GREMLIN Database
Q97WS2 - Glutamate dehydrogenase
UniProt: Q97WS2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 420 (372)
Sequences: 5000 (2443)
Seq/√Len: 126.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
233_L238_A4.3881.00
219_I230_A3.7351.00
287_I309_K3.7341.00
218_I290_C3.4651.00
263_E267_K3.3591.00
290_C312_A3.1951.00
257_D260_K3.1611.00
289_D311_K2.9721.00
201_A316_V2.8581.00
329_E333_Q2.8301.00
122_E126_Q2.5911.00
115_D118_K2.5691.00
216_R239_K2.5391.00
105_Y353_Y2.5151.00
98_N349_V2.4761.00
203_E379_N2.4681.00
203_E206_N2.4421.00
150_V298_L2.4201.00
332_R397_D2.3761.00
230_A243_I2.3591.00
43_Q84_Q2.3051.00
50_G56_K2.3041.00
207_K390_Q2.2791.00
200_I344_A2.2661.00
210_G215_A2.2571.00
133_Q163_E2.2551.00
65_H91_S2.1681.00
323_L331_M2.1661.00
197_V318_G2.1131.00
217_V233_L2.1041.00
388_Y408_D2.1001.00
397_D400_T2.0991.00
231_K235_D2.0881.00
153_D156_T2.0681.00
47_Q130_K2.0671.00
382_F386_Y2.0641.00
83_T86_E2.0401.00
408_D412_R2.0271.00
316_V344_A2.0021.00
217_V238_A2.0011.00
304_K326_D1.9891.00
203_E383_N1.9861.00
207_K386_Y1.9711.00
339_V344_A1.9351.00
242_G285_L1.9061.00
286_L293_L1.9001.00
114_V119_L1.8761.00
387_D391_K1.8701.00
76_I160_Y1.8671.00
188_V367_D1.8551.00
307_A330_I1.8521.00
303_N306_N1.8481.00
369_E373_L1.8371.00
281_T284_E1.8361.00
212_I238_A1.8261.00
198_A236_M1.7981.00
63_S91_S1.7801.00
69_L102_L1.7691.00
72_Y108_G1.7651.00
342_I403_M1.7621.00
262_M266_E1.7561.00
182_E412_R1.7321.00
204_A314_L1.7311.00
253_E278_R1.7211.00
133_Q166_K1.7181.00
100_L343_L1.7161.00
132_I160_Y1.7131.00
202_K375_V1.7041.00
158_A180_P1.7021.00
330_I334_R1.6911.00
202_K236_M1.6881.00
218_I242_G1.6761.00
207_K382_F1.6621.00
51_S120_T1.6061.00
396_H401_A1.6011.00
243_I261_A1.5921.00
136_Y168_T1.5781.00
302_I310_I1.5761.00
388_Y394_E1.5671.00
396_H404_A1.5491.00
325_A328_D1.5341.00
319_A322_P1.4891.00
246_S265_K1.4701.00
217_V294_V1.4581.00
390_Q395_D1.4541.00
60_G131_F1.4271.00
204_A339_V1.4271.00
205_A292_I1.4201.00
199_T375_V1.4161.00
331_M336_I1.4011.00
163_E166_K1.4001.00
249_G280_V1.3991.00
49_R122_E1.3951.00
304_K330_I1.3941.00
67_S72_Y1.3871.00
65_H95_T1.3841.00
316_V339_V1.3821.00
383_N387_D1.3791.00
367_D371_K1.3761.00
247_K270_S1.3671.00
211_G214_E1.3601.00
225_V318_G1.3481.00
242_G288_S1.3461.00
229_A294_V1.3391.00
199_T371_K1.3301.00
197_V316_V1.3191.00
231_K262_M1.3161.00
154_S190_L1.3131.00
229_A296_A1.3011.00
136_Y167_I1.2991.00
79_H298_L1.2911.00
382_F398_L1.2661.00
207_K383_N1.2661.00
121_K155_Q1.2651.00
46_I130_K1.2501.00
202_K206_N1.2491.00
264_I268_T1.2421.00
329_E332_R1.2391.00
182_E416_A1.2381.00
217_V292_I1.2300.99
302_I323_L1.2290.99
359_N364_I1.2260.99
391_K408_D1.2240.99
95_T410_V1.2220.99
233_L240_I1.2220.99
293_L310_I1.2140.99
308_P330_I1.2120.99
343_L385_L1.2120.99
130_K163_E1.2030.99
96_W342_I1.2000.99
218_I288_S1.2000.99
63_S84_Q1.1980.99
42_I138_Y1.1950.99
388_Y405_L1.1950.99
234_S259_G1.1930.99
168_T171_V1.1870.99
205_A212_I1.1830.99
201_A292_I1.1790.99
330_I333_Q1.1790.99
216_R253_E1.1780.99
302_I331_M1.1760.99
249_G282_N1.1710.99
44_V135_I1.1680.99
371_K375_V1.1650.99
376_D380_N1.1610.99
201_A294_V1.1610.99
216_R291_N1.1600.99
96_W410_V1.1570.99
241_V251_I1.1460.99
82_V86_E1.1450.99
261_A274_Y1.1450.99
258_V262_M1.1420.99
375_V379_N1.1420.99
260_K274_Y1.1400.99
216_R289_D1.1290.99
101_L350_V1.1270.99
198_A233_L1.1240.99
271_V274_Y1.1200.99
114_V127_L1.1180.99
210_G313_K1.1150.99
59_M113_R1.1140.99
80_P115_D1.1100.99
217_V240_I1.1040.99
314_L337_V1.1010.99
152_T157_M1.0980.99
195_L232_F1.0940.99
304_K308_P1.0870.99
61_W113_R1.0860.99
159_W162_D1.0840.99
228_Y231_K1.0780.99
241_V290_C1.0730.99
197_V296_A1.0710.99
261_A265_K1.0700.99
218_I241_V1.0700.99
47_Q57_T1.0650.99
120_T123_E1.0610.99
78_Y152_T1.0580.98
366_S369_E1.0570.98
368_E372_K1.0520.98
412_R415_K1.0510.98
380_N384_T1.0450.98
260_K263_E1.0430.98
125_E129_R1.0420.98
157_M160_Y1.0370.98
284_E287_I1.0350.98
197_V201_A1.0320.98
128_S132_I1.0270.98
195_L371_K1.0260.98
261_A271_V1.0250.98
227_Y262_M1.0230.98
394_E400_T1.0210.98
101_L346_A1.0210.98
304_K328_D1.0210.98
66_N414_M1.0160.98
366_S376_D1.0150.98
137_K169_G1.0140.98
407_V410_V1.0130.98
388_Y404_A1.0110.98
208_F313_K1.0090.98
143_L169_G1.0070.98
204_A316_V1.0070.98
43_Q59_M1.0050.98
197_V294_V1.0020.98
222_F243_I1.0000.98
252_N260_K0.9990.98
269_G273_N0.9990.98
79_H150_V0.9980.98
230_A240_I0.9930.98
119_L127_L0.9890.98
328_D399_R0.9880.98
234_S258_V0.9860.98
190_L228_Y0.9860.98
229_A233_L0.9840.98
199_T202_K0.9820.98
180_P183_L0.9790.97
250_V271_V0.9640.97
208_F337_V0.9610.97
68_A410_V0.9530.97
315_I331_M0.9440.97
252_N276_E0.9360.97
349_V352_S0.9360.97
293_L301_V0.9330.97
50_G58_F0.9320.97
201_A314_L0.9280.97
183_L416_A0.9160.96
130_K133_Q0.9160.96
234_S257_D0.9130.96
270_S273_N0.9100.96
128_S131_F0.9090.96
302_I307_A0.9090.96
305_F308_P0.9070.96
289_D312_A0.9050.96
207_K387_D0.9020.96
294_V316_V0.9020.96
44_V60_G0.8990.96
78_Y128_S0.8990.96
102_L377_R0.8980.96
49_R56_K0.8960.96
396_H400_T0.8940.96
264_I274_Y0.8920.96
195_L375_V0.8910.96
265_K279_K0.8890.96
130_K166_K0.8810.95
202_K212_I0.8730.95
135_I138_Y0.8710.95
161_L165_I0.8690.95
85_D88_E0.8620.95
389_H396_H0.8610.95
130_K134_A0.8600.95
160_Y176_F0.8570.95
268_T273_N0.8530.94
264_I273_N0.8490.94
76_I131_F0.8480.94
69_L99_S0.8450.94
73_K349_V0.8410.94
372_K376_D0.8400.94
216_R237_G0.8310.94
233_L294_V0.8300.94
109_K320_N0.8270.93
283_E287_I0.8270.93
230_A261_A0.8260.93
200_I385_L0.8250.93
78_Y112_I0.8230.93
263_E266_E0.8220.93
310_I315_I0.8220.93
234_S240_I0.8210.93
308_P334_R0.8200.93
251_I288_S0.8180.93
197_V229_A0.8150.93
158_A162_D0.8110.93
76_I146_P0.8110.93
252_N274_Y0.8090.93
262_M265_K0.8060.93
110_G128_S0.8040.92
251_I278_R0.8030.92
142_E360_K0.8030.92
250_V261_A0.8030.92
169_G172_D0.7980.92
352_S355_E0.7860.92
328_D332_R0.7850.92
56_K118_K0.7830.91
109_K193_T0.7830.91
389_H398_L0.7830.91
117_K246_S0.7830.91
394_E404_A0.7790.91
186_I365_I0.7770.91
208_F314_L0.7760.91
282_N285_L0.7730.91
304_K327_A0.7720.91
110_G131_F0.7700.91
227_Y266_E0.7690.91
350_V378_M0.7690.91
81_N86_E0.7660.91
43_Q61_W0.7650.91
157_M176_F0.7630.90
357_A363_Q0.7530.90
358_N365_I0.7530.90
302_I341_D0.7450.89
216_R241_V0.7420.89
295_P319_A0.7410.89
50_G54_K0.7400.89
280_V288_S0.7390.89
157_M162_D0.7370.89
42_I135_I0.7370.89
161_L172_D0.7360.89
387_D390_Q0.7330.89
372_K375_V0.7330.89
274_Y277_G0.7320.88
212_I217_V0.7320.88
337_V398_L0.7300.88
228_Y232_F0.7300.88
388_Y401_A0.7280.88
193_T348_G0.7270.88
232_F371_K0.7260.88
91_S95_T0.7210.88
310_I331_M0.7200.88
192_S374_I0.7160.87
64_Q143_L0.7120.87
249_G287_I0.7100.87
230_A258_V0.7090.87
264_I275_P0.7080.87
97_K320_N0.7070.87
194_G229_A0.7070.87
247_K272_T0.7070.87
245_D265_K0.7070.87
412_R416_A0.7030.86
241_V288_S0.7030.86
139_L160_Y0.7020.86
163_E167_I0.7010.86
148_P189_R0.7000.86
386_Y390_Q0.6990.86
256_I261_A0.6960.86
73_K105_Y0.6960.86
242_G249_G0.6950.86
308_P333_Q0.6940.86
151_N225_V0.6940.86
261_A279_K0.6930.86
292_I314_L0.6920.86
391_K394_E0.6900.85
51_S126_Q0.6890.85
379_N383_N0.6890.85
129_R163_E0.6880.85
186_I351_G0.6860.85
252_N277_G0.6860.85
155_Q158_A0.6840.85
406_A410_V0.6830.85
291_N313_K0.6830.85
121_K124_L0.6820.85
200_I339_V0.6820.85
48_I58_F0.6800.85
141_S173_F0.6770.84
338_V341_D0.6740.84
312_A336_I0.6720.84
303_N323_L0.6710.84
160_Y163_E0.6700.84
157_M164_Y0.6700.84
389_H394_E0.6690.84
117_K265_K0.6680.84
353_Y357_A0.6670.83
178_G352_S0.6670.83
284_E306_N0.6670.83
141_S172_D0.6670.83
248_G271_V0.6640.83
160_Y164_Y0.6630.83
282_N286_L0.6630.83
56_K119_L0.6610.83
200_I316_V0.6610.83
136_Y140_G0.6600.83
64_Q72_Y0.6560.82
249_G288_S0.6550.82
279_K282_N0.6550.82
219_I243_I0.6550.82
192_S224_N0.6520.82
46_I127_L0.6520.82
225_V246_S0.6520.82
254_N276_E0.6510.82
294_V318_G0.6500.82
388_Y396_H0.6500.82
302_I315_I0.6490.82
82_V111_G0.6480.82
350_V377_R0.6460.81
191_Y228_Y0.6440.81
245_D248_G0.6440.81
102_L380_N0.6440.81
265_K271_V0.6430.81
270_S274_Y0.6430.81
264_I269_G0.6390.81
157_M183_L0.6390.81
148_P224_N0.6390.81
283_E305_F0.6370.81
407_V411_V0.6370.81
395_D400_T0.6360.80
132_I176_F0.6350.80
99_S406_A0.6340.80
93_I321_G0.6320.80
126_Q162_D0.6310.80
76_I128_S0.6310.80
204_A337_V0.6300.80
68_A414_M0.6280.80
49_R55_L0.6270.79
206_N379_N0.6230.79
198_A202_K0.6230.79
315_I323_L0.6230.79
222_F261_A0.6220.79
115_D120_T0.6220.79
132_I135_I0.6200.79
399_R403_M0.6200.79
384_T387_D0.6200.79
315_I336_I0.6180.79
202_K379_N0.6160.78
227_Y264_I0.6150.78
386_Y398_L0.6140.78
205_A215_A0.6130.78
287_I306_N0.6110.78
78_Y114_V0.6110.78
100_L384_T0.6100.78
268_T271_V0.6100.78
358_N364_I0.6090.78
45_K57_T0.6090.78
323_L327_A0.6090.78
197_V344_A0.6090.78
133_Q165_I0.6040.77
222_F258_V0.6040.77
339_V398_L0.6040.77
157_M161_L0.6020.77
192_S351_G0.6010.77
205_A210_G0.6000.76
233_L292_I0.5980.76
273_N279_K0.5970.76
374_I378_M0.5970.76
405_L409_R0.5960.76
220_Q301_V0.5960.76
193_T224_N0.5960.76
186_I189_R0.5950.76
152_T192_S0.5950.76
328_D338_V0.5940.76
189_R351_G0.5940.76
125_E159_W0.5930.76
58_F114_V0.5920.76
318_G344_A0.5920.76
388_Y391_K0.5900.75
218_I312_A0.5900.75
97_K109_K0.5890.75
323_L338_V0.5890.75
207_K337_V0.5890.75
281_T285_L0.5890.75
346_A350_V0.5880.75
89_A321_G0.5880.75
377_R380_N0.5880.75
218_I285_L0.5870.75
218_I249_G0.5860.75
299_E321_G0.5850.75
244_S286_L0.5850.75
142_E362_G0.5840.75
178_G355_E0.5840.75
328_D331_M0.5810.74
275_P278_R0.5780.74
216_R251_I0.5780.74
105_Y356_W0.5770.74
239_K254_N0.5770.74
88_E91_S0.5770.74
69_L409_R0.5760.74
119_L123_E0.5760.74
132_I163_E0.5760.74
351_G370_A0.5750.73
404_A407_V0.5730.73
114_V120_T0.5730.73
259_G262_M0.5720.73
248_G279_K0.5710.73
131_F373_L0.5710.73
386_Y389_H0.5700.73
303_N324_T0.5690.73
323_L328_D0.5680.72
177_T352_S0.5680.72
205_A209_I0.5670.72
129_R162_D0.5660.72
189_R352_S0.5650.72
92_M96_W0.5650.72
198_A229_A0.5650.72
331_M338_V0.5630.72
177_T349_V0.5630.72
189_R224_N0.5610.72
128_S156_T0.5610.72
68_A413_A0.5590.71
293_L315_I0.5590.71
204_A386_Y0.5580.71
339_V382_F0.5570.71
389_H395_D0.5550.71
351_G365_I0.5540.71
43_Q88_E0.5500.70
394_E397_D0.5490.70
96_W407_V0.5480.70
219_I233_L0.5470.70
296_A318_G0.5460.70
312_A315_I0.5450.69
155_Q159_W0.5450.69
193_T345_N0.5450.69
54_K57_T0.5440.69
101_L381_A0.5430.69
168_T172_D0.5420.69
215_A292_I0.5420.69
261_A264_I0.5420.69
357_A361_M0.5410.69
195_L231_K0.5400.69
401_A404_A0.5380.68
158_A164_Y0.5380.68
200_I343_L0.5370.68
307_A331_M0.5370.68
198_A232_F0.5350.68
184_G355_E0.5340.68
194_G318_G0.5340.68
80_P116_P0.5330.68
249_G285_L0.5310.67
305_F309_K0.5310.67
381_A385_L0.5300.67
73_K352_S0.5290.67
232_F236_M0.5290.67
121_K125_E0.5290.67
373_L376_D0.5280.67
104_P357_A0.5260.67
302_I338_V0.5260.67
186_I370_A0.5240.66
338_V399_R0.5240.66
301_V307_A0.5230.66
354_V369_E0.5220.66
73_K98_N0.5220.66
102_L384_T0.5210.66
138_Y169_G0.5200.66
128_S160_Y0.5190.66
229_A318_G0.5190.66
209_I215_A0.5190.66
354_V373_L0.5180.66
265_K268_T0.5180.66
335_G395_D0.5180.66
218_I289_D0.5180.66
73_K356_W0.5180.66
272_T279_K0.5160.65
101_L378_M0.5160.65
181_V187_G0.5160.65
244_S282_N0.5150.65
109_K147_A0.5140.65
197_V225_V0.5140.65
83_T113_R0.5120.65
151_N246_S0.5110.65
119_L124_L0.5100.64
76_I110_G0.5100.64
205_A314_L0.5090.64
382_F385_L0.5070.64
109_K224_N0.5070.64
231_K267_K0.5060.64
63_S108_G0.5050.64
43_Q47_Q0.5030.63
132_I139_L0.5020.63
252_N256_I0.5020.63
200_I382_F0.5010.63
286_L301_V0.5010.63
87_V91_S0.5000.63
159_W164_Y0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yfqA 5 0.931 100 0.069 Contact Map
4xgiA 6 0.9786 100 0.069 Contact Map
2tmgA 5 0.969 100 0.084 Contact Map
1v9lA 4 0.9786 100 0.085 Contact Map
3aogA 8 0.9881 100 0.089 Contact Map
3k92A 5 0.9905 100 0.09 Contact Map
3aoeE 3 0.9857 100 0.091 Contact Map
3r3jA 5 0.9976 100 0.093 Contact Map
4fccA 5 0.9929 100 0.095 Contact Map
3mw9A 5 0.9952 100 0.095 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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