GREMLIN Database
Q97WU8 - Protease, putative
UniProt: Q97WU8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 385 (314)
Sequences: 2305 (1515)
Seq/√Len: 85.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_I145_V3.9571.00
5_V267_V3.7411.00
162_K166_S3.2871.00
125_A145_V3.1911.00
17_L64_I3.1431.00
88_V110_L3.0921.00
68_Y95_L2.9981.00
103_F121_L2.8831.00
243_Y251_F2.8281.00
48_K51_Q2.7761.00
165_A249_N2.5711.00
60_H101_D2.5531.00
303_S334_S2.5231.00
28_G66_F2.5001.00
53_K57_S2.4961.00
141_A172_K2.4911.00
18_K58_I2.4211.00
165_A175_V2.3881.00
122_E146_N2.3511.00
92_I114_I2.3501.00
30_F91_E2.2781.00
56_I100_V2.2301.00
56_I98_L2.2281.00
59_A66_F2.1991.00
268_K272_E2.1821.00
274_M277_G2.1781.00
13_L55_H2.1671.00
177_L243_Y2.1351.00
215_I228_N2.0881.00
49_E94_K2.0311.00
253_I267_V2.0111.00
70_M92_I2.0031.00
298_V330_C1.9831.00
236_R239_D1.9761.00
279_L282_L1.9481.00
68_Y100_V1.9101.00
244_E251_F1.9091.00
147_T174_D1.8751.00
10_D54_N1.8711.00
19_K264_L1.8651.00
305_S308_T1.8541.00
137_V148_I1.8421.00
29_S37_H1.8361.00
162_K245_E1.8161.00
17_L58_I1.8141.00
137_V173_F1.7721.00
3_L271_T1.7681.00
158_F246_I1.7621.00
141_A173_F1.7571.00
138_E141_A1.7301.00
10_D14_L1.7251.00
14_L54_N1.7121.00
14_L58_I1.7101.00
10_D55_H1.7091.00
9_F12_S1.7041.00
9_F45_P1.6981.00
241_K245_E1.6561.00
17_L62_Y1.6371.00
298_V305_S1.6181.00
324_F328_N1.6061.00
58_I62_Y1.6041.00
291_A297_M1.5931.00
70_M88_V1.5921.00
131_I136_E1.5881.00
237_P269_A1.5771.00
141_A171_N1.5661.00
138_E142_N1.5451.00
102_G124_S1.5261.00
95_L100_V1.5241.00
96_V120_D1.5151.00
278_D281_D1.5141.00
294_A297_M1.5121.00
5_V253_I1.5091.00
150_M161_L1.5081.00
28_G52_F1.5041.00
57_S61_S1.4960.99
150_M177_L1.4650.99
32_R87_K1.4640.99
237_P273_R1.4600.99
73_N106_A1.4590.99
159_K162_K1.4530.99
239_D242_Y1.4270.99
208_D213_Y1.4140.99
114_I123_V1.4120.99
88_V92_I1.3990.99
177_L248_I1.3880.99
293_K297_M1.3780.99
139_E143_L1.3740.99
265_N294_A1.3710.99
291_A296_Q1.3690.99
154_A164_I1.3680.99
93_D118_Y1.3660.99
16_E263_I1.3570.99
94_K98_L1.3530.99
122_E174_D1.3450.99
331_D334_S1.3340.99
12_S260_T1.3280.99
89_M113_L1.3250.99
92_I110_L1.3170.99
111_I125_A1.3000.99
217_L221_D1.2930.98
28_G68_Y1.2920.98
284_S288_G1.2900.98
298_V301_P1.2810.98
31_K51_Q1.2800.98
4_V250_R1.2670.98
125_A129_S1.2580.98
137_V164_I1.2550.98
13_L59_A1.2480.98
112_R116_S1.2470.98
150_M175_V1.2450.98
14_L18_K1.2420.98
189_F193_H1.2240.98
108_P139_E1.2150.98
53_K98_L1.2080.98
131_I140_Y1.2010.98
123_V145_V1.2000.98
3_L266_V1.1930.97
175_V248_I1.1860.97
131_I137_V1.1840.97
332_T335_C1.1820.97
165_A172_K1.1600.97
85_I113_L1.1540.97
285_Y288_G1.1520.97
41_G257_N1.1520.97
78_K200_T1.1500.97
177_L246_I1.1440.97
40_A202_M1.1310.96
60_H66_F1.1290.96
130_R186_G1.1230.96
89_M110_L1.1220.96
76_L134_V1.1180.96
17_L59_A1.1150.96
246_I251_F1.1130.96
18_K62_Y1.1120.96
92_I118_Y1.1010.96
182_S234_W1.0960.96
103_F114_I1.0940.96
130_R151_H1.0880.96
113_L117_E1.0840.95
37_H40_A1.0780.95
86_G89_M1.0770.95
105_I111_I1.0680.95
105_I123_V1.0660.95
217_L220_T1.0650.95
104_I251_F1.0600.95
134_V163_E1.0590.95
286_P290_A1.0560.95
37_H69_T1.0520.95
291_A294_A1.0510.95
53_K94_K1.0420.94
90_K93_D1.0380.94
275_Y279_L1.0340.94
74_T88_V1.0230.94
89_M93_D1.0230.94
111_I123_V1.0200.94
13_L26_I1.0130.93
269_A291_A1.0060.93
323_K326_L1.0040.93
96_V121_L1.0020.93
115_R146_N1.0010.93
154_A160_L1.0010.93
306_V310_V1.0000.93
114_I118_Y0.9960.93
196_I206_V0.9960.93
41_G202_M0.9940.93
238_E288_G0.9880.93
292_T296_Q0.9800.92
279_L283_V0.9790.92
31_K48_K0.9750.92
36_G87_K0.9730.92
290_A297_M0.9710.92
13_L47_I0.9640.92
55_H59_A0.9630.92
135_R138_E0.9590.91
328_N332_T0.9550.91
245_E275_Y0.9540.91
96_V118_Y0.9520.91
243_Y246_I0.9480.91
275_Y278_D0.9450.91
11_D260_T0.9420.91
323_K327_T0.9380.91
281_D284_S0.9380.91
307_L315_T0.9330.90
283_V287_Q0.9280.90
282_L288_G0.9250.90
46_D257_N0.9220.90
70_M91_E0.9220.90
301_P304_Y0.9190.90
37_H72_T0.9180.90
279_L284_S0.9180.90
50_E53_K0.9160.89
104_I149_I0.9130.89
125_A140_Y0.9120.89
301_P308_T0.9100.89
285_Y289_R0.8990.89
137_V175_V0.8950.88
49_E52_F0.8910.88
275_Y281_D0.8910.88
146_N174_D0.8890.88
95_L98_L0.8810.88
125_A131_I0.8780.87
44_I257_N0.8760.87
108_P140_Y0.8740.87
161_L246_I0.8740.87
163_E166_S0.8740.87
28_G47_I0.8720.87
322_I325_F0.8710.87
93_D117_E0.8700.87
332_T336_K0.8700.87
161_L164_I0.8660.87
129_S140_Y0.8630.87
321_G324_F0.8610.86
194_D206_V0.8560.86
137_V150_M0.8550.86
283_V286_P0.8500.86
312_I315_T0.8390.85
241_K278_D0.8340.85
150_M164_I0.8320.84
248_I251_F0.8250.84
107_V181_N0.8230.84
15_E19_K0.8230.84
89_M117_E0.8220.84
132_H151_H0.8190.84
53_K97_S0.8130.83
89_M116_S0.8120.83
25_Y250_R0.8070.83
54_N57_S0.8070.83
91_E95_L0.8020.82
302_S307_L0.7980.82
251_F291_A0.7970.82
109_F119_P0.7960.82
263_I267_V0.7930.81
65_K146_N0.7910.81
105_I114_I0.7900.81
67_L102_G0.7890.81
104_I139_E0.7870.81
55_H66_F0.7870.81
138_E172_K0.7860.81
189_F228_N0.7830.81
41_G198_S0.7820.81
127_S151_H0.7800.80
241_K244_E0.7780.80
77_G90_K0.7740.80
222_V225_D0.7730.80
100_V121_L0.7710.80
207_N231_R0.7700.80
293_K296_Q0.7690.79
299_N303_S0.7650.79
304_Y311_K0.7620.79
231_R296_Q0.7590.79
148_I173_F0.7570.78
104_I179_L0.7550.78
177_L251_F0.7540.78
290_A293_K0.7500.78
37_H41_G0.7500.78
244_E276_E0.7480.78
303_S308_T0.7460.77
48_K54_N0.7460.77
94_K97_S0.7430.77
4_V25_Y0.7420.77
306_V309_K0.7420.77
2_K250_R0.7420.77
331_D335_C0.7410.77
283_V288_G0.7410.77
300_G308_T0.7380.77
308_T315_T0.7360.76
286_P291_A0.7340.76
281_D285_Y0.7300.76
181_N207_N0.7270.76
59_A64_I0.7240.75
280_L284_S0.7240.75
287_Q290_A0.7230.75
157_D160_L0.7200.75
89_M118_Y0.7170.75
15_E260_T0.7140.74
274_M278_D0.7130.74
191_L198_S0.7130.74
284_S287_Q0.7100.74
329_D332_T0.7070.74
274_M279_L0.7040.73
240_I275_Y0.7030.73
28_G59_A0.7020.73
56_I66_F0.7020.73
92_I113_L0.6990.73
304_Y315_T0.6990.73
118_Y121_L0.6940.72
49_E53_K0.6930.72
279_L288_G0.6890.72
115_R142_N0.6870.71
75_L191_L0.6860.71
192_T197_S0.6830.71
279_L289_R0.6820.71
161_L177_L0.6810.71
284_S289_R0.6800.71
300_G304_Y0.6800.71
280_L283_V0.6800.71
319_E323_K0.6790.70
93_D97_S0.6780.70
301_P313_D0.6750.70
131_I145_V0.6740.70
3_L270_F0.6730.70
61_S334_S0.6710.70
197_S200_T0.6700.69
109_F258_K0.6680.69
12_S15_E0.6670.69
52_F98_L0.6670.69
211_F227_V0.6660.69
75_L160_L0.6650.69
215_I229_L0.6630.69
310_V313_D0.6630.69
306_V315_T0.6620.69
235_I270_F0.6620.69
12_S259_K0.6590.68
95_L103_F0.6590.68
241_K275_Y0.6570.68
266_V291_A0.6550.68
216_L220_T0.6540.68
191_L197_S0.6530.68
13_L58_I0.6510.67
179_L253_I0.6510.67
12_S261_E0.6480.67
13_L17_L0.6480.67
281_D287_Q0.6450.67
301_P307_L0.6440.66
87_K90_K0.6420.66
96_V119_P0.6410.66
52_F56_I0.6410.66
66_F157_D0.6370.66
13_L66_F0.6330.65
302_S334_S0.6300.65
134_V138_E0.6300.65
286_P289_R0.6290.65
137_V141_A0.6290.65
15_E18_K0.6280.65
136_E140_Y0.6260.64
30_F52_F0.6260.64
162_K242_Y0.6210.64
12_S16_E0.6190.63
277_G281_D0.6150.63
11_D266_V0.6150.63
278_D282_L0.6140.63
132_H186_G0.6130.63
327_T331_D0.6130.63
301_P311_K0.6100.62
189_F208_D0.6090.62
283_V289_R0.6060.62
56_I60_H0.6050.62
242_Y245_E0.6040.62
7_T46_D0.6040.62
281_D289_R0.6030.61
105_I109_F0.6010.61
165_A171_N0.6000.61
266_V270_F0.6000.61
185_Y208_D0.5990.61
72_T75_L0.5980.61
308_T311_K0.5970.61
303_S311_K0.5970.61
290_A294_A0.5950.60
317_F321_G0.5940.60
298_V311_K0.5930.60
2_K25_Y0.5910.60
329_D333_R0.5900.60
272_E287_Q0.5900.60
148_I251_F0.5900.60
184_L231_R0.5900.60
304_Y308_T0.5890.60
162_K246_I0.5880.59
324_F327_T0.5870.59
38_G106_A0.5870.59
19_K37_H0.5850.59
134_V164_I0.5840.59
300_G310_V0.5840.59
218_C221_D0.5830.59
150_M249_N0.5830.59
131_I266_V0.5820.59
154_A161_L0.5810.59
182_S186_G0.5810.59
281_D286_P0.5800.58
140_Y145_V0.5790.58
100_V103_F0.5780.58
30_F46_D0.5730.57
165_A248_I0.5720.57
185_Y231_R0.5660.57
115_R120_D0.5650.56
211_F229_L0.5650.56
44_I127_S0.5620.56
301_P306_V0.5620.56
96_V117_E0.5620.56
322_I326_L0.5610.56
298_V303_S0.5580.56
24_K67_L0.5560.55
216_L219_A0.5560.55
26_I144_G0.5560.55
19_K267_V0.5550.55
298_V317_F0.5550.55
302_S315_T0.5540.55
259_K264_L0.5530.55
228_N231_R0.5520.55
232_S292_T0.5520.55
282_L285_Y0.5500.54
37_H70_M0.5490.54
282_L286_P0.5480.54
61_S302_S0.5480.54
245_E279_L0.5480.54
85_I88_V0.5470.54
86_G90_K0.5460.54
141_A146_N0.5450.54
93_D96_V0.5440.54
19_K268_K0.5410.53
57_S98_L0.5410.53
239_D243_Y0.5390.53
151_H154_A0.5390.53
301_P315_T0.5390.53
103_F123_V0.5360.53
320_D324_F0.5360.53
300_G313_D0.5340.52
300_G303_S0.5320.52
172_K175_V0.5320.52
3_L19_K0.5320.52
116_S142_N0.5300.52
69_T208_D0.5300.52
320_D326_L0.5300.52
302_S308_T0.5300.52
69_T104_I0.5280.52
12_S295_I0.5270.51
38_G72_T0.5270.51
90_K324_F0.5270.51
325_F330_C0.5250.51
85_I134_V0.5240.51
327_T330_C0.5230.51
92_I96_V0.5230.51
244_E275_Y0.5230.51
141_A328_N0.5220.51
301_P330_C0.5210.51
282_L289_R0.5200.50
260_T263_I0.5200.50
320_D325_F0.5200.50
128_F199_I0.5200.50
10_D51_Q0.5160.50
174_D249_N0.5140.50
306_V313_D0.5140.50
322_I334_S0.5130.50
154_A157_D0.5130.50
30_F55_H0.5120.49
10_D13_L0.5110.49
283_V291_A0.5110.49
102_G182_S0.5110.49
317_F324_F0.5100.49
68_Y98_L0.5100.49
240_I244_E0.5100.49
306_V311_K0.5100.49
159_K245_E0.5090.49
179_L251_F0.5080.49
188_P191_L0.5080.49
5_V11_D0.5080.49
14_L17_L0.5080.49
278_D285_Y0.5080.49
30_F257_N0.5080.49
38_G207_N0.5060.49
320_D323_K0.5060.49
41_G213_Y0.5050.48
151_H234_W0.5050.48
302_S313_D0.5040.48
321_G328_N0.5040.48
308_T314_N0.5040.48
70_M110_L0.5020.48
105_I110_L0.5020.48
162_K280_L0.5020.48
205_G209_V0.5000.48
238_E241_K0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bdqA 2 0.4805 97.6 0.936 Contact Map
3f4wA 2 0.3636 97.3 0.94 Contact Map
3iixA 1 0.4519 96.9 0.943 Contact Map
1mzhA 2 0.3948 96.8 0.944 Contact Map
1n7kA 3 0.3662 96.8 0.944 Contact Map
2ftpA 3 0.5091 96.7 0.945 Contact Map
3t7vA 1 0.4364 96.6 0.945 Contact Map
1y0eA 2 0.3532 96.6 0.946 Contact Map
3q58A 2 0.3506 96.6 0.946 Contact Map
2e6fA 2 0.4494 96.5 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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