GREMLIN Database
Q97WU7 - Enoyl CoA hydratase (PaaF-4)
UniProt: Q97WU7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 270 (248)
Sequences: 30191 (19990)
Seq/√Len: 1269.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_K177_T3.2021.00
191_R201_E3.0261.00
131_G189_L2.9731.00
135_E194_E2.9631.00
109_A126_S2.8661.00
201_E204_E2.7171.00
24_I203_F2.6421.00
51_R104_K2.5381.00
48_V99_R2.5211.00
176_K208_Q2.3601.00
15_K28_N2.2831.00
231_P234_N2.2551.00
18_V23_G2.2341.00
182_E185_E2.2121.00
136_N195_P2.2021.00
179_S182_E2.1771.00
132_A136_N2.1181.00
170_Y176_K2.0931.00
24_I62_T2.0581.00
167_K186_L2.0441.00
18_V53_D2.0231.00
146_N212_G1.9671.00
21_G57_K1.9401.00
44_D99_R1.9221.00
16_I23_G1.9161.00
110_S202_S1.8901.00
28_N64_N1.8881.00
172_I220_T1.8801.00
26_K64_N1.8701.00
116_M140_G1.8441.00
257_R261_E1.8251.00
38_E42_E1.8121.00
130_F193_I1.8071.00
110_S199_F1.7971.00
254_E263_R1.7911.00
26_K62_T1.7801.00
197_K200_E1.7791.00
23_G50_S1.7451.00
169_I225_N1.7391.00
203_F207_R1.7301.00
135_E181_K1.7261.00
170_Y190_D1.7051.00
59_I103_T1.6581.00
182_E186_L1.6411.00
135_E195_P1.6201.00
23_G56_V1.6121.00
165_R169_I1.6081.00
41_R92_F1.6041.00
13_Y42_E1.5901.00
197_K201_E1.5791.00
49_E53_D1.5731.00
181_K185_E1.5691.00
130_F205_F1.5381.00
50_S59_I1.5211.00
127_D221_K1.5171.00
13_Y36_N1.5121.00
132_A195_P1.4831.00
170_Y191_R1.4781.00
193_I201_E1.4771.00
129_R166_S1.4751.00
131_G139_F1.4651.00
123_A129_R1.4561.00
25_I46_I1.4461.00
51_R99_R1.4461.00
169_I224_V1.4421.00
67_R112_N1.4351.00
129_R162_L1.4251.00
98_L102_S1.4231.00
98_L233_Y1.4021.00
16_I50_S1.3851.00
169_I173_V1.3831.00
112_N132_A1.3751.00
111_I123_A1.3751.00
15_K64_N1.3721.00
112_N136_N1.3631.00
20_D207_R1.3621.00
184_Y192_L1.3611.00
19_E203_F1.3581.00
111_I115_C1.3471.00
100_M107_I1.3331.00
44_D48_V1.3291.00
62_T112_N1.3201.00
47_I103_T1.3191.00
101_M158_F1.3071.00
167_K170_Y1.2961.00
120_L141_M1.2931.00
19_E207_R1.2891.00
171_L178_L1.2861.00
19_E24_I1.2851.00
82_S85_Y1.2761.00
37_L77_E1.2761.00
176_K182_E1.2661.00
198_L202_S1.2511.00
68_F114_H1.2461.00
58_A206_A1.2331.00
166_S190_D1.2211.00
51_R103_T1.2191.00
140_G177_T1.2141.00
219_F245_Q1.2101.00
114_H138_K1.2091.00
44_D95_E1.2081.00
199_F202_S1.2051.00
230_L234_N1.2001.00
36_N39_M1.1961.00
17_E26_K1.1961.00
222_L226_E1.1941.00
24_I199_F1.1921.00
252_A256_A1.1851.00
27_L39_M1.1801.00
18_V55_N1.1751.00
167_K182_E1.1691.00
144_V175_G1.1641.00
42_E46_I1.1401.00
18_V49_E1.1331.00
62_T199_F1.1261.00
199_F203_F1.1211.00
212_G217_V1.1171.00
180_P192_L1.1171.00
32_A76_N1.1151.00
230_L238_L1.1131.00
178_L186_L1.1071.00
132_A198_L1.0971.00
226_E238_L1.0661.00
15_K26_K1.0651.00
37_L41_R1.0621.00
27_L70_S1.0571.00
17_E24_I1.0521.00
70_S119_G1.0511.00
102_S233_Y1.0501.00
13_Y38_E1.0481.00
29_R32_A1.0411.00
42_E45_N1.0411.00
93_S153_E1.0381.00
59_I105_K1.0331.00
45_N49_E1.0231.00
164_G167_K1.0161.00
163_V167_K0.9991.00
128_L205_F0.9891.00
206_A210_A0.9861.00
107_I126_S0.9801.00
222_L242_M0.9541.00
200_E204_E0.9531.00
121_E155_G0.9421.00
162_L166_S0.9411.00
181_K184_Y0.9411.00
46_I49_E0.9391.00
29_R74_D0.9361.00
62_T110_S0.9351.00
203_F206_A0.9291.00
184_Y189_L0.9281.00
215_L251_D0.9281.00
60_L202_S0.9271.00
234_N237_A0.9151.00
253_K257_R0.9151.00
120_L139_F0.9131.00
22_V58_A0.9041.00
104_K218_G0.9041.00
138_K179_S0.8981.00
214_S218_G0.8981.00
59_I107_I0.8961.00
24_I60_L0.8951.00
194_E197_K0.8871.00
56_V105_K0.8861.00
110_S198_L0.8841.00
157_Q235_A0.8841.00
63_S66_P0.8821.00
87_G91_Q0.8781.00
132_A135_E0.8731.00
165_R228_M0.8651.00
112_N198_L0.8601.00
238_L241_E0.8511.00
111_I139_F0.8461.00
150_I246_A0.8401.00
144_V220_T0.8391.00
54_Q105_K0.8381.00
135_E192_L0.8341.00
156_T239_E0.8291.00
44_D92_F0.8191.00
211_K264_R0.8191.00
18_V56_V0.8181.00
132_A196_E0.8171.00
40_L96_V0.8141.00
48_V52_F0.8121.00
47_I100_M0.8041.00
116_M177_T0.8011.00
171_L186_L0.8001.00
184_Y191_R0.7981.00
159_L163_V0.7981.00
128_L190_D0.7981.00
111_I129_R0.7861.00
172_I224_V0.7841.00
51_R105_K0.7791.00
41_R45_N0.7781.00
37_L92_F0.7781.00
13_Y39_M0.7751.00
219_F242_M0.7741.00
163_V171_L0.7691.00
223_A242_M0.7641.00
25_I59_I0.7641.00
201_E205_F0.7641.00
208_Q212_G0.7591.00
76_N260_F0.7581.00
202_S206_A0.7481.00
204_E208_Q0.7481.00
146_N177_T0.7471.00
48_V95_E0.7421.00
50_S56_V0.7411.00
238_L242_M0.7411.00
121_E143_E0.7411.00
200_E203_F0.7391.00
14_F46_I0.7371.00
68_F112_N0.7361.00
97_M125_A0.7341.00
209_V217_V0.7331.00
204_E207_R0.7321.00
84_E88_L0.7301.00
232_W236_F0.7291.00
103_T107_I0.7291.00
219_F222_L0.7261.00
44_D96_V0.7251.00
29_R36_N0.7241.00
16_I46_I0.7231.00
207_R211_K0.7201.00
104_K222_L0.7191.00
250_E253_K0.7191.00
242_M245_Q0.7181.00
213_P251_D0.7101.00
191_R205_F0.7081.00
29_R34_A0.7071.00
180_P189_L0.7071.00
170_Y174_T0.7061.00
219_F246_A0.7041.00
157_Q160_A0.7031.00
61_I126_S0.7031.00
226_E230_L0.7021.00
36_N77_E0.7011.00
124_L188_I0.6991.00
16_I49_E0.6991.00
256_A260_F0.6991.00
237_A241_E0.6941.00
91_Q95_E0.6931.00
35_H39_M0.6861.00
205_F208_Q0.6861.00
164_G168_A0.6861.00
57_K214_S0.6841.00
22_V60_L0.6821.00
117_G142_P0.6761.00
165_R225_N0.6731.00
150_I223_A0.6691.00
183_A188_I0.6661.00
111_I137_I0.6641.00
174_T205_F0.6621.00
130_F191_R0.6611.00
214_S217_V0.6581.00
189_L192_L0.6581.00
81_K85_Y0.6561.00
87_G241_E0.6561.00
21_G55_N0.6551.00
91_Q240_R0.6521.00
61_I107_I0.6521.00
193_I198_L0.6501.00
38_E41_R0.6501.00
240_R244_N0.6461.00
18_V21_G0.6451.00
241_E245_Q0.6401.00
60_L110_S0.6391.00
167_K184_Y0.6391.00
233_Y237_A0.6361.00
103_T106_L0.6351.00
46_I50_S0.6351.00
79_K257_R0.6331.00
139_F189_L0.6331.00
83_P245_Q0.6291.00
223_A238_L0.6271.00
143_E152_G0.6251.00
130_F202_S0.6201.00
48_V51_R0.6191.00
140_G175_G0.6191.00
60_L203_F0.6141.00
215_L249_S0.6131.00
50_S105_K0.6131.00
130_F201_E0.6121.00
58_A108_I0.6101.00
43_L96_V0.6041.00
66_P112_N0.6021.00
58_A210_A0.6021.00
45_N48_V0.6021.00
53_D56_V0.6001.00
143_E151_P0.5991.00
151_P220_T0.5991.00
57_K210_A0.5981.00
116_M142_P0.5951.00
39_M42_E0.5951.00
73_F78_I0.5951.00
114_H177_T0.5941.00
32_A74_D0.5941.00
109_A129_R0.5941.00
181_K192_L0.5921.00
131_G137_I0.5921.00
16_I25_I0.5881.00
112_N195_P0.5811.00
250_E254_E0.5771.00
143_E243_Q0.5761.00
173_V217_V0.5731.00
165_R224_V0.5711.00
149_L252_A0.5671.00
22_V203_F0.5671.00
257_R260_F0.5641.00
254_E257_R0.5641.00
130_F198_L0.5621.00
170_Y182_E0.5571.00
53_D105_K0.5561.00
25_I61_I0.5551.00
254_E258_A0.5551.00
87_G244_N0.5531.00
95_E98_L0.5531.00
174_T209_V0.5511.00
178_L183_A0.5501.00
141_M172_I0.5491.00
47_I99_R0.5491.00
128_L209_V0.5481.00
220_T223_A0.5471.00
88_L92_F0.5451.00
144_V212_G0.5441.00
162_L190_D0.5431.00
108_I206_A0.5421.00
121_E154_G0.5411.00
121_E152_G0.5401.00
123_A126_S0.5381.00
251_D255_G0.5381.00
163_V168_A0.5381.00
156_T235_A0.5371.00
197_K204_E0.5371.00
208_Q211_K0.5341.00
13_Y29_R0.5341.00
176_K191_R0.5341.00
163_V186_L0.5321.00
38_E77_E0.5311.00
120_L188_I0.5291.00
157_Q161_R0.5291.00
132_A137_I0.5281.00
179_S185_E0.5281.00
167_K185_E0.5281.00
35_H118_G0.5271.00
169_I221_K0.5271.00
215_L246_A0.5241.00
255_G258_A0.5241.00
180_P184_Y0.5221.00
83_P87_G0.5221.00
112_N137_I0.5211.00
47_I107_I0.5191.00
95_E99_R0.5181.00
230_L235_A0.5161.00
120_L124_L0.5161.00
121_E141_M0.5141.00
170_Y205_F0.5131.00
136_N180_P0.5111.00
36_N74_D0.5111.00
75_I147_L0.5101.00
34_A71_A0.5091.00
60_L199_F0.5081.00
174_T208_Q0.5071.00
22_V206_A0.5061.00
49_E52_F0.5061.00
40_L44_D0.5051.00
25_I47_I0.5031.00
160_A163_V0.5031.00
160_A227_G0.5021.00
141_M155_G0.5011.00
109_A123_A0.5001.00
141_M159_L0.5001.00
254_E261_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ppyA 6 0.9741 100 0.103 Contact Map
3kqfA 3 0.9519 100 0.109 Contact Map
4lk5A 3 0.9259 100 0.11 Contact Map
3peaA 3 0.9519 100 0.111 Contact Map
4mi2A 3 0.9444 100 0.115 Contact Map
4og1A 3 0.9074 100 0.116 Contact Map
4k3wA 3 0.9444 100 0.118 Contact Map
1nzyA 4 0.9519 100 0.118 Contact Map
2ej5A 3 0.9259 100 0.119 Contact Map
2fbmA 3 0.9074 100 0.119 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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