GREMLIN Database
Q97WR5 - Uncharacterized protein
UniProt: Q97WR5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 262 (245)
Sequences: 2059 (1458)
Seq/√Len: 93.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_E159_K7.1431.00
79_D83_K5.3391.00
6_M158_E3.7701.00
42_K130_K3.7371.00
202_E205_K3.2771.00
44_E163_K3.1371.00
189_K215_K2.9011.00
64_S108_K2.8241.00
148_E151_E2.8191.00
144_E148_E2.7481.00
226_L230_H2.6351.00
208_K211_E2.5591.00
45_T164_A2.5481.00
91_D134_V2.4831.00
23_E28_D2.4581.00
8_I157_V2.4361.00
210_S217_Y2.3881.00
61_Y109_D2.3131.00
71_I113_G2.2391.00
142_S145_S2.1691.00
47_I136_I2.1531.00
46_I131_P2.1481.00
172_P194_L2.1461.00
166_F235_Y2.1041.00
99_V108_K1.9101.00
84_Y123_F1.9091.00
92_T95_V1.9001.00
178_L218_Q1.8851.00
193_I213_Y1.8171.00
49_S231_M1.8161.00
139_T146_H1.8161.00
194_L226_L1.7941.00
122_L133_V1.7881.00
47_I166_F1.7381.00
60_F139_T1.7331.00
101_N155_K1.7161.00
62_I99_V1.6991.00
168_A232_L1.6771.00
147_Y203_F1.6721.00
13_S171_S1.6131.00
150_G234_G1.5911.00
12_I167_L1.5891.00
51_P224_G1.5731.00
63_E135_T1.5621.00
54_V224_G1.5521.00
47_I98_I1.5491.00
243_I246_Y1.5321.00
72_Q85_C1.5281.00
191_D256_L1.5271.00
54_V222_P1.5171.00
209_I216_E1.5171.00
171_S255_M1.5151.00
138_I224_G1.5071.00
48_V118_A1.4671.00
114_L118_A1.4621.00
150_G235_Y1.4421.00
197_L205_K1.4240.99
96_E100_K1.4110.99
9_G235_Y1.4100.99
54_V140_D1.4090.99
80_E83_K1.4080.99
48_V122_L1.3960.99
97_E101_N1.3950.99
62_I98_I1.3830.99
7_T126_F1.3790.99
32_R35_K1.3790.99
191_D254_S1.3700.99
61_Y107_V1.3660.99
98_I134_V1.3570.99
59_T139_T1.3530.99
9_G232_L1.3330.99
74_Y119_W1.3320.99
208_K212_L1.2990.99
193_I197_L1.2810.99
185_P189_K1.2800.99
69_E112_W1.2690.99
7_T165_V1.2520.99
48_V167_L1.2490.99
99_V106_V1.2400.98
97_E100_K1.2170.98
197_L202_E1.2070.98
213_Y216_E1.2010.98
87_N129_Y1.2010.98
101_N156_A1.1930.98
100_K104_G1.1800.98
44_E159_K1.1770.98
70_C114_L1.1680.98
139_T145_S1.1650.98
195_M199_K1.1640.98
60_F149_I1.1550.98
188_T192_A1.1400.97
24_N27_K1.1380.97
147_Y207_L1.1330.97
151_E203_F1.1280.97
89_L92_T1.1250.97
90_N95_V1.0970.97
201_G204_E1.0960.97
98_I101_N1.0890.97
154_R237_K1.0760.96
191_D195_M1.0750.96
138_I227_N1.0720.96
147_Y233_L1.0710.96
45_T94_L1.0690.96
118_A135_T1.0620.96
143_P209_I1.0480.96
64_S110_D1.0390.95
20_L123_F1.0280.95
47_I134_V1.0220.95
146_H231_M1.0210.95
114_L133_V1.0150.95
26_W247_D1.0150.95
70_C88_A1.0080.95
62_I108_K1.0020.95
183_I188_T0.9970.94
91_D94_L0.9880.94
191_D246_Y0.9870.94
94_L134_V0.9860.94
94_L98_I0.9860.94
49_S153_I0.9760.94
126_F165_V0.9740.94
53_F135_T0.9690.93
20_L124_Y0.9680.93
76_D82_Y0.9650.93
204_E208_K0.9650.93
248_T254_S0.9600.93
91_D98_I0.9540.93
147_Y151_E0.9540.93
224_G227_N0.9520.93
7_T163_K0.9520.93
18_T81_T0.9520.93
77_F82_Y0.9510.93
178_L186_K0.9450.93
47_I164_A0.9420.92
243_I256_L0.9410.92
93_E96_E0.9380.92
192_A196_D0.9370.92
43_P126_F0.9330.92
12_I121_P0.9320.92
62_I136_I0.9250.92
96_E99_V0.9220.92
75_Y79_D0.9120.91
27_K31_R0.9110.91
184_T252_G0.9080.91
193_I212_L0.9070.91
46_I86_Y0.9060.91
81_T119_W0.9040.91
16_S19_I0.9000.91
7_T38_E0.8990.91
49_S136_I0.8990.91
13_S220_A0.8980.91
102_A152_K0.8960.90
148_E152_K0.8950.90
12_I30_L0.8920.90
99_V103_E0.8790.90
25_K247_D0.8770.90
38_E126_F0.8740.89
126_F130_K0.8710.89
43_P131_P0.8680.89
20_L120_I0.8670.89
64_S99_V0.8660.89
198_I241_A0.8630.89
151_E154_R0.8550.88
34_G37_I0.8470.88
27_K124_Y0.8290.87
60_F136_I0.8210.86
70_C85_C0.8140.86
144_E207_L0.8060.85
30_L124_Y0.8040.85
21_I81_T0.8000.85
55_S61_Y0.7980.85
203_F207_L0.7960.84
105_K109_D0.7820.83
186_K218_Q0.7800.83
172_P256_L0.7770.83
42_K131_P0.7770.83
145_S148_E0.7770.83
9_G157_V0.7760.83
54_V138_I0.7760.83
117_G135_T0.7720.83
78_P82_Y0.7680.82
254_S257_A0.7670.82
203_F233_L0.7660.82
79_D82_Y0.7650.82
248_T256_L0.7620.82
46_I165_V0.7620.82
195_M246_Y0.7570.81
50_S118_A0.7560.81
196_D200_S0.7540.81
74_Y81_T0.7500.81
21_I80_E0.7490.81
102_A149_I0.7490.81
34_G38_E0.7480.81
6_M239_K0.7430.80
244_L247_D0.7390.80
223_E227_N0.7380.80
29_L32_R0.7320.79
64_S109_D0.7260.79
58_E141_N0.7240.78
29_L257_A0.7220.78
120_I123_F0.7210.78
96_E108_K0.7180.78
14_H17_P0.7160.78
88_A114_L0.7140.77
55_S59_T0.7110.77
38_E43_P0.7090.77
10_L36_E0.7070.77
67_K87_N0.7060.77
237_K241_A0.7050.77
194_L229_L0.7050.77
69_E111_K0.7020.76
75_Y78_P0.7020.76
142_S146_H0.6980.76
189_K192_A0.6970.76
50_S63_E0.6960.76
18_T21_I0.6940.75
23_E27_K0.6940.75
157_V163_K0.6930.75
244_L256_L0.6930.75
195_M243_I0.6920.75
65_S114_L0.6900.75
31_R35_K0.6890.75
190_F193_I0.6850.74
28_D31_R0.6850.74
241_A244_L0.6840.74
155_K158_E0.6810.74
210_S223_E0.6800.74
58_E140_D0.6790.74
68_L87_N0.6720.73
18_T22_D0.6720.73
104_G152_K0.6710.73
143_P223_E0.6680.73
75_Y82_Y0.6670.72
207_L230_H0.6660.72
63_E114_L0.6660.72
128_E148_E0.6660.72
98_I136_I0.6650.72
143_P226_L0.6650.72
13_S19_I0.6640.72
10_L125_M0.6630.72
209_I217_Y0.6590.72
186_K219_T0.6590.72
173_T220_A0.6580.71
247_D250_W0.6570.71
101_N159_K0.6550.71
10_L33_V0.6550.71
47_I156_A0.6520.71
20_L27_K0.6510.71
187_P248_T0.6500.71
31_R124_Y0.6480.70
173_T219_T0.6480.70
26_W30_L0.6470.70
25_K29_L0.6470.70
74_Y173_T0.6450.70
47_I163_K0.6450.70
20_L81_T0.6420.70
17_P77_F0.6420.70
11_F15_G0.6410.70
59_T107_V0.6400.69
20_L84_Y0.6390.69
46_I172_P0.6390.69
63_E70_C0.6380.69
96_E151_E0.6350.69
63_E134_V0.6340.69
187_P219_T0.6340.69
19_I120_I0.6310.68
146_H227_N0.6300.68
199_K242_E0.6290.68
68_L114_L0.6290.68
193_I214_P0.6270.68
88_A129_Y0.6240.67
185_P188_T0.6230.67
173_T176_L0.6220.67
241_A245_G0.6180.67
53_F112_W0.6180.67
147_Y230_H0.6160.66
212_L216_E0.6160.66
51_P169_T0.6160.66
119_W173_T0.6120.66
70_C135_T0.6090.66
70_C87_N0.6080.65
67_K89_L0.6070.65
205_K208_K0.6070.65
54_V223_E0.6060.65
18_T78_P0.6040.65
26_W29_L0.6030.65
14_H169_T0.5990.64
192_A195_M0.5960.64
173_T186_K0.5960.64
22_D80_E0.5930.64
230_H233_L0.5920.63
154_R238_P0.5920.63
143_P227_N0.5920.63
43_P46_I0.5910.63
73_D77_F0.5910.63
196_D199_K0.5890.63
86_Y127_P0.5890.63
66_E92_T0.5880.63
19_I171_S0.5870.63
51_P54_V0.5840.62
85_C123_F0.5820.62
209_I226_L0.5820.62
71_I119_W0.5800.62
55_S137_S0.5790.62
195_M256_L0.5790.62
70_C119_W0.5780.62
75_Y85_C0.5760.61
166_F244_L0.5740.61
53_F138_I0.5720.61
139_T149_I0.5710.61
64_S134_V0.5710.61
12_I125_M0.5690.60
44_E91_D0.5690.60
6_M237_K0.5660.60
135_T169_T0.5650.60
13_S173_T0.5610.59
72_Q119_W0.5590.59
179_F250_W0.5580.59
252_G256_L0.5580.59
60_F146_H0.5580.59
121_P124_Y0.5560.59
133_V165_V0.5560.59
32_R36_E0.5560.59
220_A224_G0.5540.58
34_G126_F0.5530.58
172_P254_S0.5530.58
198_I229_L0.5490.58
209_I223_E0.5480.58
206_I233_L0.5480.58
105_K108_K0.5460.57
73_D76_D0.5430.57
98_I106_V0.5430.57
196_D205_K0.5420.57
11_F14_H0.5410.57
68_L88_A0.5400.56
229_L258_A0.5350.56
46_I125_M0.5350.56
128_E211_E0.5340.56
201_G236_I0.5310.55
244_L257_A0.5290.55
193_I232_L0.5270.55
172_P220_A0.5270.55
222_P255_M0.5260.54
241_A246_Y0.5250.54
74_Y77_F0.5240.54
58_E75_Y0.5230.54
215_K218_Q0.5230.54
187_P252_G0.5210.54
68_L90_N0.5200.54
16_S75_Y0.5190.54
201_G241_A0.5190.54
68_L146_H0.5170.53
73_D115_D0.5160.53
81_T120_I0.5140.53
49_S138_I0.5130.53
217_Y223_E0.5110.52
190_F216_E0.5100.52
52_H174_H0.5100.52
45_T156_A0.5070.52
10_L232_L0.5070.52
100_K128_E0.5060.52
204_E207_L0.5060.52
28_D32_R0.5050.52
55_S139_T0.5050.52
152_K155_K0.5050.52
72_Q82_Y0.5020.51
101_N164_A0.5010.51
156_A164_A0.5010.51
136_I231_M0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pw6A 2 0.8893 100 0.276 Contact Map
1b4uB 2 0.9313 100 0.54 Contact Map
3wraA 2 0.9198 100 0.545 Contact Map
3vsjA 1 0.9542 100 0.559 Contact Map
3vsjB 2 0.958 100 0.587 Contact Map
3bczA 1 0.8855 100 0.656 Contact Map
4twbA 2 0.4733 62.6 0.959 Contact Map
3dahA 5 0.4847 62.5 0.959 Contact Map
1dkuA 5 0.4771 61 0.96 Contact Map
3lrtA 2 0.3702 56.3 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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