GREMLIN Database
Q97WT6 - 2-haloalkanoic acid dehalogenase
UniProt: Q97WT6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 212 (194)
Sequences: 27200 (21703)
Seq/√Len: 1558.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_I156_K3.0731.00
123_E128_V3.0701.00
142_I146_N3.0001.00
175_A182_A2.8041.00
165_G171_D2.6611.00
4_A159_Y2.6301.00
99_E130_Y2.5941.00
95_M99_E2.4771.00
152_I155_L2.4451.00
116_P119_K2.4051.00
107_K132_D2.3811.00
116_P139_E2.3481.00
109_I133_D2.2911.00
111_L149_I2.2541.00
142_I148_K2.1691.00
199_R203_E2.1131.00
172_Y182_A2.0581.00
133_D156_K2.0541.00
154_I180_V2.0051.00
7_V108_L1.9561.00
173_V177_R1.9271.00
100_T104_T1.9111.00
5_I106_T1.8501.00
6_F163_H1.8121.00
102_R130_Y1.8111.00
163_H175_A1.8081.00
102_R132_D1.7811.00
75_I79_R1.7681.00
162_L183_I1.7661.00
36_D39_R1.7441.00
108_L131_F1.7241.00
6_F111_L1.6361.00
4_A157_G1.6351.00
186_D199_R1.6351.00
6_F153_A1.6071.00
112_S118_T1.5941.00
94_V201_L1.5801.00
154_I161_A1.5491.00
76_S80_G1.5361.00
5_I164_I1.5011.00
5_I101_I1.4771.00
186_D197_K1.4491.00
119_K128_V1.4261.00
183_I198_V1.4231.00
74_L77_H1.4001.00
12_T164_I1.3971.00
109_I157_G1.3901.00
91_Y187_R1.3861.00
97_F201_L1.3671.00
191_Y195_K1.3471.00
200_N203_E1.3401.00
100_T103_S1.3401.00
9_F14_V1.3091.00
13_L94_V1.3031.00
9_F110_L1.2931.00
30_E81_S1.2741.00
72_D76_S1.2711.00
26_T30_E1.2701.00
64_Y67_N1.2691.00
93_D96_E1.2551.00
150_F163_H1.2491.00
135_V156_K1.2401.00
90_I127_L1.2291.00
77_H81_S1.2131.00
135_V153_A1.2051.00
27_I31_H1.1841.00
169_E173_V1.1691.00
45_V49_A1.1551.00
150_F174_G1.1531.00
147_P151_A1.1471.00
176_R182_A1.1261.00
9_F118_T1.1261.00
119_K123_E1.1161.00
63_L66_L1.1161.00
150_F180_V1.1151.00
96_E202_R1.1101.00
74_L78_I1.1091.00
46_K50_V1.1071.00
111_L153_A1.1041.00
4_A107_K1.0991.00
151_A155_L1.0971.00
22_E26_T1.0841.00
99_E103_S1.0831.00
9_F114_S1.0771.00
10_G16_F1.0691.00
116_P136_L1.0661.00
118_T136_L1.0541.00
83_I86_G1.0531.00
61_E64_Y1.0531.00
45_V48_M1.0501.00
75_I78_I1.0491.00
76_S79_R1.0331.00
73_R77_H1.0321.00
126_G129_K1.0311.00
148_K152_I1.0221.00
98_L131_F1.0161.00
150_F165_G1.0081.00
25_Q29_R1.0081.00
67_N70_P1.0051.00
133_D157_G1.0051.00
95_M130_Y1.0001.00
26_T29_R0.9981.00
48_M51_N0.9931.00
102_R108_L0.9931.00
99_E129_K0.9891.00
162_L181_D0.9851.00
44_Y48_M0.9761.00
120_K124_E0.9761.00
22_E87_E0.9631.00
163_H180_V0.9611.00
96_E99_E0.9551.00
110_L131_F0.9521.00
116_P138_H0.9511.00
93_D200_N0.9411.00
30_E74_L0.9361.00
28_L33_Y0.9301.00
43_A46_K0.9301.00
170_I173_V0.9281.00
141_G148_K0.9281.00
22_E25_Q0.9271.00
164_I183_I0.9251.00
153_A157_G0.9241.00
6_F157_G0.9241.00
101_I106_T0.9231.00
184_L197_K0.9201.00
151_A178_S0.9131.00
148_K151_A0.9131.00
120_K123_E0.9131.00
25_Q37_I0.9071.00
112_S136_L0.8951.00
172_Y184_L0.8861.00
74_L81_S0.8821.00
140_I152_I0.8801.00
136_L139_E0.8761.00
98_L130_Y0.8761.00
10_G114_S0.8741.00
90_I95_M0.8741.00
72_D75_I0.8711.00
72_D79_R0.8651.00
4_A109_I0.8641.00
149_I153_A0.8611.00
60_K64_Y0.8611.00
3_R106_T0.8601.00
6_F180_V0.8571.00
135_V152_I0.8551.00
109_I153_A0.8321.00
39_R42_R0.8271.00
192_P195_K0.8241.00
59_I62_F0.8201.00
9_F121_L0.8191.00
108_L130_Y0.8181.00
198_V204_I0.8161.00
20_F24_L0.8161.00
10_G112_S0.8151.00
91_Y185_L0.8071.00
41_F44_Y0.8061.00
5_I162_L0.7971.00
91_Y94_V0.7921.00
184_L194_I0.7851.00
101_I108_L0.7831.00
23_K27_I0.7821.00
21_Y25_Q0.7801.00
61_E65_N0.7741.00
74_L79_R0.7741.00
150_F171_D0.7741.00
164_I204_I0.7711.00
95_M129_K0.7701.00
3_R107_K0.7681.00
93_D202_R0.7651.00
161_A180_V0.7631.00
174_G178_S0.7601.00
3_R159_Y0.7591.00
113_N143_V0.7571.00
167_I170_I0.7541.00
38_R42_R0.7531.00
59_I63_L0.7521.00
30_E77_H0.7441.00
26_T81_S0.7411.00
77_H80_G0.7361.00
95_M126_G0.7351.00
151_A161_A0.7331.00
191_Y199_R0.7261.00
10_G166_D0.7231.00
20_F114_S0.7221.00
73_R76_S0.7191.00
187_R201_L0.7141.00
149_I174_G0.7131.00
154_I159_Y0.7121.00
108_L132_D0.7101.00
71_S74_L0.7101.00
139_E156_K0.7051.00
37_I41_F0.7041.00
122_L128_V0.7041.00
18_P89_F0.7031.00
133_D153_A0.7001.00
44_Y47_A0.7001.00
183_I204_I0.6931.00
29_R34_D0.6931.00
96_E100_T0.6891.00
14_V125_L0.6881.00
154_I160_P0.6881.00
47_A51_N0.6851.00
135_V149_I0.6811.00
47_A50_V0.6811.00
11_N17_K0.6801.00
173_V176_R0.6781.00
45_V51_N0.6781.00
163_H171_D0.6761.00
6_F109_I0.6761.00
185_L201_L0.6731.00
93_D97_F0.6711.00
14_V121_L0.6691.00
26_T83_I0.6671.00
147_P177_R0.6631.00
119_K134_L0.6601.00
154_I178_S0.6591.00
198_V201_L0.6571.00
46_K51_N0.6551.00
90_I125_L0.6531.00
19_A88_A0.6461.00
163_H174_G0.6461.00
10_G121_L0.6441.00
21_Y40_V0.6441.00
15_G89_F0.6431.00
12_T185_L0.6411.00
107_K159_Y0.6351.00
43_A47_A0.6341.00
113_N170_I0.6311.00
39_R43_A0.6291.00
82_D86_G0.6251.00
31_H74_L0.6251.00
191_Y194_I0.6181.00
111_L135_V0.6181.00
44_Y51_N0.6151.00
44_Y49_A0.6131.00
97_F164_I0.6111.00
15_G18_P0.6101.00
14_V88_A0.6091.00
150_F175_A0.6081.00
114_S165_G0.6081.00
123_E129_K0.6001.00
41_F48_M0.5961.00
94_V97_F0.5931.00
140_I149_I0.5921.00
131_F134_L0.5901.00
85_D120_K0.5891.00
35_V39_R0.5881.00
170_I174_G0.5861.00
93_D187_R0.5851.00
94_V98_L0.5841.00
64_Y68_I0.5831.00
186_D191_Y0.5811.00
18_P22_E0.5801.00
92_D200_N0.5801.00
111_L163_H0.5751.00
62_F66_L0.5721.00
176_R196_E0.5721.00
12_T171_D0.5711.00
114_S118_T0.5691.00
102_R129_K0.5681.00
114_S171_D0.5681.00
40_V43_A0.5651.00
118_T121_L0.5621.00
21_Y37_I0.5611.00
99_E102_R0.5591.00
97_F100_T0.5591.00
118_T134_L0.5561.00
92_D202_R0.5511.00
35_V40_V0.5511.00
6_F150_F0.5501.00
137_S149_I0.5451.00
70_P73_R0.5421.00
7_V97_F0.5411.00
63_L68_I0.5401.00
151_A154_I0.5391.00
97_F198_V0.5351.00
27_I30_E0.5331.00
176_R181_D0.5271.00
38_R41_F0.5271.00
62_F68_I0.5271.00
41_F45_V0.5241.00
16_F114_S0.5221.00
30_E78_I0.5191.00
13_L110_L0.5171.00
97_F101_I0.5171.00
16_F20_F0.5131.00
64_Y71_S0.5131.00
15_G91_Y0.5111.00
22_E83_I0.5071.00
67_N71_S0.5041.00
24_L28_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zg6A 2 0.9434 100 0.282 Contact Map
4uw9A 1 0.9245 100 0.312 Contact Map
3iruA 4 0.9953 100 0.345 Contact Map
1swvA 2 0.9953 100 0.348 Contact Map
3nasA 2 0.9104 100 0.359 Contact Map
1te2A 2 0.9481 100 0.359 Contact Map
3smvA 1 0.9717 100 0.36 Contact Map
3l5kA 1 0.9623 100 0.362 Contact Map
4uasA 1 0.967 100 0.362 Contact Map
3s6jA 2 0.9623 100 0.363 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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