0.52
172_K	175_V	0.532	0.52
3_L	19_K	0.532	0.52
116_S	142_N	0.530	0.52
69_T	208_D	0.530	0.52
320_D	326_L	0.530	0.52
302_S	308_T	0.530	0.52
69_T	104_I	0.528	0.52
12_S	295_I	0.527	0.51
38_G	72_T	0.527	0.51
90_K	324_F	0.527	0.51
325_F	330_C	0.525	0.51
85_I	134_V	0.524	0.51
327_T	330_C	0.523	0.51
92_I	96_V	0.523	0.51
244_E	275_Y	0.523	0.51
141_A	328_N	0.522	0.51
301_P	330_C	0.521	0.51
282_L	289_R	0.520	0.50
260_T	263_I	0.520	0.50
320_D	325_F	0.520	0.50
128_F	199_I	0.520	0.50
10_D	51_Q	0.516	0.50
174_D	249_N	0.514	0.50
306_V	313_D	0.514	0.50
322_I	334_S	0.513	0.50
154_A	157_D	0.513	0.50
30_F	55_H	0.512	0.49
10_D	13_L	0.511	0.49
283_V	291_A	0.511	0.49
102_G	182_S	0.511	0.49
317_F	324_F	0.510	0.49
68_Y	98_L	0.510	0.49
240_I	244_E	0.510	0.49
306_V	311_K	0.510	0.49
159_K	245_E	0.509	0.49
179_L	251_F	0.508	0.49
188_P	191_L	0.508	0.49
5_V	11_D	0.508	0.49
14_L	17_L	0.508	0.49
278_D	285_Y	0.508	0.49
30_F	257_N	0.508	0.49
38_G	207_N	0.506	0.49
320_D	323_K	0.506	0.49
41_G	213_Y	0.505	0.48
151_H	234_W	0.505	0.48
302_S	313_D	0.504	0.48
321_G	328_N	0.504	0.48
308_T	314_N	0.504	0.48
70_M	110_L	0.502	0.48
105_I	110_L	0.502	0.48
162_K	280_L	0.502	0.48
205_G	209_V	0.500	0.48
238_E	241_K	0.500	0.48

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2bdqA	2	0.4805	97.6	0.936	Contact Map
3f4wA	2	0.3636	97.3	0.94	Contact Map
3iixA	1	0.4519	96.9	0.943	Contact Map
1mzhA	2	0.3948	96.8	0.944	Contact Map
1n7kA	3	0.3662	96.8	0.944	Contact Map
2ftpA	3	0.5091	96.7	0.945	Contact Map
3t7vA	1	0.4364	96.6	0.945	Contact Map
1y0eA	2	0.3532	96.6	0.946	Contact Map
3q58A	2	0.3506	96.6	0.946	Contact Map
2e6fA	2	0.4494	96.5	0.946	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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