GREMLIN Database
Q97WR4 - 4-hydroxyphenylacetate-3-hydroxylase (HpaA)
UniProt: Q97WR4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 508 (471)
Sequences: 818 (520)
Seq/√Len: 24.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
203_R280_N8.1411.00
157_E161_R5.6541.00
26_I56_I5.5421.00
426_R430_D5.0111.00
41_E49_H4.6941.00
202_V236_F4.6291.00
28_S216_E4.5151.00
370_A377_T4.4631.00
45_D48_E4.3191.00
420_F444_V3.8461.00
200_V288_I3.7941.00
22_G64_D3.7711.00
285_W288_I3.5961.00
192_I291_F3.5381.00
217_M287_R3.5291.00
30_K45_D3.4581.00
78_Y85_E3.3461.00
196_K282_L3.3221.00
200_V234_I3.2961.00
72_K85_E3.2261.00
195_E292_K3.2041.00
196_K201_V3.1981.00
153_E156_K3.1161.00
420_F429_L3.0981.00
195_E291_F3.0091.00
30_K47_T2.9741.00
237_S289_I2.9721.00
198_E282_L2.9591.00
345_V405_I2.9541.00
248_L277_V2.8801.00
334_A349_I2.8540.99
397_R400_E2.5360.99
88_I101_K2.5110.99
190_V202_V2.4940.99
330_A352_I2.4910.99
351_E397_R2.4820.98
194_E198_E2.4780.98
35_V246_K2.4630.98
201_V282_L2.4280.98
24_D27_K2.3640.98
79_N82_V2.3470.98
41_E418_K2.3210.98
20_R216_E2.2840.97
21_R67_W2.2800.97
79_N86_T2.2450.97
194_E280_N2.2440.97
21_R24_D2.2140.97
259_G264_P2.1820.96
493_V497_K2.1790.96
210_T250_R2.1660.96
277_V428_L2.1450.96
339_T345_V2.1190.96
149_E153_E2.1010.96
154_I217_M2.0990.96
80_L86_T2.0880.95
20_R28_S2.0670.95
84_E160_K1.9680.94
371_Q380_D1.9650.94
76_R85_E1.9360.93
122_D125_N1.9330.93
113_Y117_F1.9290.93
231_R292_K1.9210.93
439_D442_E1.9210.93
97_K101_K1.8950.92
194_E201_V1.8950.92
23_T27_K1.8890.92
94_K98_D1.8790.92
324_K360_E1.8610.92
335_E490_H1.8530.92
78_Y82_V1.8460.91
95_N377_T1.8400.91
190_V278_L1.8030.90
35_V42_V1.7720.90
329_L453_V1.7400.89
75_L105_G1.7320.88
422_N425_E1.7200.88
135_A152_I1.7110.88
173_M409_S1.6990.87
171_A206_A1.6610.86
193_V201_V1.6510.86
293_K296_L1.6110.84
107_V111_D1.5980.84
192_I234_I1.5920.84
146_K149_E1.5740.83
19_I84_E1.5680.83
220_Y278_L1.5620.83
261_F264_P1.5550.82
335_E340_S1.5510.82
285_W291_F1.5450.82
150_N288_I1.5330.81
71_Y108_K1.5280.81
111_D321_S1.5060.80
154_I287_R1.4990.80
227_D294_P1.4680.78
288_I291_F1.4630.78
178_R182_Q1.4610.78
153_E157_E1.4590.78
317_I363_L1.4580.78
22_G60_A1.4570.78
119_R122_D1.4520.78
103_R367_V1.4430.77
154_I237_S1.4430.77
344_N348_K1.4420.77
248_L428_L1.4300.77
200_V282_L1.4180.76
249_S272_S1.4120.76
157_E163_L1.4100.75
187_Y191_G1.4090.75
334_A339_T1.4040.75
150_N286_E1.4010.75
193_V203_R1.3930.75
81_D156_K1.3930.75
326_L450_L1.3850.74
113_Y392_M1.3840.74
81_D86_T1.3800.74
313_W367_V1.3600.73
62_Y109_I1.3590.73
323_L398_A1.3520.72
429_L444_V1.3520.72
441_L445_K1.3340.71
96_K377_T1.3270.71
251_R263_Y1.3150.70
154_I157_E1.2980.69
201_V234_I1.2960.69
397_R401_I1.2890.69
380_D383_I1.2880.69
195_E285_W1.2820.68
246_K428_L1.2740.68
413_I444_V1.2740.68
32_N241_N1.2720.68
207_M408_G1.2710.67
121_P167_H1.2540.66
336_A438_L1.2480.66
64_D67_W1.2430.66
327_A352_I1.2320.65
139_F143_F1.2260.65
66_H87_S1.2210.64
149_E152_I1.2170.64
283_I287_R1.2140.64
220_Y236_F1.2030.63
27_K30_K1.2010.63
400_E467_R1.1940.63
222_P232_Y1.1860.62
333_I450_L1.1860.62
151_A155_Y1.1750.61
348_K401_I1.1740.61
218_L240_T1.1720.61
164_F211_A1.1670.61
403_R467_R1.1610.60
185_D431_K1.1530.60
273_D322_R1.1510.60
78_Y83_G1.1390.59
239_P283_I1.1340.58
191_G231_R1.1310.58
238_I283_I1.1170.57
461_R465_Y1.1140.57
54_I57_S1.1130.57
322_R466_D1.1070.57
157_E217_M1.0980.56
69_E76_R1.0980.56
175_D178_R1.0940.56
96_K368_E1.0930.56
163_L217_M1.0920.56
358_L390_F1.0830.55
233_A408_G1.0770.54
435_M438_L1.0760.54
212_G247_F1.0720.54
40_G419_D1.0670.54
271_E461_R1.0650.54
86_T159_T1.0650.54
203_R220_Y1.0630.53
219_W356_V1.0630.53
396_P400_E1.0580.53
236_F283_I1.0570.53
277_V432_Y1.0560.53
312_N388_S1.0500.53
77_V91_L1.0420.52
448_N469_S1.0420.52
36_V297_I1.0260.51
472_D475_I1.0110.50
36_V197_P1.0090.50
250_R271_E1.0070.50
55_P214_Y1.0060.49
348_K405_I1.0050.49
218_L276_L1.0050.49
123_Y167_H1.0040.49
364_Y369_R1.0040.49
30_K46_V1.0030.49
369_R380_D0.9930.49
156_K200_V0.9920.48
79_N160_K0.9910.48
69_E72_K0.9900.48
58_T269_F0.9830.48
154_I165_Y0.9810.48
238_I242_T0.9800.48
198_E286_E0.9790.48
30_K48_E0.9760.47
181_S229_D0.9750.47
168_A209_C0.9730.47
60_A423_P0.9700.47
351_E401_I0.9650.47
142_Q295_E0.9600.46
157_E160_K0.9570.46
427_K430_D0.9540.46
323_L391_N0.9510.46
182_Q228_S0.9510.46
140_G146_K0.9490.45
127_W131_F0.9480.45
198_E201_V0.9450.45
201_V280_N0.9440.45
82_V160_K0.9430.45
187_Y203_R0.9360.44
36_V68_D0.9320.44
206_A391_N0.9320.44
150_N202_V0.9310.44
245_V281_V0.9300.44
96_K370_A0.9290.44
26_I429_L0.9280.44
396_P467_R0.9280.44
58_T114_R0.9260.44
290_F297_I0.9230.44
25_Y157_E0.9220.44
121_P125_N0.9210.43
115_G271_E0.9180.43
35_V424_E0.9170.43
275_V433_M0.9160.43
361_A383_I0.9130.43
193_V280_N0.9110.43
331_I349_I0.9090.43
461_R466_D0.9080.43
220_Y242_T0.9050.42
212_G240_T0.9030.42
157_E165_Y0.9030.42
143_F295_E0.9010.42
30_K241_N0.9010.42
158_A165_Y0.8990.42
93_P102_L0.8970.42
24_D292_K0.8970.42
337_S408_G0.8960.42
91_L101_K0.8940.42
23_T73_E0.8920.41
125_N133_A0.8920.41
468_F472_D0.8890.41
348_K404_S0.8850.41
202_V375_N0.8820.41
449_L493_V0.8810.41
49_H60_A0.8790.41
162_D236_F0.8780.40
37_Y467_R0.8750.40
39_E424_E0.8730.40
174_Y180_P0.8730.40
316_V387_A0.8670.40
107_V321_S0.8660.40
68_D71_Y0.8580.39
333_I447_F0.8550.39
42_V423_P0.8550.39
122_D132_Y0.8540.39
242_T425_E0.8540.39
343_I474_T0.8520.39
125_N130_V0.8510.39
43_V490_H0.8480.38
264_P452_D0.8480.38
37_Y443_R0.8470.38
140_G148_M0.8450.38
88_I91_L0.8410.38
95_N355_Y0.8410.38
149_E288_I0.8390.38
178_R185_D0.8380.38
165_Y237_S0.8380.38
217_M283_I0.8330.37
492_F495_L0.8320.37
348_K473_P0.8310.37
36_V192_I0.8290.37
200_V291_F0.8260.37
332_A494_K0.8260.37
26_I47_T0.8250.37
451_W455_G0.8210.37
140_G144_G0.8200.37
245_V423_P0.8130.36
118_G273_D0.8130.36
123_Y311_F0.8120.36
207_M429_L0.8090.36
23_T245_V0.8050.36
271_E466_D0.8020.35
23_T340_S0.8010.35
128_T131_F0.8000.35
290_F293_K0.7990.35
273_D461_R0.7960.35
245_V278_L0.7960.35
361_A365_A0.7940.35
170_V214_Y0.7930.35
347_E393_K0.7910.35
27_K36_V0.7900.35
307_L311_F0.7890.35
229_D245_V0.7890.35
261_F265_I0.7880.34
25_Y161_R0.7870.34
81_D286_E0.7830.34
329_L450_L0.7820.34
268_R445_K0.7820.34
407_A472_D0.7800.34
127_W132_Y0.7780.34
176_R338_G0.7780.34
124_L131_F0.7780.34
83_G335_E0.7770.34
421_E441_L0.7770.34
43_V53_K0.7740.34
94_K153_E0.7740.34
157_E287_R0.7730.34
247_F274_A0.7720.33
274_A307_L0.7710.33
103_R317_I0.7700.33
86_T160_K0.7700.33
333_I406_S0.7670.33
422_N426_R0.7660.33
342_F472_D0.7660.33
53_K57_S0.7650.33
87_S162_D0.7650.33
430_D439_D0.7630.33
58_T61_K0.7630.33
179_P182_Q0.7620.33
42_V184_E0.7610.33
42_V424_E0.7600.33
462_Y469_S0.7600.33
118_G314_H0.7590.33
242_T281_V0.7590.33
146_K196_K0.7590.33
417_I421_E0.7580.33
156_K160_K0.7570.33
276_L289_I0.7570.33
246_K277_V0.7550.32
415_A419_D0.7540.32
353_L484_V0.7510.32
211_A462_Y0.7500.32
110_Y314_H0.7500.32
110_Y113_Y0.7500.32
41_E44_K0.7490.32
363_L367_V0.7480.32
26_I60_A0.7480.32
181_S196_K0.7440.32
372_E423_P0.7440.32
277_V446_M0.7430.32
122_D134_H0.7430.32
279_D366_S0.7420.32
118_G121_P0.7400.31
122_D133_A0.7400.31
273_D465_Y0.7390.31
95_N341_N0.7390.31
368_E427_K0.7390.31
272_S453_V0.7380.31
122_D131_F0.7370.31
282_L285_W0.7370.31
336_A446_M0.7360.31
91_L313_W0.7320.31
119_R210_T0.7310.31
43_V48_E0.7290.31
90_F432_Y0.7290.31
115_G250_R0.7290.31
271_E465_Y0.7290.31
121_P451_W0.7280.31
165_Y219_W0.7250.31
54_I254_Q0.7250.31
250_R466_D0.7250.31
207_M210_T0.7240.31
42_V198_E0.7220.30
29_I454_I0.7210.30
333_I446_M0.7210.30
419_D449_L0.7190.30
207_M275_V0.7190.30
147_F150_N0.7160.30
113_Y470_R0.7160.30
423_P427_K0.7120.30
332_A446_M0.7120.30
205_A432_Y0.7080.30
166_T209_C0.7070.29
19_I24_D0.7070.29
200_V292_K0.7060.29
210_T269_F0.7040.29
350_G354_I0.7030.29
41_E280_N0.7020.29
230_P294_P0.7010.29
107_V324_K0.7010.29
487_D490_H0.6980.29
110_Y322_R0.6980.29
448_N462_Y0.6970.29
314_H322_R0.6960.29
273_D466_D0.6960.29
271_E322_R0.6950.29
383_I400_E0.6930.29
329_L338_G0.6920.29
31_E45_D0.6920.29
307_L472_D0.6900.28
246_K422_N0.6890.28
391_N462_Y0.6880.28
139_F307_L0.6850.28
337_S407_A0.6840.28
337_S447_F0.6830.28
90_F155_Y0.6820.28
465_Y469_S0.6820.28
185_D459_G0.6810.28
144_G293_K0.6810.28
36_V100_G0.6800.28
196_K285_W0.6790.28
73_E85_E0.6780.28
203_R246_K0.6780.28
230_P494_K0.6780.28
98_D233_A0.6780.28
197_P286_E0.6780.28
100_G368_E0.6770.28
308_R464_Q0.6770.28
124_L154_I0.6740.28
238_I287_R0.6740.28
80_L84_E0.6730.28
144_G429_L0.6720.27
118_G465_Y0.6710.27
121_P273_D0.6710.27
97_K100_G0.6700.27
183_W189_Q0.6670.27
358_L362_A0.6660.27
146_K150_N0.6660.27
323_L356_V0.6650.27
194_E282_L0.6640.27
173_M176_R0.6630.27
388_S392_M0.6630.27
35_V156_K0.6630.27
69_E295_E0.6620.27
35_V46_V0.6610.27
392_M476_R0.6610.27
39_E419_D0.6600.27
330_A361_A0.6590.27
178_R228_S0.6570.27
346_Q478_A0.6570.27
170_V476_R0.6560.27
367_V370_A0.6560.27
210_T271_E0.6560.27
485_F488_R0.6530.26
46_V56_I0.6530.26
174_Y434_A0.6520.26
322_R461_R0.6520.26
24_D436_K0.6520.26
207_M448_N0.6510.26
94_K194_E0.6510.26
122_D127_W0.6510.26
37_Y246_K0.6490.26
242_T423_P0.6470.26
22_G67_W0.6460.26
172_P461_R0.6460.26
243_K376_I0.6450.26
218_L247_F0.6450.26
82_V156_K0.6430.26
451_W461_R0.6430.26
61_K112_Y0.6420.26
309_G379_P0.6420.26
241_N335_E0.6420.26
149_E345_V0.6390.26
87_S105_G0.6390.26
242_T268_R0.6390.26
203_R232_Y0.6390.26
253_F462_Y0.6370.26
154_I213_P0.6360.25
95_N278_L0.6360.25
73_E153_E0.6360.25
58_T429_L0.6350.25
169_I311_F0.6350.25
278_L289_I0.6340.25
124_L133_A0.6340.25
178_R191_G0.6340.25
118_G167_H0.6330.25
189_Q206_A0.6330.25
107_V317_I0.6320.25
69_E85_E0.6320.25
213_P274_A0.6300.25
190_V234_I0.6300.25
177_S338_G0.6300.25
243_K280_N0.6300.25
100_G367_V0.6270.25
220_Y447_F0.6260.25
139_F380_D0.6260.25
358_L361_A0.6250.25
259_G263_Y0.6250.25
332_A350_G0.6250.25
67_W269_F0.6250.25
160_K277_V0.6240.25
52_F55_P0.6240.25
322_R465_Y0.6230.25
118_G208_I0.6220.25
103_R361_A0.6210.25
82_V86_T0.6210.25
162_D217_M0.6210.25
197_P285_W0.6210.25
97_K277_V0.6200.25
78_Y81_D0.6190.25
198_E432_Y0.6190.25
314_H461_R0.6180.25
149_E241_N0.6170.24
73_E101_K0.6160.24
339_T398_A0.6160.24
36_V152_I0.6140.24
403_R463_E0.6140.24
140_G145_S0.6130.24
37_Y42_V0.6130.24
42_V192_I0.6130.24
386_S478_A0.6110.24
428_L432_Y0.6110.24
135_A140_G0.6110.24
87_S289_I0.6110.24
311_F385_I0.6110.24
358_L386_S0.6100.24
364_Y368_E0.6100.24
182_Q456_S0.6090.24
390_F394_T0.6080.24
74_Y104_D0.6080.24
24_D202_V0.6070.24
52_F272_S0.6070.24
239_P289_I0.6070.24
172_P205_A0.6070.24
68_D72_K0.6060.24
318_Q461_R0.6060.24
132_Y135_A0.6050.24
28_S31_E0.6050.24
172_P250_R0.6040.24
250_R465_Y0.6030.24
273_D452_D0.6020.24
25_Y283_I0.6010.24
80_L156_K0.6010.24
151_A478_A0.6000.24
48_E201_V0.5990.24
162_D414_P0.5960.23
426_R440_A0.5950.23
360_E363_L0.5920.23
353_L486_K0.5920.23
79_N159_T0.5920.23
31_E241_N0.5900.23
317_I349_I0.5890.23
250_R461_R0.5890.23
38_Y58_T0.5880.23
119_R271_E0.5870.23
173_M177_S0.5870.23
29_I309_G0.5870.23
72_K101_K0.5840.23
52_F95_N0.5810.23
27_K182_Q0.5810.23
115_G264_P0.5790.23
43_V422_N0.5790.23
487_D494_K0.5790.23
26_I57_S0.5790.23
21_R28_S0.5780.22
352_I496_V0.5780.22
230_P292_K0.5770.22
73_E425_E0.5770.22
245_V276_L0.5770.22
35_V425_E0.5760.22
371_Q381_P0.5750.22
53_K254_Q0.5750.22
185_D297_I0.5750.22
28_S211_A0.5740.22
318_Q466_D0.5740.22
169_I476_R0.5730.22
128_T158_A0.5710.22
119_R466_D0.5700.22
114_R269_F0.5690.22
28_S32_N0.5690.22
283_I336_A0.5680.22
29_I175_D0.5680.22
90_F93_P0.5680.22
163_L287_R0.5660.22
38_Y43_V0.5650.22
123_Y469_S0.5640.22
275_V408_G0.5640.22
206_A469_S0.5640.22
55_P292_K0.5630.22
36_V429_L0.5620.22
36_V46_V0.5620.22
202_V283_I0.5620.22
24_D279_D0.5610.22
65_L108_K0.5600.22
74_Y108_K0.5600.22
43_V52_F0.5580.22
64_D371_Q0.5570.21
170_V312_N0.5560.21
408_G433_M0.5560.21
48_E430_D0.5550.21
43_V340_S0.5550.21
44_K70_K0.5540.21
455_G463_E0.5530.21
339_T405_I0.5520.21
492_F496_V0.5520.21
246_K424_E0.5510.21
132_Y361_A0.5510.21
195_E286_E0.5510.21
220_Y441_L0.5510.21
32_N240_T0.5510.21
50_S231_R0.5510.21
395_V403_R0.5510.21
166_T213_P0.5500.21
58_T112_Y0.5500.21
475_I479_Q0.5500.21
45_D487_D0.5500.21
213_P272_S0.5490.21
240_T247_F0.5490.21
332_A449_L0.5480.21
119_R318_Q0.5460.21
232_Y280_N0.5460.21
119_R250_R0.5460.21
158_A237_S0.5440.21
342_F407_A0.5440.21
437_G485_F0.5430.21
426_R441_L0.5430.21
98_D439_D0.5430.21
97_K453_V0.5420.21
343_I472_D0.5420.21
364_Y420_F0.5410.21
451_W466_D0.5410.21
286_E370_A0.5410.21
102_L162_D0.5400.21
41_E97_K0.5400.21
417_I445_K0.5390.21
27_K197_P0.5370.21
109_I401_I0.5360.20
262_E322_R0.5360.20
45_D347_E0.5360.20
455_G460_M0.5350.20
93_P398_A0.5350.20
315_F469_S0.5340.20
331_I334_A0.5330.20
449_L457_E0.5330.20
344_N472_D0.5330.20
118_G451_W0.5330.20
56_I341_N0.5320.20
156_K326_L0.5320.20
63_Y164_F0.5320.20
352_I398_A0.5310.20
24_D35_V0.5300.20
127_W219_W0.5300.20
395_V460_M0.5300.20
357_A360_E0.5290.20
37_Y422_N0.5290.20
397_R431_K0.5290.20
172_P269_F0.5280.20
125_N131_F0.5270.20
49_H65_L0.5270.20
95_N98_D0.5270.20
329_L358_L0.5270.20
285_W481_Y0.5260.20
344_N406_S0.5260.20
295_E354_I0.5250.20
24_D97_K0.5250.20
69_E94_K0.5250.20
270_E318_Q0.5240.20
113_Y194_E0.5240.20
154_I207_M0.5230.20
116_F453_V0.5230.20
125_N167_H0.5230.20
122_D128_T0.5230.20
270_E461_R0.5230.20
160_K402_L0.5220.20
79_N83_G0.5220.20
111_D324_K0.5200.20
330_A334_A0.5200.20
75_L79_N0.5200.20
115_G452_D0.5190.20
209_C212_G0.5190.20
247_F276_L0.5190.20
196_K349_I0.5180.20
312_N385_I0.5180.20
173_M222_P0.5180.20
330_A349_I0.5170.20
20_R166_T0.5170.20
149_E494_K0.5170.20
59_V164_F0.5160.20
168_A220_Y0.5160.20
186_P431_K0.5160.20
56_I410_S0.5150.20
338_G366_S0.5140.19
65_L442_E0.5130.19
42_V63_Y0.5120.19
349_I380_D0.5120.19
227_D295_E0.5120.19
21_R47_T0.5120.19
238_I281_V0.5110.19
242_T283_I0.5100.19
180_P335_E0.5100.19
128_T132_Y0.5090.19
191_G439_D0.5080.19
65_L112_Y0.5080.19
103_R107_V0.5080.19
210_T449_L0.5070.19
140_G374_P0.5070.19
69_E193_V0.5070.19
227_D334_A0.5060.19
47_T54_I0.5050.19
91_L94_K0.5050.19
311_F476_R0.5050.19
59_V444_V0.5050.19
117_F200_V0.5050.19
121_P461_R0.5040.19
190_V347_E0.5040.19
239_P281_V0.5040.19
118_G461_R0.5030.19
446_M450_L0.5020.19
408_G469_S0.5010.19
183_W229_D0.5010.19
349_I413_I0.5010.19
35_V487_D0.5010.19
118_G322_R0.5000.19
164_F359_N0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hwcA 4 0.9272 100 0.513 Contact Map
4g5eA 4 0.9075 100 0.513 Contact Map
1u8vA 3 0.9272 100 0.535 Contact Map
2yykA 3 0.9252 100 0.535 Contact Map
4oo2A 4 0.9488 100 0.537 Contact Map
1ukwA 4 0.685 99.8 0.898 Contact Map
5af7A 4 0.7106 99.8 0.9 Contact Map
2d29A 4 0.7224 99.7 0.904 Contact Map
2pg0A 4 0.6988 99.7 0.904 Contact Map
4u83A 2 0.687 99.7 0.905 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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