Q97WU1 - SULSO - GREMLIN Contacts

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Q97WU1 - Uncharacterized protein

UniProt:	Q97WU1	Sequences: MCRMLAYHGDDKEYLKRLTNCLAKASLNDPLTNETHGDGWGIVAIASNNLIHYRSHLPIFKDENLEKILNLLDGEMKVIIHARQASDKRLISPYYSHPYLESTPKSILFLAHNGSVDKYKLGNVLGIDPMLMVDSELVAKYFATYSIKEIDKLQDVTQSALNLLIMEINRIDRSSTIYFYNYYRKDRIKRKEEYYKLYFNKGAIYSSSLAYTGCEKGEEVKFGNLGEL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	228 (207)
Sequences:	1605 (995)
Seq/√Len:	69.2

ECOLI - YAFJ
SULSO - Q97WU1 Q97XM6 Q981E0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
43_V	109_F	9.587	1.00
75_E	78_V	4.270	1.00
221_K	224_N	4.078	1.00
79_I	111_A	3.954	1.00
6_A	177_I	3.709	1.00
6_A	164_L	3.208	1.00
193_E	197_L	2.965	1.00
212_T	216_K	2.754	1.00
81_H	97_H	2.672	1.00
79_I	164_L	2.469	1.00
116_V	138_V	2.334	1.00
110_L	163_L	2.333	1.00
110_L	139_A	2.323	1.00
45_I	166_M	2.315	1.00
95_Y	136_E	2.221	1.00
100_L	109_F	2.221	1.00
95_Y	133_V	2.149	1.00
153_L	157_T	2.145	1.00
128_D	131_L	2.117	1.00
67_K	100_L	2.075	1.00
138_V	163_L	2.036	1.00
204_I	226_G	2.019	1.00
139_A	143_A	2.011	1.00
179_F	204_I	1.996	1.00
108_L	165_I	1.995	1.00
133_V	136_E	1.963	1.00
112_H	135_S	1.925	1.00
193_E	201_K	1.913	1.00
167_E	170_R	1.775	1.00
85_A	88_K	1.737	1.00
170_R	178_Y	1.691	1.00
197_L	202_G	1.688	1.00
81_H	95_Y	1.687	1.00
4_M	164_L	1.633	0.99
142_F	165_I	1.620	0.99
199_F	202_G	1.611	0.99
16_K	70_N	1.611	0.99
42_I	78_V	1.605	0.99
111_A	164_L	1.598	0.99
184_R	219_E	1.574	0.99
45_I	109_F	1.554	0.99
46_A	51_I	1.487	0.99
198_Y	201_K	1.484	0.99
122_G	126_G	1.470	0.99
197_L	201_K	1.465	0.99
36_H	82_A	1.402	0.98
55_S	62_D	1.348	0.98
47_S	74_G	1.344	0.98
65_L	209_L	1.341	0.98
29_D	59_I	1.337	0.97
3_R	8_H	1.328	0.97
149_E	152_K	1.310	0.97
5_L	21_C	1.246	0.96
101_E	143_A	1.240	0.96
118_K	121_L	1.230	0.96
79_I	166_M	1.215	0.96
127_I	131_L	1.214	0.96
97_H	133_V	1.214	0.96
147_I	157_T	1.197	0.95
29_D	33_N	1.188	0.95
149_E	153_L	1.169	0.95
11_D	76_M	1.164	0.94
108_L	133_V	1.153	0.94
77_K	177_I	1.153	0.94
154_Q	157_T	1.137	0.94
44_A	72_L	1.134	0.94
153_L	158_Q	1.124	0.93
194_Y	197_L	1.124	0.93
25_A	29_D	1.120	0.93
56_H	96_S	1.116	0.93
81_H	111_A	1.096	0.92
46_A	49_N	1.093	0.92
15_L	42_I	1.091	0.92
183_Y	190_R	1.087	0.92
27_L	32_T	1.076	0.92
20_N	24_K	1.074	0.92
193_E	199_F	1.071	0.92
118_K	122_G	1.067	0.91
3_R	206_S	1.063	0.91
8_H	77_K	1.062	0.91
220_V	226_G	1.061	0.91
29_D	40_W	1.056	0.91
195_Y	198_Y	1.054	0.91
1_M	5_L	1.054	0.91
151_D	155_D	1.050	0.91
75_E	166_M	1.040	0.90
57_L	205_Y	1.039	0.90
153_L	156_V	1.037	0.90
77_K	166_M	1.034	0.90
76_M	203_A	1.023	0.90
93_P	178_Y	1.019	0.89
86_S	115_S	1.012	0.89
121_L	125_L	1.009	0.89
45_I	168_I	1.008	0.89
40_W	58_P	1.006	0.89
148_K	151_D	0.996	0.88
95_Y	139_A	0.990	0.88
162_N	205_Y	0.988	0.88
47_S	76_M	0.982	0.88
168_I	208_S	0.982	0.88
59_I	81_H	0.976	0.87
205_Y	217_G	0.974	0.87
123_N	129_P	0.971	0.87
23_A	69_L	0.959	0.86
86_S	135_S	0.958	0.86
51_I	71_L	0.955	0.86
39_G	83_R	0.943	0.85
92_S	132_M	0.938	0.85
66_E	70_N	0.937	0.85
3_R	25_A	0.927	0.84
147_I	151_D	0.921	0.84
46_A	71_L	0.917	0.84
43_V	50_L	0.913	0.83
54_R	144_T	0.907	0.83
132_M	136_E	0.906	0.83
68_I	120_K	0.903	0.83
53_Y	64_N	0.891	0.82
122_G	137_L	0.888	0.82
22_L	25_A	0.882	0.81
159_S	162_N	0.880	0.81
8_H	28_N	0.871	0.80
118_K	125_L	0.871	0.80
194_Y	201_K	0.865	0.80
51_I	75_E	0.865	0.80
124_V	144_T	0.864	0.80
52_H	100_L	0.863	0.80
120_K	125_L	0.860	0.80
119_Y	125_L	0.856	0.79
33_N	86_S	0.848	0.79
45_I	167_E	0.845	0.78
122_G	125_L	0.844	0.78
27_L	35_T	0.841	0.78
24_K	28_N	0.827	0.77
87_D	115_S	0.827	0.77
118_K	126_G	0.826	0.77
101_E	140_K	0.816	0.76
179_F	225_L	0.806	0.75
77_K	122_G	0.805	0.75
64_N	68_I	0.796	0.74
146_S	162_N	0.790	0.74
150_I	158_Q	0.786	0.73
145_Y	156_V	0.785	0.73
4_M	111_A	0.784	0.73
3_R	9_G	0.782	0.73
198_Y	211_Y	0.781	0.73
66_E	221_K	0.780	0.73
29_D	32_T	0.777	0.72
169_N	216_K	0.777	0.72
160_A	186_D	0.775	0.72
115_S	163_L	0.771	0.72
80_I	168_I	0.766	0.71
5_L	80_I	0.765	0.71
55_S	93_P	0.765	0.71
96_S	184_R	0.761	0.71
140_K	162_N	0.761	0.71
45_I	64_N	0.758	0.70
10_D	47_S	0.755	0.70
108_L	142_F	0.753	0.70
45_I	103_T	0.751	0.70
196_K	202_G	0.750	0.70
210_A	213_G	0.749	0.70
193_E	196_K	0.747	0.69
152_K	158_Q	0.746	0.69
56_H	220_V	0.745	0.69
95_Y	217_G	0.744	0.69
86_S	160_A	0.743	0.69
19_T	25_A	0.743	0.69
103_T	169_N	0.740	0.69
99_Y	110_L	0.737	0.68
99_Y	133_V	0.736	0.68
4_M	162_N	0.735	0.68
96_S	183_Y	0.732	0.68
120_K	148_K	0.729	0.67
10_D	210_A	0.728	0.67
1_M	4_M	0.726	0.67
196_K	201_K	0.726	0.67
29_D	34_E	0.725	0.67
166_M	207_S	0.723	0.67
196_K	199_F	0.723	0.67
40_W	44_A	0.720	0.66
2_C	113_N	0.718	0.66
45_I	50_L	0.714	0.66
186_D	189_K	0.714	0.66
112_H	134_D	0.712	0.66
154_Q	179_F	0.707	0.65
155_D	158_Q	0.706	0.65
163_L	180_Y	0.704	0.65
56_H	128_D	0.701	0.64
63_E	66_E	0.697	0.64
23_A	26_S	0.694	0.64
86_S	116_V	0.693	0.64
2_C	5_L	0.692	0.63
141_Y	156_V	0.689	0.63
9_G	26_S	0.688	0.63
82_A	168_I	0.682	0.62
117_D	120_K	0.679	0.62
110_L	165_I	0.678	0.62
55_S	96_S	0.678	0.62
66_E	121_L	0.676	0.62
36_H	84_Q	0.674	0.61
4_M	81_H	0.671	0.61
201_K	210_A	0.670	0.61
100_L	224_N	0.669	0.61
36_H	78_V	0.656	0.59
10_D	15_L	0.650	0.59
20_N	25_A	0.646	0.58
182_Y	223_G	0.645	0.58
203_A	209_L	0.645	0.58
148_K	152_K	0.644	0.58
79_I	177_I	0.644	0.58
147_I	156_V	0.642	0.58
117_D	185_K	0.641	0.58
71_L	93_P	0.640	0.57
36_H	97_H	0.639	0.57
26_S	60_F	0.637	0.57
21_C	29_D	0.636	0.57
56_H	204_I	0.632	0.56
3_R	34_E	0.632	0.56
186_D	219_E	0.629	0.56
196_K	220_V	0.629	0.56
97_H	136_E	0.628	0.56
190_R	222_F	0.627	0.56
145_Y	219_E	0.625	0.56
211_Y	216_K	0.624	0.56
82_A	208_S	0.623	0.55
150_I	169_N	0.622	0.55
156_V	219_E	0.618	0.55
149_E	156_V	0.617	0.55
187_R	219_E	0.616	0.55
51_I	64_N	0.616	0.55
83_R	113_N	0.613	0.54
77_K	179_F	0.612	0.54
98_P	114_G	0.612	0.54
40_W	181_N	0.610	0.54
79_I	109_F	0.609	0.54
23_A	59_I	0.608	0.54
131_L	143_A	0.607	0.53
36_H	60_F	0.607	0.53
128_D	219_E	0.605	0.53
36_H	113_N	0.598	0.52
19_T	23_A	0.598	0.52
33_N	59_I	0.595	0.52
55_S	71_L	0.593	0.52
44_A	53_Y	0.593	0.52
95_Y	132_M	0.591	0.52
89_R	92_S	0.591	0.52
37_G	61_K	0.591	0.52
121_L	157_T	0.590	0.51
26_S	37_G	0.589	0.51
83_R	114_G	0.589	0.51
53_Y	194_Y	0.588	0.51
83_R	98_P	0.585	0.51
62_D	136_E	0.584	0.51
160_A	184_R	0.583	0.51
99_Y	217_G	0.583	0.51
88_K	133_V	0.583	0.51
96_S	133_V	0.582	0.50
16_K	55_S	0.582	0.50
92_S	212_T	0.581	0.50
42_I	65_L	0.577	0.50
21_C	25_A	0.577	0.50
7_Y	10_D	0.576	0.50
193_E	202_G	0.574	0.50
44_A	75_E	0.574	0.50
142_F	146_S	0.572	0.49
37_G	60_F	0.572	0.49
119_Y	124_V	0.569	0.49
21_C	26_S	0.565	0.48
195_Y	199_F	0.564	0.48
117_D	159_S	0.562	0.48
3_R	182_Y	0.562	0.48
18_L	72_L	0.561	0.48
69_L	161_L	0.560	0.48
42_I	110_L	0.559	0.48
9_G	25_A	0.558	0.48
26_S	96_S	0.554	0.47
120_K	153_L	0.554	0.47
66_E	152_K	0.553	0.47
25_A	38_D	0.551	0.47
97_H	139_A	0.551	0.47
119_Y	122_G	0.550	0.47
123_N	177_I	0.544	0.46
180_Y	225_L	0.544	0.46
5_L	18_L	0.541	0.46
41_G	114_G	0.539	0.45
59_I	95_Y	0.537	0.45
46_A	102_S	0.536	0.45
41_G	98_P	0.536	0.45
39_G	113_N	0.535	0.45
56_H	61_K	0.534	0.45
15_L	19_T	0.532	0.44
198_Y	202_G	0.529	0.44
111_A	180_Y	0.528	0.44
23_A	140_K	0.526	0.44
199_F	209_L	0.525	0.44
25_A	207_S	0.521	0.43
5_L	19_T	0.513	0.42
41_G	83_R	0.513	0.42
4_M	59_I	0.510	0.42
39_G	114_G	0.510	0.42
25_A	35_T	0.510	0.42
124_V	154_Q	0.509	0.42
179_F	203_A	0.508	0.42
51_I	72_L	0.508	0.42
39_G	98_P	0.507	0.42
121_L	153_L	0.507	0.42
132_M	143_A	0.507	0.42
26_S	80_I	0.504	0.41
84_Q	97_H	0.502	0.41
59_I	96_S	0.500	0.41

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3mdnA	4	0.7982	100	0.425	Contact Map
4zflA	5	0.8947	100	0.437	Contact Map
1te5A	2	0.9123	100	0.479	Contact Map
4amvA	2	0.8684	100	0.581	Contact Map
1ao0A	3	0.8816	99.9	0.595	Contact Map
1xffA	2	0.8684	99.9	0.6	Contact Map
1ecfA	4	0.8991	99.9	0.61	Contact Map
1ea0A	1	0.8991	99.7	0.723	Contact Map
1ofdA	1	0.8816	99.7	0.735	Contact Map
1jgtA	2	0.75	99.6	0.738	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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