GREMLIN Database
Q97WR0 - Uncharacterized protein
UniProt: Q97WR0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 210 (197)
Sequences: 1888 (1506)
Seq/√Len: 107.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
173_A178_L4.2541.00
167_L197_Q4.1031.00
160_V164_Y3.8041.00
93_L98_V3.3871.00
157_V182_L3.2061.00
185_S188_T3.0061.00
164_Y178_L3.0031.00
188_T192_H2.9651.00
162_Y202_A2.8581.00
164_Y181_L2.8561.00
168_D172_R2.7621.00
160_V178_L2.6981.00
98_V116_T2.6861.00
173_A177_E2.6721.00
153_W192_H2.6561.00
174_T177_E2.5691.00
175_A189_F2.2311.00
55_S79_V2.1441.00
169_Y190_L2.0411.00
29_I32_E1.9871.00
11_V109_D1.9771.00
153_W156_K1.9681.00
184_I189_F1.9591.00
44_I81_F1.9251.00
153_W157_V1.8911.00
158_L201_I1.8891.00
175_A190_L1.8761.00
23_P108_K1.8311.00
155_K159_T1.8241.00
117_S120_N1.7681.00
186_K190_L1.6561.00
69_K79_V1.6381.00
29_I34_Y1.6361.00
101_L115_V1.5971.00
178_L189_F1.5911.00
68_M173_A1.5871.00
192_H195_N1.5531.00
201_I204_S1.5361.00
64_V67_V1.5281.00
171_R194_R1.5121.00
147_Y204_S1.4811.00
157_V192_H1.4511.00
175_A192_H1.4411.00
31_L34_Y1.4181.00
192_H199_K1.4031.00
180_K183_G1.3901.00
10_I114_F1.3851.00
162_Y205_I1.3621.00
11_V137_V1.3571.00
30_N34_Y1.3561.00
11_V135_K1.3431.00
66_K69_K1.3421.00
173_A181_L1.3260.99
51_N77_T1.2960.99
191_Y195_N1.2910.99
169_Y191_Y1.2880.99
188_T191_Y1.2680.99
165_G172_R1.2670.99
25_T28_T1.2280.99
77_T80_D1.2200.99
157_V189_F1.2170.99
42_S83_N1.2170.99
177_E180_K1.2140.99
157_V178_L1.2140.99
22_M61_H1.1970.99
158_L167_L1.1850.99
30_N33_V1.1700.99
123_E126_T1.1450.98
164_Y173_A1.1350.98
150_L196_A1.1340.98
185_S194_R1.1340.98
65_I84_K1.1280.98
179_A189_F1.1280.98
167_L193_L1.1210.98
166_Y175_A1.1190.98
17_C20_S1.0990.98
162_Y167_L1.0960.98
157_V184_I1.0920.98
166_Y171_R1.0910.98
54_I142_F1.0900.98
51_N54_I1.0860.98
61_H64_V1.0740.98
187_V191_Y1.0600.97
51_N55_S1.0540.97
153_W191_Y1.0510.97
175_A186_K1.0360.97
115_V167_L1.0300.97
126_T130_S1.0230.97
169_Y187_V1.0220.97
50_E53_V1.0210.97
96_K127_E1.0200.97
176_D186_K1.0160.97
157_V196_A1.0130.97
8_V11_V1.0100.96
45_L76_G1.0050.96
10_I125_L0.9950.96
63_S101_L0.9910.96
100_I114_F0.9870.96
46_I54_I0.9840.96
167_L175_A0.9830.96
198_R202_A0.9780.96
201_I205_I0.9740.96
17_C23_P0.9590.95
90_A189_F0.9560.95
169_Y192_H0.9530.95
200_L204_S0.9510.95
188_T193_L0.9500.95
46_I77_T0.9450.95
69_K77_T0.9450.95
193_L197_Q0.9440.95
178_L182_L0.9400.95
169_Y194_R0.9360.95
182_L189_F0.9290.94
70_V78_Y0.9160.94
20_S23_P0.9160.94
63_S151_T0.9060.94
111_K137_V0.9020.94
29_I33_V0.8930.93
125_L134_V0.8900.93
169_Y198_R0.8880.93
91_G95_D0.8800.93
175_A188_T0.8780.93
97_E117_S0.8740.92
139_T166_Y0.8720.92
98_V102_G0.8710.92
186_K195_N0.8640.92
53_V56_N0.8520.91
8_V121_L0.8520.91
158_L205_I0.8510.91
156_K159_T0.8470.91
188_T196_A0.8460.91
149_N203_F0.8400.91
18_W22_M0.8390.91
120_N123_E0.8370.91
100_I123_E0.8310.90
58_M196_A0.8310.90
31_L35_P0.8310.90
135_K143_N0.8230.90
103_N167_L0.8190.90
159_T163_S0.8190.90
47_D76_G0.8190.90
65_I68_M0.8180.90
84_K136_R0.8170.90
195_N198_R0.8120.89
116_T135_K0.8110.89
129_E184_I0.8030.89
94_Y178_L0.8020.89
200_L203_F0.7970.88
21_H89_I0.7910.88
105_I110_E0.7890.88
160_V181_L0.7860.88
102_G167_L0.7860.88
28_T46_I0.7850.88
195_N200_L0.7830.88
55_S67_V0.7830.88
33_V167_L0.7830.88
122_R125_L0.7800.87
176_D194_R0.7740.87
55_S58_M0.7690.87
10_I112_W0.7680.87
154_E199_K0.7650.86
196_A201_I0.7600.86
88_S91_G0.7560.86
153_W197_Q0.7420.85
23_P105_I0.7340.84
107_G145_I0.7220.83
168_D198_R0.7200.83
50_E107_G0.7180.83
101_L113_S0.7140.82
70_V105_I0.7100.82
169_Y176_D0.7100.82
156_K160_V0.7090.82
83_N90_A0.7080.82
155_K204_S0.7080.82
18_W21_H0.7070.82
26_A48_S0.7060.82
64_V69_K0.6990.81
123_E172_R0.6980.81
160_V182_L0.6980.81
164_Y189_F0.6930.80
92_V95_D0.6860.80
82_L186_K0.6830.79
52_K55_S0.6810.79
14_H17_C0.6790.79
159_T205_I0.6770.79
67_V70_V0.6770.79
52_K180_K0.6710.78
46_I150_L0.6680.78
53_V57_L0.6640.78
10_I136_R0.6640.78
12_V76_G0.6610.77
58_M195_N0.6480.76
99_L115_V0.6480.76
148_P204_S0.6470.76
124_I191_Y0.6420.75
14_H110_E0.6380.75
188_T195_N0.6370.75
41_R109_D0.6370.75
121_L156_K0.6330.74
27_Y97_E0.6290.74
52_K56_N0.6280.74
76_G200_L0.6270.73
98_V103_N0.6260.73
167_L196_A0.6250.73
66_K131_L0.6240.73
24_F108_K0.6240.73
13_S20_S0.6210.73
16_D184_I0.6200.73
78_Y86_K0.6180.72
21_H24_F0.6180.72
160_V173_A0.6170.72
90_A93_L0.6170.72
38_N180_K0.6150.72
75_G131_L0.6150.72
15_E21_H0.6110.71
154_E192_H0.6090.71
76_G152_E0.6040.71
166_Y193_L0.6040.71
87_G179_A0.6020.70
90_A196_A0.6000.70
80_D184_I0.5990.70
39_Y65_I0.5980.70
9_D18_W0.5980.70
12_V17_C0.5950.69
122_R188_T0.5940.69
34_Y112_W0.5930.69
165_G168_D0.5930.69
29_I35_P0.5920.69
182_L190_L0.5920.69
188_T204_S0.5920.69
97_E127_E0.5910.69
175_A196_A0.5910.69
184_I187_V0.5900.69
110_E188_T0.5870.68
135_K198_R0.5870.68
156_K189_F0.5860.68
100_I147_Y0.5830.68
174_T204_S0.5770.67
142_F195_N0.5770.67
14_H18_W0.5760.67
144_P168_D0.5740.67
53_V180_K0.5720.66
38_N60_T0.5720.66
170_P194_R0.5660.66
101_L174_T0.5640.65
43_R83_N0.5630.65
26_A179_A0.5630.65
12_V26_A0.5610.65
129_E132_G0.5600.65
8_V118_S0.5600.65
86_K126_T0.5590.65
14_H20_S0.5590.65
133_K163_S0.5570.64
93_L114_F0.5540.64
42_S81_F0.5530.64
68_M80_D0.5510.64
92_V127_E0.5510.64
137_V198_R0.5500.63
136_R139_T0.5490.63
149_N202_A0.5470.63
71_D76_G0.5440.63
121_L139_T0.5440.63
10_I108_K0.5430.62
127_E131_L0.5420.62
118_S185_S0.5400.62
43_R157_V0.5390.62
103_N189_F0.5390.62
114_F124_I0.5370.62
128_I132_G0.5360.61
165_G190_L0.5340.61
25_T124_I0.5330.61
173_A189_F0.5330.61
15_E20_S0.5310.61
153_W171_R0.5260.60
49_M117_S0.5250.60
46_I57_L0.5230.60
98_V101_L0.5210.59
45_L101_L0.5170.59
102_G182_L0.5160.59
61_H130_S0.5160.59
158_L197_Q0.5140.58
40_L191_Y0.5130.58
162_Y201_I0.5130.58
13_S199_K0.5090.58
155_K203_F0.5080.57
55_S59_K0.5080.57
114_F117_S0.5060.57
47_D53_V0.5050.57
118_S139_T0.5050.57
111_K179_A0.5040.57
30_N45_L0.5040.57
51_N144_P0.5030.57
74_K124_I0.5010.56
110_E113_S0.5010.56
75_G80_D0.5000.56
37_K52_K0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wszA 2 0.2762 97.7 0.837 Contact Map
1je8A 2 0.281 97.7 0.837 Contact Map
1s7oA 3 0.3429 97.6 0.84 Contact Map
3c57A 2 0.2429 97.5 0.841 Contact Map
1ku3A 1 0.2857 97.5 0.842 Contact Map
1fseA 2 0.2857 97.5 0.842 Contact Map
2o8xA 7 0.2905 97.3 0.847 Contact Map
1xsvA 2 0.3381 97.3 0.847 Contact Map
4g6dA 1 0.2952 97.3 0.848 Contact Map
1x3uA 1 0.3286 97.2 0.85 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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