GREMLIN Database
Q97WT9 - NADH oxidase
UniProt: Q97WT9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 555 (463)
Sequences: 2491 (1552)
Seq/√Len: 72.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
372_G399_L4.4411.00
149_I201_G3.9201.00
138_K187_E3.7031.00
395_Q438_K3.6811.00
391_T434_K3.2501.00
368_I393_Y3.0091.00
10_I303_V2.9581.00
47_E315_Y2.8791.00
153_I205_K2.8021.00
101_F162_G2.7621.00
325_P425_E2.7261.00
426_L433_V2.6981.00
294_A298_R2.6771.00
93_I100_I2.6451.00
122_I136_M2.6411.00
272_K300_I2.6301.00
21_I317_L2.6061.00
325_P428_R2.5831.00
80_D154_R2.5451.00
268_L295_I2.5301.00
22_A303_V2.5251.00
211_G243_Y2.5061.00
425_E428_R2.4911.00
366_E389_T2.4531.00
318_E322_R2.4331.00
46_A96_L2.3761.00
136_M144_V2.3741.00
190_D193_R2.3551.00
7_L321_K2.3301.00
138_K141_I2.2541.00
46_A95_A2.1601.00
381_R385_L2.1601.00
64_N147_D2.1251.00
379_A453_I2.1231.00
172_L194_F2.1131.00
426_L431_V2.1041.00
126_P135_E2.0931.00
136_M140_D2.0911.00
39_D88_R2.0811.00
272_K276_D2.0581.00
389_T432_E2.0551.00
293_D296_K2.0241.00
153_I157_R2.0041.00
192_V235_K2.0031.00
156_K207_K1.9981.00
378_E381_R1.9961.00
134_R140_D1.9821.00
17_L54_G1.9791.00
5_K297_A1.9731.00
393_Y439_I1.9521.00
173_L194_F1.9501.00
437_S443_D1.9381.00
368_I449_P1.8941.00
173_L198_I1.8921.00
167_G212_I1.8711.00
146_N201_G1.8601.00
391_T432_E1.8551.00
188_Y197_E1.8551.00
11_R16_V1.8501.00
385_L425_E1.8471.00
104_L151_A1.8301.00
53_V310_L1.8271.00
397_N436_N1.8261.00
372_G392_L1.8261.00
237_E279_N1.8211.00
94_H161_D1.8171.00
87_M91_E1.8141.00
424_R428_R1.8111.00
364_K389_T1.7931.00
290_T316_W1.7841.00
306_L309_Q1.7841.00
236_L241_I1.7631.00
440_E443_D1.7491.00
361_E364_K1.7471.00
173_L195_I1.7371.00
234_K277_A1.7321.00
381_R429_L1.7251.00
5_K8_E1.7051.00
149_I205_K1.7041.00
180_A222_E1.7041.00
142_E188_Y1.6971.00
50_K96_L1.6891.00
165_L202_I1.6731.00
42_I89_L1.6691.00
22_A283_F1.6611.00
318_E321_K1.6411.00
233_G278_V1.6270.99
15_I99_K1.6260.99
237_E280_I1.6260.99
15_I209_T1.6130.99
142_E187_E1.6040.99
90_T160_F1.6000.99
315_Y318_E1.5870.99
201_G204_E1.5790.99
407_K416_Q1.5750.99
295_I301_A1.5580.99
201_G205_K1.5520.99
377_L399_L1.5450.99
200_K239_A1.5360.99
392_L399_L1.5350.99
434_K437_S1.5080.99
284_L301_A1.5060.99
177_L192_V1.5060.99
47_E351_E1.4980.99
393_Y434_K1.4910.99
358_P382_V1.4860.99
244_I280_I1.4840.99
177_L195_I1.4800.99
138_K142_E1.4800.99
14_D209_T1.4800.99
138_K188_Y1.4630.99
86_F160_F1.4620.99
322_R325_P1.4480.99
5_K293_D1.4460.99
43_A356_L1.4460.99
142_E201_G1.4410.99
422_Y426_L1.4280.99
150_D154_R1.4260.99
18_K98_S1.4240.99
46_A92_L1.4180.99
226_P273_V1.4080.98
367_V379_A1.4000.98
372_G394_E1.3970.98
463_K468_S1.3840.98
442_S446_M1.3770.98
273_V276_D1.3720.98
444_C449_P1.3720.98
365_G451_Y1.3710.98
142_E197_E1.3590.98
145_K188_Y1.3560.98
46_A50_K1.3550.98
393_Y449_P1.3420.98
43_A46_A1.3340.98
230_A277_A1.3320.98
424_R427_K1.3230.98
399_L433_V1.3200.98
325_P424_R1.3150.98
150_D205_K1.3150.98
368_I439_I1.3010.97
425_E429_L1.2950.97
377_L426_L1.2930.97
195_I212_I1.2850.97
137_T140_D1.2830.97
310_L317_L1.2780.97
5_K296_K1.2740.97
443_D446_M1.2740.97
156_K208_I1.2680.97
83_T154_R1.2670.97
24_S305_V1.2640.97
39_D43_A1.2630.97
392_L431_V1.2600.97
23_M48_R1.2590.97
180_A220_D1.2580.97
243_Y283_F1.2560.97
368_I447_A1.2560.97
244_I278_V1.2480.97
11_R14_D1.2470.97
399_L423_E1.2440.97
101_F211_G1.2430.97
381_R425_E1.2300.96
7_L21_I1.2300.96
100_I160_F1.2290.96
423_E427_K1.2250.96
7_L320_A1.2190.96
156_K206_A1.2150.96
15_I162_G1.2130.96
398_K423_E1.2120.96
166_H169_H1.2060.96
146_N150_D1.2030.96
193_R197_E1.1970.96
287_S331_R1.1940.96
4_S293_D1.1920.96
367_V383_L1.1890.96
361_E388_F1.1840.95
203_K210_V1.1810.95
368_I444_C1.1810.95
365_G388_F1.1780.95
274_V282_I1.1780.95
275_R302_D1.1770.95
7_L317_L1.1770.95
439_I444_C1.1710.95
18_K321_K1.1700.95
393_Y447_A1.1690.95
91_E95_A1.1680.95
265_L295_I1.1630.95
196_E239_A1.1570.95
385_L429_L1.1570.95
127_I133_V1.1530.95
404_L407_K1.1490.95
77_M151_A1.1470.95
231_E235_K1.1460.95
288_V292_V1.1430.95
358_P361_E1.1410.94
212_I236_L1.1370.94
196_E200_K1.1360.94
14_D242_D1.1310.94
61_T102_V1.1280.94
169_H247_S1.1240.94
64_N143_R1.1240.94
47_E50_K1.1200.94
127_I183_K1.1150.94
109_R175_Q1.1130.94
288_V295_I1.1080.94
206_A210_V1.1050.93
226_P230_A1.1030.93
136_M141_I1.1010.93
123_A126_P1.0970.93
439_I443_D1.0970.93
295_I300_I1.0940.93
246_L274_V1.0930.93
378_E382_V1.0900.93
398_K404_L1.0870.93
51_G318_E1.0840.93
235_K238_K1.0820.93
306_L316_W1.0800.93
230_A234_K1.0720.92
70_G107_V1.0720.92
268_L284_L1.0630.92
67_D143_R1.0620.92
293_D297_A1.0620.92
366_E447_A1.0600.92
417_E420_N1.0580.92
45_L56_I1.0570.92
236_L244_I1.0540.92
189_K231_E1.0530.92
32_T36_Y1.0500.92
391_T447_A1.0450.91
399_L435_L1.0350.91
268_L300_I1.0340.91
209_T243_Y1.0340.91
24_S307_G1.0290.91
90_T100_I1.0240.91
162_G209_T1.0210.90
364_K388_F1.0180.90
22_A57_I1.0140.90
149_I204_E1.0100.90
216_V246_L1.0070.90
135_E185_N1.0060.90
76_G82_L1.0050.90
196_E241_I1.0030.90
37_P85_K1.0030.90
55_L101_F1.0000.89
58_T100_I1.0000.89
15_I101_F0.9960.89
382_V386_R0.9930.89
346_C349_N0.9920.89
441_C445_I0.9890.89
391_T449_P0.9860.89
377_L392_L0.9840.89
233_G244_I0.9830.89
180_A221_N0.9830.89
140_D143_R0.9790.88
212_I241_I0.9770.88
143_R147_D0.9720.88
273_V277_A0.9690.88
52_G318_E0.9680.88
57_I101_F0.9610.88
237_E278_V0.9600.87
311_L352_L0.9580.87
264_R414_E0.9550.87
393_Y443_D0.9530.87
372_G433_V0.9520.87
393_Y437_S0.9500.87
246_L271_A0.9490.87
52_G321_K0.9450.87
440_E444_C0.9440.87
372_G377_L0.9420.86
462_E468_S0.9380.86
141_I145_K0.9370.86
40_A343_E0.9350.86
166_H247_S0.9340.86
384_A429_L0.9320.86
439_I446_M0.9310.86
192_V232_I0.9300.86
42_I92_L0.9280.86
377_L381_R0.9270.86
312_A348_V0.9260.86
327_R421_Y0.9260.86
153_I156_K0.9190.85
335_T339_V0.9170.85
370_V454_P0.9110.85
150_D153_I0.9080.84
149_I198_I0.9070.84
421_Y425_E0.9010.84
465_L468_S0.9010.84
26_M307_G0.8990.84
328_P420_N0.8970.84
30_L40_A0.8970.84
94_H99_K0.8950.84
226_P277_A0.8940.83
17_L303_V0.8940.83
202_I210_V0.8920.83
103_Q164_E0.8910.83
379_A383_L0.8890.83
21_I316_W0.8880.83
50_K315_Y0.8860.83
53_V317_L0.8860.83
122_I134_R0.8840.83
442_S445_I0.8810.83
91_E94_H0.8800.82
18_K99_K0.8790.82
283_F303_V0.8740.82
394_E458_D0.8730.82
335_T338_G0.8710.82
30_L353_G0.8690.82
12_I209_T0.8690.82
382_V385_L0.8680.82
18_K97_G0.8680.82
328_P417_E0.8660.81
367_V451_Y0.8620.81
192_V195_I0.8620.81
444_C454_P0.8600.81
123_A133_V0.8540.81
90_T158_A0.8490.80
319_K326_I0.8410.80
227_E273_V0.8390.79
336_C339_V0.8380.79
388_F450_D0.8370.79
17_L55_L0.8350.79
203_K206_A0.8330.79
162_G211_G0.8320.79
92_L96_L0.8290.79
328_P418_L0.8290.79
426_L430_N0.8270.78
80_D84_P0.8270.78
434_K447_A0.8270.78
199_L239_A0.8260.78
316_W320_A0.8260.78
26_M311_L0.8250.78
414_E417_E0.8240.78
377_L433_V0.8240.78
32_T38_S0.8230.78
101_F209_T0.8230.78
168_A247_S0.8220.78
23_M26_M0.8220.78
196_E235_K0.8210.78
14_D207_K0.8210.78
144_V172_L0.8190.78
51_G317_L0.8150.77
102_V155_A0.8150.77
149_I153_I0.8120.77
165_L199_L0.8110.77
83_T158_A0.8090.77
215_S218_E0.8060.77
188_Y200_K0.8050.76
145_K149_I0.8040.76
122_I144_V0.8010.76
167_G195_I0.8000.76
134_R137_T0.8000.76
109_R170_G0.7980.76
187_E193_R0.7960.76
426_L429_L0.7940.76
55_L99_K0.7940.76
418_L422_Y0.7940.76
185_N190_D0.7930.75
37_P41_H0.7930.75
6_L291_P0.7920.75
199_L236_L0.7910.75
384_A431_V0.7900.75
25_P245_H0.7880.75
149_I206_A0.7870.75
192_V196_E0.7870.75
444_C452_E0.7860.75
21_I53_V0.7830.74
197_E200_K0.7820.74
369_V390_V0.7800.74
291_P320_A0.7800.74
214_I244_I0.7790.74
291_P326_I0.7760.74
149_I202_I0.7740.74
216_V274_V0.7730.74
366_E391_T0.7720.73
146_N205_K0.7720.73
328_P421_Y0.7700.73
214_I233_G0.7690.73
230_A273_V0.7630.73
79_S83_T0.7610.72
55_L97_G0.7600.72
443_D447_A0.7560.72
35_G38_S0.7540.72
8_E293_D0.7530.72
33_P37_P0.7530.72
200_K204_E0.7530.72
289_I331_R0.7500.71
392_L435_L0.7480.71
282_I285_V0.7460.71
87_M90_T0.7450.71
135_E183_K0.7440.71
276_D282_I0.7410.70
61_T77_M0.7400.70
202_I205_K0.7390.70
87_M157_R0.7360.70
224_L229_V0.7340.70
195_I232_I0.7330.70
443_D449_P0.7300.69
79_S82_L0.7280.69
269_E272_K0.7260.69
187_E190_D0.7230.68
26_M48_R0.7230.68
3_L293_D0.7230.68
241_I280_I0.7220.68
141_I188_Y0.7210.68
268_L301_A0.7210.68
446_M449_P0.7190.68
12_I242_D0.7170.68
211_G245_H0.7160.68
392_L432_E0.7160.68
213_R245_H0.7140.68
343_E354_W0.7120.67
123_A127_I0.7090.67
230_A274_V0.7060.67
145_K201_G0.7040.66
301_A304_V0.7030.66
124_P127_I0.7020.66
196_E236_L0.7000.66
203_K242_D0.7000.66
209_T242_D0.6990.66
324_L424_R0.6990.66
440_E446_M0.6990.66
77_M82_L0.6980.66
145_K194_F0.6970.66
34_E37_P0.6970.66
42_I46_A0.6960.66
28_S44_Y0.6930.65
145_K198_I0.6930.65
138_K145_K0.6920.65
6_L292_V0.6920.65
245_H285_V0.6920.65
80_D83_T0.6910.65
99_K161_D0.6910.65
141_I193_R0.6900.65
122_I140_D0.6890.65
33_P36_Y0.6850.64
403_F418_L0.6810.64
7_L316_W0.6800.64
287_S414_E0.6780.64
367_V453_I0.6780.64
288_V306_L0.6770.63
289_I414_E0.6770.63
92_L95_A0.6770.63
44_Y48_R0.6750.63
216_V271_A0.6750.63
13_G242_D0.6730.63
77_M102_V0.6730.63
83_T157_R0.6710.63
18_K96_L0.6710.63
60_Y105_V0.6700.63
23_M45_L0.6670.62
24_S245_H0.6660.62
189_K193_R0.6660.62
322_R428_R0.6650.62
370_V439_I0.6650.62
13_G203_K0.6650.62
444_C448_I0.6640.62
285_V305_V0.6640.62
335_T345_R0.6590.61
77_M155_A0.6580.61
218_E224_L0.6570.61
309_Q316_W0.6570.61
269_E300_I0.6550.61
327_R378_E0.6550.61
55_L98_S0.6550.61
241_I244_I0.6550.61
101_F243_Y0.6540.61
40_A356_L0.6520.60
39_D42_I0.6520.60
141_I195_I0.6520.60
369_V453_I0.6500.60
392_L426_L0.6500.60
225_T228_I0.6500.60
162_G243_Y0.6490.60
272_K298_R0.6490.60
327_R425_E0.6480.60
37_P75_L0.6450.60
136_M172_L0.6450.60
365_G450_D0.6450.60
346_C350_P0.6440.60
313_D319_K0.6440.60
142_E146_N0.6420.59
409_P412_V0.6420.59
330_I347_D0.6420.59
15_I243_Y0.6420.59
109_R181_T0.6420.59
264_R417_E0.6400.59
192_V231_E0.6390.59
63_V148_F0.6390.59
28_S41_H0.6390.59
80_D151_A0.6380.59
142_E145_K0.6370.59
3_L291_P0.6360.59
381_R421_Y0.6330.58
41_H45_L0.6330.58
17_L22_A0.6330.58
63_V104_L0.6330.58
53_V56_I0.6330.58
366_E450_D0.6320.58
378_E421_Y0.6320.58
394_E439_I0.6310.58
42_I88_R0.6290.58
28_S59_E0.6280.58
327_R418_L0.6270.58
69_R73_N0.6260.57
102_V160_F0.6260.57
394_E407_K0.6260.57
238_K279_N0.6250.57
316_W326_I0.6240.57
429_L433_V0.6240.57
274_V278_V0.6230.57
283_F305_V0.6220.57
372_G435_L0.6220.57
258_M266_A0.6180.56
396_N436_N0.6170.56
78_D82_L0.6170.56
234_K237_E0.6150.56
8_E296_K0.6150.56
269_E273_V0.6140.56
55_L94_H0.6140.56
90_T94_H0.6130.56
151_A154_R0.6130.56
419_I423_E0.6120.56
233_G274_V0.6110.56
64_N67_D0.6110.56
169_H286_G0.6100.55
169_H213_R0.6070.55
178_S218_E0.6050.55
89_L93_I0.6050.55
295_I298_R0.6040.55
216_V229_V0.6040.55
203_K241_I0.6040.55
199_L241_I0.6030.55
106_H133_V0.6020.54
421_Y429_L0.6020.54
125_S135_E0.6020.54
124_P135_E0.6000.54
58_T93_I0.6000.54
420_N423_E0.6000.54
178_S220_D0.5990.54
80_D157_R0.5990.54
23_M310_L0.5990.54
166_H286_G0.5990.54
369_V392_L0.5990.54
152_S206_A0.5970.54
129_I132_E0.5970.54
109_R133_V0.5960.54
189_K235_K0.5960.54
4_S320_A0.5940.54
94_H100_I0.5920.53
141_I194_F0.5910.53
444_C447_A0.5900.53
68_A106_H0.5890.53
15_I18_K0.5880.53
248_A267_F0.5880.53
374_V377_L0.5870.53
289_I417_E0.5860.53
334_Q347_D0.5860.53
56_I100_I0.5860.53
77_M154_R0.5840.52
110_K251_D0.5840.52
368_I448_I0.5840.52
27_I166_H0.5830.52
120_K134_R0.5830.52
124_P181_T0.5830.52
416_Q420_N0.5830.52
82_L151_A0.5810.52
10_I13_G0.5810.52
194_F198_I0.5810.52
13_G209_T0.5800.52
100_I161_D0.5800.52
104_L148_F0.5780.52
17_L99_K0.5780.52
320_A326_I0.5770.51
258_M286_G0.5770.51
103_Q240_G0.5770.51
277_A282_I0.5770.51
80_D150_D0.5760.51
23_M171_Y0.5740.51
34_E38_S0.5740.51
439_I449_P0.5730.51
25_P103_Q0.5730.51
21_I320_A0.5730.51
10_I17_L0.5730.51
268_L288_V0.5720.51
77_M104_L0.5720.51
317_L320_A0.5710.51
214_I229_V0.5710.51
177_L224_L0.5710.51
72_V128_P0.5700.51
7_L18_K0.5700.51
216_V244_I0.5690.50
441_C444_C0.5680.50
28_S344_V0.5670.50
216_V270_E0.5650.50
384_A430_N0.5640.50
24_S306_L0.5640.50
334_Q337_R0.5640.50
105_V258_M0.5630.50
59_E344_V0.5630.50
75_L82_L0.5630.50
152_S202_I0.5630.50
350_P381_R0.5620.50
291_P316_W0.5620.50
313_D326_I0.5610.49
51_G314_P0.5610.49
250_R256_S0.5600.49
399_L426_L0.5590.49
164_E211_G0.5580.49
271_A284_L0.5570.49
202_I206_A0.5560.49
237_E281_P0.5560.49
368_I446_M0.5560.49
198_I201_G0.5560.49
219_F248_A0.5540.49
378_E426_L0.5530.48
61_T93_I0.5500.48
69_R113_K0.5500.48
374_V394_E0.5480.48
88_R91_E0.5470.48
350_P382_V0.5460.48
181_T218_E0.5460.48
275_R282_I0.5450.47
64_N144_V0.5440.47
366_E434_K0.5430.47
258_M267_F0.5430.47
213_R247_S0.5420.47
179_P222_E0.5420.47
175_Q215_S0.5410.47
218_E223_G0.5400.47
125_S183_K0.5390.47
434_K439_I0.5390.47
244_I274_V0.5390.47
27_I60_Y0.5380.47
284_L295_I0.5370.47
220_D253_P0.5350.46
272_K275_R0.5350.46
347_D402_Q0.5350.46
106_H247_S0.5340.46
378_E422_Y0.5330.46
4_S8_E0.5320.46
267_F287_S0.5310.46
22_A54_G0.5310.46
268_L294_A0.5310.46
402_Q405_L0.5310.46
328_P348_V0.5300.46
307_G412_V0.5290.46
370_V443_D0.5270.45
214_I224_L0.5270.45
109_R171_Y0.5260.45
174_A218_E0.5260.45
34_E150_D0.5250.45
423_E426_L0.5240.45
129_I133_V0.5240.45
178_S221_N0.5220.45
30_L352_L0.5220.45
361_E382_V0.5210.45
43_A47_E0.5200.44
23_M56_I0.5200.44
140_D144_V0.5170.44
243_Y303_V0.5170.44
331_R405_L0.5170.44
141_I176_F0.5170.44
335_T340_V0.5170.44
214_I246_L0.5160.44
74_E105_V0.5160.44
199_L210_V0.5160.44
26_M44_Y0.5160.44
370_V452_E0.5150.44
11_R242_D0.5150.44
361_E365_G0.5150.44
8_E320_A0.5150.44
318_E324_L0.5140.44
406_Y409_P0.5130.44
464_L468_S0.5130.44
314_P317_L0.5120.43
175_Q249_G0.5110.43
150_D201_G0.5100.43
344_V353_G0.5100.43
334_Q338_G0.5090.43
23_M307_G0.5090.43
230_A276_D0.5090.43
372_G423_E0.5090.43
374_V403_F0.5080.43
310_L316_W0.5070.43
108_G171_Y0.5070.43
167_G173_L0.5060.43
191_G228_I0.5050.43
146_N448_I0.5030.42
227_E231_E0.5030.42
128_P132_E0.5030.42
324_L428_R0.5030.42
145_K197_E0.5030.42
164_E245_H0.5010.42
146_N149_I0.5010.42
123_A175_Q0.5000.42
44_Y307_G0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1o94A 2 0.9856 100 0.486 Contact Map
3k30A 2 0.9748 100 0.487 Contact Map
1ps9A 1 0.9784 100 0.505 Contact Map
2hsaB 2 0.6144 100 0.616 Contact Map
3l5aA 1 0.6396 100 0.618 Contact Map
3tjlA 2 0.6486 100 0.619 Contact Map
4tmbA 2 0.6378 100 0.622 Contact Map
4qnwA 1 0.6288 100 0.623 Contact Map
4gbuA 2 0.6378 100 0.624 Contact Map
4e2bA 1 0.6018 100 0.626 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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