GREMLIN Database
Q97WU2 - Ring oxydation complex/ phenylacetic acid degradation related protein
UniProt: Q97WU2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 266 (254)
Sequences: 1162 (815)
Seq/√Len: 51.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
203_S258_E5.5001.00
181_E237_I4.4301.00
184_Y241_A4.3141.00
110_R114_R3.7201.00
13_D210_R3.5871.00
176_N179_E3.3241.00
232_L238_G3.2871.00
45_L54_I3.0071.00
104_E107_R2.9381.00
21_T57_I2.8821.00
232_L236_W2.7711.00
55_V67_K2.7381.00
95_W133_P2.6951.00
102_I150_S2.5661.00
32_K38_E2.5131.00
23_S63_K2.3511.00
192_T240_T2.2971.00
96_R158_I2.2931.00
24_S45_L2.2241.00
97_I129_T2.2131.00
25_K63_K2.1951.00
23_S26_S2.1881.00
94_K162_N2.1831.00
91_W230_D2.1581.00
6_L36_F2.0491.00
243_D247_K2.0371.00
166_E169_G2.0051.00
194_V209_T1.9971.00
30_I207_F1.9831.00
7_F41_I1.9671.00
97_I161_A1.9591.00
110_R113_L1.9370.99
13_D249_R1.9190.99
99_V129_T1.9080.99
184_Y224_D1.8380.99
57_I60_E1.8340.99
104_E111_D1.8100.99
100_Y128_S1.7910.99
215_H218_R1.7890.99
18_S261_Y1.7800.99
28_I120_L1.7660.99
98_V158_I1.7310.99
255_K258_E1.7020.99
91_W94_K1.6870.98
181_E185_R1.6740.98
183_A223_I1.6700.98
49_K54_I1.6640.98
4_Q231_L1.6590.98
75_R221_L1.6490.98
8_F48_M1.5890.98
185_R240_T1.5590.97
145_N151_S1.5180.97
224_D232_L1.4790.97
106_N109_L1.4730.96
103_P131_I1.4300.96
96_R122_F1.4280.96
91_W231_L1.4240.96
207_F259_F1.4230.96
192_T195_L1.4110.95
178_S188_L1.4010.95
239_Y243_D1.4010.95
157_D173_K1.3810.95
45_L56_G1.3800.95
208_V212_L1.3360.94
21_T67_K1.3030.93
53_L215_H1.2880.93
53_L75_R1.2870.93
97_I131_I1.2550.92
122_F140_L1.2320.91
73_M77_L1.2260.91
7_F175_W1.2260.91
33_E204_N1.2170.90
182_Q186_A1.2160.90
214_V245_F1.2160.90
175_W224_D1.2010.90
11_Y157_D1.1930.89
117_L122_F1.1840.89
90_R230_D1.1810.89
177_L233_P1.1790.89
125_L174_C1.1650.88
25_K65_S1.1650.88
110_R123_G1.1630.88
133_P236_W1.1580.88
195_L247_K1.1570.88
76_L79_G1.1330.87
179_E182_Q1.1330.87
31_F242_Y1.1270.87
168_K171_V1.1250.86
182_Q202_K1.1180.86
3_I43_A1.1060.85
97_I159_F1.0990.85
24_S62_R1.0960.85
13_D43_A1.0850.84
24_S66_Y1.0850.84
161_A165_G1.0720.84
196_E206_A1.0700.84
107_R245_F1.0680.83
149_G152_N1.0660.83
218_R222_N1.0610.83
49_K174_C1.0600.83
254_P258_E1.0590.83
240_T244_L1.0560.83
11_Y41_I1.0470.82
239_Y247_K1.0440.82
229_E239_Y1.0420.82
172_E234_P1.0270.81
100_Y103_P1.0250.81
210_R257_N1.0250.81
82_R121_G1.0240.81
36_F41_I1.0240.81
214_V249_R1.0220.81
79_G215_H1.0210.81
43_A64_V1.0210.81
162_N179_E1.0160.80
103_P106_N1.0120.80
67_K129_T1.0050.79
185_R235_N0.9940.79
3_I53_L0.9930.79
102_I109_L0.9900.78
214_V222_N0.9900.78
185_R237_I0.9870.78
230_D243_D0.9780.78
53_L222_N0.9730.77
58_K61_N0.9720.77
192_T244_L0.9710.77
183_A230_D0.9650.77
253_T256_A0.9630.76
185_R188_L0.9590.76
151_S234_P0.9560.76
247_K251_E0.9500.76
84_Y218_R0.9400.75
83_V218_R0.9380.75
152_N188_L0.9360.74
8_F11_Y0.9340.74
243_D254_P0.9320.74
116_E148_Y0.9300.74
39_G46_H0.9270.74
33_E259_F0.9250.74
140_L183_A0.9200.73
257_N261_Y0.9090.72
80_T83_V0.9050.72
66_Y206_A0.9040.72
104_E110_R0.9030.72
101_N159_F0.9010.72
10_L211_I0.9000.71
102_I107_R0.8980.71
98_V156_V0.8960.71
17_D235_N0.8930.71
115_R161_A0.8920.71
107_R121_G0.8900.71
177_L238_G0.8750.69
31_F41_I0.8720.69
190_K216_E0.8690.69
247_K250_E0.8690.69
34_F208_V0.8680.69
182_Q254_P0.8680.69
168_K247_K0.8620.68
104_E114_R0.8610.68
199_S247_K0.8610.68
76_L130_W0.8590.68
103_P107_R0.8560.68
100_Y114_R0.8440.67
13_D91_W0.8420.66
5_S170_L0.8410.66
162_N203_S0.8380.66
162_N258_E0.8310.65
186_A190_K0.8300.65
43_A249_R0.8290.65
121_G184_Y0.8250.65
161_A178_S0.8240.65
37_S125_L0.8210.64
20_G41_I0.8200.64
13_D64_V0.8190.64
202_K205_E0.8160.64
100_Y115_R0.8140.64
142_N186_A0.8100.63
133_P224_D0.8090.63
178_S182_Q0.8080.63
28_I211_I0.8070.63
107_R131_I0.8070.63
66_Y252_L0.8060.63
5_S238_G0.8060.63
201_L206_A0.8050.63
44_G218_R0.7980.62
172_E216_E0.7980.62
182_Q185_R0.7960.62
244_L248_L0.7960.62
121_G175_W0.7940.62
25_K117_L0.7930.62
61_N92_D0.7900.61
92_D119_W0.7870.61
61_N64_V0.7810.60
210_R214_V0.7810.60
248_L252_L0.7790.60
218_R245_F0.7790.60
140_L150_S0.7790.60
14_Y245_F0.7750.60
79_G249_R0.7730.60
152_N178_S0.7710.59
79_G221_L0.7710.59
40_A82_R0.7700.59
46_H252_L0.7680.59
168_K189_E0.7540.58
185_R189_E0.7510.57
45_L181_E0.7480.57
195_L199_S0.7450.57
70_E258_E0.7400.56
35_G204_N0.7390.56
99_V126_A0.7390.56
78_E128_S0.7390.56
4_Q40_A0.7390.56
122_F136_I0.7380.56
144_I156_V0.7350.56
100_Y104_E0.7340.56
23_S191_W0.7340.56
69_S72_G0.7340.56
138_D142_N0.7280.55
88_R142_N0.7270.55
29_V33_E0.7250.55
88_R138_D0.7250.55
72_G260_F0.7230.55
9_T215_H0.7210.54
16_K27_L0.7190.54
193_G206_A0.7180.54
19_G105_N0.7170.54
189_E234_P0.7150.54
113_L156_V0.7140.54
58_K62_R0.7130.54
241_A245_F0.7100.53
122_F132_S0.7090.53
95_W236_W0.7080.53
103_P121_G0.7060.53
84_Y245_F0.7050.53
210_R249_R0.7030.53
57_I243_D0.7020.52
222_N238_G0.7000.52
204_N259_F0.6990.52
21_T65_S0.6920.51
105_N138_D0.6880.51
224_D241_A0.6820.50
201_L255_K0.6820.50
100_Y111_D0.6810.50
4_Q10_L0.6810.50
132_S135_P0.6790.50
11_Y20_G0.6780.50
117_L187_F0.6770.50
10_L261_Y0.6760.50
114_R232_L0.6740.50
214_V218_R0.6740.50
198_V201_L0.6730.49
138_D185_R0.6730.49
131_I257_N0.6720.49
55_V202_K0.6710.49
92_D110_R0.6710.49
177_L212_L0.6710.49
43_A79_G0.6670.49
177_L232_L0.6660.49
188_L240_T0.6640.48
30_I33_E0.6620.48
179_E183_A0.6610.48
204_N254_P0.6600.48
240_T254_P0.6600.48
199_S251_E0.6580.48
70_E151_S0.6570.48
31_F226_D0.6560.48
58_K64_V0.6540.47
70_E230_D0.6540.47
152_N156_V0.6520.47
110_R130_W0.6510.47
191_W207_F0.6480.47
3_I6_L0.6480.47
6_L48_M0.6420.46
169_G261_Y0.6410.46
215_H222_N0.6400.46
120_L146_D0.6400.46
233_P236_W0.6400.46
54_I243_D0.6400.46
217_Y241_A0.6380.46
57_I67_K0.6370.46
43_A210_R0.6370.46
89_R239_Y0.6340.45
7_F27_L0.6330.45
18_S257_N0.6330.45
97_I165_G0.6300.45
26_S29_V0.6260.45
222_N245_F0.6260.45
35_G116_E0.6260.45
182_Q200_S0.6230.44
98_V111_D0.6190.44
28_I119_W0.6170.44
172_E178_S0.6170.44
109_L200_S0.6150.43
26_S161_A0.6150.43
71_K203_S0.6150.43
72_G116_E0.6150.43
187_F241_A0.6140.43
78_E167_P0.6140.43
172_E176_N0.6130.43
67_K239_Y0.6120.43
111_D114_R0.6110.43
186_A200_S0.6090.43
224_D236_W0.6070.43
122_F191_W0.6070.43
188_L244_L0.6060.43
64_V222_N0.6050.42
165_G234_P0.6040.42
16_K80_T0.6030.42
25_K35_G0.6020.42
168_K234_P0.6020.42
128_S181_E0.6010.42
84_Y238_G0.6000.42
23_S249_R0.5980.42
124_M189_E0.5980.42
209_T230_D0.5950.41
57_I152_N0.5910.41
27_L42_R0.5840.40
11_Y24_S0.5800.40
179_E247_K0.5790.40
196_E199_S0.5750.39
48_M218_R0.5720.39
81_R171_V0.5710.39
248_L251_E0.5710.39
217_Y249_R0.5710.39
131_I187_F0.5660.39
39_G43_A0.5650.38
64_V249_R0.5620.38
16_K77_L0.5620.38
54_I101_N0.5600.38
187_F191_W0.5590.38
169_G172_E0.5590.38
10_L207_F0.5580.38
36_F58_K0.5560.38
3_I11_Y0.5560.38
98_V120_L0.5520.37
83_V97_I0.5500.37
182_Q234_P0.5480.37
52_G200_S0.5470.37
32_K142_N0.5460.37
95_W117_L0.5450.36
99_V231_L0.5430.36
18_S215_H0.5420.36
102_I152_N0.5420.36
12_G82_R0.5410.36
11_Y77_L0.5390.36
100_Y215_H0.5380.36
131_I161_A0.5360.36
73_M117_L0.5360.36
55_V258_E0.5360.36
138_D182_Q0.5330.35
103_P113_L0.5320.35
135_P237_I0.5300.35
5_S22_I0.5300.35
40_A130_W0.5290.35
48_M75_R0.5280.35
114_R123_G0.5280.35
204_N208_V0.5270.35
63_K180_V0.5260.35
203_S213_L0.5250.35
83_V117_L0.5250.35
180_V220_F0.5250.35
43_A49_K0.5230.34
46_H120_L0.5210.34
190_K199_S0.5190.34
114_R119_W0.5170.34
160_V205_E0.5170.34
45_L68_L0.5140.34
83_V217_Y0.5130.33
125_L198_V0.5120.33
39_G249_R0.5110.33
108_E118_K0.5100.33
89_R182_Q0.5090.33
169_G216_E0.5080.33
43_A214_V0.5080.33
74_L145_N0.5060.33
93_N170_L0.5030.33
111_D217_Y0.5030.33
84_Y215_H0.5010.32
211_I249_R0.5010.32
181_E233_P0.5010.32
83_V219_K0.5000.32
172_E202_K0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kfwX 4 0.8722 100 0.226 Contact Map
3l09A 4 0.8722 100 0.304 Contact Map
2co5A 2 0.3158 97.5 0.885 Contact Map
3f6vA 2 0.3271 97 0.893 Contact Map
2qvoA 2 0.2895 97 0.893 Contact Map
1yg2A 2 0.6128 97 0.894 Contact Map
1hsjA 2 0.3083 97 0.894 Contact Map
4k2eA 2 0.2857 97 0.894 Contact Map
3cuoA 2 0.2857 96.9 0.895 Contact Map
1tbxA 3 0.3346 96.9 0.895 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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