GREMLIN Database
Q97WR3 - Catechol 2,3-dioxygenase (Metapyrocatechase)
UniProt: Q97WR3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 316 (259)
Sequences: 3487 (2400)
Seq/√Len: 149.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_Y27_E5.2901.00
155_E159_R5.1201.00
81_R93_K4.1771.00
149_D152_R3.7371.00
17_D20_K3.5871.00
9_S116_Y3.1371.00
73_K76_E2.8681.00
82_E86_N2.7391.00
71_V115_L2.6891.00
19_D23_Y2.5541.00
71_V77_L2.5181.00
105_F115_L2.4411.00
76_E135_V2.3481.00
104_L114_L2.2931.00
33_E36_K2.2931.00
22_R36_K2.2881.00
81_R103_L2.2121.00
81_R85_E2.1961.00
187_S191_A2.1371.00
165_E168_R2.1331.00
22_R33_E2.1161.00
14_R59_A2.1151.00
212_V241_T2.0871.00
208_Y261_N2.0571.00
80_A115_L2.0461.00
107_S157_F1.9781.00
74_G101_E1.9671.00
188_H191_A1.9501.00
211_D214_D1.9361.00
74_G78_D1.9231.00
82_E85_E1.9051.00
79_K83_E1.8101.00
92_R104_L1.8041.00
93_K101_E1.7951.00
245_Y259_F1.7761.00
90_K106_E1.7761.00
78_D82_E1.7551.00
154_L158_K1.7261.00
209_V258_F1.7171.00
14_R63_G1.7001.00
20_K23_Y1.6801.00
179_V182_T1.6751.00
18_L41_I1.6721.00
221_I225_V1.6611.00
39_D58_K1.6531.00
12_C66_Y1.6221.00
33_E41_I1.6151.00
10_H68_G1.6071.00
143_V205_E1.6031.00
104_L112_P1.5961.00
12_C57_K1.5871.00
74_G117_Y1.5811.00
249_R255_R1.5501.00
232_E255_R1.5461.00
66_Y114_L1.5331.00
85_E91_V1.5261.00
113_I157_F1.5091.00
69_F113_I1.5031.00
236_G245_Y1.4901.00
15_V56_L1.4831.00
75_E117_Y1.4711.00
14_R65_S1.4711.00
18_L58_K1.4641.00
25_Y250_D1.4561.00
154_L165_E1.4381.00
222_L248_L1.4281.00
186_D191_A1.4111.00
67_I143_V1.3961.00
106_E112_P1.3781.00
212_V216_I1.3771.00
68_G114_L1.3661.00
186_D189_E1.3541.00
210_H214_D1.3481.00
166_T182_T1.3371.00
269_D272_K1.3341.00
180_W183_R1.3291.00
268_P272_K1.3261.00
75_E78_D1.3151.00
78_D101_E1.3081.00
105_F113_I1.3001.00
204_H257_E1.2931.00
70_R118_D1.2821.00
107_S113_I1.2801.00
22_R41_I1.2771.00
220_D224_S1.2681.00
216_I234_G1.2651.00
16_S62_A1.2571.00
219_P223_A1.2461.00
26_S33_E1.2321.00
84_L87_L1.2221.00
22_R26_S1.2181.00
84_L103_L1.2071.00
40_Y57_K1.2061.00
126_R129_F1.2001.00
153_E157_F1.1871.00
14_R54_L1.1741.00
151_E155_E1.1691.00
234_G241_T1.1661.00
151_E194_K1.1571.00
204_H247_Y1.1521.00
226_G230_S1.1501.00
56_L59_A1.1401.00
158_K181_L1.1331.00
19_D36_K1.1331.00
84_L105_F1.1270.99
8_T140_L1.1050.99
24_F248_L1.1020.99
150_L194_K1.1020.99
54_L59_A1.0990.99
152_R155_E1.0980.99
79_K131_R1.0910.99
83_E87_L1.0890.99
187_S195_S1.0880.99
147_V150_L1.0790.99
107_S111_I1.0730.99
70_R141_A1.0700.99
154_L179_V1.0680.99
177_A180_W1.0650.99
218_A258_F1.0500.99
18_L22_R1.0490.99
22_R43_L1.0380.99
50_Q54_L1.0380.99
96_E101_E1.0310.99
232_E249_R1.0290.99
219_P235_P1.0280.99
6_L210_H1.0170.99
68_G116_Y1.0160.99
206_T259_F1.0110.99
84_L91_V0.9970.99
97_K114_L0.9960.99
64_L67_I0.9950.99
128_A131_R0.9940.99
50_Q57_K0.9920.99
59_A63_G0.9910.99
231_I246_I0.9870.99
187_S192_I0.9710.98
241_T245_Y0.9660.98
247_Y257_E0.9550.98
103_L115_L0.9500.98
213_K217_K0.9480.98
11_V205_E0.9460.98
76_E79_K0.9460.98
51_H57_K0.9370.98
50_Q59_A0.9360.98
66_Y104_L0.9340.98
54_L199_V0.9320.98
156_F161_M0.9300.98
182_T185_G0.9160.98
187_S190_I0.9150.98
96_E99_I0.9140.98
28_L87_L0.9120.98
248_L258_F0.9070.98
78_D81_R0.8960.97
83_E86_N0.8960.97
77_L101_E0.8910.97
57_K65_S0.8880.97
109_E148_K0.8760.97
239_G276_W0.8730.97
24_F256_I0.8690.97
151_E154_L0.8680.97
143_V190_I0.8680.97
132_H135_V0.8600.97
180_W184_R0.8590.97
221_I224_S0.8520.96
213_K237_R0.8520.96
33_E43_L0.8490.96
85_E90_K0.8470.96
188_H193_A0.8450.96
125_L128_A0.8430.96
164_Y182_T0.8410.96
92_R106_E0.8400.96
153_E192_I0.8380.96
45_G239_G0.8380.96
4_N76_E0.8370.96
145_Y192_I0.8370.96
93_K103_L0.8350.96
241_T262_D0.8340.96
164_Y268_P0.8340.96
166_T181_L0.8310.96
266_L269_D0.8250.96
214_D217_K0.8250.96
147_V153_E0.8240.96
167_E187_S0.8240.96
154_L181_L0.8240.96
209_V214_D0.8190.96
203_H255_R0.8160.95
12_C65_S0.8130.95
89_H105_F0.8130.95
139_R259_F0.8130.95
74_G119_M0.8110.95
235_P246_I0.8100.95
31_F137_P0.8070.95
233_R238_H0.8070.95
180_W185_G0.8050.95
50_Q56_L0.8030.95
126_R131_R0.8000.95
233_R241_T0.8000.95
72_S76_E0.7930.95
34_T47_E0.7900.95
13_I111_I0.7900.95
219_P234_G0.7870.95
125_L132_H0.7830.94
234_G245_Y0.7790.94
64_L202_F0.7770.94
42_Y52_H0.7740.94
102_A114_L0.7670.94
67_I111_I0.7670.94
127_L130_H0.7640.94
31_F207_Y0.7630.94
94_F102_A0.7580.93
272_K275_V0.7570.93
179_V183_R0.7530.93
217_K220_D0.7490.93
126_R130_H0.7460.93
36_K41_I0.7460.93
163_Y183_R0.7450.93
28_L225_V0.7360.92
54_L57_K0.7360.92
16_S199_V0.7360.92
169_F178_V0.7330.92
216_I219_P0.7320.92
31_F69_F0.7240.92
127_L131_R0.7220.92
65_S146_M0.7220.92
150_L192_I0.7130.91
18_L36_K0.7120.91
84_L89_H0.7120.91
107_S110_G0.7110.91
168_R275_V0.7090.91
88_G91_V0.7090.91
179_V184_R0.7080.91
129_F132_H0.7040.91
80_A83_E0.7030.91
68_G144_N0.7030.91
51_H55_I0.7020.90
185_G264_V0.6990.90
208_Y213_K0.6990.90
19_D22_R0.6980.90
59_A106_E0.6980.90
209_V215_V0.6900.90
206_T247_Y0.6870.89
53_S56_L0.6870.89
169_F191_A0.6860.89
76_E80_A0.6800.89
146_M201_G0.6730.89
60_N155_E0.6710.88
163_Y207_Y0.6710.88
69_F140_L0.6700.88
269_D275_V0.6670.88
81_R91_V0.6650.88
100_N117_Y0.6640.88
52_H55_I0.6640.88
61_S148_K0.6630.88
68_G141_A0.6620.88
273_P276_W0.6620.88
55_I58_K0.6550.87
111_I201_G0.6540.87
178_V183_R0.6490.87
92_R112_P0.6470.86
181_L184_R0.6460.86
9_S70_R0.6440.86
10_H99_I0.6430.86
240_V259_F0.6410.86
143_V163_Y0.6390.86
11_V143_V0.6360.86
240_V263_Y0.6350.85
188_H194_K0.6350.85
20_K109_E0.6310.85
21_A46_I0.6310.85
272_K276_W0.6310.85
178_V182_T0.6280.85
50_Q55_I0.6260.85
29_L256_I0.6250.85
52_H56_L0.6250.85
178_V193_A0.6240.84
51_H56_L0.6200.84
38_G41_I0.6160.84
26_S43_L0.6130.83
51_H59_A0.6100.83
53_S59_A0.6090.83
71_V103_L0.6030.82
125_L129_F0.6010.82
73_K79_K0.6010.82
147_V152_R0.6000.82
238_H247_Y0.5970.82
57_K201_G0.5960.82
11_V140_L0.5950.82
15_V50_Q0.5950.82
79_K82_E0.5920.81
5_T183_R0.5910.81
219_P246_I0.5900.81
11_V67_I0.5890.81
32_V133_R0.5890.81
219_P231_I0.5870.81
151_E159_R0.5840.80
45_G137_P0.5830.80
28_L108_P0.5830.80
188_H238_H0.5810.80
267_D272_K0.5800.80
215_V258_F0.5800.80
34_T44_R0.5790.80
21_A250_D0.5790.80
145_Y256_I0.5780.80
94_F106_E0.5770.80
31_F45_G0.5770.80
215_V234_G0.5760.79
148_K153_E0.5750.79
53_S57_K0.5740.79
36_K40_Y0.5720.79
91_V103_L0.5720.79
178_V181_L0.5700.79
149_D194_K0.5690.79
178_V185_G0.5690.79
220_D223_A0.5670.78
248_L255_R0.5670.78
235_P238_H0.5650.78
155_E158_K0.5640.78
55_I59_A0.5630.78
157_F190_I0.5630.78
186_D241_T0.5610.78
25_Y113_I0.5600.78
141_A144_N0.5600.78
83_E162_G0.5590.77
85_E93_K0.5570.77
44_R48_E0.5560.77
64_L254_N0.5560.77
43_L46_I0.5560.77
203_H247_Y0.5530.77
142_H238_H0.5520.77
94_F104_L0.5490.76
144_N180_W0.5480.76
161_M216_I0.5480.76
50_Q53_S0.5460.76
238_H267_D0.5450.76
98_G120_E0.5450.76
156_F251_F0.5440.76
168_R179_V0.5430.75
206_T255_R0.5430.75
150_L154_L0.5390.75
32_V136_S0.5380.75
68_G142_H0.5370.75
75_E82_E0.5360.74
13_I54_L0.5360.74
187_S193_A0.5350.74
44_R47_E0.5340.74
150_L153_E0.5340.74
148_K152_R0.5340.74
240_V276_W0.5310.74
91_V94_F0.5300.74
181_L185_G0.5290.74
206_T250_D0.5290.74
125_L130_H0.5290.74
215_V260_T0.5290.74
77_L94_F0.5280.73
86_N223_A0.5280.73
142_H188_H0.5260.73
23_Y225_V0.5250.73
150_L179_V0.5250.73
147_V192_I0.5220.73
8_T205_E0.5220.73
178_V191_A0.5210.72
63_G201_G0.5210.72
250_D254_N0.5210.72
23_Y26_S0.5210.72
143_V162_G0.5200.72
45_G207_Y0.5200.72
207_Y256_I0.5200.72
73_K117_Y0.5190.72
115_L161_M0.5180.72
236_G241_T0.5180.72
191_A196_S0.5170.72
178_V184_R0.5170.72
212_V215_V0.5170.72
148_K200_P0.5160.72
166_T180_W0.5150.72
66_Y97_K0.5150.72
25_Y254_N0.5140.71
241_T259_F0.5140.71
21_A252_D0.5140.71
204_H238_H0.5130.71
141_A259_F0.5120.71
209_V260_T0.5110.71
50_Q58_K0.5100.71
80_A103_L0.5090.71
139_R250_D0.5070.70
67_I145_Y0.5010.69
8_T163_Y0.5000.69
21_A254_N0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ghgA 4 0.9842 100 0.328 Contact Map
1f1uA 4 0.981 100 0.336 Contact Map
3lm4A 4 0.9842 100 0.348 Contact Map
3b59A 5 0.9304 100 0.356 Contact Map
3hpyA 4 0.8956 100 0.406 Contact Map
1mpyA 3 0.9367 100 0.422 Contact Map
3vb0A 1 0.8703 100 0.447 Contact Map
2zyqA 2 0.8861 100 0.45 Contact Map
2ehzA 5 0.9051 100 0.454 Contact Map
2wl9A 5 0.9051 100 0.456 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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