GREMLIN Database
Q97WU4 - Acetyl-CoA synthetase (Acetate-CoA ligase) amino-end (AcsA-4)
UniProt: Q97WU4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 288 (248)
Sequences: 70490 (53274)
Seq/√Len: 3382.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
183_M200_V3.7081.00
47_N83_K3.3051.00
65_L109_A3.0711.00
31_Y251_S3.0231.00
43_I83_K2.9551.00
62_N110_K2.6731.00
106_D188_Y2.6731.00
58_V86_A2.6251.00
17_S43_I2.6231.00
225_R251_S2.5931.00
45_E76_S2.5571.00
102_F195_H2.5061.00
28_I36_V2.5011.00
24_A27_R2.4141.00
43_I47_N2.4101.00
52_A56_L2.3891.00
19_W24_A2.3771.00
31_Y36_V2.3491.00
81_A86_A2.2191.00
31_Y271_T1.9911.00
32_Y72_P1.9711.00
63_R89_V1.9691.00
77_I113_A1.9521.00
38_S41_K1.9341.00
224_D275_S1.8851.00
59_E62_N1.8831.00
179_S182_D1.8761.00
63_R87_I1.8521.00
17_S83_K1.7981.00
271_T274_L1.7881.00
215_K248_N1.7841.00
101_L105_E1.7791.00
40_R44_E1.7791.00
54_R84_I1.7781.00
26_K40_R1.7331.00
279_C284_T1.7241.00
60_K182_D1.7151.00
20_E43_I1.6831.00
61_E182_D1.6731.00
18_K23_E1.6621.00
188_Y198_A1.6561.00
49_V76_S1.6441.00
266_R270_N1.6401.00
25_D40_R1.6341.00
65_L91_V1.6191.00
202_L205_D1.5971.00
64_I81_A1.5931.00
75_I242_S1.5901.00
180_P204_K1.5821.00
236_Y278_E1.5791.00
267_P271_T1.5741.00
82_M184_A1.5591.00
37_W76_S1.5551.00
69_Y115_E1.5481.00
46_I83_K1.5461.00
225_R253_V1.5251.00
227_F274_L1.4961.00
263_G266_R1.4941.00
102_F106_D1.4941.00
56_L135_H1.4901.00
260_E263_G1.4851.00
35_E72_P1.4841.00
28_I31_Y1.4821.00
89_V107_T1.4811.00
52_A165_L1.4581.00
19_W23_E1.4511.00
37_W72_P1.4391.00
255_M267_P1.4221.00
63_R186_W1.4221.00
28_I251_S1.4211.00
253_V274_L1.4111.00
224_D276_S1.4091.00
221_S224_D1.4091.00
32_Y35_E1.4031.00
181_N204_K1.3921.00
245_A250_A1.3851.00
29_A39_Y1.3821.00
79_Y246_F1.3621.00
110_K134_K1.3351.00
104_L109_A1.3201.00
92_N233_F1.3111.00
253_V271_T1.3081.00
107_T188_Y1.2761.00
201_H205_D1.2761.00
230_S236_Y1.2681.00
47_N51_N1.2681.00
97_P124_P1.2631.00
186_W198_A1.2601.00
29_A42_V1.2281.00
178_T182_D1.2251.00
181_N202_L1.2191.00
97_P101_L1.2181.00
87_I183_M1.2131.00
67_I100_Y1.2121.00
106_D195_H1.2111.00
65_L104_L1.2081.00
50_G83_K1.2001.00
45_E48_R1.1931.00
31_Y253_V1.1861.00
55_E169_A1.1791.00
27_R223_K1.1771.00
227_F255_M1.1671.00
111_V135_H1.1561.00
97_P121_K1.1551.00
225_R275_S1.1221.00
58_V111_V1.1211.00
58_V62_N1.1161.00
37_W45_E1.1161.00
189_T199_A1.1081.00
17_S47_N1.1081.00
52_A55_E1.1051.00
64_I86_A1.0911.00
78_F88_P1.0741.00
44_E48_R1.0721.00
50_G84_I1.0721.00
42_V76_S1.0641.00
49_V80_S1.0501.00
74_F232_L1.0481.00
102_F105_E1.0481.00
33_K256_P1.0421.00
225_R274_L1.0401.00
73_F76_S1.0221.00
63_R108_G1.0191.00
226_L245_A1.0131.00
78_F238_L1.0021.00
52_A169_A0.9991.00
43_I173_L0.9951.00
98_E102_F0.9921.00
45_E73_F0.9861.00
95_L103_L0.9761.00
116_P140_P0.9711.00
224_D250_A0.9711.00
253_V267_P0.9711.00
69_Y117_D0.9651.00
58_V64_I0.9641.00
105_E195_H0.9631.00
41_K44_E0.9521.00
30_I75_I0.9481.00
65_L112_L0.9421.00
66_I77_I0.9351.00
68_A139_L0.9331.00
259_V283_I0.9331.00
78_F82_M0.9301.00
42_V79_Y0.9261.00
37_W42_V0.9181.00
68_A71_T0.9121.00
54_R59_E0.9101.00
75_I254_L0.9061.00
62_N86_A0.9051.00
71_T115_E0.9051.00
96_K99_E0.9051.00
137_I141_S0.8971.00
45_E72_P0.8951.00
91_V100_Y0.8951.00
49_V113_A0.8891.00
66_I88_P0.8891.00
116_P138_I0.8851.00
239_G278_E0.8841.00
65_L89_V0.8821.00
51_N54_R0.8701.00
280_L283_I0.8641.00
36_V251_S0.8591.00
72_P76_S0.8581.00
49_V77_I0.8541.00
209_V239_G0.8531.00
41_K45_E0.8481.00
229_A283_I0.8471.00
210_L247_G0.8431.00
245_A252_T0.8391.00
56_L111_V0.8391.00
16_F20_E0.8321.00
114_I136_V0.8281.00
183_M202_L0.8271.00
54_R173_L0.8231.00
53_L113_A0.8211.00
98_E101_L0.8181.00
115_E118_I0.8171.00
13_D178_T0.8171.00
229_A280_L0.8161.00
121_K124_P0.8141.00
81_A88_P0.8131.00
46_I80_S0.8081.00
68_A74_F0.8071.00
88_P238_L0.8051.00
16_F43_I0.8031.00
211_D247_G0.8031.00
227_F267_P0.8021.00
31_Y225_R0.8021.00
240_N278_E0.7981.00
27_R251_S0.7931.00
17_S22_S0.7891.00
36_V271_T0.7871.00
30_I72_P0.7841.00
15_L211_D0.7831.00
225_R273_L0.7831.00
185_F201_H0.7821.00
80_S84_I0.7771.00
119_W123_S0.7771.00
53_L81_A0.7721.00
15_L19_W0.7711.00
44_E171_T0.7681.00
60_K178_T0.7661.00
18_K22_S0.7641.00
42_V46_I0.7591.00
184_A203_H0.7571.00
201_H235_A0.7531.00
215_K244_F0.7521.00
27_R222_E0.7471.00
185_F238_L0.7451.00
13_D17_S0.7451.00
28_I32_Y0.7441.00
28_I38_S0.7441.00
105_E132_K0.7431.00
55_E168_T0.7431.00
267_P270_N0.7431.00
78_F243_Y0.7401.00
268_Y274_L0.7401.00
226_L276_S0.7331.00
209_V214_V0.7301.00
48_R52_A0.7201.00
51_N174_E0.7191.00
49_V52_A0.7191.00
24_A249_G0.7161.00
30_I252_T0.7151.00
51_N170_S0.7131.00
24_A222_E0.7081.00
282_Y285_Q0.7021.00
67_I112_L0.7021.00
89_V109_A0.7011.00
220_I276_S0.7011.00
114_I138_I0.6981.00
26_K38_S0.6981.00
67_I118_I0.6951.00
35_E45_E0.6941.00
228_S237_G0.6921.00
13_D82_M0.6901.00
266_R269_I0.6881.00
79_Y243_Y0.6791.00
65_L107_T0.6791.00
185_F206_I0.6771.00
268_Y277_L0.6761.00
228_S252_T0.6761.00
114_I119_W0.6761.00
118_I121_K0.6751.00
263_G267_P0.6751.00
230_S278_E0.6711.00
19_W249_G0.6691.00
64_I111_V0.6691.00
59_E86_A0.6681.00
265_W269_I0.6681.00
108_G132_K0.6661.00
116_P141_S0.6661.00
14_A18_K0.6651.00
76_S80_S0.6651.00
131_D134_K0.6651.00
227_F268_Y0.6621.00
102_F188_Y0.6611.00
262_E266_R0.6591.00
16_F79_Y0.6561.00
51_N171_T0.6561.00
191_G197_K0.6551.00
211_D215_K0.6531.00
15_L207_L0.6501.00
22_S25_D0.6481.00
14_A17_S0.6471.00
231_K234_F0.6411.00
178_T203_H0.6391.00
184_A206_I0.6391.00
251_S271_T0.6381.00
193_T197_K0.6371.00
101_L130_A0.6371.00
51_N55_E0.6351.00
229_A279_C0.6351.00
255_M264_Y0.6311.00
98_E195_H0.6281.00
112_L122_L0.6281.00
220_I224_D0.6241.00
49_V53_L0.6241.00
120_P123_S0.6221.00
51_N172_H0.6211.00
87_I186_W0.6211.00
192_T197_K0.6191.00
42_V75_I0.6181.00
51_N173_L0.6121.00
81_A84_I0.6111.00
210_L243_Y0.6041.00
45_E166_V0.6041.00
67_I121_K0.6031.00
194_G197_K0.6031.00
186_W200_V0.6021.00
114_I122_L0.6021.00
256_P263_G0.6021.00
138_I141_S0.6021.00
76_S162_Y0.6001.00
187_L235_A0.5981.00
68_A115_E0.5961.00
32_Y256_P0.5911.00
51_N169_A0.5901.00
111_V137_I0.5891.00
82_M88_P0.5871.00
236_Y239_G0.5871.00
67_I122_L0.5871.00
69_Y118_I0.5861.00
119_W138_I0.5851.00
37_W41_K0.5841.00
212_T217_V0.5821.00
122_L125_Y0.5791.00
103_L198_A0.5791.00
135_H139_L0.5781.00
164_G167_S0.5761.00
13_D83_K0.5751.00
95_L100_Y0.5751.00
48_R171_T0.5721.00
50_G80_S0.5681.00
66_I74_F0.5671.00
43_I46_I0.5671.00
214_V239_G0.5661.00
54_R176_E0.5631.00
60_K176_E0.5611.00
182_D203_H0.5611.00
130_A133_L0.5601.00
106_D198_A0.5571.00
78_F242_S0.5561.00
48_R170_S0.5551.00
46_I50_G0.5541.00
46_I49_V0.5521.00
89_V103_L0.5521.00
255_M263_G0.5491.00
166_V169_A0.5491.00
278_E281_L0.5491.00
82_M203_H0.5471.00
190_S197_K0.5421.00
77_I81_A0.5421.00
89_V188_Y0.5421.00
15_L247_G0.5401.00
52_A166_V0.5391.00
58_V84_I0.5371.00
73_F115_E0.5361.00
165_L169_A0.5351.00
68_A77_I0.5351.00
227_F264_Y0.5321.00
228_S254_L0.5321.00
54_R174_E0.5301.00
22_S43_I0.5301.00
228_S240_N0.5301.00
105_E130_A0.5281.00
35_E73_F0.5281.00
135_H138_I0.5261.00
47_N173_L0.5251.00
13_D203_H0.5251.00
259_V264_Y0.5231.00
255_M259_V0.5231.00
74_F78_F0.5221.00
264_Y277_L0.5221.00
279_C283_I0.5201.00
45_E49_V0.5201.00
91_V104_L0.5191.00
220_I244_F0.5181.00
48_R166_V0.5171.00
114_I118_I0.5161.00
210_L244_F0.5161.00
64_I113_A0.5151.00
225_R228_S0.5141.00
57_G86_A0.5131.00
189_T197_K0.5131.00
78_F185_F0.5121.00
59_E110_K0.5081.00
28_I225_R0.5041.00
56_L134_K0.5021.00
264_Y268_Y0.5021.00
223_K275_S0.5001.00
204_K208_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pg4A 1 0.9722 100 0.175 Contact Map
3tsyA 2 0.9479 100 0.18 Contact Map
3g7sA 2 0.9167 100 0.18 Contact Map
1ry2A 1 0.9722 100 0.183 Contact Map
2d1sA 1 0.941 100 0.186 Contact Map
3ivrA 2 0.8958 100 0.189 Contact Map
1mdbA 1 0.9236 100 0.189 Contact Map
2v7bA 1 0.8785 100 0.191 Contact Map
1v25A 2 0.9306 100 0.191 Contact Map
3o83A 1 0.934 100 0.192 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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