GREMLIN Database
Q97WT7 - Uncharacterized protein
UniProt: Q97WT7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 189 (149)
Sequences: 14721 (10988)
Seq/√Len: 900.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_T65_T2.7301.00
73_E95_V2.7021.00
50_C68_A2.6311.00
130_E133_R2.3701.00
43_Y111_F2.2861.00
67_Y109_I2.2521.00
56_T66_V2.2471.00
104_I109_I2.2031.00
69_V96_A2.1561.00
79_L93_P2.1321.00
46_V109_I2.1011.00
131_I141_A2.0891.00
49_G117_M2.0571.00
40_K43_Y2.0421.00
65_T92_I2.0041.00
112_V131_I1.9941.00
132_K171_I1.9801.00
67_Y94_Y1.9531.00
76_I93_P1.9471.00
73_E77_R1.9341.00
135_L139_G1.8391.00
123_D126_G1.8111.00
110_D136_K1.8011.00
45_V59_L1.7841.00
125_N129_K1.7731.00
76_I95_V1.7651.00
48_L131_I1.7381.00
76_I80_K1.7321.00
61_R86_L1.6791.00
135_L141_A1.6191.00
44_T136_K1.6091.00
44_T67_Y1.5951.00
112_V135_L1.5941.00
48_L98_A1.5711.00
130_E134_I1.5391.00
57_T83_V1.5381.00
117_M121_T1.5331.00
83_V93_P1.4971.00
50_C56_T1.4911.00
94_Y104_I1.4681.00
78_R81_E1.4641.00
71_P97_P1.4551.00
96_A102_E1.4391.00
67_Y92_I1.4231.00
45_V111_F1.4081.00
57_T82_K1.3511.00
121_T127_A1.3231.00
39_L43_Y1.3231.00
70_D76_I1.3191.00
114_S117_M1.3101.00
44_T109_I1.3021.00
106_D133_R1.2811.00
163_K167_G1.2431.00
105_K108_S1.2351.00
60_A90_N1.2261.00
68_A93_P1.1991.00
56_T68_A1.1961.00
119_C145_V1.1831.00
44_T108_S1.1811.00
125_N168_Q1.1741.00
116_L119_C1.1471.00
74_R77_R1.1071.00
164_K168_Q1.1011.00
77_R80_K1.0921.00
57_T86_L1.0871.00
97_P100_K1.0831.00
49_G114_S1.0731.00
72_D75_A1.0671.00
30_R34_R1.0601.00
101_L134_I1.0591.00
98_A121_T1.0531.00
118_L121_T1.0471.00
127_A131_I1.0441.00
67_Y104_I1.0381.00
58_I61_R1.0221.00
116_L120_C1.0161.00
101_L104_I1.0101.00
47_D50_C1.0091.00
46_V112_V1.0041.00
24_L27_P1.0021.00
50_C79_L0.9901.00
29_N58_I0.9851.00
68_A79_L0.9821.00
44_T110_D0.9751.00
158_S161_E0.9691.00
98_A117_M0.9641.00
112_V134_I0.9641.00
59_L113_F0.9621.00
52_P82_K0.9591.00
56_T91_V0.9571.00
53_G79_L0.9521.00
30_R33_S0.9491.00
39_L42_D0.9451.00
120_C145_V0.9451.00
29_N33_S0.9281.00
46_V134_I0.9261.00
159_G163_K0.9211.00
115_N144_S0.9201.00
82_K85_K0.9131.00
126_G129_K0.9121.00
101_L130_E0.9091.00
83_V91_V0.9051.00
55_F113_F0.8971.00
126_G130_E0.8871.00
164_K167_G0.8671.00
52_P75_A0.8591.00
58_I62_I0.8591.00
24_L28_P0.8471.00
69_V101_L0.8361.00
108_S136_K0.8211.00
102_E130_E0.8211.00
99_Q123_D0.8191.00
69_V94_Y0.8171.00
45_V66_V0.8131.00
81_E85_K0.8121.00
116_L144_S0.8091.00
56_T93_P0.7981.00
55_F115_N0.7931.00
81_E84_Q0.7891.00
116_L146_T0.7851.00
82_K86_L0.7841.00
111_F140_L0.7841.00
57_T88_L0.7831.00
77_R81_E0.7771.00
70_D75_A0.7631.00
80_K93_P0.7621.00
33_S62_I0.7611.00
167_G171_I0.7561.00
131_I135_L0.7551.00
128_I166_L0.7401.00
48_L112_V0.7341.00
32_L35_F0.7171.00
43_Y110_D0.7151.00
118_L128_I0.7141.00
124_H165_I0.7131.00
28_P31_I0.7111.00
47_D120_C0.7081.00
57_T60_A0.7071.00
114_S131_I0.7061.00
167_G173_R0.7041.00
159_G162_W0.6981.00
168_Q171_I0.6961.00
99_Q122_S0.6931.00
54_F58_I0.6891.00
42_D64_K0.6891.00
57_T61_R0.6871.00
31_I142_Y0.6871.00
100_K126_G0.6781.00
61_R88_L0.6741.00
45_V113_F0.6721.00
80_K84_Q0.6711.00
124_H127_A0.6711.00
75_A116_L0.6671.00
35_F142_Y0.6641.00
88_L91_V0.6611.00
52_P78_R0.6601.00
109_I134_I0.6551.00
47_D66_V0.6531.00
68_A91_V0.6511.00
31_I34_R0.6501.00
78_R82_K0.6341.00
161_E167_G0.6291.00
106_D130_E0.6281.00
125_N165_I0.6271.00
23_S27_P0.6231.00
99_Q126_G0.6231.00
157_V161_E0.6201.00
125_N169_F0.6181.00
74_R78_R0.6171.00
25_V29_N0.6161.00
53_G93_P0.6141.00
114_S141_A0.6101.00
48_L69_V0.6061.00
156_D159_G0.6001.00
99_Q127_A0.5981.00
160_D163_K0.5971.00
28_P55_F0.5941.00
119_C146_T0.5921.00
28_P32_L0.5921.00
161_E164_K0.5911.00
80_K83_V0.5911.00
50_C76_I0.5861.00
80_K92_I0.5861.00
83_V87_S0.5841.00
166_L170_K0.5841.00
114_S121_T0.5841.00
129_K133_R0.5831.00
166_L171_I0.5761.00
83_V86_L0.5751.00
160_D167_G0.5751.00
73_E80_K0.5701.00
114_S143_I0.5641.00
22_R26_S0.5601.00
118_L143_I0.5591.00
111_F139_G0.5571.00
50_C93_P0.5461.00
36_V40_K0.5451.00
25_V28_P0.5431.00
56_T60_A0.5391.00
102_E134_I0.5381.00
47_D68_A0.5371.00
151_I154_K0.5331.00
63_V66_V0.5331.00
160_D164_K0.5331.00
118_L124_H0.5301.00
107_K137_D0.5291.00
118_L127_A0.5281.00
55_F59_L0.5271.00
35_F39_L0.5231.00
157_V162_W0.5221.00
167_G172_I0.5211.00
155_M158_S0.5211.00
166_L173_R0.5201.00
39_L111_F0.5171.00
54_F82_K0.5161.00
66_V91_V0.5141.00
49_G121_T0.5101.00
104_I134_I0.5091.00
32_L59_L0.5081.00
156_D161_E0.5081.00
26_S29_N0.5061.00
129_K132_K0.5061.00
135_L171_I0.5061.00
96_A101_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vl5A 1 0.8571 100 0.375 Contact Map
4pneA 2 0.9788 100 0.399 Contact Map
2o57A 2 0.9735 100 0.4 Contact Map
1xxlA 1 0.8624 100 0.402 Contact Map
4htfA 2 0.9524 100 0.408 Contact Map
3sm3A 2 0.8466 100 0.412 Contact Map
3dh0A 1 0.9577 100 0.413 Contact Map
4ineA 2 0.9841 100 0.415 Contact Map
3vc1A 5 0.9841 100 0.416 Contact Map
1ve3A 2 0.9683 100 0.416 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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