GREMLIN Database
Q97WS3 - Amino acid transporter related protein
UniProt: Q97WS3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 616 (470)
Sequences: 2955 (2023)
Seq/√Len: 93.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_I384_L5.9831.00
319_A323_V5.2601.00
351_S361_K3.6361.00
189_M193_F3.3321.00
155_L384_L3.1851.00
374_I378_I2.9701.00
57_I437_V2.9401.00
475_K479_L2.9371.00
360_F375_V2.9261.00
152_I381_I2.7871.00
222_L225_I2.7651.00
159_F377_L2.7581.00
148_L152_I2.7091.00
420_P424_R2.7021.00
420_P423_K2.6661.00
410_I439_T2.6471.00
90_Y471_N2.4711.00
65_A435_A2.4431.00
418_T422_L2.4291.00
414_T417_K2.3411.00
107_P380_S2.2991.00
191_L275_A2.2971.00
84_V92_G2.2621.00
491_Q495_N2.2331.00
152_I156_F2.2321.00
359_I371_W2.2211.00
480_K485_I2.2211.00
198_S201_T2.2041.00
460_A464_G2.1731.00
438_A442_S2.1611.00
80_V353_E2.1591.00
478_G481_K2.1561.00
219_V223_Y2.1531.00
303_S309_L2.1411.00
221_M224_A2.1051.00
227_S230_I2.1051.00
100_L376_S2.1031.00
436_P440_I2.1011.00
418_T421_D2.0911.00
305_F309_L2.0281.00
419_A422_L2.0251.00
474_V478_G2.0201.00
406_I443_L1.9601.00
473_A476_I1.9541.00
219_V222_L1.9451.00
20_L247_A1.9361.00
205_G209_K1.9331.00
220_G223_Y1.9241.00
454_L457_I1.9201.00
87_H91_T1.9051.00
206_L209_K1.8851.00
461_L465_I1.8771.00
47_S206_L1.8721.00
418_T423_K1.8611.00
47_S50_L1.8371.00
421_D424_R1.8301.00
475_K478_G1.8111.00
42_S45_G1.8101.00
146_P149_L1.7961.00
223_Y226_P1.7751.00
413_Q439_T1.7701.00
41_A48_G1.7681.00
88_G472_Y1.7571.00
225_I228_A1.7511.00
221_M225_I1.7481.00
481_K484_G1.7401.00
409_G438_A1.7391.00
104_I376_S1.7341.00
471_N475_K1.7281.00
354_E358_L1.7171.00
459_S462_F1.7141.00
468_F479_L1.7031.00
205_G208_P1.6971.00
459_S463_I1.6931.00
358_L361_K1.6931.00
281_N284_S1.6911.00
471_N474_V1.6911.00
479_L482_W1.6911.00
406_I439_T1.6901.00
97_F356_F1.6871.00
419_A423_K1.6861.00
252_R256_R1.6701.00
458_I465_I1.6611.00
48_G51_S1.6361.00
122_N125_L1.6351.00
214_N217_G1.6191.00
207_F282_W1.6061.00
303_S307_S1.6021.00
223_Y227_S1.5931.00
433_I437_V1.5901.00
159_F374_I1.5831.00
219_V224_A1.5831.00
301_A304_P1.5521.00
46_P277_I1.5501.00
413_Q436_P1.5491.00
208_P212_A1.5421.00
309_L313_G1.5361.00
192_F196_K1.5331.00
301_A309_L1.5291.00
47_S205_G1.5041.00
303_S308_E1.4971.00
199_N202_N1.4931.00
454_L459_S1.4921.00
280_I284_S1.4921.00
461_L464_G1.4831.00
208_P213_S1.4801.00
127_K147_G1.4741.00
122_N126_S1.4741.00
492_L496_I1.4661.00
475_K482_W1.4631.00
284_S311_A1.4621.00
434_I438_A1.4591.00
304_P309_L1.4531.00
465_I469_W1.4471.00
478_G482_W1.4441.00
347_L356_F1.4391.00
488_G491_Q1.4370.99
246_E345_R1.4160.99
304_P307_S1.4140.99
455_F462_F1.3970.99
450_G453_T1.3950.99
435_A453_T1.3930.99
466_P470_I1.3890.99
454_L458_I1.3880.99
197_S201_T1.3870.99
199_N203_Y1.3850.99
20_L23_L1.3810.99
417_K482_W1.3800.99
371_W374_I1.3780.99
190_L314_L1.3770.99
100_L104_I1.3720.99
477_L481_K1.3680.99
364_N370_I1.3670.99
90_Y472_Y1.3650.99
438_A453_T1.3540.99
235_L401_T1.3450.99
149_L153_L1.3450.99
440_I444_L1.3380.99
478_G485_I1.3380.99
435_A442_S1.3350.99
183_I323_V1.3270.99
274_I278_G1.3220.99
210_S213_S1.3220.99
45_G51_S1.3220.99
461_L466_P1.2930.99
449_S453_T1.2880.99
204_G207_F1.2810.99
65_A409_G1.2750.99
435_A438_A1.2730.99
45_G52_W1.2660.99
163_Y374_I1.2650.99
213_S216_G1.2580.99
224_A227_S1.2510.99
343_S376_S1.2500.99
307_S311_A1.2500.99
300_W303_S1.2440.99
192_F195_F1.2440.99
126_S149_L1.2430.99
269_Y272_L1.2400.98
418_T424_R1.2350.98
45_G50_L1.2270.98
474_V485_I1.2260.98
459_S466_P1.2200.98
123_P126_S1.2160.98
458_I461_L1.2150.98
154_L333_S1.2110.98
478_G484_G1.2110.98
11_L363_L1.2100.98
509_N512_N1.2070.98
406_I410_I1.2050.98
185_V189_M1.2040.98
304_P308_E1.2040.98
281_N311_A1.2020.98
412_L416_R1.2000.98
190_L194_A1.1970.98
83_P353_E1.1950.98
222_L448_W1.1910.98
186_V320_W1.1870.98
181_L185_V1.1810.98
439_T443_L1.1800.98
474_V477_L1.1800.98
301_A307_S1.1780.98
242_E342_T1.1760.98
45_G48_G1.1740.98
15_L170_G1.1640.98
152_I385_L1.1580.98
434_I449_S1.1570.98
419_A424_R1.1550.98
309_L314_L1.1530.98
95_I407_M1.1530.98
471_N478_G1.1520.98
70_G82_Y1.1500.98
240_P258_I1.1490.98
223_Y228_A1.1470.97
118_L329_V1.1430.97
184_P269_Y1.1400.97
431_A435_A1.1400.97
216_G220_G1.1390.97
309_L324_L1.1370.97
225_I230_I1.1370.97
474_V481_K1.1350.97
179_W327_D1.1270.97
106_T110_E1.1260.97
155_L380_S1.1250.97
263_V267_L1.1230.97
281_N286_G1.1200.97
459_S464_G1.1190.97
224_A228_A1.1180.97
217_G220_G1.1170.97
449_S452_T1.1150.97
277_I284_S1.1130.97
455_F459_S1.1110.97
188_F271_F1.1080.97
127_K146_P1.1030.97
424_R428_I1.1010.97
432_S435_A1.0940.97
182_I323_V1.0900.97
436_P439_T1.0880.97
282_W285_A1.0870.97
476_I479_L1.0810.96
508_L512_N1.0790.96
52_W55_A1.0780.96
211_V215_Y1.0620.96
24_S28_M1.0550.96
459_S465_I1.0520.96
188_F191_L1.0480.96
61_F437_V1.0460.96
202_N283_V1.0430.96
395_G398_S1.0420.96
470_I474_V1.0400.96
457_I460_A1.0390.96
406_I442_S1.0350.95
204_G213_S1.0340.95
362_K371_W1.0330.95
114_T154_L1.0310.95
61_F438_A1.0300.95
19_D23_L1.0290.95
208_P217_G1.0290.95
104_I379_A1.0280.95
56_G234_Y1.0250.95
275_A279_A1.0240.95
183_I327_D1.0190.95
204_G209_K1.0150.95
462_F465_I1.0140.95
50_L54_I1.0130.95
117_Y328_A1.0130.95
100_L347_L1.0120.95
204_G208_P1.0080.95
271_F274_I1.0070.95
216_G223_Y1.0050.95
277_I282_W1.0030.95
306_Y309_L1.0020.95
509_N513_P1.0020.95
158_Y336_G1.0010.95
433_I436_P1.0000.94
340_T344_A1.0000.94
371_W375_V1.0000.94
41_A45_G0.9980.94
29_I34_L0.9980.94
57_I61_F0.9970.94
85_Y490_S0.9960.94
93_F97_F0.9880.94
215_Y219_V0.9870.94
175_A178_V0.9860.94
220_G226_P0.9830.94
457_I465_I0.9780.94
391_Y394_V0.9780.94
110_E335_T0.9770.94
81_R85_Y0.9720.94
359_I362_K0.9710.94
17_L21_T0.9680.93
16_G248_K0.9630.93
214_N218_P0.9610.93
457_I462_F0.9600.93
431_A434_I0.9550.93
475_K481_K0.9520.93
49_I274_I0.9520.93
32_G36_A0.9520.93
438_A452_T0.9510.93
219_V226_P0.9500.93
88_G477_L0.9490.93
219_V225_I0.9480.93
448_W453_T0.9460.93
51_S54_I0.9460.93
443_L447_Y0.9400.92
273_Q276_F0.9380.92
267_L271_F0.9360.92
439_T462_F0.9330.92
217_G221_M0.9320.92
34_L75_K0.9250.92
44_A224_A0.9230.92
455_F466_P0.9190.92
455_F458_I0.9180.92
304_P312_E0.9160.91
481_K485_I0.9130.91
39_S43_I0.9100.91
222_L226_P0.9080.91
148_L384_L0.9070.91
170_G337_L0.9050.91
347_L360_F0.9030.91
348_Y352_A0.8980.91
434_I450_G0.8980.91
441_V445_I0.8950.90
307_S313_G0.8950.90
249_N255_W0.8900.90
299_K304_P0.8890.90
345_R363_L0.8880.90
125_L149_L0.8870.90
105_S400_A0.8870.90
250_P255_W0.8820.90
302_N306_Y0.8820.90
340_T373_L0.8820.90
469_W473_A0.8800.90
182_I186_V0.8780.90
183_I324_L0.8730.89
363_L367_R0.8720.89
240_P337_L0.8720.89
71_S256_R0.8690.89
156_F381_I0.8680.89
430_F434_I0.8630.89
305_F308_E0.8630.89
77_G80_V0.8610.89
460_A467_I0.8610.89
507_V511_D0.8590.89
277_I280_I0.8510.88
49_I53_I0.8500.88
83_P411_G0.8500.88
18_L171_K0.8490.88
56_G59_V0.8460.88
340_T377_L0.8460.88
273_Q277_I0.8450.88
425_G428_I0.8430.88
466_P469_W0.8420.88
455_F468_F0.8380.87
218_P222_L0.8340.87
432_S450_G0.8300.87
209_K213_S0.8300.87
111_A336_G0.8290.87
340_T376_S0.8290.87
438_A449_S0.8270.87
58_M441_V0.8260.87
438_A450_G0.8250.87
24_S27_A0.8200.86
434_I453_T0.8180.86
471_N479_L0.8160.86
173_N177_T0.8130.86
306_Y321_G0.8100.86
282_W286_G0.8100.86
18_L174_S0.8080.85
63_G262_I0.8070.85
435_A439_T0.8060.85
265_A269_Y0.8060.85
197_S200_F0.8040.85
44_A48_G0.8030.85
151_S387_F0.8030.85
461_L468_F0.8030.85
93_F467_I0.8030.85
203_Y206_L0.8000.85
112_L386_P0.7990.85
77_G81_R0.7980.85
80_V96_A0.7970.85
486_S489_I0.7970.85
203_Y207_F0.7960.85
115_I154_L0.7930.84
508_L511_D0.7930.84
179_W183_I0.7920.84
486_S490_S0.7900.84
253_N257_A0.7890.84
171_K175_A0.7840.84
186_V190_L0.7840.84
319_A322_Y0.7840.84
483_I486_S0.7830.84
455_F461_L0.7820.83
51_S224_A0.7810.83
151_S384_L0.7810.83
454_L466_P0.7800.83
198_S202_N0.7710.83
66_Y82_Y0.7690.82
301_A305_F0.7660.82
471_N477_L0.7640.82
119_T147_G0.7620.82
256_R260_L0.7620.82
62_I409_G0.7610.82
34_L180_K0.7610.82
432_S438_A0.7610.82
85_Y89_S0.7590.82
464_G468_F0.7560.81
263_V270_T0.7560.81
436_P450_G0.7540.81
84_V353_E0.7480.81
300_W309_L0.7480.81
23_L177_T0.7460.80
191_L279_A0.7450.80
212_A225_I0.7420.80
506_L510_N0.7390.80
203_Y281_N0.7380.80
473_A480_K0.7370.80
372_S376_S0.7350.79
89_S355_Y0.7320.79
510_N513_P0.7310.79
302_N305_F0.7310.79
45_G49_I0.7290.79
477_L485_I0.7280.79
84_V89_S0.7270.79
417_K432_S0.7260.79
260_L263_V0.7260.79
210_S214_N0.7250.79
149_L156_F0.7240.78
37_S276_F0.7240.78
348_Y363_L0.7230.78
413_Q417_K0.7230.78
105_S158_Y0.7230.78
61_F434_I0.7210.78
264_I268_I0.7210.78
458_I464_G0.7200.78
495_N498_L0.7200.78
183_I320_W0.7200.78
465_I468_F0.7170.78
52_W56_G0.7160.78
162_N337_L0.7150.78
451_F455_F0.7150.78
221_M228_A0.7150.78
502_G507_V0.7130.77
303_S313_G0.7110.77
360_F372_S0.7110.77
58_M442_S0.7110.77
504_Y507_V0.7100.77
206_L213_S0.7100.77
73_I86_S0.7100.77
474_V484_G0.7100.77
28_M239_Q0.7090.77
110_E339_Y0.7070.77
115_I118_L0.7070.77
309_L320_W0.7050.77
477_L484_G0.7040.77
467_I470_I0.7030.76
195_F278_G0.7030.76
58_M402_V0.7010.76
215_Y222_L0.6990.76
155_L381_I0.6990.76
248_K253_N0.6970.76
126_S147_G0.6970.76
253_N256_R0.6970.76
331_S336_G0.6960.76
233_S445_I0.6930.75
471_N476_I0.6920.75
277_I281_N0.6910.75
230_I234_Y0.6900.75
187_T272_L0.6890.75
464_G469_W0.6890.75
48_G52_W0.6820.74
216_G219_V0.6810.74
102_S401_T0.6790.74
190_L309_L0.6790.74
75_K81_R0.6770.74
197_S202_N0.6760.74
80_V349_G0.6740.73
170_G173_N0.6740.73
481_K486_S0.6720.73
272_L275_A0.6720.73
432_S453_T0.6720.73
269_Y273_Q0.6710.73
208_P211_V0.6700.73
85_Y489_I0.6670.73
30_G34_L0.6660.72
307_S312_E0.6660.72
83_P95_I0.6650.72
100_L172_T0.6650.72
159_F340_T0.6650.72
69_L408_G0.6630.72
160_L508_L0.6610.72
490_S494_V0.6610.72
477_L482_W0.6610.72
16_G19_D0.6590.72
465_I471_N0.6580.72
96_A350_L0.6560.71
169_L337_L0.6560.71
403_L464_G0.6560.71
108_S111_A0.6550.71
482_W485_I0.6550.71
26_S29_I0.6540.71
435_A449_S0.6530.71
60_M259_I0.6520.71
185_V268_I0.6510.71
118_L122_N0.6490.71
54_I58_M0.6480.70
99_Y103_A0.6480.70
118_L150_F0.6470.70
379_A389_S0.6470.70
462_F466_P0.6460.70
45_G369_P0.6450.70
246_E348_Y0.6440.70
83_P407_M0.6420.70
76_T81_R0.6410.70
286_G310_E0.6410.70
451_F468_F0.6400.69
68_E416_R0.6390.69
458_I462_F0.6380.69
345_R369_P0.6380.69
262_I276_F0.6360.69
299_K309_L0.6340.69
262_I269_Y0.6320.69
111_A158_Y0.6310.68
214_N226_P0.6310.68
259_I263_V0.6300.68
345_R348_Y0.6300.68
482_W487_L0.6300.68
37_S41_A0.6280.68
410_I414_T0.6270.68
352_A367_R0.6270.68
115_I150_F0.6260.68
218_P226_P0.6250.68
487_L493_V0.6240.68
205_G211_V0.6240.68
102_S109_I0.6230.67
101_L166_I0.6230.67
506_L511_D0.6220.67
106_T397_N0.6220.67
55_A58_M0.6220.67
422_L425_G0.6210.67
77_G165_G0.6170.67
214_N220_G0.6170.67
121_V321_G0.6170.67
44_A456_Y0.6140.66
161_V165_G0.6140.66
478_G483_I0.6130.66
263_V277_I0.6120.66
474_V482_W0.6120.66
268_I272_L0.6120.66
18_L22_F0.6110.66
179_W330_L0.6110.66
193_F473_A0.6110.66
47_S51_S0.6090.66
200_F204_G0.6070.65
77_G236_G0.6060.65
299_K303_S0.6050.65
488_G496_I0.6040.65
457_I466_P0.6030.65
247_A401_T0.6030.65
82_Y346_T0.6030.65
300_W306_Y0.6020.65
431_A450_G0.6010.65
308_E313_G0.6000.65
14_E17_L0.5990.64
146_P150_F0.5990.64
11_L76_T0.5980.64
305_F313_G0.5980.64
458_I471_N0.5980.64
502_G505_S0.5980.64
490_S493_V0.5980.64
67_A258_I0.5970.64
375_V379_A0.5950.64
118_L127_K0.5950.64
262_I270_T0.5950.64
156_F377_L0.5940.64
495_N500_I0.5940.64
127_K199_N0.5930.64
459_S468_F0.5930.64
358_L443_L0.5930.64
252_R360_F0.5920.63
505_S510_N0.5920.63
71_S252_R0.5920.63
116_E147_G0.5920.63
202_N440_I0.5910.63
49_I378_I0.5910.63
48_G53_I0.5900.63
20_L240_P0.5900.63
417_K447_Y0.5890.63
47_S207_F0.5890.63
215_Y226_P0.5870.63
407_M464_G0.5840.62
498_L504_Y0.5840.62
160_L302_N0.5830.62
80_V346_T0.5830.62
241_I408_G0.5810.62
17_L22_F0.5810.62
209_K212_A0.5800.62
87_H410_I0.5800.62
178_V182_I0.5790.62
84_V355_Y0.5780.62
65_A82_Y0.5780.62
218_P382_I0.5770.62
192_F271_F0.5770.62
164_Y168_I0.5760.61
173_N180_K0.5750.61
442_S449_S0.5750.61
416_R431_A0.5750.61
504_Y509_N0.5750.61
39_S42_S0.5720.61
463_I468_F0.5700.61
273_Q286_G0.5700.61
439_T450_G0.5690.60
352_A361_K0.5690.60
53_I56_G0.5690.60
437_V440_I0.5680.60
435_A441_V0.5670.60
22_F264_I0.5670.60
26_S177_T0.5660.60
161_V172_T0.5630.60
423_K426_I0.5630.60
185_V310_E0.5630.60
323_V327_D0.5600.59
100_L343_S0.5590.59
276_F281_N0.5580.59
409_G435_A0.5570.59
336_G339_Y0.5560.59
495_N511_D0.5560.59
441_V449_S0.5560.59
46_P51_S0.5550.59
299_K302_N0.5550.59
504_Y511_D0.5550.59
202_N205_G0.5550.59
78_G355_Y0.5540.58
262_I274_I0.5540.58
453_T457_I0.5540.58
52_W58_M0.5540.58
33_W272_L0.5530.58
242_E401_T0.5520.58
468_F472_Y0.5520.58
422_L487_L0.5510.58
82_Y411_G0.5500.58
192_F378_I0.5500.58
480_K483_I0.5480.58
188_F275_A0.5470.57
374_I434_I0.5470.57
92_G407_M0.5470.57
91_T94_V0.5470.57
330_L413_Q0.5460.57
65_A442_S0.5460.57
249_N252_R0.5450.57
86_S346_T0.5450.57
303_S320_W0.5420.57
188_F272_L0.5400.57
50_L55_A0.5400.57
48_G273_Q0.5400.57
201_T318_G0.5400.57
163_Y373_L0.5390.56
304_P313_G0.5380.56
221_M495_N0.5350.56
72_S77_G0.5350.56
95_I99_Y0.5350.56
493_V497_I0.5330.56
76_T349_G0.5330.56
214_N223_Y0.5320.55
314_L318_G0.5310.55
95_I244_S0.5310.55
281_N285_A0.5310.55
216_G228_A0.5310.55
406_I446_V0.5310.55
52_W59_V0.5300.55
155_L377_L0.5300.55
206_L379_A0.5300.55
71_S255_W0.5290.55
50_L56_G0.5290.55
48_G55_A0.5290.55
385_L388_P0.5290.55
111_A155_L0.5290.55
302_N307_S0.5280.55
443_L466_P0.5280.55
255_W258_I0.5270.55
58_M445_I0.5270.55
460_A465_I0.5260.55
182_I463_I0.5260.55
470_I473_A0.5260.55
37_S233_S0.5250.54
72_S491_Q0.5240.54
78_G346_T0.5240.54
235_L239_Q0.5240.54
492_L495_N0.5230.54
66_Y70_G0.5230.54
431_A436_P0.5230.54
111_A154_L0.5230.54
212_A216_G0.5230.54
266_I270_T0.5220.54
182_I447_Y0.5210.54
361_K372_S0.5210.54
49_I270_T0.5210.54
202_N206_L0.5200.54
218_P271_F0.5190.54
432_S436_P0.5180.53
494_V498_L0.5180.53
491_Q494_V0.5180.53
97_F348_Y0.5180.53
39_S44_A0.5180.53
279_A282_W0.5170.53
150_F154_L0.5140.53
90_Y94_V0.5120.53
318_G321_G0.5110.52
238_R335_T0.5110.52
206_L217_G0.5100.52
448_W452_T0.5100.52
160_L212_A0.5090.52
106_T235_L0.5090.52
29_I268_I0.5080.52
21_T264_I0.5070.52
15_L166_I0.5070.52
503_Y510_N0.5040.52
156_F489_I0.5030.51
472_Y477_L0.5030.51
216_G226_P0.5020.51
125_L150_F0.5020.51
507_V513_P0.5020.51
265_A272_L0.5000.51
300_W304_P0.5000.51
300_W307_S0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.6769 100 0.531 Contact Map
3giaA 1 0.6948 100 0.563 Contact Map
4djkA 2 0.6932 100 0.57 Contact Map
2jlnA 1 0.6981 98.5 0.919 Contact Map
3dh4A 3 0.7549 98.3 0.924 Contact Map
2xq2A 2 0.7484 98 0.93 Contact Map
4wgvA 2 0.6071 97.7 0.935 Contact Map
4xp4A 1 0.7484 97.6 0.937 Contact Map
4us3A 1 0.6526 97.4 0.939 Contact Map
2a65A 2 0.7143 96.3 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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