Q97WR4 - SULSO - GREMLIN Contacts

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Q97WR4 - 4-hydroxyphenylacetate-3-hydroxylase (HpaA)

UniProt:	Q97WR4	Sequences: MGCRGGYFHGSIKGVVWMIRRGTDYIKSIKENPPVVYYEGEVVKDVTEHSAFKIPISTVAKYYDLHWDEKYKEYLRVYNLDVGEETSISFLRPKNKKDLGKLRDGLVKIYDYYRGFFGRSPDYLNLWTMVFYAHAEDYFGKQFGSKFMENAIEIYKEATKRDLFYTHAIVAPMYDRSRPPSQWEDPYIQVGIVEEKPEGVVVRGAAMICTAGPYAEMLWYLPNVRRDSDPRYAIYFSIPTNTKGVKFLSRRGFQPREGGEFEYPISSRFEESDAVLVLDNVLIPWERIIFFKKPELIEDLMWHTVQLRGWFNWHFVIQHYSRLKFLAGLAIAIAEASGTSNFINVQEKIGEILIYVALNEAALYASVERAQELPNITRPDPYISISASHFNMKTVPRANEILRSISAGSSIPIPAGIKDFENPEERKLLDKYMAMKGLDALERVKMFNLLWDVIGSEAGMRYEQYDRFSRGDPTIRWAQTYTEVFKDRKHEFVKLVKDIIDQMPNPKA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	508 (471)
Sequences:	818 (520)
Seq/√Len:	24.0

BACSU - YOAI
SULSO - Q97WR4 Q97V96 Q97VV3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
203_R	280_N	8.141	1.00
157_E	161_R	5.654	1.00
26_I	56_I	5.542	1.00
426_R	430_D	5.011	1.00
41_E	49_H	4.694	1.00
202_V	236_F	4.629	1.00
28_S	216_E	4.515	1.00
370_A	377_T	4.463	1.00
45_D	48_E	4.319	1.00
420_F	444_V	3.846	1.00
200_V	288_I	3.794	1.00
22_G	64_D	3.771	1.00
285_W	288_I	3.596	1.00
192_I	291_F	3.538	1.00
217_M	287_R	3.529	1.00
30_K	45_D	3.458	1.00
78_Y	85_E	3.346	1.00
196_K	282_L	3.322	1.00
200_V	234_I	3.296	1.00
72_K	85_E	3.226	1.00
195_E	292_K	3.204	1.00
196_K	201_V	3.198	1.00
153_E	156_K	3.116	1.00
420_F	429_L	3.098	1.00
195_E	291_F	3.009	1.00
30_K	47_T	2.974	1.00
237_S	289_I	2.972	1.00
198_E	282_L	2.959	1.00
345_V	405_I	2.954	1.00
248_L	277_V	2.880	1.00
334_A	349_I	2.854	0.99
397_R	400_E	2.536	0.99
88_I	101_K	2.511	0.99
190_V	202_V	2.494	0.99
330_A	352_I	2.491	0.99
351_E	397_R	2.482	0.98
194_E	198_E	2.478	0.98
35_V	246_K	2.463	0.98
201_V	282_L	2.428	0.98
24_D	27_K	2.364	0.98
79_N	82_V	2.347	0.98
41_E	418_K	2.321	0.98
20_R	216_E	2.284	0.97
21_R	67_W	2.280	0.97
79_N	86_T	2.245	0.97
194_E	280_N	2.244	0.97
21_R	24_D	2.214	0.97
259_G	264_P	2.182	0.96
493_V	497_K	2.179	0.96
210_T	250_R	2.166	0.96
277_V	428_L	2.145	0.96
339_T	345_V	2.119	0.96
149_E	153_E	2.101	0.96
154_I	217_M	2.099	0.96
80_L	86_T	2.088	0.95
20_R	28_S	2.067	0.95
84_E	160_K	1.968	0.94
371_Q	380_D	1.965	0.94
76_R	85_E	1.936	0.93
122_D	125_N	1.933	0.93
113_Y	117_F	1.929	0.93
231_R	292_K	1.921	0.93
439_D	442_E	1.921	0.93
97_K	101_K	1.895	0.92
194_E	201_V	1.895	0.92
23_T	27_K	1.889	0.92
94_K	98_D	1.879	0.92
324_K	360_E	1.861	0.92
335_E	490_H	1.853	0.92
78_Y	82_V	1.846	0.91
95_N	377_T	1.840	0.91
190_V	278_L	1.803	0.90
35_V	42_V	1.772	0.90
329_L	453_V	1.740	0.89
75_L	105_G	1.732	0.88
422_N	425_E	1.720	0.88
135_A	152_I	1.711	0.88
173_M	409_S	1.699	0.87
171_A	206_A	1.661	0.86
193_V	201_V	1.651	0.86
293_K	296_L	1.611	0.84
107_V	111_D	1.598	0.84
192_I	234_I	1.592	0.84
146_K	149_E	1.574	0.83
19_I	84_E	1.568	0.83
220_Y	278_L	1.562	0.83
261_F	264_P	1.555	0.82
335_E	340_S	1.551	0.82
285_W	291_F	1.545	0.82
150_N	288_I	1.533	0.81
71_Y	108_K	1.528	0.81
111_D	321_S	1.506	0.80
154_I	287_R	1.499	0.80
227_D	294_P	1.468	0.78
288_I	291_F	1.463	0.78
178_R	182_Q	1.461	0.78
153_E	157_E	1.459	0.78
317_I	363_L	1.458	0.78
22_G	60_A	1.457	0.78
119_R	122_D	1.452	0.78
103_R	367_V	1.443	0.77
154_I	237_S	1.443	0.77
344_N	348_K	1.442	0.77
248_L	428_L	1.430	0.77
200_V	282_L	1.418	0.76
249_S	272_S	1.412	0.76
157_E	163_L	1.410	0.75
187_Y	191_G	1.409	0.75
334_A	339_T	1.404	0.75
150_N	286_E	1.401	0.75
193_V	203_R	1.393	0.75
81_D	156_K	1.393	0.75
326_L	450_L	1.385	0.74
113_Y	392_M	1.384	0.74
81_D	86_T	1.380	0.74
313_W	367_V	1.360	0.73
62_Y	109_I	1.359	0.73
323_L	398_A	1.352	0.72
429_L	444_V	1.352	0.72
441_L	445_K	1.334	0.71
96_K	377_T	1.327	0.71
251_R	263_Y	1.315	0.70
154_I	157_E	1.298	0.69
201_V	234_I	1.296	0.69
397_R	401_I	1.289	0.69
380_D	383_I	1.288	0.69
195_E	285_W	1.282	0.68
246_K	428_L	1.274	0.68
413_I	444_V	1.274	0.68
32_N	241_N	1.272	0.68
207_M	408_G	1.271	0.67
121_P	167_H	1.254	0.66
336_A	438_L	1.248	0.66
64_D	67_W	1.243	0.66
327_A	352_I	1.232	0.65
139_F	143_F	1.226	0.65
66_H	87_S	1.221	0.64
149_E	152_I	1.217	0.64
283_I	287_R	1.214	0.64
220_Y	236_F	1.203	0.63
27_K	30_K	1.201	0.63
400_E	467_R	1.194	0.63
222_P	232_Y	1.186	0.62
333_I	450_L	1.186	0.62
151_A	155_Y	1.175	0.61
348_K	401_I	1.174	0.61
218_L	240_T	1.172	0.61
164_F	211_A	1.167	0.61
403_R	467_R	1.161	0.60
185_D	431_K	1.153	0.60
273_D	322_R	1.151	0.60
78_Y	83_G	1.139	0.59
239_P	283_I	1.134	0.58
191_G	231_R	1.131	0.58
238_I	283_I	1.117	0.57
461_R	465_Y	1.114	0.57
54_I	57_S	1.113	0.57
322_R	466_D	1.107	0.57
157_E	217_M	1.098	0.56
69_E	76_R	1.098	0.56
175_D	178_R	1.094	0.56
96_K	368_E	1.093	0.56
163_L	217_M	1.092	0.56
358_L	390_F	1.083	0.55
233_A	408_G	1.077	0.54
435_M	438_L	1.076	0.54
212_G	247_F	1.072	0.54
40_G	419_D	1.067	0.54
271_E	461_R	1.065	0.54
86_T	159_T	1.065	0.54
203_R	220_Y	1.063	0.53
219_W	356_V	1.063	0.53
396_P	400_E	1.058	0.53
236_F	283_I	1.057	0.53
277_V	432_Y	1.056	0.53
312_N	388_S	1.050	0.53
77_V	91_L	1.042	0.52
448_N	469_S	1.042	0.52
36_V	297_I	1.026	0.51
472_D	475_I	1.011	0.50
36_V	197_P	1.009	0.50
250_R	271_E	1.007	0.50
55_P	214_Y	1.006	0.49
348_K	405_I	1.005	0.49
218_L	276_L	1.005	0.49
123_Y	167_H	1.004	0.49
364_Y	369_R	1.004	0.49
30_K	46_V	1.003	0.49
369_R	380_D	0.993	0.49
156_K	200_V	0.992	0.48
79_N	160_K	0.991	0.48
69_E	72_K	0.990	0.48
58_T	269_F	0.983	0.48
154_I	165_Y	0.981	0.48
238_I	242_T	0.980	0.48
198_E	286_E	0.979	0.48
30_K	48_E	0.976	0.47
181_S	229_D	0.975	0.47
168_A	209_C	0.973	0.47
60_A	423_P	0.970	0.47
351_E	401_I	0.965	0.47
142_Q	295_E	0.960	0.46
157_E	160_K	0.957	0.46
427_K	430_D	0.954	0.46
323_L	391_N	0.951	0.46
182_Q	228_S	0.951	0.46
140_G	146_K	0.949	0.45
127_W	131_F	0.948	0.45
198_E	201_V	0.945	0.45
201_V	280_N	0.944	0.45
82_V	160_K	0.943	0.45
187_Y	203_R	0.936	0.44
36_V	68_D	0.932	0.44
206_A	391_N	0.932	0.44
150_N	202_V	0.931	0.44
245_V	281_V	0.930	0.44
96_K	370_A	0.929	0.44
26_I	429_L	0.928	0.44
396_P	467_R	0.928	0.44
58_T	114_R	0.926	0.44
290_F	297_I	0.923	0.44
25_Y	157_E	0.922	0.44
121_P	125_N	0.921	0.43
115_G	271_E	0.918	0.43
35_V	424_E	0.917	0.43
275_V	433_M	0.916	0.43
361_A	383_I	0.913	0.43
193_V	280_N	0.911	0.43
331_I	349_I	0.909	0.43
461_R	466_D	0.908	0.43
220_Y	242_T	0.905	0.42
212_G	240_T	0.903	0.42
157_E	165_Y	0.903	0.42
143_F	295_E	0.901	0.42
30_K	241_N	0.901	0.42
158_A	165_Y	0.899	0.42
93_P	102_L	0.897	0.42
24_D	292_K	0.897	0.42
337_S	408_G	0.896	0.42
91_L	101_K	0.894	0.42
23_T	73_E	0.892	0.41
125_N	133_A	0.892	0.41
468_F	472_D	0.889	0.41
348_K	404_S	0.885	0.41
202_V	375_N	0.882	0.41
449_L	493_V	0.881	0.41
49_H	60_A	0.879	0.41
162_D	236_F	0.878	0.40
37_Y	467_R	0.875	0.40
39_E	424_E	0.873	0.40
174_Y	180_P	0.873	0.40
316_V	387_A	0.867	0.40
107_V	321_S	0.866	0.40
68_D	71_Y	0.858	0.39
333_I	447_F	0.855	0.39
42_V	423_P	0.855	0.39
122_D	132_Y	0.854	0.39
242_T	425_E	0.854	0.39
343_I	474_T	0.852	0.39
125_N	130_V	0.851	0.39
43_V	490_H	0.848	0.38
264_P	452_D	0.848	0.38
37_Y	443_R	0.847	0.38
140_G	148_M	0.845	0.38
88_I	91_L	0.841	0.38
95_N	355_Y	0.841	0.38
149_E	288_I	0.839	0.38
178_R	185_D	0.838	0.38
165_Y	237_S	0.838	0.38
217_M	283_I	0.833	0.37
492_F	495_L	0.832	0.37
348_K	473_P	0.831	0.37
36_V	192_I	0.829	0.37
200_V	291_F	0.826	0.37
332_A	494_K	0.826	0.37
26_I	47_T	0.825	0.37
451_W	455_G	0.821	0.37
140_G	144_G	0.820	0.37
245_V	423_P	0.813	0.36
118_G	273_D	0.813	0.36
123_Y	311_F	0.812	0.36
207_M	429_L	0.809	0.36
23_T	245_V	0.805	0.36
271_E	466_D	0.802	0.35
23_T	340_S	0.801	0.35
128_T	131_F	0.800	0.35
290_F	293_K	0.799	0.35
273_D	461_R	0.796	0.35
245_V	278_L	0.796	0.35
361_A	365_A	0.794	0.35
170_V	214_Y	0.793	0.35
347_E	393_K	0.791	0.35
27_K	36_V	0.790	0.35
307_L	311_F	0.789	0.35
229_D	245_V	0.789	0.35
261_F	265_I	0.788	0.34
25_Y	161_R	0.787	0.34
81_D	286_E	0.783	0.34
329_L	450_L	0.782	0.34
268_R	445_K	0.782	0.34
407_A	472_D	0.780	0.34
127_W	132_Y	0.778	0.34
176_R	338_G	0.778	0.34
124_L	131_F	0.778	0.34
83_G	335_E	0.777	0.34
421_E	441_L	0.777	0.34
43_V	53_K	0.774	0.34
94_K	153_E	0.774	0.34
157_E	287_R	0.773	0.34
247_F	274_A	0.772	0.33
274_A	307_L	0.771	0.33
103_R	317_I	0.770	0.33
86_T	160_K	0.770	0.33
333_I	406_S	0.767	0.33
422_N	426_R	0.766	0.33
342_F	472_D	0.766	0.33
53_K	57_S	0.765	0.33
87_S	162_D	0.765	0.33
430_D	439_D	0.763	0.33
58_T	61_K	0.763	0.33
179_P	182_Q	0.762	0.33
42_V	184_E	0.761	0.33
42_V	424_E	0.760	0.33
462_Y	469_S	0.760	0.33
118_G	314_H	0.759	0.33
242_T	281_V	0.759	0.33
146_K	196_K	0.759	0.33
417_I	421_E	0.758	0.33
156_K	160_K	0.757	0.33
276_L	289_I	0.757	0.33
246_K	277_V	0.755	0.32
415_A	419_D	0.754	0.32
353_L	484_V	0.751	0.32
211_A	462_Y	0.750	0.32
110_Y	314_H	0.750	0.32
110_Y	113_Y	0.750	0.32
41_E	44_K	0.749	0.32
363_L	367_V	0.748	0.32
26_I	60_A	0.748	0.32
181_S	196_K	0.744	0.32
372_E	423_P	0.744	0.32
277_V	446_M	0.743	0.32
122_D	134_H	0.743	0.32
279_D	366_S	0.742	0.32
118_G	121_P	0.740	0.31
122_D	133_A	0.740	0.31
273_D	465_Y	0.739	0.31
95_N	341_N	0.739	0.31
368_E	427_K	0.739	0.31
272_S	453_V	0.738	0.31
122_D	131_F	0.737	0.31
282_L	285_W	0.737	0.31
336_A	446_M	0.736	0.31
91_L	313_W	0.732	0.31
119_R	210_T	0.731	0.31
43_V	48_E	0.729	0.31
90_F	432_Y	0.729	0.31
115_G	250_R	0.729	0.31
271_E	465_Y	0.729	0.31
121_P	451_W	0.728	0.31
165_Y	219_W	0.725	0.31
54_I	254_Q	0.725	0.31
250_R	466_D	0.725	0.31
207_M	210_T	0.724	0.31
42_V	198_E	0.722	0.30
29_I	454_I	0.721	0.30
333_I	446_M	0.721	0.30
419_D	449_L	0.719	0.30
207_M	275_V	0.719	0.30
147_F	150_N	0.716	0.30
113_Y	470_R	0.716	0.30
423_P	427_K	0.712	0.30
332_A	446_M	0.712	0.30
205_A	432_Y	0.708	0.30
166_T	209_C	0.707	0.29
19_I	24_D	0.707	0.29
200_V	292_K	0.706	0.29
210_T	269_F	0.704	0.29
350_G	354_I	0.703	0.29
41_E	280_N	0.702	0.29
230_P	294_P	0.701	0.29
107_V	324_K	0.701	0.29
487_D	490_H	0.698	0.29
110_Y	322_R	0.698	0.29
448_N	462_Y	0.697	0.29
314_H	322_R	0.696	0.29
273_D	466_D	0.696	0.29
271_E	322_R	0.695	0.29
383_I	400_E	0.693	0.29
329_L	338_G	0.692	0.29
31_E	45_D	0.692	0.29
307_L	472_D	0.690	0.28
246_K	422_N	0.689	0.28
391_N	462_Y	0.688	0.28
139_F	307_L	0.685	0.28
337_S	407_A	0.684	0.28
337_S	447_F	0.683	0.28
90_F	155_Y	0.682	0.28
465_Y	469_S	0.682	0.28
185_D	459_G	0.681	0.28
144_G	293_K	0.681	0.28
36_V	100_G	0.680	0.28
196_K	285_W	0.679	0.28
73_E	85_E	0.678	0.28
203_R	246_K	0.678	0.28
230_P	494_K	0.678	0.28
98_D	233_A	0.678	0.28
197_P	286_E	0.678	0.28
100_G	368_E	0.677	0.28
308_R	464_Q	0.677	0.28
124_L	154_I	0.674	0.28
238_I	287_R	0.674	0.28
80_L	84_E	0.673	0.28
144_G	429_L	0.672	0.27
118_G	465_Y	0.671	0.27
121_P	273_D	0.671	0.27
97_K	100_G	0.670	0.27
183_W	189_Q	0.667	0.27
358_L	362_A	0.666	0.27
146_K	150_N	0.666	0.27
323_L	356_V	0.665	0.27
194_E	282_L	0.664	0.27
173_M	176_R	0.663	0.27
388_S	392_M	0.663	0.27
35_V	156_K	0.663	0.27
69_E	295_E	0.662	0.27
35_V	46_V	0.661	0.27
392_M	476_R	0.661	0.27
39_E	419_D	0.660	0.27
330_A	361_A	0.659	0.27
178_R	228_S	0.657	0.27
346_Q	478_A	0.657	0.27
170_V	476_R	0.656	0.27
367_V	370_A	0.656	0.27
210_T	271_E	0.656	0.27
485_F	488_R	0.653	0.26
46_V	56_I	0.653	0.26
174_Y	434_A	0.652	0.26
322_R	461_R	0.652	0.26
24_D	436_K	0.652	0.26
207_M	448_N	0.651	0.26
94_K	194_E	0.651	0.26
122_D	127_W	0.651	0.26
37_Y	246_K	0.649	0.26
242_T	423_P	0.647	0.26
22_G	67_W	0.646	0.26
172_P	461_R	0.646	0.26
243_K	376_I	0.645	0.26
218_L	247_F	0.645	0.26
82_V	156_K	0.643	0.26
451_W	461_R	0.643	0.26
61_K	112_Y	0.642	0.26
309_G	379_P	0.642	0.26
241_N	335_E	0.642	0.26
149_E	345_V	0.639	0.26
87_S	105_G	0.639	0.26
242_T	268_R	0.639	0.26
203_R	232_Y	0.639	0.26
253_F	462_Y	0.637	0.26
154_I	213_P	0.636	0.25
95_N	278_L	0.636	0.25
73_E	153_E	0.636	0.25
58_T	429_L	0.635	0.25
169_I	311_F	0.635	0.25
278_L	289_I	0.634	0.25
124_L	133_A	0.634	0.25
178_R	191_G	0.634	0.25
118_G	167_H	0.633	0.25
189_Q	206_A	0.633	0.25
107_V	317_I	0.632	0.25
69_E	85_E	0.632	0.25
213_P	274_A	0.630	0.25
190_V	234_I	0.630	0.25
177_S	338_G	0.630	0.25
243_K	280_N	0.630	0.25
100_G	367_V	0.627	0.25
220_Y	447_F	0.626	0.25
139_F	380_D	0.626	0.25
358_L	361_A	0.625	0.25
259_G	263_Y	0.625	0.25
332_A	350_G	0.625	0.25
67_W	269_F	0.625	0.25
160_K	277_V	0.624	0.25
52_F	55_P	0.624	0.25
322_R	465_Y	0.623	0.25
118_G	208_I	0.622	0.25
103_R	361_A	0.621	0.25
82_V	86_T	0.621	0.25
162_D	217_M	0.621	0.25
197_P	285_W	0.621	0.25
97_K	277_V	0.620	0.25
78_Y	81_D	0.619	0.25
198_E	432_Y	0.619	0.25
314_H	461_R	0.618	0.25
149_E	241_N	0.617	0.24
73_E	101_K	0.616	0.24
339_T	398_A	0.616	0.24
36_V	152_I	0.614	0.24
403_R	463_E	0.614	0.24
140_G	145_S	0.613	0.24
37_Y	42_V	0.613	0.24
42_V	192_I	0.613	0.24
386_S	478_A	0.611	0.24
428_L	432_Y	0.611	0.24
135_A	140_G	0.611	0.24
87_S	289_I	0.611	0.24
311_F	385_I	0.611	0.24
358_L	386_S	0.610	0.24
364_Y	368_E	0.610	0.24
182_Q	456_S	0.609	0.24
390_F	394_T	0.608	0.24
74_Y	104_D	0.608	0.24
24_D	202_V	0.607	0.24
52_F	272_S	0.607	0.24
239_P	289_I	0.607	0.24
172_P	205_A	0.607	0.24
68_D	72_K	0.606	0.24
318_Q	461_R	0.606	0.24
132_Y	135_A	0.605	0.24
28_S	31_E	0.605	0.24
172_P	250_R	0.604	0.24
250_R	465_Y	0.603	0.24
273_D	452_D	0.602	0.24
25_Y	283_I	0.601	0.24
80_L	156_K	0.601	0.24
151_A	478_A	0.600	0.24
48_E	201_V	0.599	0.24
162_D	414_P	0.596	0.23
426_R	440_A	0.595	0.23
360_E	363_L	0.592	0.23
353_L	486_K	0.592	0.23
79_N	159_T	0.592	0.23
31_E	241_N	0.590	0.23
317_I	349_I	0.589	0.23
250_R	461_R	0.589	0.23
38_Y	58_T	0.588	0.23
119_R	271_E	0.587	0.23
173_M	177_S	0.587	0.23
29_I	309_G	0.587	0.23
72_K	101_K	0.584	0.23
52_F	95_N	0.581	0.23
27_K	182_Q	0.581	0.23
115_G	264_P	0.579	0.23
43_V	422_N	0.579	0.23
487_D	494_K	0.579	0.23
26_I	57_S	0.579	0.23
21_R	28_S	0.578	0.22
352_I	496_V	0.578	0.22
230_P	292_K	0.577	0.22
73_E	425_E	0.577	0.22
245_V	276_L	0.577	0.22
35_V	425_E	0.576	0.22
371_Q	381_P	0.575	0.22
53_K	254_Q	0.575	0.22
185_D	297_I	0.575	0.22
28_S	211_A	0.574	0.22
318_Q	466_D	0.574	0.22
169_I	476_R	0.573	0.22
128_T	158_A	0.571	0.22
119_R	466_D	0.570	0.22
114_R	269_F	0.569	0.22
28_S	32_N	0.569	0.22
283_I	336_A	0.568	0.22
29_I	175_D	0.568	0.22
90_F	93_P	0.568	0.22
163_L	287_R	0.566	0.22
38_Y	43_V	0.565	0.22
123_Y	469_S	0.564	0.22
275_V	408_G	0.564	0.22
206_A	469_S	0.564	0.22
55_P	292_K	0.563	0.22
36_V	429_L	0.562	0.22
36_V	46_V	0.562	0.22
202_V	283_I	0.562	0.22
24_D	279_D	0.561	0.22
65_L	108_K	0.560	0.22
74_Y	108_K	0.560	0.22
43_V	52_F	0.558	0.22
64_D	371_Q	0.557	0.21
170_V	312_N	0.556	0.21
408_G	433_M	0.556	0.21
48_E	430_D	0.555	0.21
43_V	340_S	0.555	0.21
44_K	70_K	0.554	0.21
455_G	463_E	0.553	0.21
339_T	405_I	0.552	0.21
492_F	496_V	0.552	0.21
246_K	424_E	0.551	0.21
132_Y	361_A	0.551	0.21
195_E	286_E	0.551	0.21
220_Y	441_L	0.551	0.21
32_N	240_T	0.551	0.21
50_S	231_R	0.551	0.21
395_V	403_R	0.551	0.21
166_T	213_P	0.550	0.21
58_T	112_Y	0.550	0.21
475_I	479_Q	0.550	0.21
45_D	487_D	0.550	0.21
213_P	272_S	0.549	0.21
240_T	247_F	0.549	0.21
332_A	449_L	0.548	0.21
119_R	318_Q	0.546	0.21
232_Y	280_N	0.546	0.21
119_R	250_R	0.546	0.21
158_A	237_S	0.544	0.21
342_F	407_A	0.544	0.21
437_G	485_F	0.543	0.21
426_R	441_L	0.543	0.21
98_D	439_D	0.543	0.21
97_K	453_V	0.542	0.21
343_I	472_D	0.542	0.21
364_Y	420_F	0.541	0.21
451_W	466_D	0.541	0.21
286_E	370_A	0.541	0.21
102_L	162_D	0.540	0.21
41_E	97_K	0.540	0.21
417_I	445_K	0.539	0.21
27_K	197_P	0.537	0.21
109_I	401_I	0.536	0.20
262_E	322_R	0.536	0.20
45_D	347_E	0.536	0.20
455_G	460_M	0.535	0.20
93_P	398_A	0.535	0.20
315_F	469_S	0.534	0.20
331_I	334_A	0.533	0.20
449_L	457_E	0.533	0.20
344_N	472_D	0.533	0.20
118_G	451_W	0.533	0.20
56_I	341_N	0.532	0.20
156_K	326_L	0.532	0.20
63_Y	164_F	0.532	0.20
352_I	398_A	0.531	0.20
24_D	35_V	0.530	0.20
127_W	219_W	0.530	0.20
395_V	460_M	0.530	0.20
357_A	360_E	0.529	0.20
37_Y	422_N	0.529	0.20
397_R	431_K	0.529	0.20
172_P	269_F	0.528	0.20
125_N	131_F	0.527	0.20
49_H	65_L	0.527	0.20
95_N	98_D	0.527	0.20
329_L	358_L	0.527	0.20
285_W	481_Y	0.526	0.20
344_N	406_S	0.526	0.20
295_E	354_I	0.525	0.20
24_D	97_K	0.525	0.20
69_E	94_K	0.525	0.20
270_E	318_Q	0.524	0.20
113_Y	194_E	0.524	0.20
154_I	207_M	0.523	0.20
116_F	453_V	0.523	0.20
125_N	167_H	0.523	0.20
122_D	128_T	0.523	0.20
270_E	461_R	0.523	0.20
160_K	402_L	0.522	0.20
79_N	83_G	0.522	0.20
111_D	324_K	0.520	0.20
330_A	334_A	0.520	0.20
75_L	79_N	0.520	0.20
115_G	452_D	0.519	0.20
209_C	212_G	0.519	0.20
247_F	276_L	0.519	0.20
196_K	349_I	0.518	0.20
312_N	385_I	0.518	0.20
173_M	222_P	0.518	0.20
330_A	349_I	0.517	0.20
20_R	166_T	0.517	0.20
149_E	494_K	0.517	0.20
59_V	164_F	0.516	0.20
168_A	220_Y	0.516	0.20
186_P	431_K	0.516	0.20
56_I	410_S	0.515	0.20
338_G	366_S	0.514	0.19
65_L	442_E	0.513	0.19
42_V	63_Y	0.512	0.19
349_I	380_D	0.512	0.19
227_D	295_E	0.512	0.19
21_R	47_T	0.512	0.19
238_I	281_V	0.511	0.19
242_T	283_I	0.510	0.19
180_P	335_E	0.510	0.19
128_T	132_Y	0.509	0.19
191_G	439_D	0.508	0.19
65_L	112_Y	0.508	0.19
103_R	107_V	0.508	0.19
210_T	449_L	0.507	0.19
140_G	374_P	0.507	0.19
69_E	193_V	0.507	0.19
227_D	334_A	0.506	0.19
47_T	54_I	0.505	0.19
91_L	94_K	0.505	0.19
311_F	476_R	0.505	0.19
59_V	444_V	0.505	0.19
117_F	200_V	0.505	0.19
121_P	461_R	0.504	0.19
190_V	347_E	0.504	0.19
239_P	281_V	0.504	0.19
118_G	461_R	0.503	0.19
446_M	450_L	0.502	0.19
408_G	469_S	0.501	0.19
183_W	229_D	0.501	0.19
349_I	413_I	0.501	0.19
35_V	487_D	0.501	0.19
118_G	322_R	0.500	0.19
164_F	359_N	0.500	0.19

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3hwcA	4	0.9272	100	0.513	Contact Map
4g5eA	4	0.9075	100	0.513	Contact Map
1u8vA	3	0.9272	100	0.535	Contact Map
2yykA	3	0.9252	100	0.535	Contact Map
4oo2A	4	0.9488	100	0.537	Contact Map
1ukwA	4	0.685	99.8	0.898	Contact Map
5af7A	4	0.7106	99.8	0.9	Contact Map
2d29A	4	0.7224	99.7	0.904	Contact Map
2pg0A	4	0.6988	99.7	0.904	Contact Map
4u83A	2	0.687	99.7	0.905	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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