GREMLIN Database
Q97WQ8 - Acyl-CoA dehydrogenase (Acd-3)
UniProt: Q97WQ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 371 (356)
Sequences: 33720 (18982)
Seq/√Len: 1006.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_S203_E4.2181.00
276_K315_E3.4571.00
140_K201_N3.3481.00
18_D39_K3.2131.00
132_K206_N3.1701.00
102_P107_E3.0421.00
102_P108_I2.9011.00
180_E200_H2.8801.00
93_E97_K2.7841.00
25_K29_E2.6771.00
269_Y319_I2.6741.00
133_R203_E2.6581.00
142_H198_I2.4991.00
12_R64_E2.3731.00
240_E281_K2.2831.00
248_K252_S2.2611.00
289_S293_E2.2111.00
133_R138_I2.1251.00
215_N218_N2.1071.00
169_S209_V2.0551.00
142_H196_E2.0431.00
13_E17_R1.9851.00
212_E215_N1.9691.00
243_L277_L1.9351.00
331_K336_E1.9251.00
39_K42_E1.9241.00
265_G268_W1.8911.00
259_S262_D1.8831.00
155_F175_R1.8701.00
93_E96_K1.8451.00
159_A171_F1.8381.00
245_E334_N1.8141.00
336_E340_R1.8031.00
180_E198_I1.7961.00
254_F259_S1.7941.00
290_K301_Y1.7901.00
111_S155_F1.7691.00
48_P88_R1.7641.00
38_R42_E1.7631.00
286_D290_K1.7601.00
92_N95_Q1.7581.00
250_A323_V1.7371.00
138_I201_N1.7261.00
280_V309_S1.7241.00
133_R136_S1.7151.00
67_K244_E1.6981.00
49_L55_N1.6871.00
311_N352_D1.6771.00
63_E281_K1.6761.00
315_E319_I1.6751.00
258_N262_D1.6731.00
137_W171_F1.6461.00
34_R38_R1.6451.00
138_I203_E1.6371.00
131_E140_K1.6321.00
314_N346_R1.6251.00
64_E67_K1.6251.00
98_E102_P1.6161.00
98_E207_D1.6161.00
97_K101_E1.6111.00
149_G195_A1.5841.00
174_P208_Y1.5801.00
150_L195_A1.5711.00
240_E244_E1.5581.00
242_A317_I1.5541.00
6_L10_S1.5431.00
132_K213_V1.5381.00
205_S208_Y1.5381.00
279_A308_L1.5331.00
327_M333_T1.5191.00
273_A316_V1.5171.00
245_E248_K1.5101.00
247_F251_K1.5081.00
241_A245_E1.5061.00
9_Q13_E1.5021.00
250_A266_I1.4941.00
90_Y222_S1.4801.00
101_E105_K1.4751.00
132_K136_S1.4651.00
140_K200_H1.4511.00
94_R98_E1.4451.00
246_A320_S1.4281.00
15_L68_V1.4181.00
209_V213_V1.4041.00
239_A277_L1.4031.00
206_N209_V1.3971.00
278_N286_D1.3961.00
102_P105_K1.3951.00
67_K240_E1.3901.00
266_I323_V1.3891.00
38_R41_G1.3881.00
118_S127_K1.3851.00
273_A319_I1.3681.00
6_L9_Q1.3651.00
255_A263_F1.3621.00
135_G206_N1.3601.00
274_I278_N1.3451.00
318_D343_R1.3411.00
182_R196_E1.3381.00
136_S206_N1.3371.00
239_A316_V1.3341.00
39_K43_L1.3201.00
108_I153_D1.3101.00
276_K312_I1.3061.00
286_D289_S1.3011.00
63_E240_E1.2991.00
314_N318_D1.2921.00
258_N263_F1.2871.00
185_E331_K1.2811.00
8_I64_E1.2781.00
22_I26_I1.2751.00
204_V208_Y1.2731.00
113_A146_I1.2711.00
290_K295_S1.2691.00
175_R181_T1.2671.00
116_E143_K1.2641.00
245_E324_F1.2641.00
51_S96_K1.2601.00
132_K137_W1.2601.00
313_A342_A1.2601.00
11_L45_F1.2591.00
94_R207_D1.2511.00
137_W206_N1.2411.00
182_R185_E1.2411.00
59_M288_S1.2401.00
272_D356_R1.2391.00
131_E138_I1.2361.00
158_V170_V1.2311.00
243_L247_F1.2271.00
10_S43_L1.2231.00
276_K319_I1.2221.00
98_E208_Y1.2041.00
161_T169_S1.2021.00
115_T145_W1.2021.00
130_A171_F1.1981.00
103_L110_G1.1961.00
225_E299_G1.1951.00
307_L352_D1.1951.00
8_I60_I1.1901.00
99_F154_V1.1821.00
24_N28_K1.1821.00
41_G46_L1.1801.00
280_V312_I1.1691.00
69_S72_L1.1671.00
157_T173_V1.1641.00
110_G154_V1.1591.00
318_D346_R1.1541.00
63_E285_K1.1501.00
282_S286_D1.1471.00
22_I25_K1.1461.00
320_S335_I1.1451.00
241_A338_I1.1421.00
96_K100_M1.1421.00
89_L222_S1.1411.00
113_A155_F1.1321.00
26_I191_G1.1281.00
139_I171_F1.1221.00
277_L316_V1.1171.00
311_N315_E1.1141.00
233_G284_A1.1131.00
175_R179_V1.1101.00
251_K261_Y1.1071.00
312_I315_E1.0951.00
269_Y353_E1.0931.00
47_I104_S1.0901.00
130_A159_A1.0881.00
250_A261_Y1.0871.00
59_M233_G1.0791.00
272_D276_K1.0731.00
314_N339_Y1.0731.00
343_R346_R1.0661.00
38_R107_E1.0661.00
95_Q99_F1.0611.00
179_V202_C1.0601.00
94_R97_K1.0581.00
303_S355_Q1.0581.00
158_V168_L1.0561.00
35_D38_R1.0561.00
113_A199_F1.0551.00
217_W221_N1.0531.00
12_R16_N1.0531.00
129_L140_K1.0511.00
307_L356_R1.0461.00
317_I342_A1.0441.00
90_Y219_M1.0421.00
272_D319_I1.0381.00
236_I277_L1.0321.00
35_D39_K1.0311.00
14_F39_K1.0271.00
247_F270_F1.0271.00
10_S45_F1.0261.00
122_D125_S1.0261.00
83_A110_G1.0231.00
155_F179_V1.0231.00
321_L339_Y1.0201.00
50_T97_K1.0141.00
157_T199_F1.0101.00
144_M196_E1.0081.00
235_A345_L1.0061.00
154_V174_P1.0021.00
135_G203_E1.0001.00
131_E201_N0.9941.00
128_T139_I0.9931.00
108_I154_V0.9931.00
178_C202_C0.9911.00
182_R198_I0.9881.00
227_G349_E0.9871.00
137_W161_T0.9841.00
287_V305_L0.9821.00
91_A95_Q0.9701.00
47_I84_G0.9691.00
98_E174_P0.9691.00
346_R352_D0.9491.00
66_A73_A0.9411.00
171_F209_V0.9391.00
156_I170_V0.9391.00
11_L15_L0.9391.00
177_N203_E0.9381.00
300_V362_Y0.9371.00
238_L313_A0.9351.00
34_R151_Y0.9341.00
268_W272_D0.9321.00
276_K308_L0.9321.00
10_S13_E0.9261.00
236_I284_A0.9251.00
274_I304_M0.9241.00
187_M339_Y0.9221.00
203_E206_N0.9121.00
14_F43_L0.9121.00
95_Q208_Y0.9121.00
137_W213_V0.9091.00
11_L61_I0.9091.00
139_I204_V0.9091.00
318_D339_Y0.9061.00
136_S205_S0.9061.00
236_I280_V0.9011.00
50_T93_E0.9011.00
160_K168_L0.8991.00
181_T197_V0.8981.00
60_I285_K0.8951.00
242_A338_I0.8951.00
16_N20_E0.8911.00
311_N356_R0.8911.00
308_L312_I0.8911.00
238_L338_I0.8821.00
315_E318_D0.8801.00
275_A304_M0.8751.00
155_F197_V0.8741.00
8_I12_R0.8731.00
190_R331_K0.8701.00
153_D176_S0.8691.00
250_A270_F0.8671.00
47_I51_S0.8641.00
83_A156_I0.8631.00
250_A260_I0.8631.00
244_E248_K0.8621.00
243_L274_I0.8611.00
169_S213_V0.8601.00
267_R357_H0.8591.00
139_I157_T0.8571.00
139_I159_A0.8571.00
345_L348_G0.8521.00
95_Q172_I0.8501.00
283_M305_L0.8501.00
272_D315_E0.8481.00
15_L65_I0.8471.00
28_K331_K0.8471.00
179_V197_V0.8461.00
71_S191_G0.8451.00
339_Y343_R0.8431.00
22_I35_D0.8421.00
310_A352_D0.8351.00
298_K301_Y0.8351.00
15_L19_V0.8321.00
268_W357_H0.8311.00
344_L348_G0.8301.00
269_Y272_D0.8301.00
57_D292_D0.8291.00
317_I338_I0.8271.00
199_F202_C0.8231.00
16_N68_V0.8211.00
60_I64_E0.8171.00
189_N344_L0.8151.00
153_D175_R0.8131.00
145_W330_A0.8131.00
154_V172_I0.8101.00
242_A320_S0.8101.00
314_N343_R0.8101.00
246_A323_V0.8091.00
187_M336_E0.8091.00
245_E338_I0.8041.00
269_Y322_Q0.8041.00
278_N281_K0.8031.00
239_A312_I0.8021.00
232_S305_L0.7951.00
352_D356_R0.7951.00
248_K251_K0.7911.00
51_S93_E0.7911.00
275_A307_L0.7871.00
84_G103_L0.7841.00
27_D340_R0.7831.00
111_S152_A0.7811.00
13_E16_N0.7801.00
137_W209_V0.7781.00
25_K28_K0.7781.00
249_W327_M0.7751.00
16_N67_K0.7741.00
171_F204_V0.7731.00
246_A324_F0.7731.00
130_A161_T0.7711.00
286_D301_Y0.7701.00
231_I349_E0.7701.00
273_A320_S0.7681.00
126_M158_V0.7681.00
150_L193_G0.7671.00
130_A137_W0.7661.00
92_N96_K0.7641.00
275_A308_L0.7611.00
145_W327_M0.7601.00
149_G181_T0.7581.00
278_N282_S0.7571.00
26_I31_Y0.7521.00
14_F18_D0.7521.00
114_L224_L0.7501.00
311_N346_R0.7501.00
276_K279_A0.7421.00
129_L163_S0.7351.00
209_V212_E0.7351.00
243_L363_I0.7341.00
134_N203_E0.7331.00
36_L72_L0.7311.00
269_Y323_V0.7301.00
99_F208_Y0.7291.00
232_S284_A0.7271.00
162_G167_D0.7261.00
317_I339_Y0.7231.00
264_Q268_W0.7231.00
160_K167_D0.7221.00
241_A244_E0.7201.00
283_M304_M0.7181.00
28_K185_E0.7151.00
60_I63_E0.7141.00
281_K285_K0.7141.00
20_E23_V0.7101.00
240_E277_L0.7091.00
288_S292_D0.7071.00
279_A283_M0.7071.00
267_R360_A0.7061.00
215_N219_M0.7051.00
240_E274_I0.7051.00
113_A157_T0.7031.00
324_F335_I0.7021.00
48_P51_S0.7011.00
321_L335_I0.7011.00
232_S309_S0.7001.00
188_G341_D0.6981.00
173_V199_F0.6981.00
34_R153_D0.6971.00
235_A310_A0.6961.00
131_E162_G0.6931.00
113_A197_V0.6931.00
263_F267_R0.6911.00
24_N334_N0.6901.00
276_K311_N0.6901.00
357_H361_K0.6891.00
85_E89_L0.6891.00
50_T55_N0.6881.00
246_A250_A0.6881.00
30_D190_R0.6881.00
260_I263_F0.6841.00
239_A280_V0.6831.00
12_R67_K0.6831.00
146_I197_V0.6791.00
14_F40_L0.6761.00
91_A96_K0.6761.00
86_M223_V0.6761.00
150_L183_K0.6761.00
151_Y193_G0.6761.00
181_T195_A0.6721.00
312_I316_V0.6701.00
126_M168_L0.6671.00
24_N337_R0.6651.00
218_N222_S0.6651.00
321_L328_G0.6631.00
355_Q358_I0.6631.00
98_E101_E0.6621.00
162_G214_N0.6611.00
280_V308_L0.6601.00
67_K241_A0.6591.00
136_S207_D0.6581.00
121_S354_V0.6571.00
241_A334_N0.6571.00
99_F172_I0.6571.00
176_S179_V0.6561.00
50_T53_L0.6561.00
19_V36_L0.6551.00
186_V194_T0.6541.00
284_A309_S0.6531.00
50_T96_K0.6531.00
314_N342_A0.6531.00
337_R341_D0.6521.00
117_P142_H0.6521.00
135_G207_D0.6511.00
238_L342_A0.6501.00
161_T213_V0.6501.00
283_M308_L0.6491.00
88_R96_K0.6441.00
158_V220_V0.6431.00
27_D190_R0.6421.00
184_I196_E0.6411.00
40_L45_F0.6411.00
116_E128_T0.6391.00
128_T141_G0.6391.00
8_I63_E0.6371.00
160_K165_R0.6361.00
111_S175_R0.6331.00
160_K163_S0.6291.00
272_D311_N0.6281.00
48_P53_L0.6281.00
17_R21_K0.6281.00
85_E88_R0.6271.00
278_N283_M0.6241.00
128_T143_K0.6231.00
169_S214_N0.6231.00
334_N338_I0.6231.00
31_Y34_R0.6231.00
225_E302_V0.6211.00
128_T157_T0.6191.00
274_I363_I0.6181.00
351_T354_V0.6171.00
58_M230_A0.6161.00
34_R109_I0.6151.00
119_G127_K0.6111.00
161_T167_D0.6111.00
179_V199_F0.6101.00
239_A313_A0.6081.00
226_I291_F0.6071.00
334_N337_R0.6061.00
18_D21_K0.6061.00
275_A279_A0.6061.00
114_L158_V0.6051.00
28_K31_Y0.6031.00
246_A273_A0.6031.00
154_V208_Y0.6001.00
260_I266_I0.6001.00
255_A260_I0.5981.00
236_I240_E0.5971.00
99_F108_I0.5961.00
189_N348_G0.5951.00
297_D301_Y0.5941.00
49_L52_G0.5931.00
103_L154_V0.5931.00
40_L72_L0.5911.00
283_M287_V0.5911.00
36_L39_K0.5901.00
86_M90_Y0.5891.00
266_I269_Y0.5881.00
290_K293_E0.5871.00
313_A317_I0.5851.00
173_V202_C0.5811.00
265_G269_Y0.5811.00
239_A242_A0.5801.00
206_N213_V0.5781.00
317_I335_I0.5761.00
112_F220_V0.5741.00
25_K31_Y0.5711.00
139_I173_V0.5691.00
156_I210_V0.5671.00
266_I270_F0.5651.00
10_S54_S0.5611.00
12_R68_V0.5601.00
263_F266_I0.5571.00
58_M81_E0.5571.00
229_L284_A0.5551.00
279_A282_S0.5531.00
133_R206_N0.5531.00
278_N304_M0.5531.00
256_F263_F0.5501.00
291_F298_K0.5501.00
132_K135_G0.5491.00
294_N297_D0.5481.00
229_L288_S0.5481.00
304_M359_I0.5461.00
243_L273_A0.5421.00
128_T199_F0.5401.00
149_G197_V0.5401.00
126_M160_K0.5391.00
310_A345_L0.5391.00
276_K280_V0.5381.00
229_L291_F0.5381.00
83_A86_M0.5371.00
128_T159_A0.5361.00
299_G362_Y0.5351.00
327_M330_A0.5331.00
233_G237_G0.5331.00
322_Q343_R0.5331.00
114_L123_I0.5291.00
183_K196_E0.5281.00
48_P55_N0.5281.00
95_Q98_E0.5251.00
307_L311_N0.5251.00
22_I36_L0.5251.00
150_L181_T0.5231.00
224_L227_G0.5231.00
58_M62_L0.5221.00
109_I151_Y0.5221.00
62_L66_A0.5211.00
34_R37_V0.5201.00
70_G238_L0.5191.00
20_E241_A0.5191.00
295_S298_K0.5181.00
51_S97_K0.5181.00
254_F262_D0.5171.00
161_T171_F0.5171.00
40_L76_A0.5171.00
49_L54_S0.5171.00
159_A169_S0.5161.00
84_G100_M0.5161.00
37_V75_I0.5161.00
89_L226_I0.5141.00
280_V316_V0.5141.00
111_S146_I0.5121.00
74_L189_N0.5121.00
7_F11_L0.5111.00
249_W252_S0.5111.00
79_Q103_L0.5101.00
129_L162_G0.5071.00
157_T202_C0.5071.00
30_D331_K0.5061.00
59_M285_K0.5061.00
276_K316_V0.5041.00
59_M284_A0.5021.00
132_K138_I0.5011.00
224_L228_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l1fA 4 0.9838 100 0.146 Contact Map
2z1qA 2 0.9811 100 0.149 Contact Map
2jifA 4 0.9838 100 0.149 Contact Map
3owaA 3 0.9919 100 0.15 Contact Map
3p4tA 4 0.9892 100 0.151 Contact Map
1ivhA 4 0.9838 100 0.151 Contact Map
2d29A 4 0.9865 100 0.152 Contact Map
3pfdA 4 0.9704 100 0.152 Contact Map
3r7kA 4 0.9811 100 0.154 Contact Map
4rm7A 4 0.9596 100 0.155 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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