GREMLIN Database
Q97WT3 - Uncharacterized protein
UniProt: Q97WT3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 321 (250)
Sequences: 3126 (2524)
Seq/√Len: 159.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
286_F291_Y5.8061.00
136_W151_L3.7981.00
55_K180_T3.6721.00
133_T154_E3.6501.00
215_L259_G3.5271.00
134_V152_T3.3991.00
54_T286_F3.3821.00
52_P284_L3.1711.00
133_T153_L3.0301.00
45_T48_Y2.9911.00
50_L293_G2.9911.00
134_V137_T2.8131.00
140_S149_Q2.7681.00
58_L297_I2.6301.00
135_I156_L2.5721.00
79_L168_P2.4521.00
234_K237_S2.4401.00
50_L54_T2.4001.00
44_N49_K2.3901.00
217_D221_K2.3491.00
291_Y295_A2.3251.00
55_K179_T2.2941.00
85_Y175_L2.2791.00
54_T294_T2.2101.00
94_K98_A2.2001.00
189_F194_I2.1521.00
302_I306_V2.1211.00
219_S223_Q2.1081.00
134_V150_Q2.0621.00
193_K196_I2.0381.00
137_T150_Q1.9641.00
288_R292_Y1.9371.00
274_A277_S1.9161.00
220_V224_Y1.8921.00
115_P159_G1.7241.00
60_I64_T1.7151.00
156_L160_L1.6961.00
47_L89_N1.6781.00
47_L85_Y1.6741.00
131_Q154_E1.6541.00
208_M263_L1.6531.00
286_F294_T1.6431.00
115_P151_L1.6231.00
194_I198_I1.6211.00
292_Y296_I1.5991.00
59_T176_F1.5841.00
219_S252_T1.5761.00
212_I256_L1.5661.00
157_I160_L1.5441.00
139_P149_Q1.4861.00
233_P238_S1.4851.00
136_W139_P1.4661.00
46_F88_L1.4271.00
221_K224_Y1.4081.00
66_A78_T1.4001.00
131_Q134_V1.3981.00
236_V243_Y1.3951.00
200_F204_V1.3811.00
231_S238_S1.3771.00
187_R190_T1.3721.00
140_S150_Q1.3701.00
136_W140_S1.3651.00
98_A101_L1.3591.00
233_P237_S1.3391.00
137_T140_S1.3371.00
189_F193_K1.3181.00
176_F185_I1.3171.00
287_T290_D1.3131.00
153_L157_I1.2961.00
49_K289_V1.2931.00
61_V301_I1.2851.00
62_V172_S1.2821.00
111_W163_T1.2761.00
223_Q251_P1.2761.00
135_I151_L1.2471.00
206_I210_P1.2361.00
265_I268_D1.2231.00
158_Y162_T1.2231.00
164_F168_P1.2091.00
200_F272_F1.2031.00
75_A168_P1.1981.00
105_T109_G1.1891.00
43_G46_F1.1861.00
216_L220_V1.1811.00
72_W76_I1.1691.00
96_G171_L1.1671.00
50_L289_V1.1631.00
289_V292_Y1.1501.00
201_S205_G1.1481.00
43_G90_D1.1421.00
73_I76_I1.1351.00
103_L107_L1.1331.00
72_W161_Q1.1321.00
210_P251_P1.1261.00
135_I138_F1.1251.00
157_I161_Q1.1151.00
197_A212_I1.1121.00
199_T210_P1.1101.00
212_I216_L1.1001.00
59_T172_S1.0971.00
234_K238_S1.0910.99
296_I299_A1.0840.99
135_I152_T1.0830.99
87_T90_D1.0730.99
135_I153_L1.0680.99
82_L172_S1.0630.99
210_P264_A1.0610.99
103_L106_I1.0560.99
267_A272_F1.0460.99
187_R191_K1.0460.99
192_I195_P1.0300.99
295_A302_I1.0190.99
92_V95_F1.0100.99
73_I77_L1.0070.99
43_G48_Y1.0020.99
100_F103_L1.0000.99
233_P244_A0.9910.99
65_V300_L0.9830.99
65_V301_I0.9780.99
38_T41_E0.9780.99
135_I154_E0.9770.99
71_W74_G0.9750.99
46_F289_V0.9710.99
205_G258_R0.9610.99
110_T114_A0.9600.99
288_R291_Y0.9530.99
128_S131_Q0.9530.99
162_T209_I0.9470.99
237_S243_Y0.9460.99
212_I263_L0.9440.99
65_V74_G0.9420.98
155_A159_G0.9390.98
72_W157_I0.9330.98
160_L163_T0.9310.98
101_L105_T0.9260.98
186_F189_F0.9260.98
105_T108_G0.9230.98
159_G189_F0.9210.98
66_A168_P0.9110.98
133_T137_T0.9110.98
54_T293_G0.9040.98
291_Y294_T0.9030.98
66_A172_S0.8960.98
154_E158_Y0.8950.98
62_V66_A0.8930.98
53_V188_M0.8920.98
303_I306_V0.8920.98
128_S152_T0.8910.98
227_G251_P0.8890.98
197_A272_F0.8860.98
252_T267_A0.8850.98
223_Q244_A0.8850.98
53_V284_L0.8850.98
173_A199_T0.8750.98
296_I300_L0.8710.97
211_R263_L0.8700.97
83_L87_T0.8700.97
64_T67_A0.8610.97
286_F290_D0.8540.97
102_A105_T0.8460.97
54_T291_Y0.8440.97
96_G175_L0.8430.97
97_Y101_L0.8400.97
207_R263_L0.8360.97
259_G262_N0.8290.97
104_S167_A0.8290.97
65_V69_T0.8210.96
94_K101_L0.8170.96
215_L218_T0.8150.96
218_T262_N0.8140.96
220_V248_A0.8100.96
197_A274_A0.8090.96
287_T291_Y0.8080.96
190_T193_K0.8050.96
131_Q152_T0.8020.96
182_G212_I0.8010.96
297_I301_I0.8010.96
58_L85_Y0.7980.96
293_G297_I0.7970.96
87_T93_R0.7940.96
113_I126_F0.7930.96
80_V83_L0.7920.96
295_A298_A0.7910.96
207_R252_T0.7880.95
303_I307_A0.7880.95
59_T163_T0.7870.95
78_T300_L0.7840.95
285_K288_R0.7840.95
51_N284_L0.7790.95
84_S88_L0.7790.95
292_Y302_I0.7710.95
138_F149_Q0.7630.95
149_Q155_A0.7550.94
106_I166_V0.7550.94
87_T303_I0.7540.94
213_F296_I0.7500.94
298_A301_I0.7470.94
139_P150_Q0.7460.94
223_Q247_E0.7450.94
47_L50_L0.7430.94
78_T168_P0.7360.94
58_L293_G0.7350.93
102_A113_I0.7350.93
69_T74_G0.7340.93
237_S244_A0.7290.93
189_F196_I0.7290.93
302_I305_I0.7260.93
138_F150_Q0.7250.93
183_S188_M0.7220.93
295_A306_V0.7220.93
153_L158_Y0.7200.93
50_L290_D0.7200.93
185_I252_T0.7190.93
182_G210_P0.7160.93
271_G274_A0.7140.92
165_R216_L0.7100.92
199_T264_A0.7050.92
216_L252_T0.7020.92
288_R302_I0.6980.92
77_L80_V0.6970.92
69_T107_L0.6940.91
44_N90_D0.6920.91
57_V294_T0.6910.91
168_P172_S0.6900.91
154_E157_I0.6880.91
84_S87_T0.6840.91
53_V290_D0.6820.91
182_G185_I0.6810.91
39_R214_E0.6810.91
47_L88_L0.6770.90
257_F264_A0.6760.90
190_T196_I0.6720.90
198_I248_A0.6720.90
85_Y138_F0.6710.90
45_T49_K0.6700.90
103_L205_G0.6700.90
79_L83_L0.6670.90
201_S259_G0.6650.90
255_Y268_D0.6640.90
87_T288_R0.6620.89
177_I272_F0.6610.89
77_L303_I0.6600.89
69_T304_A0.6580.89
41_E92_V0.6570.89
184_D280_S0.6560.89
94_K97_Y0.6540.89
77_L256_L0.6490.88
76_I288_R0.6490.88
93_R97_Y0.6480.88
107_L110_T0.6480.88
298_A302_I0.6480.88
131_Q136_W0.6460.88
46_F78_T0.6450.88
62_V82_L0.6370.88
62_V297_I0.6360.87
197_A200_F0.6340.87
85_Y307_A0.6340.87
175_L180_T0.6320.87
253_M257_F0.6310.87
229_G257_F0.6310.87
114_A159_G0.6300.87
114_A162_T0.6280.87
74_G308_N0.6260.87
80_V87_T0.6260.87
218_T259_G0.6240.86
208_M211_R0.6240.86
86_L96_G0.6220.86
84_S96_G0.6210.86
138_F160_L0.6190.86
39_R265_I0.6180.86
172_S175_L0.6160.86
188_M272_F0.6150.86
186_F190_T0.6140.86
250_I258_R0.6110.85
259_G267_A0.6100.85
225_I269_T0.6100.85
63_M181_T0.6090.85
132_F136_W0.6080.85
190_T204_V0.6070.85
79_L164_F0.6070.85
258_R263_L0.6060.85
184_D187_R0.6040.85
93_R303_I0.6040.85
246_F249_I0.6030.85
57_V95_F0.6030.85
70_I75_A0.6030.85
204_V263_L0.6020.84
51_N188_M0.5990.84
79_L172_S0.5980.84
46_F288_R0.5970.84
291_Y296_I0.5960.84
106_I110_T0.5960.84
199_T203_L0.5960.84
78_T299_A0.5960.84
114_A155_A0.5960.84
67_A263_L0.5940.84
46_F83_L0.5940.84
96_G200_F0.5910.83
59_T173_A0.5880.83
134_V138_F0.5880.83
127_P131_Q0.5870.83
131_Q153_L0.5860.83
210_P227_G0.5830.83
57_V306_V0.5820.82
210_P215_L0.5820.82
57_V185_I0.5810.82
87_T306_V0.5800.82
212_I259_G0.5780.82
99_F178_T0.5760.82
193_K199_T0.5760.82
208_M259_G0.5740.82
204_V267_A0.5740.82
109_G113_I0.5710.81
214_E217_D0.5680.81
155_A265_I0.5670.81
65_V306_V0.5660.81
203_L282_V0.5640.80
134_V140_S0.5640.80
289_V306_V0.5620.80
218_T222_M0.5610.80
106_I113_I0.5610.80
63_M233_P0.5570.80
157_I292_Y0.5570.80
254_V257_F0.5570.80
205_G267_A0.5550.79
181_T184_D0.5530.79
271_G281_L0.5530.79
300_L304_A0.5520.79
56_V196_I0.5480.79
116_Y151_L0.5450.78
166_V200_F0.5450.78
289_V303_I0.5410.78
273_R280_S0.5390.77
132_F152_T0.5370.77
245_I257_F0.5370.77
47_L170_L0.5360.77
224_Y248_A0.5360.77
208_M264_A0.5360.77
65_V193_K0.5350.77
161_Q165_R0.5340.77
136_W153_L0.5310.76
266_S279_T0.5310.76
284_L290_D0.5300.76
68_T305_I0.5290.76
228_L269_T0.5290.76
231_S236_V0.5270.76
207_R211_R0.5260.76
91_G178_T0.5260.76
238_S244_A0.5230.75
267_A270_R0.5230.75
211_R259_G0.5220.75
200_F255_Y0.5210.75
90_D288_R0.5210.75
136_W149_Q0.5190.75
293_G296_I0.5180.75
66_A81_L0.5180.75
223_Q248_A0.5180.75
84_S157_I0.5170.74
278_R290_D0.5160.74
161_Q256_L0.5130.74
55_K226_R0.5130.74
160_L288_R0.5130.74
187_R224_Y0.5130.74
137_T285_K0.5130.74
49_K296_I0.5110.74
182_G206_I0.5100.73
84_S288_R0.5060.73
76_I80_V0.5050.73
105_T115_P0.5050.73
103_L114_A0.5040.73
41_E91_G0.5040.73
162_T271_G0.5030.72
82_L171_L0.5020.72
76_I236_V0.5010.72
46_F296_I0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4huqT 1 0.7383 100 0.348 Contact Map
1rh5C 1 0.0997 15.1 0.961 Contact Map
2l0eA 1 0.0966 10.9 0.964 Contact Map
2mc7A 1 0.0935 4.3 0.97 Contact Map
3hd7A 1 0.2523 3.1 0.972 Contact Map
1lbjA 1 0.0654 2.6 0.973 Contact Map
3p0bA 1 0.1776 2.3 0.974 Contact Map
3dinD 1 0.1433 2.2 0.974 Contact Map
3dl8C 1 0.0872 2.1 0.974 Contact Map
2b5dX 3 0.1869 2 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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