GREMLIN Database
Q97WS4 - Allantoin permease
UniProt: Q97WS4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 492 (425)
Sequences: 4814 (3122)
Seq/√Len: 151.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
408_A476_I7.0351.00
419_K422_D6.7601.00
408_A480_L5.9141.00
446_I478_I4.4101.00
98_G255_P4.3311.00
77_L284_F3.4831.00
443_A478_I3.4251.00
443_A447_G3.2911.00
211_I215_T3.2881.00
236_I240_I3.0781.00
447_G475_S2.9871.00
412_I476_I2.9601.00
447_G478_I2.9471.00
79_I236_I2.8821.00
36_P39_A2.8571.00
443_A482_L2.8021.00
82_I240_I2.7501.00
404_G408_A2.7011.00
409_H414_G2.6711.00
405_V444_M2.6651.00
450_V474_L2.6301.00
72_G75_I2.5601.00
438_V442_V2.5591.00
86_T244_A2.5321.00
339_N343_N2.2961.00
412_I480_L2.2511.00
441_L445_I2.2381.00
377_A380_L2.1871.00
207_G211_I2.1841.00
40_K102_G2.1491.00
210_M281_L2.0901.00
404_G472_L2.0711.00
30_P39_A2.0651.00
451_P471_G2.0571.00
37_K263_S2.0021.00
76_A287_V1.9851.00
474_L478_I1.9631.00
310_P314_M1.9601.00
120_V441_L1.9581.00
95_G258_T1.9571.00
262_R266_D1.9541.00
478_I482_L1.9381.00
137_T180_N1.9361.00
133_F339_N1.9231.00
111_P418_I1.9171.00
133_F373_G1.9091.00
171_I175_L1.9071.00
116_R119_R1.8951.00
97_I108_S1.8741.00
309_N312_N1.8721.00
480_L484_R1.8551.00
100_K264_Q1.8301.00
447_G474_L1.8261.00
366_A370_A1.8221.00
310_P313_I1.8211.00
140_G176_F1.7991.00
422_D425_K1.7981.00
73_P77_L1.7901.00
132_W135_V1.7791.00
112_M409_H1.7781.00
30_P33_A1.7611.00
446_I474_L1.7461.00
178_F182_L1.7291.00
469_Y473_F1.7231.00
473_F476_I1.7151.00
193_K196_L1.7131.00
177_W374_L1.7111.00
404_G475_S1.6981.00
477_A481_G1.6951.00
44_W266_D1.6851.00
78_M236_I1.6751.00
54_M341_A1.6741.00
419_K429_R1.6571.00
131_F391_V1.6521.00
186_K190_D1.6481.00
442_V482_L1.6041.00
269_I273_I1.5861.00
98_G258_T1.5811.00
74_L78_M1.5791.00
210_M285_I1.5601.00
422_D429_R1.5601.00
359_L368_V1.5561.00
476_I480_L1.5531.00
405_V443_A1.5461.00
376_Y380_L1.5451.00
145_D172_S1.5331.00
92_Y272_T1.5331.00
174_F178_F1.5131.00
118_A353_S1.5081.00
481_G484_R1.5071.00
204_I208_G1.4961.00
120_V436_Y1.4931.00
141_G172_S1.4791.00
80_I287_V1.4711.00
449_S453_I1.4691.00
180_N339_N1.4661.00
436_Y441_L1.4641.00
79_I239_A1.4601.00
108_S255_P1.4571.00
46_N196_L1.4561.00
404_G476_I1.4491.00
473_F477_A1.4151.00
228_G231_V1.4071.00
401_S471_G1.3891.00
440_A443_A1.3871.00
422_D428_G1.3851.00
43_T46_N1.3851.00
181_V370_A1.3841.00
405_V440_A1.3841.00
236_I239_A1.3791.00
263_S266_D1.3721.00
113_F440_A1.3691.00
347_P369_S1.3471.00
413_L480_L1.3411.00
458_P461_S1.3361.00
409_H413_L1.3321.00
134_S373_G1.3231.00
425_K428_G1.3171.00
71_F79_I1.3001.00
183_V194_F1.2981.00
440_A479_Y1.2951.00
266_D270_G1.2941.00
458_P462_L1.2751.00
80_I283_S1.2611.00
136_E343_N1.2501.00
407_I411_W1.2401.00
112_M406_M1.2381.00
129_A253_N1.2331.00
276_P280_L1.2271.00
30_P35_L1.2231.00
403_A407_I1.2211.00
454_G470_L1.2181.00
170_T174_F1.2161.00
265_K269_I1.2121.00
445_I449_S1.2071.00
30_P36_P1.1921.00
78_M82_I1.1911.00
83_A240_I1.1901.00
281_L285_I1.1851.00
133_F370_A1.1821.00
52_A278_L1.1781.00
89_I93_L1.1761.00
260_F349_Y1.1731.00
142_L309_N1.1701.00
131_F392_I1.1671.00
366_A369_S1.1631.00
474_L477_A1.1611.00
234_P237_A1.1571.00
380_L383_N1.1551.00
236_I243_M1.1541.00
96_H100_K1.1541.00
94_N406_M1.1531.00
84_Y283_S1.1491.00
481_G485_K1.1481.00
257_F346_S1.1461.00
124_M399_L1.1321.00
255_P258_T1.1311.00
136_E339_N1.1301.00
93_L411_W1.1271.00
405_V447_G1.1210.99
83_A243_M1.1150.99
377_A381_W1.1110.99
364_K367_I1.1070.99
79_I240_I1.1060.99
65_G139_A1.1050.99
479_Y483_E1.1040.99
147_L325_L1.1000.99
248_A400_G1.0950.99
210_M289_L1.0870.99
334_A338_V1.0810.99
439_N442_V1.0790.99
367_I371_I1.0740.99
439_N483_E1.0730.99
311_V314_M1.0720.99
28_Y33_A1.0690.99
280_L284_F1.0680.99
88_L92_Y1.0650.99
111_P423_L1.0590.99
58_V335_T1.0570.99
90_A251_V1.0530.99
82_I236_I1.0500.99
137_T177_W1.0480.99
430_Y435_G1.0470.99
110_R118_A1.0440.99
378_P381_W1.0420.99
439_N443_A1.0390.99
360_N364_K1.0390.99
374_L377_A1.0380.99
463_L470_L1.0330.99
439_N482_L1.0320.99
80_I84_Y1.0260.99
184_L366_A1.0190.99
471_G475_S1.0140.99
116_R435_G1.0140.99
97_I101_W1.0120.99
193_K197_I1.0110.99
443_A479_Y1.0050.99
231_V236_I1.0020.99
47_Y258_T1.0010.99
113_F117_G1.0010.99
77_L81_A1.0000.99
373_G376_Y0.9990.99
81_A280_L0.9990.99
477_A480_L0.9950.99
86_T240_I0.9950.99
96_H411_W0.9880.99
105_F255_P0.9860.99
85_F276_P0.9820.99
113_F121_P0.9760.99
147_L328_G0.9720.99
309_N313_I0.9720.99
261_S264_Q0.9720.99
79_I83_A0.9710.99
200_P203_I0.9680.99
446_I453_I0.9630.98
437_N483_E0.9620.98
214_I288_G0.9610.98
95_G267_Q0.9570.98
132_W392_I0.9560.98
126_A351_L0.9550.98
208_G211_I0.9530.98
448_F451_P0.9520.98
32_I107_S0.9510.98
408_A413_L0.9460.98
96_H416_T0.9400.98
227_R230_N0.9380.98
308_V311_V0.9330.98
227_R231_V0.9310.98
312_N316_L0.9300.98
457_I462_L0.9210.98
107_S110_R0.9210.98
207_G446_I0.9180.98
450_V470_L0.9150.98
448_F453_I0.9110.98
466_Y470_L0.9100.98
290_A293_V0.9090.98
189_D193_K0.9080.98
133_F344_I0.9060.98
96_H264_Q0.9040.98
359_L365_S0.8980.98
115_I426_P0.8960.98
424_F430_Y0.8960.98
360_N363_S0.8960.98
97_I406_M0.8950.98
101_W418_I0.8940.97
87_L247_W0.8930.97
221_S225_Q0.8920.97
75_I231_V0.8900.97
141_G145_D0.8890.97
310_P317_F0.8880.97
36_P40_K0.8880.97
213_A217_A0.8870.97
226_I230_N0.8870.97
459_K462_L0.8840.97
124_M395_I0.8810.97
442_V446_I0.8790.97
285_I289_L0.8790.97
75_I78_M0.8790.97
275_L279_T0.8750.97
195_E340_V0.8750.97
208_G212_H0.8740.97
450_V453_I0.8720.97
442_V445_I0.8700.97
136_E335_T0.8700.97
251_V403_A0.8680.97
376_Y381_W0.8680.97
240_I244_A0.8640.97
447_G471_G0.8640.97
238_L242_T0.8630.97
478_I481_G0.8620.97
221_S224_F0.8590.97
138_Y141_G0.8580.97
99_T267_Q0.8560.97
412_I415_K0.8530.97
60_A63_L0.8510.97
140_G335_T0.8490.97
117_G441_L0.8480.97
346_S350_D0.8470.97
375_L379_W0.8470.97
334_A337_S0.8460.96
363_S367_I0.8460.96
81_A284_F0.8410.96
195_E337_S0.8360.96
214_I218_N0.8350.96
45_I49_T0.8340.96
51_W106_P0.8330.96
470_L473_F0.8320.96
253_N257_F0.8300.96
56_H202_V0.8290.96
233_L237_A0.8260.96
133_F136_E0.8260.96
54_M250_L0.8250.96
113_F444_M0.8250.96
105_F346_S0.8250.96
123_I354_L0.8240.96
334_A341_A0.8240.96
476_I479_Y0.8240.96
26_S38_N0.8240.96
122_V350_D0.8210.96
95_G98_G0.8210.96
61_F289_L0.8200.96
202_V338_V0.8170.96
284_F288_G0.8170.96
429_R481_G0.8110.96
183_V336_I0.8080.95
84_Y279_T0.8070.95
312_N315_Y0.8050.95
420_L424_F0.8050.95
242_T389_E0.8040.95
345_V349_Y0.8010.95
200_P204_I0.8010.95
443_A476_I0.8010.95
28_Y345_V0.8000.95
452_V456_L0.7990.95
375_L438_V0.7970.95
145_D168_H0.7960.95
213_A289_L0.7950.95
365_S369_S0.7930.95
445_I448_F0.7920.95
413_L483_E0.7890.95
474_L483_E0.7890.95
359_L364_K0.7820.95
65_G290_A0.7820.95
99_T261_S0.7770.94
237_A245_G0.7770.94
112_M405_V0.7730.94
272_T276_P0.7730.94
409_H483_E0.7690.94
106_P350_D0.7690.94
137_T339_N0.7680.94
147_L329_I0.7660.94
185_F367_I0.7640.94
358_K364_K0.7640.94
249_T399_L0.7610.94
289_L293_V0.7580.94
110_R409_H0.7570.94
273_I277_I0.7560.94
110_R353_S0.7560.94
80_I280_L0.7540.93
203_I207_G0.7530.93
88_L276_P0.7530.93
91_L94_N0.7520.93
443_A475_S0.7520.93
181_V185_F0.7510.93
237_A241_S0.7500.93
387_S391_V0.7470.93
445_I478_I0.7470.93
340_V344_I0.7460.93
366_A380_L0.7440.93
56_H338_V0.7430.93
213_A285_I0.7390.93
397_A455_F0.7370.93
94_N254_I0.7360.93
410_Y413_L0.7360.93
140_G183_V0.7350.93
373_G381_W0.7330.92
438_V441_L0.7310.92
242_T245_G0.7300.92
423_L430_Y0.7280.92
46_N192_K0.7280.92
62_M65_G0.7280.92
84_Y246_F0.7270.92
273_I442_V0.7240.92
460_L463_L0.7230.92
359_L363_S0.7230.92
447_G451_P0.7230.92
147_L332_V0.7230.92
201_L330_S0.7210.92
85_F280_L0.7210.92
150_I175_L0.7200.92
76_A80_I0.7180.92
81_A175_L0.7180.92
320_N324_T0.7170.92
59_P141_G0.7160.92
93_L412_I0.7160.92
347_P350_D0.7130.91
412_I416_T0.7100.91
457_I461_S0.7080.91
202_V334_A0.7070.91
467_G471_G0.7050.91
184_L370_A0.7050.91
369_S381_W0.7030.91
188_M260_F0.7020.91
134_S138_Y0.7010.91
33_A39_A0.7010.91
313_I317_F0.6990.91
215_T219_G0.6990.91
91_L249_T0.6970.90
328_G337_S0.6970.90
174_F222_S0.6970.90
291_S295_Y0.6960.90
205_I330_S0.6950.90
269_I272_T0.6950.90
365_S368_V0.6920.90
373_G378_P0.6910.90
405_V475_S0.6900.90
43_T262_R0.6890.90
120_V444_M0.6890.90
401_S447_G0.6880.90
109_I118_A0.6880.90
259_R345_V0.6870.90
94_N407_I0.6850.90
170_T378_P0.6830.90
323_I326_I0.6830.90
120_V445_I0.6830.90
103_I107_S0.6830.90
146_A312_N0.6800.89
274_G278_L0.6790.89
133_F181_V0.6790.89
336_I341_A0.6780.89
427_N478_I0.6780.89
171_I174_F0.6770.89
129_A347_P0.6770.89
109_I112_M0.6750.89
103_I108_S0.6750.89
473_F481_G0.6740.89
437_N440_A0.6740.89
375_L415_K0.6710.89
195_E341_A0.6700.89
408_A412_I0.6700.89
64_A286_A0.6700.89
138_Y142_L0.6700.89
32_I110_R0.6690.89
448_F452_V0.6690.89
387_S390_N0.6670.88
321_P325_L0.6670.88
311_V315_Y0.6660.88
55_I279_T0.6640.88
145_D169_L0.6630.88
226_I231_V0.6630.88
225_Q229_N0.6610.88
71_F75_I0.6590.88
128_S392_I0.6580.88
239_A243_M0.6580.88
110_R115_I0.6570.88
58_V61_F0.6560.88
458_P465_D0.6550.88
241_S469_Y0.6550.88
308_V314_M0.6540.87
176_F336_I0.6530.87
266_D269_I0.6520.87
81_A462_L0.6520.87
238_L245_G0.6490.87
92_Y95_G0.6490.87
125_R253_N0.6480.87
59_P335_T0.6470.87
141_G169_L0.6460.87
41_T189_D0.6460.87
207_G351_L0.6450.87
125_R346_S0.6430.87
288_G292_A0.6430.87
218_N222_S0.6420.87
379_W385_A0.6390.86
48_A52_A0.6390.86
48_A277_I0.6380.86
237_A242_T0.6380.86
230_N233_L0.6370.86
331_L335_T0.6360.86
65_G98_G0.6350.86
236_I441_L0.6340.86
57_N60_A0.6330.86
129_A343_N0.6330.86
63_L468_W0.6290.85
320_N323_I0.6290.85
213_A292_A0.6270.85
48_A273_I0.6260.85
348_V365_S0.6250.85
425_K429_R0.6230.85
84_Y128_S0.6220.85
144_L172_S0.6200.85
447_G476_I0.6180.84
250_L388_I0.6160.84
54_M335_T0.6140.84
141_G173_F0.6140.84
193_K198_A0.6120.84
447_G450_V0.6120.84
168_H171_I0.6110.84
88_L335_T0.6100.84
200_P404_G0.6100.84
183_V340_V0.6060.83
270_G274_G0.6040.83
430_Y437_N0.6040.83
427_N470_L0.6030.83
241_S250_L0.6030.83
423_L429_R0.6030.83
47_Y261_S0.6020.83
54_M247_W0.6020.83
73_P291_S0.6020.83
122_V354_L0.6020.83
207_G281_L0.6020.83
140_G191_I0.6010.83
247_W279_T0.6000.83
42_W188_M0.6000.83
109_I402_V0.5990.83
446_I450_V0.5990.83
187_G345_V0.5950.82
226_I229_N0.5940.82
247_W275_L0.5940.82
457_I460_L0.5920.82
221_S227_R0.5920.82
197_I200_P0.5920.82
92_Y268_L0.5910.82
111_P414_G0.5910.82
120_V457_I0.5890.81
119_R354_L0.5880.81
143_I147_L0.5880.81
214_I220_L0.5870.81
465_D470_L0.5870.81
38_N477_A0.5850.81
244_A472_L0.5850.81
39_A336_I0.5850.81
314_M323_I0.5850.81
133_F180_N0.5840.81
124_M402_V0.5830.81
74_L77_L0.5820.81
470_L474_L0.5820.81
178_F405_V0.5800.80
83_A87_L0.5790.80
180_N183_V0.5790.80
446_I460_L0.5780.80
308_V313_I0.5780.80
212_H216_L0.5780.80
60_A246_F0.5770.80
87_L91_L0.5770.80
47_Y95_G0.5770.80
244_A251_V0.5760.80
111_P430_Y0.5750.80
360_N366_A0.5750.80
55_I106_P0.5740.80
127_I421_A0.5740.80
428_G442_V0.5740.80
335_T338_V0.5730.80
131_F395_I0.5730.80
225_Q230_N0.5700.79
263_S267_Q0.5690.79
96_H410_Y0.5690.79
42_W261_S0.5670.79
443_A446_I0.5670.79
39_A189_D0.5670.79
247_W251_V0.5660.79
27_Y31_N0.5660.79
53_G195_E0.5660.79
33_A36_P0.5650.79
60_A286_A0.5640.79
86_T116_R0.5640.79
371_I375_L0.5640.79
230_N235_N0.5620.78
136_E337_S0.5620.78
204_I211_I0.5600.78
355_F473_F0.5600.78
148_I172_S0.5580.78
285_I333_I0.5570.78
208_G485_K0.5570.78
202_V337_S0.5560.78
51_W271_Q0.5560.78
278_L282_F0.5550.78
407_I413_L0.5550.78
446_I482_L0.5540.77
69_F235_N0.5510.77
130_L395_I0.5500.77
206_L334_A0.5490.77
197_I480_L0.5490.77
134_S376_Y0.5480.77
199_G330_S0.5480.77
62_M139_A0.5470.76
31_N352_I0.5450.76
94_N98_G0.5450.76
50_I70_E0.5450.76
309_N314_M0.5440.76
129_A346_S0.5440.76
124_M348_V0.5430.76
323_I327_L0.5430.76
67_L70_E0.5420.76
400_G475_S0.5400.76
195_E338_V0.5380.75
63_L389_E0.5380.75
59_P135_V0.5370.75
40_K262_R0.5370.75
369_S376_Y0.5370.75
117_G436_Y0.5370.75
174_F374_L0.5350.75
34_P101_W0.5350.75
63_L275_L0.5340.75
336_I368_V0.5330.75
120_V396_G0.5310.74
180_N336_I0.5310.74
55_I278_L0.5310.74
207_G316_L0.5300.74
241_S452_V0.5280.74
57_N61_F0.5280.74
414_G418_I0.5280.74
168_H172_S0.5270.74
178_F375_L0.5270.74
133_F253_N0.5260.74
372_L438_V0.5260.74
120_V171_I0.5250.74
245_G400_G0.5250.74
400_G404_G0.5240.73
182_L186_K0.5240.73
351_L354_L0.5240.73
370_A374_L0.5230.73
85_F89_I0.5230.73
143_I311_V0.5230.73
418_I423_L0.5230.73
179_L182_L0.5230.73
54_M279_T0.5220.73
35_L102_G0.5210.73
170_T446_I0.5210.73
184_L344_I0.5210.73
128_S399_L0.5200.73
120_V453_I0.5190.73
221_S266_D0.5190.73
106_P353_S0.5180.73
182_L421_A0.5170.72
100_K416_T0.5160.72
116_R121_P0.5160.72
369_S373_G0.5150.72
263_S429_R0.5110.72
237_A240_I0.5100.71
333_I337_S0.5090.71
253_N346_S0.5090.71
247_W250_L0.5090.71
418_I424_F0.5090.71
91_L251_V0.5090.71
287_V326_I0.5080.71
252_L403_A0.5070.71
205_I327_L0.5070.71
216_L219_G0.5070.71
322_Y326_I0.5060.71
171_I325_L0.5050.71
468_W472_L0.5050.71
57_N246_F0.5050.71
243_M246_F0.5040.71
426_P429_R0.5020.70
147_L330_S0.5020.70
397_A451_P0.5010.70
178_F386_S0.5010.70
368_V372_L0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jlnA 1 0.872 100 0.235 Contact Map
4djkA 2 0.8354 99.4 0.862 Contact Map
3dh4A 3 0.8211 99.2 0.874 Contact Map
3l1lA 2 0.815 99.2 0.877 Contact Map
3giaA 1 0.8354 99.1 0.881 Contact Map
2xq2A 2 0.8313 99 0.885 Contact Map
4wgvA 2 0.7317 98 0.915 Contact Map
4us3A 1 0.815 97.6 0.922 Contact Map
2a65A 2 0.8862 96.8 0.932 Contact Map
4xp4A 1 0.9045 93.3 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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