GREMLIN Database
Q97WU3 - Acetyl-CoA synthetase (Acetate-CoA ligase) carboxy-end (AcsA-4)
UniProt: Q97WU3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (257)
Sequences: 68513 (47069)
Seq/√Len: 2936.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
185_H228_Y3.1771.00
129_D132_S2.8641.00
149_Y157_Y2.7871.00
96_E118_K2.7811.00
114_D143_R2.6491.00
167_K172_W2.4561.00
151_D157_Y2.4361.00
149_Y159_V2.4311.00
257_Q260_K2.4161.00
115_L148_F2.4141.00
116_Y143_R2.3931.00
100_V116_Y2.3321.00
164_D258_R2.2761.00
206_V243_R2.2721.00
98_K106_E2.2441.00
190_E250_K2.2421.00
183_L191_A2.1061.00
98_K116_Y2.0001.00
130_Y134_R1.9991.00
132_S135_K1.9761.00
177_E237_K1.9661.00
182_L207_G1.9561.00
112_I147_K1.9461.00
184_S232_K1.9411.00
48_P52_I1.9231.00
151_D155_Y1.9041.00
194_V208_F1.8931.00
87_C157_Y1.8451.00
209_V244_F1.8301.00
101_D105_N1.7831.00
8_K35_S1.7521.00
179_E193_V1.7511.00
112_I159_V1.7251.00
197_P203_V1.7071.00
181_A232_K1.6921.00
189_L212_K1.6911.00
150_R156_Y1.6801.00
147_K162_S1.6541.00
228_Y232_K1.6441.00
183_L190_E1.6371.00
138_M143_R1.6321.00
14_G19_Y1.5771.00
260_K263_L1.5741.00
75_Y117_V1.5731.00
206_V241_E1.5691.00
226_R242_I1.5671.00
109_P150_R1.5441.00
112_I149_Y1.5271.00
208_F245_I1.5271.00
90_K155_Y1.5131.00
68_S142_F1.5091.00
98_K141_W1.5061.00
251_T257_Q1.4991.00
5_H31_Y1.4831.00
211_L244_F1.4791.00
187_A215_Y1.4731.00
230_R238_V1.4731.00
193_V207_G1.4691.00
210_T248_I1.4661.00
187_A224_E1.4651.00
78_N155_Y1.4471.00
208_F261_F1.4441.00
190_E210_T1.4421.00
176_I180_S1.4381.00
195_G203_V1.4231.00
20_N50_I1.4211.00
101_D107_V1.4161.00
99_I148_F1.4051.00
108_P111_T1.4011.00
76_I97_V1.3931.00
17_T44_E1.3891.00
11_I38_F1.3881.00
148_F158_Y1.3761.00
204_R240_K1.3761.00
131_E135_K1.3741.00
84_K155_Y1.3731.00
164_D176_I1.3721.00
222_A226_R1.3651.00
196_I206_V1.3621.00
84_K153_E1.3591.00
114_D162_S1.3541.00
91_P97_V1.3541.00
21_A200_V1.3481.00
61_E79_I1.3351.00
181_A184_S1.3321.00
136_N142_F1.3311.00
41_S46_L1.3241.00
171_L236_Y1.3201.00
166_V175_P1.3171.00
123_A137_M1.3151.00
189_L210_T1.2931.00
19_Y39_C1.2881.00
204_R241_E1.2871.00
165_M174_S1.2861.00
168_T173_V1.2811.00
13_F74_I1.2611.00
226_R230_R1.2611.00
169_A201_G1.2541.00
118_K141_W1.2521.00
198_D204_R1.2511.00
222_A244_F1.2511.00
209_V242_I1.2421.00
132_S136_N1.2331.00
12_F36_L1.2281.00
228_Y231_E1.2261.00
230_R235_H1.2201.00
23_L53_K1.2101.00
78_N87_C1.2091.00
116_Y141_W1.2031.00
47_P50_I1.1941.00
166_V205_V1.1801.00
234_D237_K1.1751.00
87_C155_Y1.1651.00
49_L53_K1.1631.00
116_Y138_M1.1521.00
95_Y121_S1.1481.00
168_T240_K1.1411.00
38_F63_L1.1381.00
229_L238_V1.1341.00
227_N231_E1.1301.00
88_T158_Y1.1191.00
223_E227_N1.1151.00
196_I241_E1.1131.00
54_W58_Y1.1061.00
179_E258_R1.1041.00
119_G122_V1.1031.00
118_K139_G1.1021.00
97_V117_V1.1011.00
102_E162_S1.0951.00
208_F262_R1.0931.00
65_G74_I1.0921.00
227_N230_R1.0761.00
20_N47_P1.0711.00
52_I56_E1.0591.00
19_Y54_W1.0541.00
24_H53_K1.0501.00
107_V111_T1.0491.00
164_D179_E1.0361.00
185_H225_I1.0321.00
133_T137_M1.0191.00
46_L51_Y1.0151.00
235_H238_V1.0101.00
110_K152_D1.0021.00
4_I35_S0.9961.00
117_V144_T0.9951.00
245_I248_I0.9921.00
20_N24_H0.9851.00
192_A248_I0.9841.00
15_V18_L0.9821.00
102_E114_D0.9821.00
10_T37_R0.9811.00
13_F65_G0.9801.00
40_V65_G0.9701.00
210_T247_E0.9631.00
53_K57_R0.9631.00
224_E227_N0.9561.00
222_A242_I0.9561.00
207_G242_I0.9531.00
71_A122_V0.9511.00
185_H224_E0.9511.00
248_I256_I0.9481.00
38_F61_E0.9461.00
63_L79_I0.9371.00
122_V142_F0.9341.00
71_A75_Y0.9301.00
19_Y41_S0.9271.00
192_A256_I0.9161.00
224_E228_Y0.9161.00
98_K118_K0.9151.00
76_I156_Y0.9101.00
214_G217_P0.9081.00
104_G116_Y0.9081.00
115_L158_Y0.9011.00
97_V156_Y0.9001.00
226_R238_V0.8941.00
129_D133_T0.8911.00
71_A117_V0.8841.00
181_A229_L0.8831.00
84_K151_D0.8831.00
192_A261_F0.8771.00
53_K56_E0.8741.00
259_Y263_L0.8691.00
99_I107_V0.8621.00
68_S71_A0.8501.00
30_N33_L0.8501.00
131_E134_R0.8441.00
241_E244_F0.8431.00
118_K140_S0.8401.00
101_D111_T0.8401.00
20_N53_K0.8361.00
196_I204_R0.8351.00
229_L233_L0.8341.00
194_V262_R0.8261.00
104_G138_M0.8261.00
5_H32_N0.8261.00
176_I179_E0.8231.00
66_I75_Y0.8201.00
27_D30_N0.8181.00
180_S184_S0.8111.00
99_I156_Y0.8081.00
192_A258_R0.8071.00
218_S224_E0.8071.00
211_L215_Y0.7991.00
182_L229_L0.7931.00
36_L39_C0.7901.00
31_Y34_T0.7881.00
68_S144_T0.7791.00
147_K160_G0.7751.00
197_P202_L0.7721.00
168_T201_G0.7721.00
168_T205_V0.7711.00
20_N49_L0.7691.00
181_A233_L0.7681.00
112_I162_S0.7651.00
184_S228_Y0.7601.00
13_F42_A0.7571.00
41_S62_I0.7561.00
50_I53_K0.7561.00
148_F156_Y0.7541.00
143_R162_S0.7541.00
109_P152_D0.7531.00
14_G18_L0.7511.00
222_A241_E0.7491.00
100_V106_E0.7491.00
51_Y64_D0.7421.00
21_A24_H0.7391.00
211_L217_P0.7341.00
197_P200_V0.7331.00
249_P261_F0.7311.00
123_A136_N0.7301.00
92_V95_Y0.7271.00
166_V195_G0.7261.00
55_K61_E0.7251.00
180_S183_L0.7241.00
26_E30_N0.7241.00
110_K149_Y0.7231.00
5_H34_T0.7221.00
74_I77_S0.7221.00
51_Y55_K0.7201.00
168_T195_G0.7181.00
223_E226_R0.7171.00
198_D201_G0.7161.00
49_L52_I0.7131.00
97_V115_L0.7131.00
106_E116_Y0.7091.00
29_K57_R0.7001.00
181_A228_Y0.6951.00
42_A74_I0.6931.00
189_L211_L0.6921.00
65_G77_S0.6911.00
130_Y133_T0.6871.00
182_L191_A0.6851.00
46_L62_I0.6791.00
41_S64_D0.6791.00
12_F39_C0.6791.00
136_N163_D0.6781.00
5_H35_S0.6781.00
97_V148_F0.6761.00
13_F40_V0.6761.00
96_E141_W0.6751.00
168_T204_R0.6741.00
225_I242_I0.6741.00
129_D135_K0.6731.00
259_Y262_R0.6731.00
138_M141_W0.6701.00
42_A65_G0.6681.00
23_L50_I0.6651.00
11_I37_R0.6651.00
75_Y95_Y0.6591.00
190_E248_I0.6591.00
39_C54_W0.6581.00
175_P258_R0.6571.00
198_D202_L0.6571.00
208_F243_R0.6551.00
99_I113_G0.6541.00
78_N81_S0.6541.00
197_P201_G0.6521.00
28_W31_Y0.6431.00
4_I9_P0.6421.00
203_V262_R0.6411.00
196_I208_F0.6381.00
133_T136_N0.6381.00
26_E29_K0.6341.00
71_A142_F0.6331.00
137_M143_R0.6321.00
52_I55_K0.6301.00
247_E250_K0.6291.00
46_L64_D0.6271.00
189_L213_Q0.6221.00
160_G175_P0.6201.00
226_R229_L0.6201.00
187_A211_L0.6191.00
88_T148_F0.6181.00
179_E183_L0.6181.00
196_I263_L0.6181.00
68_S73_H0.6171.00
145_G163_D0.6171.00
41_S54_W0.6161.00
100_V143_R0.6161.00
185_H188_V0.6151.00
160_G176_I0.6141.00
54_W62_I0.6141.00
188_V191_A0.6141.00
32_N35_S0.6121.00
187_A212_K0.6121.00
39_C60_V0.6091.00
165_M172_W0.6091.00
45_P158_Y0.6051.00
101_D104_G0.6041.00
209_V222_A0.6041.00
99_I115_L0.6011.00
17_T21_A0.6001.00
163_D203_V0.5991.00
179_E207_G0.5981.00
29_K32_N0.5971.00
212_K215_Y0.5961.00
52_I85_P0.5951.00
64_D86_G0.5951.00
213_Q216_S0.5921.00
87_C151_D0.5911.00
125_F130_Y0.5901.00
106_E150_R0.5881.00
96_E139_G0.5871.00
115_L156_Y0.5861.00
79_I90_K0.5861.00
28_W57_R0.5851.00
164_D175_P0.5851.00
76_I88_T0.5841.00
5_H33_L0.5791.00
4_I12_F0.5751.00
68_S72_L0.5751.00
215_Y218_S0.5741.00
72_L75_Y0.5731.00
253_T257_Q0.5731.00
11_I40_V0.5711.00
10_T35_S0.5711.00
13_F41_S0.5701.00
188_V209_V0.5691.00
42_A73_H0.5691.00
91_P95_Y0.5681.00
99_I150_R0.5641.00
13_F18_L0.5621.00
8_K34_T0.5571.00
161_R255_K0.5551.00
14_G39_C0.5551.00
64_D88_T0.5541.00
233_L237_K0.5531.00
48_P86_G0.5521.00
191_A229_L0.5511.00
114_D147_K0.5441.00
217_P222_A0.5441.00
178_V205_V0.5421.00
190_E247_E0.5411.00
111_T149_Y0.5401.00
16_P44_E0.5371.00
86_G157_Y0.5361.00
26_E57_R0.5341.00
100_V104_G0.5321.00
104_G143_R0.5321.00
17_T20_N0.5311.00
168_T203_V0.5301.00
51_Y86_G0.5301.00
148_F159_V0.5301.00
47_P183_L0.5281.00
98_K150_R0.5261.00
74_I92_V0.5261.00
27_D31_Y0.5241.00
199_E202_L0.5211.00
85_P157_Y0.5211.00
91_P150_R0.5201.00
75_Y121_S0.5181.00
100_V141_W0.5181.00
194_V258_R0.5181.00
175_P193_V0.5141.00
68_S75_Y0.5101.00
166_V203_V0.5091.00
65_G73_H0.5091.00
217_P244_F0.5081.00
4_I33_L0.5071.00
187_A228_Y0.5051.00
209_V225_I0.5031.00
179_E192_A0.5021.00
4_I8_K0.5021.00
107_V110_K0.5011.00
71_A74_I0.5001.00
163_D172_W0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3etcA 2 0.9326 100 0.053 Contact Map
3tsyA 2 0.6142 100 0.09 Contact Map
3c5eA 1 0.9963 100 0.091 Contact Map
2v7bA 1 0.9663 100 0.095 Contact Map
3ni2A 1 0.9775 100 0.102 Contact Map
1pg4A 1 1 100 0.104 Contact Map
2d1sA 1 0.9888 100 0.107 Contact Map
1mdbA 1 0.985 100 0.108 Contact Map
3rixA 1 0.5955 100 0.112 Contact Map
3g7sA 2 0.8502 100 0.113 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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