GREMLIN Database
Q97WR2 - Uncharacterized protein
UniProt: Q97WR2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 155 (146)
Sequences: 4991 (3489)
Seq/√Len: 288.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_K131_I3.4291.00
115_Y129_E2.8051.00
51_K119_D2.7811.00
113_K129_E2.6721.00
76_F150_Y2.6591.00
65_F128_G2.5451.00
94_F104_A2.3701.00
56_D124_T2.3341.00
73_E77_N2.0381.00
117_T124_T2.0221.00
20_T66_I1.9891.00
14_L33_N1.9771.00
60_I117_T1.9181.00
23_W26_N1.7991.00
92_K104_A1.7951.00
96_G111_E1.7661.00
29_G79_F1.7451.00
66_I102_V1.7351.00
109_Y134_K1.7301.00
51_K124_T1.7201.00
48_T125_I1.6861.00
68_N106_S1.6811.00
120_I125_I1.6651.00
35_F45_V1.6561.00
10_R148_R1.6251.00
12_F15_G1.6071.00
77_N150_Y1.6011.00
31_T76_F1.5781.00
98_D111_E1.5531.00
8_I108_A1.5531.00
56_D60_I1.5351.00
112_V128_G1.5181.00
111_E132_N1.5111.00
44_L127_V1.5091.00
118_I127_V1.4941.00
107_Y140_F1.4801.00
86_E89_K1.4621.00
100_I111_E1.4531.00
30_M49_A1.4201.00
36_N48_T1.3951.00
78_T90_E1.3941.00
27_L95_E1.3831.00
8_I110_M1.3801.00
11_L147_N1.3691.00
63_N114_K1.3371.00
5_I9_M1.3231.00
17_V35_F1.2501.00
22_K95_E1.2421.00
36_N46_M1.2131.00
10_R147_N1.2111.00
22_K27_L1.2091.00
30_M55_N1.1981.00
102_V109_Y1.1981.00
46_M125_I1.1951.00
119_D124_T1.1821.00
136_V140_F1.1701.00
45_V67_V1.1671.00
114_K126_V1.1611.00
32_V35_F1.1511.00
44_L120_I1.1461.00
38_L46_M1.1371.00
64_G113_K1.1331.00
22_K25_D1.1191.00
20_T68_N1.1111.00
18_V79_F1.1061.00
21_T62_S1.0811.00
31_T80_A1.0751.00
13_P144_V1.0711.00
18_V31_T1.0691.00
4_T7_N1.0651.00
38_L120_I1.0301.00
65_F112_V1.0201.00
72_D105_D1.0171.00
64_G100_I1.0141.00
98_D131_I1.0091.00
44_L115_Y1.0071.00
56_D126_V1.0031.00
68_N103_L1.0011.00
65_F114_K0.9941.00
117_T126_V0.9911.00
50_D122_D0.9901.00
45_V110_M0.9791.00
78_T91_A0.9721.00
96_G102_V0.9711.00
120_I127_V0.9591.00
57_V61_E0.9551.00
19_V47_F0.9451.00
38_L48_T0.9451.00
74_K78_T0.9431.00
11_L135_I0.9351.00
64_G131_I0.9251.00
97_L132_N0.9241.00
96_G100_I0.9091.00
55_N59_F0.8931.00
107_Y146_Y0.8881.00
9_M37_S0.8861.00
21_T59_F0.8791.00
115_Y118_I0.8781.00
33_N145_Y0.8691.00
29_G88_F0.8691.00
69_F110_M0.8691.00
18_V75_I0.8561.00
68_N109_Y0.8541.00
57_V60_I0.8541.00
141_S151_W0.8441.00
66_I100_I0.8421.00
114_K117_T0.8381.00
6_R40_L0.8371.00
49_A59_F0.8351.00
34_T47_F0.8321.00
102_V111_E0.8271.00
116_K120_I0.8241.00
23_W62_S0.8201.00
71_D105_D0.8201.00
66_I109_Y0.8201.00
44_L129_E0.8181.00
24_S61_E0.8171.00
47_F126_V0.8171.00
116_K119_D0.8171.00
63_N117_T0.8111.00
19_V32_V0.8091.00
15_G33_N0.8070.99
17_V69_F0.8070.99
28_V58_P0.8060.99
98_D132_N0.8040.99
81_F84_I0.7880.99
70_V76_F0.7860.99
27_L93_F0.7830.99
71_D140_F0.7790.99
77_N81_F0.7740.99
74_K77_N0.7740.99
23_W61_E0.7730.99
4_T135_I0.7720.99
17_V32_V0.7610.99
44_L122_D0.7580.99
60_I124_T0.7520.99
13_P146_Y0.7480.99
9_M45_V0.7470.99
55_N87_R0.7400.99
12_F35_F0.7400.99
40_L122_D0.7380.99
145_Y148_R0.7360.99
8_I133_G0.7360.99
9_M110_M0.7320.99
51_K56_D0.7280.99
38_L127_V0.7260.99
54_G82_K0.7110.99
64_G98_D0.7090.99
17_V67_V0.7070.99
145_Y150_Y0.6940.98
20_T29_G0.6920.98
47_F59_F0.6870.98
66_I111_E0.6850.98
19_V67_V0.6790.98
50_D53_K0.6750.98
144_V151_W0.6740.98
59_F63_N0.6680.98
93_F104_A0.6660.98
28_V87_R0.6650.98
44_L121_G0.6590.98
36_N47_F0.6580.98
45_V112_V0.6570.98
4_T133_G0.6560.98
32_V47_F0.6510.98
32_V67_V0.6490.98
73_E150_Y0.6490.98
34_T37_S0.6470.98
116_K127_V0.6470.98
28_V55_N0.6290.97
39_S44_L0.6250.97
54_G84_I0.6230.97
54_G87_R0.6150.97
69_F108_A0.6110.97
60_I126_V0.6100.97
63_N113_K0.6050.96
7_N148_R0.6050.96
49_A56_D0.6040.96
13_P33_N0.5990.96
75_I103_L0.5970.96
71_D137_R0.5950.96
91_A104_A0.5920.96
146_Y151_W0.5910.96
110_M133_G0.5910.96
12_F33_N0.5860.96
59_F126_V0.5840.96
77_N80_A0.5830.96
5_I43_P0.5790.95
147_N151_W0.5650.95
11_L108_A0.5600.95
46_M120_I0.5580.94
27_L101_P0.5580.94
21_T100_I0.5540.94
36_N125_I0.5510.94
6_R145_Y0.5440.94
94_F134_K0.5440.94
31_T48_T0.5420.94
92_K105_D0.5410.93
11_L137_R0.5400.93
142_P146_Y0.5380.93
21_T28_V0.5360.93
23_W58_P0.5350.93
35_F67_V0.5350.93
11_L146_Y0.5320.93
48_T123_H0.5270.93
71_D74_K0.5240.92
92_K95_E0.5240.92
38_L44_L0.5240.92
27_L88_F0.5230.92
110_M130_V0.5230.92
109_Y133_G0.5180.92
17_V34_T0.5180.92
12_F17_V0.5170.92
18_V29_G0.5130.92
26_N61_E0.5110.91
13_P69_F0.5080.91
58_P62_S0.5060.91
33_N36_N0.5030.91
39_S72_D0.5010.91
59_F114_K0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d37A 2 0.9935 100 0.192 Contact Map
3pftA 2 0.9871 100 0.207 Contact Map
3k86A 2 0.9935 100 0.207 Contact Map
4l82A 2 0.9806 100 0.211 Contact Map
3cb0A 2 0.9935 100 0.215 Contact Map
2r0xA 2 0.9806 100 0.218 Contact Map
3nfwA 2 0.9935 100 0.219 Contact Map
3rh7A 2 0.9806 100 0.222 Contact Map
4r82A 2 0.9806 100 0.23 Contact Map
1rz1A 3 0.9677 100 0.233 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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