GREMLIN Database
Q97WU1 - Uncharacterized protein
UniProt: Q97WU1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 228 (207)
Sequences: 1605 (995)
Seq/√Len: 69.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_V109_F9.5871.00
75_E78_V4.2701.00
221_K224_N4.0781.00
79_I111_A3.9541.00
6_A177_I3.7091.00
6_A164_L3.2081.00
193_E197_L2.9651.00
212_T216_K2.7541.00
81_H97_H2.6721.00
79_I164_L2.4691.00
116_V138_V2.3341.00
110_L163_L2.3331.00
110_L139_A2.3231.00
45_I166_M2.3151.00
95_Y136_E2.2211.00
100_L109_F2.2211.00
95_Y133_V2.1491.00
153_L157_T2.1451.00
128_D131_L2.1171.00
67_K100_L2.0751.00
138_V163_L2.0361.00
204_I226_G2.0191.00
139_A143_A2.0111.00
179_F204_I1.9961.00
108_L165_I1.9951.00
133_V136_E1.9631.00
112_H135_S1.9251.00
193_E201_K1.9131.00
167_E170_R1.7751.00
85_A88_K1.7371.00
170_R178_Y1.6911.00
197_L202_G1.6881.00
81_H95_Y1.6871.00
4_M164_L1.6330.99
142_F165_I1.6200.99
199_F202_G1.6110.99
16_K70_N1.6110.99
42_I78_V1.6050.99
111_A164_L1.5980.99
184_R219_E1.5740.99
45_I109_F1.5540.99
46_A51_I1.4870.99
198_Y201_K1.4840.99
122_G126_G1.4700.99
197_L201_K1.4650.99
36_H82_A1.4020.98
55_S62_D1.3480.98
47_S74_G1.3440.98
65_L209_L1.3410.98
29_D59_I1.3370.97
3_R8_H1.3280.97
149_E152_K1.3100.97
5_L21_C1.2460.96
101_E143_A1.2400.96
118_K121_L1.2300.96
79_I166_M1.2150.96
127_I131_L1.2140.96
97_H133_V1.2140.96
147_I157_T1.1970.95
29_D33_N1.1880.95
149_E153_L1.1690.95
11_D76_M1.1640.94
108_L133_V1.1530.94
77_K177_I1.1530.94
154_Q157_T1.1370.94
44_A72_L1.1340.94
153_L158_Q1.1240.93
194_Y197_L1.1240.93
25_A29_D1.1200.93
56_H96_S1.1160.93
81_H111_A1.0960.92
46_A49_N1.0930.92
15_L42_I1.0910.92
183_Y190_R1.0870.92
27_L32_T1.0760.92
20_N24_K1.0740.92
193_E199_F1.0710.92
118_K122_G1.0670.91
3_R206_S1.0630.91
8_H77_K1.0620.91
220_V226_G1.0610.91
29_D40_W1.0560.91
195_Y198_Y1.0540.91
1_M5_L1.0540.91
151_D155_D1.0500.91
75_E166_M1.0400.90
57_L205_Y1.0390.90
153_L156_V1.0370.90
77_K166_M1.0340.90
76_M203_A1.0230.90
93_P178_Y1.0190.89
86_S115_S1.0120.89
121_L125_L1.0090.89
45_I168_I1.0080.89
40_W58_P1.0060.89
148_K151_D0.9960.88
95_Y139_A0.9900.88
162_N205_Y0.9880.88
47_S76_M0.9820.88
168_I208_S0.9820.88
59_I81_H0.9760.87
205_Y217_G0.9740.87
123_N129_P0.9710.87
23_A69_L0.9590.86
86_S135_S0.9580.86
51_I71_L0.9550.86
39_G83_R0.9430.85
92_S132_M0.9380.85
66_E70_N0.9370.85
3_R25_A0.9270.84
147_I151_D0.9210.84
46_A71_L0.9170.84
43_V50_L0.9130.83
54_R144_T0.9070.83
132_M136_E0.9060.83
68_I120_K0.9030.83
53_Y64_N0.8910.82
122_G137_L0.8880.82
22_L25_A0.8820.81
159_S162_N0.8800.81
8_H28_N0.8710.80
118_K125_L0.8710.80
194_Y201_K0.8650.80
51_I75_E0.8650.80
124_V144_T0.8640.80
52_H100_L0.8630.80
120_K125_L0.8600.80
119_Y125_L0.8560.79
33_N86_S0.8480.79
45_I167_E0.8450.78
122_G125_L0.8440.78
27_L35_T0.8410.78
24_K28_N0.8270.77
87_D115_S0.8270.77
118_K126_G0.8260.77
101_E140_K0.8160.76
179_F225_L0.8060.75
77_K122_G0.8050.75
64_N68_I0.7960.74
146_S162_N0.7900.74
150_I158_Q0.7860.73
145_Y156_V0.7850.73
4_M111_A0.7840.73
3_R9_G0.7820.73
198_Y211_Y0.7810.73
66_E221_K0.7800.73
29_D32_T0.7770.72
169_N216_K0.7770.72
160_A186_D0.7750.72
115_S163_L0.7710.72
80_I168_I0.7660.71
5_L80_I0.7650.71
55_S93_P0.7650.71
96_S184_R0.7610.71
140_K162_N0.7610.71
45_I64_N0.7580.70
10_D47_S0.7550.70
108_L142_F0.7530.70
45_I103_T0.7510.70
196_K202_G0.7500.70
210_A213_G0.7490.70
193_E196_K0.7470.69
152_K158_Q0.7460.69
56_H220_V0.7450.69
95_Y217_G0.7440.69
86_S160_A0.7430.69
19_T25_A0.7430.69
103_T169_N0.7400.69
99_Y110_L0.7370.68
99_Y133_V0.7360.68
4_M162_N0.7350.68
96_S183_Y0.7320.68
120_K148_K0.7290.67
10_D210_A0.7280.67
1_M4_M0.7260.67
196_K201_K0.7260.67
29_D34_E0.7250.67
166_M207_S0.7230.67
196_K199_F0.7230.67
40_W44_A0.7200.66
2_C113_N0.7180.66
45_I50_L0.7140.66
186_D189_K0.7140.66
112_H134_D0.7120.66
154_Q179_F0.7070.65
155_D158_Q0.7060.65
163_L180_Y0.7040.65
56_H128_D0.7010.64
63_E66_E0.6970.64
23_A26_S0.6940.64
86_S116_V0.6930.64
2_C5_L0.6920.63
141_Y156_V0.6890.63
9_G26_S0.6880.63
82_A168_I0.6820.62
117_D120_K0.6790.62
110_L165_I0.6780.62
55_S96_S0.6780.62
66_E121_L0.6760.62
36_H84_Q0.6740.61
4_M81_H0.6710.61
201_K210_A0.6700.61
100_L224_N0.6690.61
36_H78_V0.6560.59
10_D15_L0.6500.59
20_N25_A0.6460.58
182_Y223_G0.6450.58
203_A209_L0.6450.58
148_K152_K0.6440.58
79_I177_I0.6440.58
147_I156_V0.6420.58
117_D185_K0.6410.58
71_L93_P0.6400.57
36_H97_H0.6390.57
26_S60_F0.6370.57
21_C29_D0.6360.57
56_H204_I0.6320.56
3_R34_E0.6320.56
186_D219_E0.6290.56
196_K220_V0.6290.56
97_H136_E0.6280.56
190_R222_F0.6270.56
145_Y219_E0.6250.56
211_Y216_K0.6240.56
82_A208_S0.6230.55
150_I169_N0.6220.55
156_V219_E0.6180.55
149_E156_V0.6170.55
187_R219_E0.6160.55
51_I64_N0.6160.55
83_R113_N0.6130.54
77_K179_F0.6120.54
98_P114_G0.6120.54
40_W181_N0.6100.54
79_I109_F0.6090.54
23_A59_I0.6080.54
131_L143_A0.6070.53
36_H60_F0.6070.53
128_D219_E0.6050.53
36_H113_N0.5980.52
19_T23_A0.5980.52
33_N59_I0.5950.52
55_S71_L0.5930.52
44_A53_Y0.5930.52
95_Y132_M0.5910.52
89_R92_S0.5910.52
37_G61_K0.5910.52
121_L157_T0.5900.51
26_S37_G0.5890.51
83_R114_G0.5890.51
53_Y194_Y0.5880.51
83_R98_P0.5850.51
62_D136_E0.5840.51
160_A184_R0.5830.51
99_Y217_G0.5830.51
88_K133_V0.5830.51
96_S133_V0.5820.50
16_K55_S0.5820.50
92_S212_T0.5810.50
42_I65_L0.5770.50
21_C25_A0.5770.50
7_Y10_D0.5760.50
193_E202_G0.5740.50
44_A75_E0.5740.50
142_F146_S0.5720.49
37_G60_F0.5720.49
119_Y124_V0.5690.49
21_C26_S0.5650.48
195_Y199_F0.5640.48
117_D159_S0.5620.48
3_R182_Y0.5620.48
18_L72_L0.5610.48
69_L161_L0.5600.48
42_I110_L0.5590.48
9_G25_A0.5580.48
26_S96_S0.5540.47
120_K153_L0.5540.47
66_E152_K0.5530.47
25_A38_D0.5510.47
97_H139_A0.5510.47
119_Y122_G0.5500.47
123_N177_I0.5440.46
180_Y225_L0.5440.46
5_L18_L0.5410.46
41_G114_G0.5390.45
59_I95_Y0.5370.45
46_A102_S0.5360.45
41_G98_P0.5360.45
39_G113_N0.5350.45
56_H61_K0.5340.45
15_L19_T0.5320.44
198_Y202_G0.5290.44
111_A180_Y0.5280.44
23_A140_K0.5260.44
199_F209_L0.5250.44
25_A207_S0.5210.43
5_L19_T0.5130.42
41_G83_R0.5130.42
4_M59_I0.5100.42
39_G114_G0.5100.42
25_A35_T0.5100.42
124_V154_Q0.5090.42
179_F203_A0.5080.42
51_I72_L0.5080.42
39_G98_P0.5070.42
121_L153_L0.5070.42
132_M143_A0.5070.42
26_S80_I0.5040.41
84_Q97_H0.5020.41
59_I96_S0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mdnA 4 0.7982 100 0.425 Contact Map
4zflA 5 0.8947 100 0.437 Contact Map
1te5A 2 0.9123 100 0.479 Contact Map
4amvA 2 0.8684 100 0.581 Contact Map
1ao0A 3 0.8816 99.9 0.595 Contact Map
1xffA 2 0.8684 99.9 0.6 Contact Map
1ecfA 4 0.8991 99.9 0.61 Contact Map
1ea0A 1 0.8991 99.7 0.723 Contact Map
1ofdA 1 0.8816 99.7 0.735 Contact Map
1jgtA 2 0.75 99.6 0.738 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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