Q97WQ8 - SULSO - GREMLIN Contacts

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Q97WQ8 - Acyl-CoA dehydrogenase (Acd-3)

UniProt:	Q97WQ8	Sequences: MSEKELFIQSLREFLNRDVEKIVNKIDKEDYYPRDLVRKLGELGFLIPLTSGLSNYDMMIILEEIAKVSGSLALIADAQGELAGEMIRLYANERQKKEFMEPLSKGEIIGSFALTEPSGGSDIGSMKTLAEKRNGSWIIKGHKMWITQGLYADVFITVAKTGSSRRDLSVFIVPRSNCVETRKIEVMGNRGTGTAEVIFHNCEVSNDYVVGEVNNGWNMVNSVLEIGRLAISGIAIGLAEAALEEAFKWAKSRFAFGNSIYDFQGIRWYFADAIAKLNAVKSMAKDVSSKFDENSKDKGVYVSMLKLLSANIANEVIDISLQVFGGMGYAKGTNIERIYRDARLLRIGEGTDEVQRHIIAKYIEQYGIPYI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	371 (356)
Sequences:	33720 (18982)
Seq/√Len:	1006.0

ECOLI - CAIA YDIO AIDB FADE
BACSU - FADE ACDC ACDA ACDB YDBM
HALSA - Q9HS75 Q9HRI6 Q9HPT2 Q9HRB3 Q9HQF0 Q9HMK7
SULSO - Q97WQ8 Q97U78 Q97V73 Q97UW6 Q97XW3 Q97VU6 Q97YZ6 Q97VV8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
136_S	203_E	4.218	1.00
276_K	315_E	3.457	1.00
140_K	201_N	3.348	1.00
18_D	39_K	3.213	1.00
132_K	206_N	3.170	1.00
102_P	107_E	3.042	1.00
102_P	108_I	2.901	1.00
180_E	200_H	2.880	1.00
93_E	97_K	2.784	1.00
25_K	29_E	2.677	1.00
269_Y	319_I	2.674	1.00
133_R	203_E	2.658	1.00
142_H	198_I	2.499	1.00
12_R	64_E	2.373	1.00
240_E	281_K	2.283	1.00
248_K	252_S	2.261	1.00
289_S	293_E	2.211	1.00
133_R	138_I	2.125	1.00
215_N	218_N	2.107	1.00
169_S	209_V	2.055	1.00
142_H	196_E	2.043	1.00
13_E	17_R	1.985	1.00
212_E	215_N	1.969	1.00
243_L	277_L	1.935	1.00
331_K	336_E	1.925	1.00
39_K	42_E	1.924	1.00
265_G	268_W	1.891	1.00
259_S	262_D	1.883	1.00
155_F	175_R	1.870	1.00
93_E	96_K	1.845	1.00
159_A	171_F	1.838	1.00
245_E	334_N	1.814	1.00
336_E	340_R	1.803	1.00
180_E	198_I	1.796	1.00
254_F	259_S	1.794	1.00
290_K	301_Y	1.790	1.00
111_S	155_F	1.769	1.00
48_P	88_R	1.764	1.00
38_R	42_E	1.763	1.00
286_D	290_K	1.760	1.00
92_N	95_Q	1.758	1.00
250_A	323_V	1.737	1.00
138_I	201_N	1.726	1.00
280_V	309_S	1.724	1.00
133_R	136_S	1.715	1.00
67_K	244_E	1.698	1.00
49_L	55_N	1.687	1.00
311_N	352_D	1.677	1.00
63_E	281_K	1.676	1.00
315_E	319_I	1.675	1.00
258_N	262_D	1.673	1.00
137_W	171_F	1.646	1.00
34_R	38_R	1.645	1.00
138_I	203_E	1.637	1.00
131_E	140_K	1.632	1.00
314_N	346_R	1.625	1.00
64_E	67_K	1.625	1.00
98_E	102_P	1.616	1.00
98_E	207_D	1.616	1.00
97_K	101_E	1.611	1.00
149_G	195_A	1.584	1.00
174_P	208_Y	1.580	1.00
150_L	195_A	1.571	1.00
240_E	244_E	1.558	1.00
242_A	317_I	1.554	1.00
6_L	10_S	1.543	1.00
132_K	213_V	1.538	1.00
205_S	208_Y	1.538	1.00
279_A	308_L	1.533	1.00
327_M	333_T	1.519	1.00
273_A	316_V	1.517	1.00
245_E	248_K	1.510	1.00
247_F	251_K	1.508	1.00
241_A	245_E	1.506	1.00
9_Q	13_E	1.502	1.00
250_A	266_I	1.494	1.00
90_Y	222_S	1.480	1.00
101_E	105_K	1.475	1.00
132_K	136_S	1.465	1.00
140_K	200_H	1.451	1.00
94_R	98_E	1.445	1.00
246_A	320_S	1.428	1.00
15_L	68_V	1.418	1.00
209_V	213_V	1.404	1.00
239_A	277_L	1.403	1.00
206_N	209_V	1.397	1.00
278_N	286_D	1.396	1.00
102_P	105_K	1.395	1.00
67_K	240_E	1.390	1.00
266_I	323_V	1.389	1.00
38_R	41_G	1.388	1.00
118_S	127_K	1.385	1.00
273_A	319_I	1.368	1.00
6_L	9_Q	1.365	1.00
255_A	263_F	1.362	1.00
135_G	206_N	1.360	1.00
274_I	278_N	1.345	1.00
318_D	343_R	1.341	1.00
182_R	196_E	1.338	1.00
136_S	206_N	1.337	1.00
239_A	316_V	1.334	1.00
39_K	43_L	1.320	1.00
108_I	153_D	1.310	1.00
276_K	312_I	1.306	1.00
286_D	289_S	1.301	1.00
63_E	240_E	1.299	1.00
314_N	318_D	1.292	1.00
258_N	263_F	1.287	1.00
185_E	331_K	1.281	1.00
8_I	64_E	1.278	1.00
22_I	26_I	1.275	1.00
204_V	208_Y	1.273	1.00
113_A	146_I	1.271	1.00
290_K	295_S	1.269	1.00
175_R	181_T	1.267	1.00
116_E	143_K	1.264	1.00
245_E	324_F	1.264	1.00
51_S	96_K	1.260	1.00
132_K	137_W	1.260	1.00
313_A	342_A	1.260	1.00
11_L	45_F	1.259	1.00
94_R	207_D	1.251	1.00
137_W	206_N	1.241	1.00
182_R	185_E	1.241	1.00
59_M	288_S	1.240	1.00
272_D	356_R	1.239	1.00
131_E	138_I	1.236	1.00
158_V	170_V	1.231	1.00
243_L	247_F	1.227	1.00
10_S	43_L	1.223	1.00
276_K	319_I	1.222	1.00
98_E	208_Y	1.204	1.00
161_T	169_S	1.202	1.00
115_T	145_W	1.202	1.00
130_A	171_F	1.198	1.00
103_L	110_G	1.196	1.00
225_E	299_G	1.195	1.00
307_L	352_D	1.195	1.00
8_I	60_I	1.190	1.00
99_F	154_V	1.182	1.00
24_N	28_K	1.182	1.00
41_G	46_L	1.180	1.00
280_V	312_I	1.169	1.00
69_S	72_L	1.167	1.00
157_T	173_V	1.164	1.00
110_G	154_V	1.159	1.00
318_D	346_R	1.154	1.00
63_E	285_K	1.150	1.00
282_S	286_D	1.147	1.00
22_I	25_K	1.146	1.00
320_S	335_I	1.145	1.00
241_A	338_I	1.142	1.00
96_K	100_M	1.142	1.00
89_L	222_S	1.141	1.00
113_A	155_F	1.132	1.00
26_I	191_G	1.128	1.00
139_I	171_F	1.122	1.00
277_L	316_V	1.117	1.00
311_N	315_E	1.114	1.00
233_G	284_A	1.113	1.00
175_R	179_V	1.110	1.00
251_K	261_Y	1.107	1.00
312_I	315_E	1.095	1.00
269_Y	353_E	1.093	1.00
47_I	104_S	1.090	1.00
130_A	159_A	1.088	1.00
250_A	261_Y	1.087	1.00
59_M	233_G	1.079	1.00
272_D	276_K	1.073	1.00
314_N	339_Y	1.073	1.00
343_R	346_R	1.066	1.00
38_R	107_E	1.066	1.00
95_Q	99_F	1.061	1.00
179_V	202_C	1.060	1.00
94_R	97_K	1.058	1.00
303_S	355_Q	1.058	1.00
158_V	168_L	1.056	1.00
35_D	38_R	1.056	1.00
113_A	199_F	1.055	1.00
217_W	221_N	1.053	1.00
12_R	16_N	1.053	1.00
129_L	140_K	1.051	1.00
307_L	356_R	1.046	1.00
317_I	342_A	1.044	1.00
90_Y	219_M	1.042	1.00
272_D	319_I	1.038	1.00
236_I	277_L	1.032	1.00
35_D	39_K	1.031	1.00
14_F	39_K	1.027	1.00
247_F	270_F	1.027	1.00
10_S	45_F	1.026	1.00
122_D	125_S	1.026	1.00
83_A	110_G	1.023	1.00
155_F	179_V	1.023	1.00
321_L	339_Y	1.020	1.00
50_T	97_K	1.014	1.00
157_T	199_F	1.010	1.00
144_M	196_E	1.008	1.00
235_A	345_L	1.006	1.00
154_V	174_P	1.002	1.00
135_G	203_E	1.000	1.00
131_E	201_N	0.994	1.00
128_T	139_I	0.993	1.00
108_I	154_V	0.993	1.00
178_C	202_C	0.991	1.00
182_R	198_I	0.988	1.00
227_G	349_E	0.987	1.00
137_W	161_T	0.984	1.00
287_V	305_L	0.982	1.00
91_A	95_Q	0.970	1.00
47_I	84_G	0.969	1.00
98_E	174_P	0.969	1.00
346_R	352_D	0.949	1.00
66_A	73_A	0.941	1.00
171_F	209_V	0.939	1.00
156_I	170_V	0.939	1.00
11_L	15_L	0.939	1.00
177_N	203_E	0.938	1.00
300_V	362_Y	0.937	1.00
238_L	313_A	0.935	1.00
34_R	151_Y	0.934	1.00
268_W	272_D	0.932	1.00
276_K	308_L	0.932	1.00
10_S	13_E	0.926	1.00
236_I	284_A	0.925	1.00
274_I	304_M	0.924	1.00
187_M	339_Y	0.922	1.00
203_E	206_N	0.912	1.00
14_F	43_L	0.912	1.00
95_Q	208_Y	0.912	1.00
137_W	213_V	0.909	1.00
11_L	61_I	0.909	1.00
139_I	204_V	0.909	1.00
318_D	339_Y	0.906	1.00
136_S	205_S	0.906	1.00
236_I	280_V	0.901	1.00
50_T	93_E	0.901	1.00
160_K	168_L	0.899	1.00
181_T	197_V	0.898	1.00
60_I	285_K	0.895	1.00
242_A	338_I	0.895	1.00
16_N	20_E	0.891	1.00
311_N	356_R	0.891	1.00
308_L	312_I	0.891	1.00
238_L	338_I	0.882	1.00
315_E	318_D	0.880	1.00
275_A	304_M	0.875	1.00
155_F	197_V	0.874	1.00
8_I	12_R	0.873	1.00
190_R	331_K	0.870	1.00
153_D	176_S	0.869	1.00
250_A	270_F	0.867	1.00
47_I	51_S	0.864	1.00
83_A	156_I	0.863	1.00
250_A	260_I	0.863	1.00
244_E	248_K	0.862	1.00
243_L	274_I	0.861	1.00
169_S	213_V	0.860	1.00
267_R	357_H	0.859	1.00
139_I	157_T	0.857	1.00
139_I	159_A	0.857	1.00
345_L	348_G	0.852	1.00
95_Q	172_I	0.850	1.00
283_M	305_L	0.850	1.00
272_D	315_E	0.848	1.00
15_L	65_I	0.847	1.00
28_K	331_K	0.847	1.00
179_V	197_V	0.846	1.00
71_S	191_G	0.845	1.00
339_Y	343_R	0.843	1.00
22_I	35_D	0.842	1.00
310_A	352_D	0.835	1.00
298_K	301_Y	0.835	1.00
15_L	19_V	0.832	1.00
268_W	357_H	0.831	1.00
344_L	348_G	0.830	1.00
269_Y	272_D	0.830	1.00
57_D	292_D	0.829	1.00
317_I	338_I	0.827	1.00
199_F	202_C	0.823	1.00
16_N	68_V	0.821	1.00
60_I	64_E	0.817	1.00
189_N	344_L	0.815	1.00
153_D	175_R	0.813	1.00
145_W	330_A	0.813	1.00
154_V	172_I	0.810	1.00
242_A	320_S	0.810	1.00
314_N	343_R	0.810	1.00
246_A	323_V	0.809	1.00
187_M	336_E	0.809	1.00
245_E	338_I	0.804	1.00
269_Y	322_Q	0.804	1.00
278_N	281_K	0.803	1.00
239_A	312_I	0.802	1.00
232_S	305_L	0.795	1.00
352_D	356_R	0.795	1.00
248_K	251_K	0.791	1.00
51_S	93_E	0.791	1.00
275_A	307_L	0.787	1.00
84_G	103_L	0.784	1.00
27_D	340_R	0.783	1.00
111_S	152_A	0.781	1.00
13_E	16_N	0.780	1.00
137_W	209_V	0.778	1.00
25_K	28_K	0.778	1.00
249_W	327_M	0.775	1.00
16_N	67_K	0.774	1.00
171_F	204_V	0.773	1.00
246_A	324_F	0.773	1.00
130_A	161_T	0.771	1.00
286_D	301_Y	0.770	1.00
231_I	349_E	0.770	1.00
273_A	320_S	0.768	1.00
126_M	158_V	0.768	1.00
150_L	193_G	0.767	1.00
130_A	137_W	0.766	1.00
92_N	96_K	0.764	1.00
275_A	308_L	0.761	1.00
145_W	327_M	0.760	1.00
149_G	181_T	0.758	1.00
278_N	282_S	0.757	1.00
26_I	31_Y	0.752	1.00
14_F	18_D	0.752	1.00
114_L	224_L	0.750	1.00
311_N	346_R	0.750	1.00
276_K	279_A	0.742	1.00
129_L	163_S	0.735	1.00
209_V	212_E	0.735	1.00
243_L	363_I	0.734	1.00
134_N	203_E	0.733	1.00
36_L	72_L	0.731	1.00
269_Y	323_V	0.730	1.00
99_F	208_Y	0.729	1.00
232_S	284_A	0.727	1.00
162_G	167_D	0.726	1.00
317_I	339_Y	0.723	1.00
264_Q	268_W	0.723	1.00
160_K	167_D	0.722	1.00
241_A	244_E	0.720	1.00
283_M	304_M	0.718	1.00
28_K	185_E	0.715	1.00
60_I	63_E	0.714	1.00
281_K	285_K	0.714	1.00
20_E	23_V	0.710	1.00
240_E	277_L	0.709	1.00
288_S	292_D	0.707	1.00
279_A	283_M	0.707	1.00
267_R	360_A	0.706	1.00
215_N	219_M	0.705	1.00
240_E	274_I	0.705	1.00
113_A	157_T	0.703	1.00
324_F	335_I	0.702	1.00
48_P	51_S	0.701	1.00
321_L	335_I	0.701	1.00
232_S	309_S	0.700	1.00
188_G	341_D	0.698	1.00
173_V	199_F	0.698	1.00
34_R	153_D	0.697	1.00
235_A	310_A	0.696	1.00
131_E	162_G	0.693	1.00
113_A	197_V	0.693	1.00
263_F	267_R	0.691	1.00
24_N	334_N	0.690	1.00
276_K	311_N	0.690	1.00
357_H	361_K	0.689	1.00
85_E	89_L	0.689	1.00
50_T	55_N	0.688	1.00
246_A	250_A	0.688	1.00
30_D	190_R	0.688	1.00
260_I	263_F	0.684	1.00
239_A	280_V	0.683	1.00
12_R	67_K	0.683	1.00
146_I	197_V	0.679	1.00
14_F	40_L	0.676	1.00
91_A	96_K	0.676	1.00
86_M	223_V	0.676	1.00
150_L	183_K	0.676	1.00
151_Y	193_G	0.676	1.00
181_T	195_A	0.672	1.00
312_I	316_V	0.670	1.00
126_M	168_L	0.667	1.00
24_N	337_R	0.665	1.00
218_N	222_S	0.665	1.00
321_L	328_G	0.663	1.00
355_Q	358_I	0.663	1.00
98_E	101_E	0.662	1.00
162_G	214_N	0.661	1.00
280_V	308_L	0.660	1.00
67_K	241_A	0.659	1.00
136_S	207_D	0.658	1.00
121_S	354_V	0.657	1.00
241_A	334_N	0.657	1.00
99_F	172_I	0.657	1.00
176_S	179_V	0.656	1.00
50_T	53_L	0.656	1.00
19_V	36_L	0.655	1.00
186_V	194_T	0.654	1.00
284_A	309_S	0.653	1.00
50_T	96_K	0.653	1.00
314_N	342_A	0.653	1.00
337_R	341_D	0.652	1.00
117_P	142_H	0.652	1.00
135_G	207_D	0.651	1.00
238_L	342_A	0.650	1.00
161_T	213_V	0.650	1.00
283_M	308_L	0.649	1.00
88_R	96_K	0.644	1.00
158_V	220_V	0.643	1.00
27_D	190_R	0.642	1.00
184_I	196_E	0.641	1.00
40_L	45_F	0.641	1.00
116_E	128_T	0.639	1.00
128_T	141_G	0.639	1.00
8_I	63_E	0.637	1.00
160_K	165_R	0.636	1.00
111_S	175_R	0.633	1.00
160_K	163_S	0.629	1.00
272_D	311_N	0.628	1.00
48_P	53_L	0.628	1.00
17_R	21_K	0.628	1.00
85_E	88_R	0.627	1.00
278_N	283_M	0.624	1.00
128_T	143_K	0.623	1.00
169_S	214_N	0.623	1.00
334_N	338_I	0.623	1.00
31_Y	34_R	0.623	1.00
225_E	302_V	0.621	1.00
128_T	157_T	0.619	1.00
274_I	363_I	0.618	1.00
351_T	354_V	0.617	1.00
58_M	230_A	0.616	1.00
34_R	109_I	0.615	1.00
119_G	127_K	0.611	1.00
161_T	167_D	0.611	1.00
179_V	199_F	0.610	1.00
239_A	313_A	0.608	1.00
226_I	291_F	0.607	1.00
334_N	337_R	0.606	1.00
18_D	21_K	0.606	1.00
275_A	279_A	0.606	1.00
114_L	158_V	0.605	1.00
28_K	31_Y	0.603	1.00
246_A	273_A	0.603	1.00
154_V	208_Y	0.600	1.00
260_I	266_I	0.600	1.00
255_A	260_I	0.598	1.00
236_I	240_E	0.597	1.00
99_F	108_I	0.596	1.00
189_N	348_G	0.595	1.00
297_D	301_Y	0.594	1.00
49_L	52_G	0.593	1.00
103_L	154_V	0.593	1.00
40_L	72_L	0.591	1.00
283_M	287_V	0.591	1.00
36_L	39_K	0.590	1.00
86_M	90_Y	0.589	1.00
266_I	269_Y	0.588	1.00
290_K	293_E	0.587	1.00
313_A	317_I	0.585	1.00
173_V	202_C	0.581	1.00
265_G	269_Y	0.581	1.00
239_A	242_A	0.580	1.00
206_N	213_V	0.578	1.00
317_I	335_I	0.576	1.00
112_F	220_V	0.574	1.00
25_K	31_Y	0.571	1.00
139_I	173_V	0.569	1.00
156_I	210_V	0.567	1.00
266_I	270_F	0.565	1.00
10_S	54_S	0.561	1.00
12_R	68_V	0.560	1.00
263_F	266_I	0.557	1.00
58_M	81_E	0.557	1.00
229_L	284_A	0.555	1.00
279_A	282_S	0.553	1.00
133_R	206_N	0.553	1.00
278_N	304_M	0.553	1.00
256_F	263_F	0.550	1.00
291_F	298_K	0.550	1.00
132_K	135_G	0.549	1.00
294_N	297_D	0.548	1.00
229_L	288_S	0.548	1.00
304_M	359_I	0.546	1.00
243_L	273_A	0.542	1.00
128_T	199_F	0.540	1.00
149_G	197_V	0.540	1.00
126_M	160_K	0.539	1.00
310_A	345_L	0.539	1.00
276_K	280_V	0.538	1.00
229_L	291_F	0.538	1.00
83_A	86_M	0.537	1.00
128_T	159_A	0.536	1.00
299_G	362_Y	0.535	1.00
327_M	330_A	0.533	1.00
233_G	237_G	0.533	1.00
322_Q	343_R	0.533	1.00
114_L	123_I	0.529	1.00
183_K	196_E	0.528	1.00
48_P	55_N	0.528	1.00
95_Q	98_E	0.525	1.00
307_L	311_N	0.525	1.00
22_I	36_L	0.525	1.00
150_L	181_T	0.523	1.00
224_L	227_G	0.523	1.00
58_M	62_L	0.522	1.00
109_I	151_Y	0.522	1.00
62_L	66_A	0.521	1.00
34_R	37_V	0.520	1.00
70_G	238_L	0.519	1.00
20_E	241_A	0.519	1.00
295_S	298_K	0.518	1.00
51_S	97_K	0.518	1.00
254_F	262_D	0.517	1.00
161_T	171_F	0.517	1.00
40_L	76_A	0.517	1.00
49_L	54_S	0.517	1.00
159_A	169_S	0.516	1.00
84_G	100_M	0.516	1.00
37_V	75_I	0.516	1.00
89_L	226_I	0.514	1.00
280_V	316_V	0.514	1.00
111_S	146_I	0.512	1.00
74_L	189_N	0.512	1.00
7_F	11_L	0.511	1.00
249_W	252_S	0.511	1.00
79_Q	103_L	0.510	1.00
129_L	162_G	0.507	1.00
157_T	202_C	0.507	1.00
30_D	331_K	0.506	1.00
59_M	285_K	0.506	1.00
276_K	316_V	0.504	1.00
59_M	284_A	0.502	1.00
132_K	138_I	0.501	1.00
224_L	228_R	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4l1fA	4	0.9838	100	0.146	Contact Map
2z1qA	2	0.9811	100	0.149	Contact Map
2jifA	4	0.9838	100	0.149	Contact Map
3owaA	3	0.9919	100	0.15	Contact Map
3p4tA	4	0.9892	100	0.151	Contact Map
1ivhA	4	0.9838	100	0.151	Contact Map
2d29A	4	0.9865	100	0.152	Contact Map
3pfdA	4	0.9704	100	0.152	Contact Map
3r7kA	4	0.9811	100	0.154	Contact Map
4rm7A	4	0.9596	100	0.155	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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